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BASIC VIROLOGY
Ubiquitous
Some viruses cause disease
Some viruses are useful
Why Important?
Capsid
+ internal membrane?
+ envelope?
+ virus RNA in DNA viruses?
+ cell molecules?
Genome:
VIRION COMPONENTS
Picornaviridae
Caliciviridae
Astroviridae
Togaviridae
Flaviviridae
Coronaviridae
Ateriviridae
Arteriviridae
Rhabdoviridae
Filoviridae
Paramyxoviridae
Orthomyxoviridae
Bunyaviridae
Arenaviridae
Bornaviridae
Reoviridae
Retroviridae
Polyomaviridae
Papillomaviridae
Adenoviridae
Parvoviridae
Herpesviridae
Poxviridae
Hepadnaviridae
Unclassified Agents
IMPORTANT FAMILIES
Entry
Barriers?
Virus receptors & attachment factors?
Spread
Replication
Shedding
Attachment
Entry & Uncoating
Genome replication + protein production
Replication sites?
Intracellular trafficking?
Assembly
Release
>>> See Baltimore classification
Infection
Acute
Chronic
Productive
Abortive
Latent
re-initiating / reactivation
Permissive cells
Tropism
CONCEPTS
Disease
Virulence
Invasiveness
Essential genes, virulence genes, and virulence
determinants
Inflammatory responses to viral infection
Fate of the infected cell, tissue, and host
Cytopathicity and cell death
CONCEPTS
CONCEPTS
Oncogenic viruses
Virus-induced transformation
The transformed cellular phenotype
Viral transduction of an oncogene
Activation of the transforming potential of oncogenes
Oncogene activation
Transformation by molecular mimicry and insertional
mutagenesis
Oncogenesis mediated by essential viral proteins
INNATE RESPONSES
TO VIRAL INFECTIONS
DIAGNOSTIC VIROLOGY
Important variables?
The best specimens for the diagnosis of acute viral
infections?
Viral culture?
Immunological assays?
Molecular assays?
The significant of viral detection?
ANTIVIRAL AGENTS
Medical value
Drug selectivity, resistance, and drug targets
General aspects of antiviral drug targets
Factors affecting the development of drug resistance
OVERVIEW
MECHANISMS OF SPECIFIC
ANTIVIRAL DRUGS