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Tracheal Diseases
Diseases of the trachea (or windpipe) affect breathing and are often difficult to treat because of the complexity of the respiratory
system. At Memorial Sloan-Kettering, our Complex Airway Program provides comprehensive care for people with cancerous and
noncancerous diseases of the trachea and bronchi from diagnosis to treatment to surveillance following therapy.
Tracheal Stenosis
Tracheal stenosis, which includes subglottic stenosis, is a narrowing or constriction of the trachea. Most cases of tracheal stenosis
develop when scar tissue develops in a person's trachea due to prolonged intubation when a breathing tube is inserted into the
trachea to help maintain breathing during a medical procedure or from a tracheostomy, which is a surgery to create an opening in
the neck to access the trachea.
Tracheal stenosis can also develop from a number of other causes, including: external injury to the throat; a benign or malignant
tumor pressing on the trachea; certain autoimmune disorders (polychondritis, sarcoidosis, papillomatosis, amyloidosis, and
Wegener's granulomatosis); and infections. It can also develop as a side effect when radiation therapy is used to treat a tumor in the
head or neck.
Symptoms of tracheal stenosis can include:
shortness of breath or difficulty breathing
coughing, sometimes with blood (known as hemoptysis)
wheezing
stridor, a high-pitched musical sound that occurs as the breath is drawn in, which is caused
by a blockage in the airways
frequent or recurrent respiratory infections
VIDEO
Tracheal Stenosis
(14 seconds)
Because tracheal stenosis can develop slowly, early signs and symptoms may be mistaken for a
variety of other disorders, including difficult-to-treat asthma in an adult.
Tracheobronchomalacia
Tracheobronchomalacia is a condition that occurs when the airways collapse during breathing or coughing. Symptoms most
commonly include coughing, wheezing, shortness of breath, difficulty clearing phlegm, and repeated respiratory infections, such as
pneumonia or bronchitis.
Most cases of tracheobronchomalacia develop from a type of lung disease called chronic obstructive pulmonary disease (COPD).
Usually caused by smoking cigarettes, COPD involves permanent damage to tissues in the lungs. People with COPD have breathing
problems that tend to get worse over time. Emphysema and chronic bronchitis are two types of COPD.
Other causes of tracheobronchomalacia include:
repeated infections
injury after prolonged intubation, when a breathing tube is inserted into the trachea to help maintain breathing during a
medical procedure
injury from a tracheostomy, which is a surgery to create an opening in the neck to access the trachea
tumors or blood vessels pressing on the windpipe
chronic inflammation
In addition, some individuals are born with a very rare form of tracheobronchomalacia called tracheobronchomegaly (also known as
giant trachea or Mounier-Kuhn syndrome). People with this condition have an abnormally wide or dilated trachea and bronchi and
often have respiratory infections.
For unknown reasons, many people who have had a breathing tube inserted for a long period of time have developed
tracheobronchomalacia. These people have trouble breathing or clearing phlegm when the ventilator is no longer being used. The
insertion of a new breathing tube can relieve the symptoms, but is only a temporary solution to this complex problem.
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Treatment varies according to the type, location, and extent of the tracheal disease, but often includes surgery, radiation therapy, and
therapies that can be delivered through a bronchoscope such as laser therapy. Our physicians provide highly specialized surgical
options such as tracheobronchoplasty and tracheal resection and reconstruction, performed at only a few hospitals in the world.
Our goal is to provide exceptional care for our patients while working to develop new and improved diagnostic approaches and
treatments. We continually evaluate new technologies, surgical techniques, and other strategies to improve the standard of care for
tracheal diseases.
Learn more about how we diagnose and treat tracheal and bronchial diseases.
Diagnosis of Tracheal Diseases
Tracheal and bronchial diseases can be difficult to diagnose. Early signs and symptoms may progress slowly over time and are often
mistaken for a variety of other respiratory disorders.
Treatment of Tracheal & Bronchial Tumors
Memorial Sloan-Kettering provides comprehensive treatment for squamous cell carcinoma, adenoid cystic carcinoma, and carcinoid
tumors.
Treatment of Tracheal Stenosis
Memorial Sloan-Kettering provides treatment for tracheal stenosis, a narrowing of the trachea that can result from cancer treatment,
external injury, or infection, or as a result of an autoimmune disorder.
Treatment of Tracheobronchomalacia
Memorial Sloan-Kettering provides comprehensive treatment for tracheobronchomalacia, which occurs when the airways collapse
during breathing or coughing.
Follow-Up Care
At Memorial Sloan-Kettering, we offer rehabilitation services for people after surgery as well as for those receiving outpatient
treatment for tracheal diseases.
comprehensive evaluation, including a review of your medical history and a physical examination. Following this evaluation, a
number of additional tests may be used to confirm your diagnosis and stabilize your airway:
Three-Dimensional Chest CT Scan We have developed a CT-scanning technique that enables us to see a three-dimensional view of
the airway. This technique is effective in determining both the underlying cause and the extent of tracheal diseases.
Laryngoscopy A flexible, narrow tube that has a tiny camera on the tip (called an endoscope) is inserted through the nose to
examine the larynx and the upper portion of the airway. This can typically be performed in the doctors office under topical
anesthesia.
Bronchoscopy A rigid or flexible tube that has a tiny camera on the tip (called a bronchoscope) is inserted through the nose or
mouth into the airway to examine the trachea and bronchi.
Biopsy A small sample of tracheal or bronchial tissue is removed through a bronchoscope. A
pathologist then examines the tissue under a microscope to establish a diagnosis.
In addition, our experts often measure your respiratory function with the following tests:
Pulmonary Function Test This test measures how much air you can inhale and exhale. You
will take a deep breath and exhale as hard as you can into a mouthpiece that is attached to a
machine. The test is used to assess lung function, and can help your doctor determine the
location of certain types of airway blockages.
Six-Minute Walk Test For this test, you will walk back and forth on a hard, flat surface as
quickly and as far as possible for six minutes. Your heart rate and oxygen level will be
monitored. The test is used to measure endurance.
VIDEO
Virtual
Bronchoscopy
(16 seconds)
Your doctor will use the results of these tests and your medical history to make an accurate diagnosis and select the most-effective
treatments for your tracheal disease.
Surgery
Surgical removal of the tumor is the preferred treatment if you have a cancerous (malignant) or noncancerous (benign) tumor that
involves less than half of the trachea. Our surgeons can remove the tumor and a small amount of healthy tissue surrounding it before
rejoining upper and lower sections of the trachea.
Surgical removal of a tracheal tumor can be a complex procedure. The blood supply to the trachea is delicate and easily damaged. Any
damage to the blood vessels around the trachea makes it more difficult for the trachea to heal, potentially increasing the
complications of surgery.
Our surgeons are specially trained in techniques to preserve the blood supply and reduce the risk of these complications, improving
the chance of a successful outcome.
Bronchoscopic Treatments
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If your tumor is more extensive and you cannot have surgery, you may be eligible for a number of palliative therapies to help restore
your breathing and slow tumor growth.
Bronchoscopic treatments are delivered through a bronchoscope, a tube attached to a tiny camera that is inserted through the mouth.
The doctor uses the bronchoscope to look inside the airways and inserts additional instruments through it for example, to
administer laser therapy or insert airway stents.
At Memorial Sloan-Kettering, we commonly perform these bronchoscopic treatments for our patients:
Stent Therapy This technique involves placing a narrow tube made out of metal or silicone known as a tracheobronchial
airway stent in a narrowed or constricted airway to keep it open.
Laser Therapy This treatment involves using a highly focused beam of light to shrink or remove the tumor.
Argon Beam Coagulation Similar to laser therapy, this treatment uses electricity and argon gas to kill tumor tissue.
Brachytherapy A bronchoscope is used to help deliver radiation therapy directly to the tumor site, destroying tumor cells.
Brachytherapy may be recommended when a patient is not eligible for external-beam radiation therapy (described below).
Rigid Bronchoscopy This palliative procedure involves inserting a rigid bronchoscope (a straight, hollow tube) into the trachea
and removing the tumor tissue inside the airway with the scope.
The above bronchoscopic treatments are often used in combination to relieve symptoms and provide the best possible outcome.
Radiation Therapy
Some patients with tumors of the trachea or bronchi, or those that have spread to nearby lymph nodes or other areas within the
chest, may be treated with radiation therapy alone or after surgery.
External-beam radiation, in which a beam of radiation is delivered from an external source to the tumor site, is the main type of
radiation therapy used to treat people with tracheal tumors. Brachytherapy a localized form of radiation therapy may be used to
treat patients who are not candidates for external-beam radiation therapy.
Chemotherapy
Chemotherapy is a drug or combination of drugs that is given intravenously to stop or slow the growth of tumor cells. Chemotherapy
may be used, usually in combination with radiation therapy, to treat large squamous cell tracheal tumors that cannot be surgically
removed.
VIDEO
Tracheal Stenosis
(14 seconds)
Tracheal Resection and Reconstruction During a tracheal resection, our surgeons remove
the constricted section of the trachea and then rejoin the upper and lower sections. This is usually a very successful treatment for
stenosis, with excellent long-term results.
Bronchoscopic Tracheal Dilation Widening of the trachea, either with a balloon or surgical instruments called tracheal
dilators, provides temporary relief of symptoms and allows our experts to determine how much of the trachea is affected by the
stenosis. During the dilation procedure, we can also diagnose the cause of the stenosis if it is not already known.
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Laser Bronchoscopy In some cases, our surgeons use lasers to remove the scar tissue that is causing the stenosis. Laser surgery
offers good short-term results and provides temporary relief, but is usually not a long-term solution. In some situations, laser
surgery can actually worsen the stenosis. For those reasons, it is important to consider the underlying disorder before using laser
surgery to treat tracheal stenosis.
Tracheobronchial Airway Stent A tracheal stent is a tube made out of metal or silicone that is placed in the airway to help
keep it open. Stents are used as both short- and long-term treatments for stenosis.
Treatment of Tracheobronchomalacia
Tracheobronchomalacia is a condition that occurs when the airway walls are weak and the
airways collapse during breathing or coughing. Because tracheobronchomalacia can sometimes
develop as a result of an underlying medical condition such as chronic obstructive pulmonary
disease (COPD) or pulmonary fibrosis, doctors will focus on the other condition first before
treating the tracheobronchomalacia.
One or more techniques can be used to treat tracheobronchomalacia at Memorial SloanKettering. The treatment your doctor selects depends on the exact location and the extent of the
tracheobronchomalacia.
Common treatment options for tracheobronchomalacia include:
Tracheobronchial Airway Stent An airway stent is a silicone tube that is placed at the site of the collapse to help keep the
airway open. Stents are used as both short- and long-term treatments for tracheobronchomalacia. Airway stenting can be a
diagnostic tool as well. Patients whose symptoms improve after airway stenting are likely to benefit from surgical repair.
Tracheobronchoplasty This surgery can be used to treat the most severe forms of tracheobronchomalacia, especially when the
doctor finds that airway stenting has improved symptoms. A surgically placed mesh is used to reinforce and stabilize the wall of the
trachea and minimize collapse. This is usually a successful treatment for tracheobronchomalacia with excellent long-term results.
Tracheal Resection and Reconstruction In rare instances, this type of surgery can be used if the collapse is only in a small
part of the windpipe. During a tracheal removal, also called a tracheal resection, the surgeon removes the injured section of the
windpipe and rejoins the upper and lower portions.
Follow-Up Care
At Memorial Sloan-Kettering, we offer rehabilitation services for people after surgery as well as for those receiving outpatient
treatment for tracheal diseases.
Physical Therapy
After your surgery, Memorial Sloan-Kettering's experienced physical therapists will perform a comprehensive chest physical therapy
evaluation that focuses on coughing, deep breathing, and management of phlegm (thick mucous that lines the airway and lungs). In
addition, we will evaluate your mobility, including your ability to get out of bed and walk.
Based on this evaluation, you will be given an individualized treatment plan that addresses any movement challenges and outlines
the goals of your physical therapy. This proactive approach to postoperative care including chest physical therapy, mobility, and
exercise will maximize your breathing function and ability to walk long distances, with the goal of helping you return home feeling
steady and strong.
Although most patients are discharged to their homes, occasionally some people require additional rehabilitation prior to going home.
Your physical therapist will be involved in making recommendations regarding the most appropriate discharge plan for you.
Respiratory Therapy
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Our respiratory therapists will work with you to assess breathing and deliver treatments as guided by your physician. Some
treatments include oxygen therapy and medication that is inhaled through a nebulizer (a device that turns liquid medication into a
mist that can be inhaled by mouth). This medication helps open up the airways and makes it easier to clear out phlegm.
Our therapists are also able to assist in your transition from the hospital to your home. In addition, we work with patients who are
undergoing a type of respiratory treatment known as continuous positive airway pressure therapy (CPAP).
Smoking Cessation
Our Smoking Cessation Programs specialize in addressing the needs of patients who want to improve their health by quitting
smoking. We use a range of individually tailored methods to help each person find alternative, healthy ways to resist the craving to
smoke and to quit smoking permanently. We also welcome family members who want to stop smoking, as it may be easier to quit
together.
workers, nutritionists, and psychiatrists, as well as members of the Pain and Palliative Care and Integrative Medicine Services.
For more information about our services for older patients as well as for their family and friends, visit the Help for Older Patients
section of our website.