Professional Documents
Culture Documents
Insight
Issue 2 | 2012
Contents
Welcome Letter............................................................................................................................... 3
Pursuing Growth in the Age of LoE...................................................................................... 4
The top 20 multinational pharmaceutical companies in Asia will see an average of $950 million in sales become at risk
in the next 5 years due to the loss of exclusivity of their top brands. How can MNCs survive and thrive in this increasingly
genericized era?
The pharma distribution landscape is drastically changing in China, with thousands of independent distributors
consolidating into larger joint enterprises. How can pharmacos prepare for these changes?
Dear Reader
The worldwide pharmaceutical market is at a crossroads. At first glance
the fundamentals seem strong: pharmerging market growth, ageing global
populations, the growing prevalence of chronic disease, and personalized
medicine all seem poised to spell renewal for an industry that has faced
its share of recent turmoil. Take a deeper look, however, and apparent
threats aboundnot just the widespread loss of exclusivity for originator
molecules, but cost containment initiatives at both the public and private
level that are forcing widespread changes in the way pharmaceutical
companies can and should develop and launch new medicines.
As this greater global drama unfolds, the Asia-Pacific region is making for some of the most compelling theatre. The juxtaposition of mature markets such as Australia, Japan, South Korea, and Singapore with some of the worlds most dynamic
pharmerging markets in China, India, and Indonesia underscores the need for tailored strategies across
geographies and reinforces the fact that there simply are no one-size fits all solutions. The rate of change
and degree of impact from global, regional, and local developments are, quite frankly, infinitely variable. The
companies that succeed will recognize the importance of treating every target market as its own distinct entity.
It is against this dynamic backdrop that I am pleased to bring you the second issue of IMS Asia-Pacific Insights.
In this edition, we address strategies for originator brands to maintain growth when facing loss of exclusivity,
outline the tools being adopted by Asian markets intent on containing pharmaceutical costs, explore the
strategies now being employed by thriving pharma companies, and identify key strategic imperatives in two of
Asia-Pacifics most vibrant markets, China and India.
Taken together, the stories represent the in-depth industry expertise of IMS Health throughout the region,
powered by our superior information assets.
Success in todays Asia-Pacific environment is by no means guaranteed, but ample opportunities prevail for those
companies that are well prepared. We at IMS look forward to working with you in the near future to identify
strategies, challenge assumptions, implement innovations, and measure success.
Andy Liu
President, Asia Pacific and China
IMS Health
14
5.0
12
4.5
4.0
3.7
3.5
3.0
10
2.1
3.1
3.0
3.7
2.5
2.5
2.0
1.5
1.0
0.5
0.0
1.5
0.2
2005
1.3
2.1
2.1
2.6
1.2
0.5
0.4
0.6
2006
2007
2008
0.9
2009
0.5
1.4
1.8
1.6
0.4
2010
1.8
0.4
2011
Specialist driven
2012
2013
2014
2015
2016
Figure 1
Constant us$BN
2
0
Source: IMS Health MIDAS MAT JUNE 2011, RX-only; Markets included: Japan, India, Australia, New Zealand, Korea, Singapore, Hong Kong, China, Taiwan, Philippines
LoE Planning & Life Cycle Management
Figure 2
Representative
Clopidrogel value sales in
Indonesia (2006-10)
USD Mn
28
26
24
22
20
18
16
14
12
10
8
6
4
2
0
LoE
48%
18.1
1.1
4.3
35%
12.2
8.8
1.3
0.6
4.3
2006
18
4.0
16
1.1
2.7
14
4.9
0.4
13.6
8.8
2007
10.3
10.1
2009
2010
17.6
55%
10
37%
4.0
0.9
2.3
Sanofi-Aventis (Plavix)
12
2008
LoE
7.3
6.7
6.7
0.6
26.7
3.9
4.8
1.1
3.9
0.6
3.7
0.4
3.9
4.8
5.6
5.2
6.1
2006
2007
2008
2009
2010
Both volume and value growth significantly expanded post-LoE, which is reflective of a broader trend of several key molecules across
therapy classes in the APAC region ramping up in volume and value sales after LoE. Pharmaceutical companies who have a clear
strategy and strong capabilities to leverage such growth are likely to emerge as winners
Source: IMS Health MIDAS data and analysis
Figure 3
Illustrative, Non-exhaustive
Macroeconomic
status
Healthcare
infrastructure
Middle class
growth
Channel
demand
How do post-LoE
product performance
differ in reimbursed
versus semireimbursed
versus out-of-pocket
markets?
How is post-LoE
product performance
influenced by broader
macroeconomic factors
(i.e. GDP, population,
etc.)?
How influential is
middle class growth
on the performance of
post-LoE products?
Do channel structures
play an integral role
in driving post-LoE
growth?
Segmenting the relevant LoE market appropriately helps a firm determine how to optimally allocate
its assets across multiple geographic markets in the APAC region
merger/acquisition
relationships
several commonalities will define success in the APAC region going forward.
Every company does its own analysis
and makes its own decisions based on its
existing infrastructure and long-term
goals, says Morton-Small. Still, we
see greatest success emerging from
those clients with strong marketing
and commercial capabilities, broad
investments in brand equity, a good
understanding of local markets and
stakeholder decision drivers, a firm
knowledge of pricing-volume tradeoffs, steady on-the-ground resource
management, and healthy launch
readiness.
Consider the life cycle
To all companies, Morton-Small
and Afable recommend that careful
asset-level evaluation and prioritization
be applied to every strategic option.
Companies need to remember that
every decision that is made has a
potential impact on the many interlocking components of the company,
says Afable.
Figure 4
-5yrs
-3yrs
Product
Performance
Product
Strategy
Options
LoE
+1yrs
+3yrs
Field Force/
Promotion
Should we
monetize our
assets/out-license?
Pricing &
Contracting
Should we license a
2nd brand/
authorized generic?
Manufacturing
IP/Legal
-1yrs
Should we change
our messaging?
Do we require
a discontinuation
plan?
Should we outsource
manufacturing production?
(see figure 4)
10
Figure 1
China:
Price cuts (2011)
Increased price controls
Thailand:
CSMBS budget cuts; stricter
spending controls (2010 & 2011)
Hospital audits 2010 & 2011
NLED delistings
Taiwan:
Second generation NHI reforms (2010)
Biannual price cuts
Health insurance premiums up (2010)
Philippines:
Price cuts (2009 & 2010)
Cheaper Medicines Act (2008)
Australia:
Reimbursement forfits (2011)
New price reference groups (2009)
PBS price reductions
Frequency of Use
Low
Low
Physician
prescribing
budgets
Level of Agressiveness
High
11
12
Budget Control
Strategy
Spending caps
Generic substitution
Decentralization
Prescribing control
Price
Management
Promote
Innovation
Reference pricing
Parallel trade
Price cuts
Clinical guidelines
Clinical value assessment
Pay for performance
Specific objectives
Budget
control
Price
mgmt
Promote
innovation
Unbranded Gx
44%
70,000
Branded Gx
42%
Originals
45%
40%
38%
60,000
24,184
50,000
23,645
20%
15%
20,160
16,886
10,000
35%
30%
26,873
17,204
14,027
40%
25%
19,518
20,000
36%
21,886
40,000
30,000
26,165
Figure 4
Segment
CAGR
MATQ1 2006MATQ1 2011
50%
% of total Market Sales from Orginals
Figure 3
Its abundantly clear that cost containment can only be effective when
introduced through a systematic and
coordinated effort, says Strydom. A
number of national health systems
including Thailand, China, Japan, and
Taiwanhave recently put forward
a variety of capping provisions in an
effort to keep spending down.
Taiwan, Japan, and Thailand have
introduced DRG-type (DiagnosisRelated Group) reimbursement rates
to cap the spend on patients and treatment, and talk of introducing the same
sort of measures has arisen in Indonesia.
At the hospital level, China and
Thailand are capping expensive drug
use to limit the number of prescriptions written and filled for expensive
drugs; Thailand has also instituted
capping programs for nine diseases
considered to have above-average
branded drug use.
11%
16%
10%
7,965
9,870
12,721
15,958
MAT Q1 07
MAT Q1 08
MAT Q1 09
MAT Q1 10
19,173
MAT Q1 11
5%
21%
0%
21%
Finally,
its
imperative
that
multinational pharma companies at
work in developing nations share
what they have learned from their
There are real opportunities to build experiences in developed countries.
bridges in this environmentto The companies that are getting
Multinational pharma companies offer the technical expertise that ahead have found ways to bring their
cant just sit on the sidelines and wait regulators and health officials are knowledge to the ASEAN countries,
for the forces to play out, says Benoff. seeking. Multinational companies says Benoff. These are companies
There are very real opportunities to with a strong local presence have the like those that have invested in
step in and work with payers to help chance to make a real differenceto specialty training for nurses requiring
shape long-term development plans strengthen the health of a country as IV infusion treatments in oncology
that can promote favorable operating well as their own position within it, and
rheumatoid
arthritis
care
environments. There are opportunities says Benoff. Weve seen companies environments. Companies that bring
as well for multinational companies to step in and work with payers in ways partnering solutions to governments
assert their knowledge and expertise that shape the future of healthcare in need.
Companies that take an
in the region and to become a valued strategies. Weve watched real partner- active role in industry organizations
resource to healthcare stakeholders.
ships emerge between manufacturers forging ties with peer companies to
and healthcare authoritiespartner- help create the right kind of changes.
Consider the recent concerns ships that include risk-sharing agreeexpressed by a public healthcare ments, price/volume agreements, and Everyone benefits when real
representativea regulatory advisor pay-for-performance schemes.
solutions are put forth, and its
who overtly recognizes the importance
incumbent upon these pharma
of incorporating cost effectiveness into There are also very real opportunities companies to see themselves not just
reimbursement decisions, but who has for multinational pharmaceutical com- as organizations with products to sell,
been thwarted by a lack of internal panies to align their local and regional but as organizations with important
know-how. We just do not have the strategies with the national health- lessons to share.
technical expertise to implement this care strategies by streamlining their
overnight and even if we did, which businesses, expanding their generics
disease areas and patients should take and branded generics presence, and
priority? she asked. Right now the adapting their commercial models to
best we can do to is to make quality better serve key accounts.
13
14
15
40%
35%
35%
30%
25%
20%
Operating Profit %
Operating Profit %
30%
25%
Indian Companies
Figure 2
20%
16
15%
15%
10%
Account based
selling: managing
groups of prescribers
based on % effort and
not reach & frequency
Key Account Mgt:
relationship rep can
call in specialized
personnel as needed
Figure 3
Prescriber Knowledge
Opportunity - Accessibility - Responsiveness
The Sales
Model of
Today
Organizational Models
Therapy focused - Team based - Outsourcing
Specialist - Key Account Mgt.
New bonus and compensation models
The Sales
Model of
The Future
17
18
19
20
21
info.sg@sg.imshealth.com
+65 6227 3006
www.imshealth.com/viewpoints/apac
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