Professional Documents
Culture Documents
Tuia Ma
Thuja occidentalis / Thuja plicata
A rvore da Vida
Por Fabian Laszlo
Folhas de Cupressus
sempervirens (cipreste europeu)
Referncias:
1. Toxicokinetics of -thujone following intravenous and gavage administration of -thujone or - and -thujone
mixture in male and female F344/N rats and B6C3F1 mice. Waidyanatha S, Johnson JD, Hong SP, Robinson VG,
Gibbs S, Graves SW, Hooth MJ, Smith CS. Toxicol Appl Pharmacol. 2013 May 10;271(2):216-228
2. The choice of thujone as drug for diabetes. Lachenmeier DW, Walch SG. Nat Prod Res. 2011 Dec;25(20):1890-2
3. Thujone inhibits lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. Siveen KS, Kuttan G. Can
J Physiol Pharmacol. 2011 Oct;89(10):691-703.
4. Anticancer activity of Salvia officinalis essential oil against HNSCC cell line (UMSCC1). Sertel S, Eichhorn T,
Plinkert PK, Efferth T. HNO. 2011 Dec;59(12):1203-8.
5. Augmentation of humoral and cell mediated immune responses by Thujone. Siveen KS, Kuttan G.
Int Immunopharmacol. 2011 Dec;11(12):1967-75.
6. Thujone corrects cholesterol and triglyceride profiles in diabetic rat model. Baddar NW, Aburjai TA, Taha MO,
Disi AM. Nat Prod Res. 2011 Jul;25(12):1180-4
7. Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials: Evidences from In Vitro
Studies on A375 Cells. Biswas R, Mandal SK, Dutta S, Bhattacharyya SS, Boujedaini N, Khuda-Bukhsh AR. Evid
Based Complement Alternat Med. 2011;2011:568148.
8. Metabolism of -thujone in human hepatic preparations in vitro. Abass K, Reponen P, Mattila S, Pelkonen O.
Xenobiotica. 2011 Feb;41(2):101-11.
9. Risk assessment of thujone in foods and medicines containing sage and wormwood--evidence for a need of
regulatory changes? Lachenmeier DW, Uebelacker M. Regul Toxicol Pharmacol. 2010 Dec;58(3):437-43.
10. Thujone, a component of medicinal herbs, rescues palmitate-induced insulin resistance in skeletal muscle.
Alkhateeb H, Bonen A. Am J Physiol Regul Integr Comp Physiol. 2010 Sep;299(3):R804-12.
11. Wormwood (Artemisia absinthium L.)--a curious plant with both neurotoxic and neuroprotective properties?
Lachenmeier DW. J Ethnopharmacol. 2010 Aug 19;131(1):224-7.
12. Absinthe, the nervous system and painting. Rekand T. Int Rev Neurobiol. 2006;74:271-8.
13. Thuja occidentalis (Arbor vitae): A Review of its Pharmaceutical, Pharmacological and Clinical Properties. Naser
B, Bodinet C, Tegtmeier M, Lindequist U. Evid Based Complement Alternat Med. 2005 Mar;2(1):69-78.
14. Absinthe: attention performance and mood under the influence of thujone. Dettling A, Grass H, Schuff A, Skopp
G, Strohbeck-Kuehner P, Haffner HT. J Stud Alcohol. 2004 Sep;65(5):573-81.
15. Alpha-thujone reduces 5-HT3 receptor activity by an effect on the agonist-reduced desensitization.
Deiml T, Haseneder R, Zieglgnsberger W, Rammes G, Eisensamer B, Rupprecht R, Hapfelmeier G.
Neuropharmacology. 2004 Feb;46(2):192-201.
16. Absinthe and gamma-aminobutyric acid receptors. Olsen RW. Proc Natl Acad Sci U S A. 2000 Apr
25;97(9):4417-8.
17. Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses.
Meschler JP, Howlett AC. Pharmacol Biochem Behav. 1999 Mar;62(3):473-80.
18. Porphyrogenic properties of the terpenes camphor, pinene, and thujone (with a note on historic implications for
absinthe and the illness of Vincent van Gogh).Bonkovsky HL, Cable EE, Cable JW, Donohue SE, White EC, Greene
YJ, Lambrecht RW, Srivastava KK, Arnold WN. Biochem Pharmacol. 1992 Jun 9;43(11):2359-68.
19. (-)-3-Isothujone, a small nonnitrogenous molecule with antinociceptive activity in mice.
Rice KC, Wilson RS. J Med Chem. 1976 Aug;19(8):1054-7.
20. Effects of thujone on spontaneous activity and on conditioned behavior of rats. Pinto-Scognamiglio W. Boll Chim
Farm. 1968 Dec;107(12):780-91.
21. Current knowledge on the pharmacodynamic activity of the prolonged administration of thujone, a natural
flavoring agent. Pinto-Scognamiglio W. Boll Chim Farm. 1967 May;106(5):292-300.
22. Monoterpene -thujone exerts a differential inhibitory action on GABA(A) receptors implicated in phasic and
tonic GABAergic inhibition. Czyzewska MM, Mozrzymas JW. Eur J Pharmacol. 2013 Feb 28;702(1-3):38-43.
23. Thujone and thujone-containing herbal medicinal and botanical products: toxicological assessment.
Pelkonen O, Abass K, Wiesner J. Regul Toxicol Pharmacol. 2013 Feb;65(1):100-7.
24. Modulation of GABAergic synaptic currents and current responses by -thujone and dihydroumbellulone. Szczot
M, Czyzewska MM, Appendino G, Mozrzymas JW. J Nat Prod. 2012 Apr 27;75(4):622-9.
25. Thuja occidentalis (Arbor vitae): A Review of its Pharmaceutical, Pharmacological and Clinical Properties. Naser
B, Bodinet C, Tegtmeier M, Lindequist U. Evid Based Complement Alternat Med. 2005 Mar;2(1):69-78. Epub 2005
Feb 9
26. The antimicrobial properties of cedar leaf (Thuja plicata) oil; a safe and efficient decontamination agent for
buildings. Hudson J, Kuo M, Vimalanathan S. Int J Environ Res Public Health. 2011 Dec;8(12):4477-87. doi:
10.3390/ijerph8124477. Epub 2011 Nov 30.
27. Anemia imunolgica: http://www.sciencedaily.com/releases/2010/06/100609083231.htm (em 08/2013)
28. CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation.
Nathan C. Boles, Kuanyin K. Lin, Georgi L. Lukov, Teresa V. Bowman, Megan T. Baldridge and Margaret A.
Goodell - BLOOD 2011 118: 80-87 (visitado em agosto de 2013):
http://bloodjournal.hematologylibrary.org/content/118/1/80.full.pdf
29. http://www.thujone.info