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ABSTRACT

Differences in levels of Nitric Oxide in depressed patients after an acute coronary syndrome
Hasanah Mumpuni1, Noor Asyiqah Sofia2, Iswandi Darwis3

Cardiovascular Division, Department of Internal Medicine, Faculty of Medicine Universitas Gadjah

Mada Dr. Sardjito Hospital


Cardiovascular Division, Department of Internal Medicine, Faculty of Medicine Universitas Gadjah

Mada Dr. Sardjito Hospital


Resident in Department of Internal Medicine, Faculty of Medicine Universitas Gadjah Mada Dr.
Sardjito Hospital

Background. Acute coronary syndrome (ACS) is a cardiovascular disease that causes many
deaths in developed countries. The incidence of depression in patients with ACS are 2-3 times
higher than the general population. Inflammation and endothelial dysfunction are two things that
are thought to play an important role in the link between depression and coronary heart disease.
Elevated levels of inflammatory markers and decrease of endothelial function are found in
patients with depression. Inflammation plays a role in the synthesis of endothelium Nitric Oxide
(NO). The aim of this study is to determine the differences in levels of Nitric Oxide in depressed
patients after an acute coronary syndrome.
Methods. This was an observational study with cross-sectional design that investigate the
differences in the levels of NO in depressed patients after acute coronary syndromes and were
taken at one time. The study was conducted at the Dr. Sardjito Hospital from May to August
2015. Populations of this study are patients with at least 1 month post-ACS of age 40-60 years
who went to RSUP Dr. Sardjito and willing to follow the course of the study. The subjects of this
study are populations that meet the inclusion criteria and without exclusion criteria.
Results. The amount of nitric oxide in patients with depression is lower 32.22 + 2.38 compared
to patients with no depression 32.45 + 2.38 with p value of 0.583. It can be concluded that the
amount of nitric oxide in patients with depression is lower but not significantly different with the
amount of nitric oxide in patients with no depression. Depressive patients also received fewer
treatment of organic nitrate 37.5% compared to non-depressed patients 55% (p-value 0.116) but
there is no relation between organic nitrates with depressive symptoms.
Conclusions. The amount of nitric oxide in depressed patients is lower than non-depressed
patients but there is no significant difference.
Keywords. Acute coronary syndrome, depression, nitric oxide.