Professional Documents
Culture Documents
1.) ..the results reported herein represent clear-cut evidence for the specific binding of
chlorpromazine and trifluoperazine to ferrous human adult haemoglobin..
http://www.ncbi.nlm.nih.gov/pubmed/?term=low+hemoglobin+trifluoperazine
Paolo, A., Alberto, B., Massimo, C. and Antonio, L. (1999), Stabilization of the T-state of ferrous human adult
haemoglobin by chlorpromazine and trifluoperazine. Biotechnology and Applied Biochemistry, 30: 185187.
doi: 10.1111/j.1470-8744.1999.tb00911.x
2.) Analogous binding behavior has also been obtained with trifluoperazine binding to
haemoglobin and myoglobin
http://www.ncbi.nlm.nih.gov/pubmed/8910864
Bhattacharyya, J., Bhattacharyya, M., Chakraborti, A. S., Chaudhuri, U. and Poddar, R. K. (1996), Trifluoperazine is
More Effective than Chlorpromazine in Releasing Oxygen from Haemoglobin and Myoglobin. Journal of Pharmacy
and Pharmacology, 48: 965967. doi: 10.1111/j.2042-7158.1996.tb06013.x
3.) , previous research has shown that low hemoglobin level (anemia) is associated with
more depressive symptoms. Such an association could be expected since symptoms of low
hemoglobin level also often occur when having depressive (or anxiety) symptoms.
http://www.sciencedirect.com/science/article/pii/S002239991400021X
4.) A majority of the Beta-thalassemia patients were also suffered from mild to severe
depression, anxiety, and stress.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779154/
Adib-Hajbaghery M, Ahmadi M, S P. Health Related Quality of Life, Depression, Anxiety and Stress in Patients with
Beta-Thalassemia Major. Iranian Journal of Pediatric Hematology and Oncology. 2015;5(4):193-205.
Choroideremia
Choroideremia (CHM) is a rare inherited disorder that causes progressive vision loss, ultimately
leading to complete blindness.
Drug: Tipifarnib-P1, Enzalutamide (Xtandi)
Tipifarnib is a class of experimental cancer drugs that target protein farnesyltransferase with the
downstream effect of preventing the proper functioning of the Ras (protein), which is commonly
abnormally active in cancer.
Enzalutamide is a synthetic, non-steroidal pure antiandrogen used for the treatment of
metastatic castration-resistant prostate cancer.
1.) There was a case of sudden loss of vision due to breast cancer metastasis to the eyeball.
http://www.ncbi.nlm.nih.gov/pubmed/25038605
2.) There was a case of a pregnant woman with lung cancer presenting with choroidal
metastasis.
http://www.ncbi.nlm.nih.gov/pubmed/25962199
1.) There was a case of a dog with right-sided congestive heart failure because of a primary
intracavitary myocardial lymphoma.
http://www.ncbi.nlm.nih.gov/pubmed/25708789
2.) Survivors of childhood lymphoma (CL) have markedly increased risk of developing heart
failure.
http://www.ncbi.nlm.nih.gov/pubmed/24948492
Fanconi Anaemia
FA is a rare genetic disease.People with FA have hbone marrow failure, physical abnormalities,
organ defects.
90 percent of people with Fanconi anemia have impaired bone marrow function that leads to a
decrease in the production of all blood cells (aplastic anemia).Most develop cancer(AML)
FA is the result of a genetic defect in a cluster of proteins responsible for DNA repair
Treatment : Gene Therapy,Blood Transplant
medcines called growth factors (such as erythropoietin, G-CSF, and GM-CSF) can improve blood counts for a short
while.
Barrett's Esophagus
Barrett's esophagus is a serious complication of GERD, which stands for gastroesophageal reflux
disease.
In Barrett's esophagus, normal tissue lining the esophagus changes to tissue that resembles the
lining of the intestine.
BE has strong associaton with esophageal adenocarcinoma, a very often deadly cancer
In high-grade dysplasia, the risk of developing cancer might be at 10% per patient-year or greater.
Paper1 Cediranib 20 mg/day in combination with cisplatin and S-1 or capecitabine was tolerable, with
no new toxicities identified, and showed preliminary evidence of antitumour activity.
http://www.ncbi.nlm.nih.gov/pubmed/27025186
Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for
patients with advanced colorectal cancer: a double-blind, randomized phase III study
(HORIZON III).
http://www.ncbi.nlm.nih.gov/pubmed/22965961
Bacterial infection