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Eso s, quienes ocupen shampoo con sulfato les recomiendo evitar los
que venden en el supermercado, o fijarse porque ya existen algunos que
vienen sin sal. Ojo eso s con los shampoo que son solo una gotita hacen
un kilo de espuma, esos elimnenlos por completo de su lista de
compras.
Te recomiendo para shampoo con sulfato comprar marcas ms naturales
como Weleda o esos Loreal que venden en peluqueras. Para shampoo
sin sulfato lo mejor son marcas como Davines o Elgon que los puedes
encontrar en Casa Pichara.
Names
IUPAC name
Sodium [dodecanoyl(methyl)amino]acetate
Identifiers
CAS Number
137-16-6
Jmol 3D model
Interactive image
PubChem
23668817
InChI[show]
SMILES[show]
Properties
Chemical formula
C15H28NNaO3
Molar mass
293.38 gmol1
Melting point
?)
Infobox references
Sodium lauroyl sarcosinate (INCI), also known as sarkosyl, is an ionic surfactant derived
from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam,
toothpaste, and foam wash products.[1] In molecular biology experiments, sarkosyl is used to
inhibit the initiation of DNA transcription.
This surfactant is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the
hydrophilic carboxylate. Since the nitrogen atom is in an amide linkage, the nitrogen is not
pH active and is neutrally charged in all aqueous solutions regardless of pH. The
carboxylate has a pKa of about 3.6 and is therefore negatively charged in solutions of pH
greater than about 5.5.
pH-sensitive vesicles can be prepared using this surfactant with another cationic or waterinsoluble amphiphiles such as 1-decanol.[2]
Addition of an mixture of equal parts of sodium lauroyl sarcosinate and the non-ionic
surfactant sorbitan monolaurate (S20) to water led to the formation of micelle-like
aggregates, even though neither surfactant formed micelles when present alone. Such
aggregates can help carry other small molecules, such as drugs, through the skin.[3]
In culture[edit]
Sodium lauroyl sarcosinate was sold as a special ingredient called 'Gardol' in Colgate
Dental Cream (toothpaste) during the 1950s[4][5][6] through the mid-1960s in the US[7][8] and the
mid-1970s in France.[9] Current use as a preventive dentifrice is in Arm & Hammer
toothpaste.
Sarkosyl is generally used if a lysis procedure is conducted under refrigerated
conditions (significantly lower than room temperature) because at these
temperatures SDS precipitates. SDS is the detergent of choice for most
denaturation applications when lysis procedures are conducted at room
temperature.
SDS clearly is the stronger detergent, since it is commonly used to denature proteins
prior to gel electrophoresis.
Sarkosyl is also a strong detergent and can denature many proteins, but leaves
others unchanged.
If you use 1% sarkosyl and 0.1% SDS that creates a big difference as well. Your
sample could easily bind a lot of the SDS, effectively dropping the concentration
below the CMC and hence removing all SDS micelles. With 1% sarkosyl this
wouldn't happen so quickly. Something to keep in mind.
The major difference between these detergents is that SDS has a negative charge
and sarkosyl is zwitterionic (at pH> 5.5).
Once these detergents bind to proteins through hydrophobic interaction, it is
very difficult to remove them or exchange them with other detergents, especially if
they have the same hydrophobic tail.
If you treat your proteins either first with sarkosyl and then add SDS or the other
way around will probably have no effect, since the first detergent is already tightly
bound and is not easily exchanged.