H2

H2 1776 249
78%N2 N2

2007
2014 80 23-1

Pharmacology & Therapeutics 2014 Molecular hydrogen as

a preventive and therapeutic medical gas:initiation, development and potential of hydrogen
medicine.
23-2 23-3

23-1

23-2H2

23-3H2
2

NK-Tcell
23-4 23-5 23-6 23-7

23-4

23-5

23-6

23-7 DNA

CO2C H2O N2
CHOCHON

CHCHO
3


23-8
23-9C
HO 23-10N
H H+ ADP ATPH+
CHON OCO2
CO2
CO2 350~400ppm
CO2 40,000~53,000ppm

23-8

23-9

23-10

HTOYOTA
3000oC

H
H2 ADP
ATP H2 OH
O2 O2 H H O2
O2
O2 H2 O2
O2 H2 H2O

1.

Krebs cycle TCA cycle citric acid cycle 23-18

ATP
Endogenesis water
23-18
Q10
23-18 H+ ATP
PADP ATP 23-18

O H

 23-11Krebs cycle

23-12

 Hans Adolf Krebs

Hans Adolf Krebs1900825

19811122

Krebs
cycle1953

23-13Hans Adolf Krebs

19181923
1925
1930
19331945
1954
1958 1979 1981
http://ppt.cc/nuUY

2.
HOCHO
HOH2OO2
HHH
17H2
H2H2

H2O
23-14

Active transport

23-14

Endogenesis waterH2O2
ATP

ATP1953
Hans Adolf KrebsKrebs CycleATPH2O
YouTubeCellular Respiration Glycolysis Krebs cycle Electron Transport 3D
AnimationKreb cycle

1. 13 L
2. 17/
8

 H2 O2
1. H2O23-6
outer membraneinner membrane
mitochondrial matriccytochrome oxidaseATPATP Synthase
23-15
2. HNAD+NADH23-18
3. NADHNADHNADH DehydrogenaseubiquinoneQ10
Cytochrome b-c1Cytochrome cCytochrome oxidase
4. FADH2Q10Cytochrome oxidase23-18
5. Cytochrome oxidase
O2H2OCytochrome oxidase
Endogenesis23-18
6. NADH DehydrogenaseNADHNAD+HQ10H+
intermembrane spaceH+
H+
7. Cytochrome oxidaseH+
H+H+
Hydrogen Ion Gradient
8. H+ATPATP Synthase
ADPADPATP23-18
9. ADPAdenosine DiphosphateATPAdenosine Triphosphate
D2Tr3PhosphatePAdenosineADPATP
ADPATP
ADPAdenosine-P+P
ATPAdenosine-P+P+P
PATPPADP
10. ATPADPPPH+
9

ATPATP SynthaseH+
11. ATPATPPP
ADPADP
ATPADPATP

ATP Synthase
ATP

YouTube - Cellular Respiration: Glycolysis, Krebs cycle, Electron Transport [3D Animation]

23-15

ATP

YouTube - Cellular Respiration: Glycolysis, Krebs cycle, Electron Transport [3D Animation]

23-16

10

Cytochrome Oxidase
ATP Synthase

ADP

4 H
2 H+

2 OH

YouTube - Cellular Respiration: Glycolysis, Krebs cycle, Electron Transport [3D Animation]

23-17

Cytochrome Oxidase ATP Synthase

(ADP )

Q10

2 H2O

NADH
- Q10
NADH H

ADP
ATP

ADP

YouTube - Cellular Respiration: Glycolysis, Krebs cycle, Electron Transport [3D Animation]

23-18
100%H2OH
H2OOH23-19OH
H2H2NADHQ10
OH OH 23-20H2 OH 2OH+
H22H2OOHH2DNA
H2
3D EEG

H2
11

OHOH
H2+O2HRV

23-19OH

23-20H2O

H2 OH

23-21
H2 OH
H2

23-21
12

H2+O2 H2O
H2+O2
H2O H2O H2 O2H2+O2
cytochrome oxidase H2 O2
H2 ADP
ATP H2+O2 3D EEG
O2
50 XX H2+O2 EEG
23-22 23-23

H2+O2

23-22 H2+O2 EEG

23-23 H2+O2 EEG

H2+O2

23-24 H2+O2

23-25 H2+O2

13

 H2+O2

23-26 H2+O2

23-27 H2+O2

23-28 H2+O2

1199 1547 23-28

1.

H2O H2O H2 O2
2H2O2H2+O2

14

2.

H2 O2
H2 O2 H2O
H2O H2

3.

H2 H2 ATP
cytochrome oxidase ADP ATP 23-18
2H2O2H2+O2
2H2+O22H2OH+ ADP ATP H2O
H2 H2O
H2
H2
H2+O2

4.

H2 O2
ATP

5.

ATP ADP ADP

ATP ATP Synthase H+

YouTube-Cellular

Respiration Glycolysis Chain Krebs cycle Electron Transport 3D Animation

6.

OH H2 OH
H2 H2O2 OH+ H22H2O
H2 H2

7.

H2 H2 H+ ADP ATP
H2

8.

H2 OH H2
ADP
H2

15

9.

1953 Hans Adolf Krebs Krebs cycle

ATP H2O

10. Krebs ATP Electron

transferEndogenesis water
Krebs Cycle
11. H2 OH
ATP H2

H2
H2 H2 H2

H2+O2
1. H
H2
H2 10 500 O2 21%
2. 17 H2
17 H2
H2
H2 H2+O2 H2 H2+O2

3. H2
H2 O2 H2 78%N2
16

 N2 78% H2
H2 1 1atm=760mmHg
H H2 O2 16
H2 H2+O2 O2
33%H2 66% O2 20%N2 78% N2 H2

H2 H2

H2+O2

O2 H2
1. O2 H2
2H2+O22H2O

OH
H2 2OH+H22H2O
23-29

O2 ATP
OH H2
OH 2OH+H22H2O
OH H2 OH

17

O2

+O2

ATP + OH

H2

2OH + H2

2H2O

23-29O2 H2

2. H2+O2

O2 H2
2OH 2H2O 2OH+H22H2O

kidney

OH
H2+O2
O2
OH H2
OH
3. H2+O2
H2H2

coherenesynchronizeentrainment
harmonyhomeostasisefficiencyintuition

18

OH

4. H2
H2

14.3 Hz
20.8 Hz27.3 Hz33.8 Hz39.8 Hz

50%H2+O2

5. H2+O2-
a.

SpO2 99%
H2 H2
c.c.
H2+O2 5
10-30
H2
side effect

adverse effect
19

 H2+O2

b.
H2+O2
H2
adverse effect
c.
H2+O2
d.
H2+O2
e.
H2+O2
adverse effect

1. H2O H2O
2. H2+O2 H2O 100% H2
O2 H2
3. H2+O2 H2
H2+O2

H2
H2+O2

passive transport
H2O

H2+O2

1.
20

2.

H2+O2
1.
H2+O2
H2+O2
2.

3D
H2+O2HRV
H2+O2

H2
3.
H2H2+O2EEGHRV
H2+O2
15551015
H2+O2
4.
1080H2+O2HRVEEG
60EEGHRV

H2
21

H2
2014319

H2+O2
3D EEGHRV

H2

H2
1.
You Tube
Cellular Respiration Electron Transport
Cellular Respiration Glycolysis Chain Krebs cycle Electron Transport 3D Animation
How Cells obtain energy
ATP-energy of the cell
Cellular Respiration-Energy in a cell
What ATP is and How it Works- BioVid Episode 3
Powering the Mitochondria BioVid Episode-3
H2
2.
a.
b. 800 H2bestdrug.blogspot.com
c. http://hydrogenconference/blogspot.tw/

22