Dissolution 1.

0
Developed By
Surajit Goon

Seemanchala Rath

Sr. Lecturer
BCDA College of Pharmacy
& Technology

Lecturer
BCDA College of Pharmacy &
Technology

Dissolution is an important step in the development & evaluation of

different types of dosage forms, which portrays the release pattern as well as
release kinetic of the active ingredient from the dosage form. Till now there is no
specific software which can interpret the dissolution data by fitting it into different
mathematical models (zero order. First order, Higuchi plot, Hixson Crowell plot, &
Korsmeyer Peppas plot).In industries as well as in academic field dissolution
data is interpreted using Microsoft excel or any other work sheet, which is
tedious, time taking & may be erroneous.
Dissolution 1.0 is first time created in such a manner that it can
calculate all the parameters related to dissolution data interpretation such as
%drug released, %amount remaining to be released, there logarithmic
transformations etc.along with 5 graphs for fitting the dissolution data into 5
different mathematical models.

Features of Dissolution

1.0

It requires the data in a triplicate manner

It calculates parameters for all the 3 replicates along with their average &
standard deviation (sd) values.

It displays 5 graphs along with their R2 values & linear Regression
equation by method of least square.

It calculates the amount of drug loss due to sampling.

It imports all the data (input & output) into a text file (output.txt)
automatically.

Operating instructions:
Step 1:

Maximum 20 numbers of absorbencies can be given, which may be
generated by any suitable analytical method.

C= Y-intercept of the standard curve.

m= slope of the standard curve.

df= (Vd.V)/1000.Vs, where df=dilution factor,Vd=volume of the sample
diluted upto in ml,V=volume of the dissolution fluid in ml & Vs=volume of
the sample withdrawn in ml.

f=Vd/1000=loss factor. It is introduced to calculate the amount of drug loss
due to sampling.

dc= Drug content of the dosage form in mg.

time=sampling interval from the starting of dissolution in minutes. Tme
given should always be a whole number; no fractional values should be
entertained.

Step 2:

Input the absorbance values for Replicate I obtained after analyzing the
dissolution sample by a suitable analytical technique.

Step 3:

dr=% of drug released.

logarr=common logarithmic transformation of % of amount remaining to be
released (%ARR)=log(%ARR).

logd= common logarithmic transformation of % of drug released
(%DR)=log(%DR).

w=W 01/3-W 1/3, where W0=ARR in mg & W=dc in mg.

sqroot=square root of the time=(time)1/2.

logt= common logarithmic transformation of time.

Step 4:

Input the absorbance values for Replicate II obtained after analyzing the
dissolution sample by the same analytical technique as in case of
Replicate I.

Input the absorbance values for Replicate III obtained after analyzing the
dissolution sample by the same analytical technique as in case of
Replicate I.

Step 5:

sd_perdr=standard deviation values of the triplicate for % drug released.

sd_lgarr=standard deviation values of the triplicate for log(%ARR).

sd_lgd=standard deviation values of the triplicate for log (% drug
released).

sd_w=standard deviation values of the triplicate for w (W 01/3-W 1/3).

Step 6:

Linear regression equations & R2 values of the 5 mathematical models are
displayed.

Step 7:

After displaying the regression equations & R2 values of the 5
mathematical models, Dissolution 1.0 automatically generate the Zero
order plot.


Press the right arrow key to see the First order plot .


Press the right arrow key to see the Higuchi plot .

Press the right arrow key to see the Hixson Crowll plot .


Press the right arrow key to see the Korsmeyer Peppas plot .