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2008,
,
www.rjptonline.org
ISSN 0974-3618
RESEARCH ARTICLE
ABSTRACT:
Three simple, precise and economical UV methods have been developed for the estimation of Satranidazole in tablet
dosage form. Satranidazole has the absorbance maxima at 320 nm (Method A), and in the first order derivative spectra,
showed sharp peak at 290 nm (Method B). Method C applied was area under curve (AUC) in the wavelength range of
325-315 nm. Linearity for detector response was observed in the concentration range of 5-35 g/ml for Method A and 540 g/ml for Method B and Method C. The proposed methods were successfully applied for the simultaneous
determination of Satranidazole in commercial tablet preparation. The results of the analysis were validated statistically
and by recovery studies and were found to be satisfactory.
Modified on 28.08.2008
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ACKNOWLEDGEMENTS:
The authors are very thankful to Dr. Avinash D.
Deshpande, Director of Pharmacy, Pad. Dr. D. Y. Patil
Institute of Pharmaceutical Sciences and Research, Pimpri,
Pune for providing necessary facilities. The authors are also
thankful to Alkem Laboratories Limited, Baddi, for
providing gift samples of Satranidazole.
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