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heart rate slows down. As low as 20 bpm. Heart on its own would go 100
bpm, but vegas nerve keeps it at about 70 bpm.
Think of all the things besides that that can affect love, lust, hate,
emotions, fear, fever, anxiety, breathing.
The baroreceptors in the walls of the aorta and internal carotid arteries detect
changes in blood pressure and alert the cardiac center. That then responds
through the stimulation of the sympathetic nervous system (SNS) or the
parasympathetic nervous system (PNS) to alter the rate and force of cardiac
contractions appropriately.
Proprioceptors in the muscle and joints = changes in physical activity. Heart
rate responds even before the metabolic demands of the muscles require it.
Chemoreceptors sensitive to blood pH, carbon dioxide, and oxygen are
found in the aortic arch, carotid arteries and medulla oblongata. Respiratory
control why do you breathe Oxygen = NO.
SNS, innervation increases heart rate ( Tachycardia) and contractility > 100
bpm
PNS or vagus nerve stimulation slow the heart rate ( Bradycardia) < 60 bpm
Factors that raise the heart rate are called positive chronotropic agents and
factors that lower it are negative chronotropic agents
Heart rate is affected by many chemicals. Epinephrine and norepinephrine =
cardiac nerves and adrenal medulla. These first bind to beta-adrenergic
receptors on the myocytes and trigger the intracellular production of the
second messenger cAMP , cyclic adenosine monophosphate
The sympathetic or beta, adrenergic receptors in the heart are an important
site of action for some drugs ( beta blockers).
CLASSES OF DRUGS:
ACE Inhibitors
Angiotensin-Converting Enzyme Inhibitors
These enzymes help the body to convert angiotensin I into angiotensin
II. ACE inhibitors are non-habit forming medications that block the effects
Osmotic diuretics they draw fluid from the cells of the brain and eyes.
And toxins, clears them.
Potassium sparing diuretic, liver function testing.
Action is within hours, you will see increased urine flow. Other solutes fom
the body: Sodium , potassium, calcium, magnesium, chloride, phosphorus,
uric acid and of course water to make the urine.
Nitrates = Nitroglycerine
Used for more than 100 years. They are commonly used to prevent
and relieve angina, a type of chest pain. The main symptom of coronary
artery disease is chest pain, pressure or discomfort. Nitrates deal with this by
addressing the lack of oxygen-rich blood to the heart (cardiac ischemia).
They widen the blood vessels, by relaxing the smooth muscles , most
notably the muscles of the heart and blood vessels. As a result, pressure on
blood vessel walls is reduced, which allows more blood to circulate with less
effort by the heart. Nitrates affect veins as well as arteries, but less
pronounced.
Lots of delivery methods. Spray under the tongue, tablets, patches,
IV.
Heart attack = myocardial infarction.
Heart failure
After stenting
Pulmonary hypertension.
Pharmacogenetics your own specific DNA genetic code with your
specific receptors a specific medication that will work on just those
areas as opposed to systemic dosing.