Cancer as an Evolving and Systemic Disease

Memorial Sloan Kettering Cancer Center

New York, NY
March 12-15, 2016

Conference Program
Saturday, March 12
5:00 p.m.

Welcome reception
Zuckerman Building Lobby
417 E. 68th Street, NY, NY 10065

7:00 p.m.

Close of the day

Sunday, March 13
Keynotes, Scientific and Poster Sessions
Rockefeller Research Laboratories
430 E. 67th Street, NY, NY 10065

Keynote

8:00 a.m.

Registration and breakfast

9:00 a.m.

Opening Remarks
Scott Lowe, Memorial Sloan Kettering Cancer Center

Chair: Scott Lowe

9:15 a.m.

Session I

Mechanistic insights into multi-step tumorigenesis and its

(evolutionary) adaptations
Douglas Hanahan, ISREC, Swiss Institute for Experimental Cancer
Research

Cancer Origins and Evolution

Chair: Alexia-Ileana Zaromytidou, Nature Cell Biology
10:15 a.m.

Epigenetic stochasticity in cancer evolution

Andrew Feinberg, Johns Hopkins University School of Medicine

10:45 a.m.

Single cell mapping of developmental trajectories in health and

disease
Dana Peer, Columbia University

11:15 a.m.

Coffee break

11:45 a.m.

Inhibition and degradation of bromodomain proteins

Jay Bradner, Novartis Institutes for Biomedical Research

12:15 p.m.

The dynamic interplay between extrinsic and intrinsic force regulates

cancer progression
Valerie Weaver, University of California, San Francisco

12:45 p.m.

Short talk
Connecting cancer to aging: An evolutionary approach using in silico
and in vivo modeling
James DeGregori, University of Colorado School of Medicine

Session II

1:00 p.m.

Midday break

1:45 p.m.

Meet the Editors

The Tumor Niche: Local and Systemic Effects

Chair: Johanna Joyce, Memorial Sloan Kettering Cancer Center
2:30 p.m.

CYP3A5 mediates basal and acquired therapy resistance in different

subtypes of pancreatic ductal adenocarcinoma
Andreas Trumpp, DKFZ, Germany Cancer Research Center

3:00 p.m.

Intravital imaging of therapy failure

Erik Sahai, The Francis Crick Institute

3:30 p.m.

Deconstruction and in silico reconstruction of the evolving tumour

microenvironment of ovarian cancer
Frances Balkwill, Queen Mary, University of London

4:00 p.m.

Coffee break

4:30 p.m.

The biology and function of exosomes in pancreatic cancer

Raghu Kalluri, The University of Texas MD Anderson Cancer Center

5:00 p.m.

Local and systemic effects of senescent cells

Judith Campisi, Buck Institute California

5:30 p.m.

Short talk
BRD4 connects super enhancer remodeling to senescence immune
surveillance
Ana Banito, Memorial Sloan Kettering Cancer Center

5:45 p.m.

Poster Session A and Reception

7:45 p.m.

Close of day

Monday, March 14
8:00 a.m.
Session III

Registration and breakfast

Cancer Metabolism: Cancer-cell-intrinsic and -systemic effects

Chair: Victoria Aranda, Nature
9:00 a.m.

Exploring how cancer cell metabolism influences the stromal

environment
Craig Thompson, Memorial Sloan Kettering Cancer Center

9:30 a.m.

Oncogenes strike a balance between cellular growth and

homeostasis
Celeste Simon, University of Pennsylvania

10:00 a.m.

PI3K and cancer metabolism

Lewis Cantley, Weill Medical College of Cornell University

10:30 a.m.

Coffee break

11:00 a.m.
11:30 a.m.

Keynote

12:00 p.m.

An oncogenic metabolic switch mediates resistance to NOTCH1

inhibition in T-ALL
Daniel Herranz, Columbia University

12:15 p.m.

Midday Break

Chair: Scott Lowe, Memorial Sloan Kettering Cancer Center

1:45 p.m.

Session IV

Microbial metabolites and development of colorectal cancer

Christian Jobin, University of Florida School of Medicine
Cachexia, wasting and the browning of adipose tissues: Role of
PTHRP
Bruce Spiegelman, Dana-Farber Cancer Institute

The mutations that drive tumor evolution

Bert Vogelstein, Ludwig Center at Johns Hopkins University

The metastatic cascade and systemic effects

Chair: Ross Levine, Memorial Sloan Kettering Cancer Center

2:45 p.m.

Tumor exosomes dictate pre-metastatic niches

David Lyden, Weill Medical College of Cornell University

3:15 p.m.

Maladapted vascular niche initiates tumor invasion and metastasis

Shahin Rafii, Weill Medical College of Cornell University

3:45 p.m.

Coffee break

4:15 p.m.

Metastasis through the prism of CTCS

Shyamala Maheswaran, Massachusetts General Hospital Cancer
Center, Harvard University

4:45 p.m.

Metastatic colonization of vital organs

Joan Massagu, Memorial Sloan Kettering Cancer Center

5:15 p.m.

Oxidative stress inhibits distant metastasis by human melanoma cells

Sean Morrison, University of Texas Southwestern Medical Center

5:45 p.m.

Short talk
Quantitative clonal dynamics define mechanisms for CLL evolution in
response to combination chemotherapy
Dan Landau, Weill Cornell Medical College and the New York
Genome Center

6:00 p.m.

Poster Session B and Reception

8:00 p.m.

Close of the day

Tuesday, March 15
8:00 a.m.
Memorial

Registration and breakfast

Alan Hall and Chris Marshall Memorial Lecture

Chair: Joan Massagu, Memorial Sloan Kettering Cancer Center
9:00 a.m.

TKS adaptors, invadopodia and tumor progression

Sara Courtneidge, Oregon Health & Science University

Session V

Therapeutic prospects
Chair: Sarah Seton-Rogers, Nature Reviews Cancer
9:50 a.m.

PD-1 blockade in cancer: Immunotherapy meets precision medicine

Suzanne Topalian, Kimmel Cancer Center at Johns Hopkins University

10:20 a.m.

Inflammation and cancer: Reprogramming the immune

microenvironment as an anti-cancer therapeutic strategy
Lisa Coussens, Knight Cancer Institute of the Oregon Health &
Science University

10:50 a.m.

Coffee break

11:20 a.m.

Ag-221 offers a survival advantage in a primary human IDH2 mutant

AML xenograft model
Katharine Yen, Agios Pharmaceuticals

11:50 a.m.

Targeting actionable genomic alterations and tumor evolution

Jose Baselga, Memorial Sloan Kettering Cancer Center

12:20 p.m.

Cancer Diversity and Evolution

Charles Swanton, The Francis Crick Institute

12:50 p.m.

Closing Remarks

1:20 p.m.

Close of conference