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  • Bioavailability and Bioequivalence Calculations

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    This document discusses calculations related to bioavailability, bioequivalence, volume of distribution, elimination half-life, and drug concentration in the blood for various drug administration scenarios. It provides 18 word problems involving intravenous or oral drug doses and measured blood concentrations to calculate values like bioavailability, volume of distribution, elimination rate constant, and amount of drug in the bloodstream.

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    ansel calculation pharm sciences chemistry college high school university phd

    Original Title

    Chapter 22. Calculations worksheet

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    This document discusses calculations related to bioavailability, bioequivalence, volume of distribution, elimination half-life, and drug concentration in the blood for various drug administration scenarios. It provides 18 word problems involving intravenous or oral drug doses and measured blood concentrations to calculate values like bioavailability, volume of distribution, elimination rate constant, and amount of drug in the bloodstream.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    281 views4 pages

    Bioavailability and Bioequivalence Calculations

    Uploaded by

    Zain
    This document discusses calculations related to bioavailability, bioequivalence, volume of distribution, elimination half-life, and drug concentration in the blood for various drug administration scenarios. It provides 18 word problems involving intravenous or oral drug doses and measured blood concentrations to calculate values like bioavailability, volume of distribution, elimination rate constant, and amount of drug in the bloodstream.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    of 4

    Calculations of Bioavailability and Bioequivalence

    1.

    Ifthebioavailabilityfactor(F)fora100mgtabletofadrugis0.70comparedwiththe
    bioavailabilityfactorof1.0foraninjectionofthesamedrug,howmanymillilitersof
    theinjectioncontaining40mg/mLwouldbeconsideredbioequivalenttothetablet?

    2.If5mLofanelixircontaining2mg/mLofadrugisbioequivalenttoa15mgtablet
    havingabioavailabilityfactorof0.60,whatisthebioavailabilityfactor(F)oftheelixir?

    3.If500mgofadrugareadministeredorallyand300mgareabsorbedintothe
    circulation,calculatethebioavailabilityfactor(F).

    4.Adrugis40%bioavailablebytheoralrouteand58%bioavailablebythetransdermal
    route.Ifapatientistakinga2.5mgoraldosetwiceadayandisswitchedtothe
    counterpart2%ointment,howmanygramsoftheointmentshouldbeadministeredto
    providetheequivalentdoseofthedrug?

    5.

    Adrugusedtotreatasthmais55%bioavailableas5mgtablets.Ifapatientis
    switchedtotheinhalantformofthedrug,whichis87%bioavailable,howmanymetered
    500gspraysshouldthepatientadministerevery12hourstoreceiveanequivalentdrug
    dose?

    Calculations of Bound Drug, Elimination Half-Life, and Volume of Distribution

    6.4Ifa6mgdoseofadrugisadministeredintravenouslyandproducesabloodcon
    centrationof0.4g/mL,calculateitsapparentvolumeofdistribution.

    7.Ifatequilibrium,twothirdsoftheamountofadrugsubstanceinthebloodisboundto
    protein,whatwouldbethealpha()valueofthedrug?

    8.Thealpha()valueforadruginthebloodis0.90,equatingto0.55ng/mL.Whatisthe
    concentrationoftotaldrugintheblood?

    9.Apatientreceivedanintravenousdoseof10mgofadrug.Abloodsamplewasdrawn,
    anditcontained40g/100mL.Calculatetheapparentvolumeofdistributionforthe
    drug.

    10.Thevolumeofdistributionforadrugwasfoundtobe10literswithabloodlevel
    concentrationof2g/mL.Calculatethetotalamountofdrugpresentinthepatient.

    11.Calculatetheeliminationrateconstantforadrughavinganeliminationhalflifeof
    1.7hours.

    12.Plotthefollowingdataonsemilogarithmicgraphpaperanddetermine(a)the
    eliminationhalflifeofthedrugand(b)theeliminationrateconstant.
    PlasmaDrugConcentration/Time
    (g/100mL)8.50.56.81.05.41.54.02.03.22.52.53.0

    13.Whatpercentageofanoriginallyadministeredintravenousdoseofadrugremainsin
    thebodyfollowingthreehalflives?

    14.Ifthehalflifeofadrugis4hours,approximatelywhatpercentageofthedrug
    administeredwouldremaininthebody15hoursafteradministration?

    15.If100mgofadrugareadministeredintravenously,andtheresultantdrugplasma
    concentrationisdeterminedtobe2.5g/mL,calculatetheapparentvolumeofdistribution.
    (hours)

    16.Ifadoseof1gofadrugisadministeredintravenouslytoapatientandthedrug
    plasmaconcentrationisdeterminedtobe65g/mL,calculatetheapparentvolumeof
    distribution.

    17.Thevolumeofdistributionforchlordiazepoxidehasbeendeterminedtobe34liters.
    Calculatetheexpecteddrugplasmaconcentrationofthedrug,inmicrogramsper
    deciliter,immediatelyafteranintravenousdoseof5mg.

    18.Innormalsubjects,bloodmakesupabout7%ofthebodyweight.
    .

    (a)Calculatetheapproximatebloodvolume,inliters,foramanweighing70kg.

    (b)IfthedrugZANTACreachedpeakbloodlevelsofabout500ng/mL2to3hours
    afteranoraldose,calculatethetotalamountofthedrug,inmilligrams,inthebloodof
    thepatientdescribedin(a)whenpeakbloodlevelsareachieved.

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