17

Go, Jenicca Pamela Y.

Tablet
defect
Picking

Remedy

Produces an
overly wet
tablet bed
where adjacent
tablets can
stick together
and then break
apart.

Use optimum and

efficient drying
conditions.
Increase the inlet
air temperature.
Decrease the rater
of application of
coating solution by
increasing
viscosity of coating
solution.

Roughness It is a surface
defect
resulting in
film being
rough and
nonglossy.

Inadequate
spreading of
the coating
solution before
drying.

Moving the nozzle

closer enough.
Reducing the
degree of
atomization.

Orange
Peel effect

Coating
texture that
resembles the
surface of an
orange.

Rapid Drying

Thinning the
solution with
additional solvent.
Controlling the
drying procedures.

It is a defect in
which the film
cracks across
the crown of
the tablet.

Absorption of
moisture.
Internal stress
relaxation after
compaction.
Excessive
coating
material
concentration.

It is a defect
where isolated
areas of film
are pulled
away from the
surface when
the tablet
sticks together
and then
break apart.

Illustration

Sept. 30, 2015

Reason

Cracking

Definition

2F-PH

High solution
viscosity

Adjusting the
coating solution
concentration.

Bridging/fill
ing

Blistering

Colour
Variation

Coating fills in
the letter or
logo on the
tablet.

It is a local
detachment of
film from the
substance
forming blister.
Variation in
the proposed
colour for
coating.

Improper
application of
the solution.
Poor design of
the tablet
embossing.
High coating
viscosity.
Improper
atomization
pressure.
Overheating
during spraying
coating
solution.

Increase
plasticizer
contents or
change plasticizer
concentration.

Alteration of
the frequency
and duration of
appearance of
tablets in the
spray zone or
the size/shape
of the spray
zone.

Use of lake dyes

eliminates dye
migration.

Increase hardness
of the film.

Chipping

It is the defect
where film
become
chipped and
dented,
usually at the
edges of
tablet.

Excessive
attrition during
coating
process.

Peeling

Coating peels
off tablet
during coating
process.

Coating is
rubbing off due
to excessive
attritional
effects.
Coating
robustness is

Reduce viscosity
of coating solution.

Use mild drying

condition.

A reformulation
with different
plasticizer and
additives is the
best way to solve
film instability.

Reduce pan
speed.
Reduce process
air temperature
and/or increase

being affected
by excessive
heat in the
coating
process.
Twinning

Two tablets
stick together.
Most common
in capsule
shaped tablets
.

spray rate.

Coating
Reducing spray
suspension can rate
not be
evaporated.
Increasing pan
speed