Fabtec Training 23 to 25 June 2016

Hotel Park View Mumbai

contact@sasidharanmenon.com
+919820698100

Operate under positive pressure to

minimize the ingress of dirty air
Internal finish should be non-shedding
Provide access to all sections
Unit must be cleanable
Attenuators should be non-shedding
and located upstream of HEPAs

Humidifiers present a risk of microbiological

growth use clean steam
Drain pans must not allow standing water
Provision for HEPA filter testing with aerosol
injection ports and downstream access

Make-Up air is required for:

Exhaust air
Space pressurization
Leakage (refer to ASHRAE Fundamentals)

Must remove external contamination sources

Dehumidification to control dew point

Outside Air Load

Direct Drive Fan with VFD
Dual Fans
Humidifier

Pre-filter

& Final Filter

TEAO Motor
Direct Digital Controls
Flexibility & Redundancy
6

Understand peak load coil

conditions
Sensible
Latent (dehumidification)

Velocity and air pressure drop

Chilled water operating
temperatures

Reduce the airs capacity to hold

moisture
Increase pressure or cool it

Attract water vapor with a desiccant

Liquid
Solid

Moves air in & out of cleanroom

Recirculating air handlers with
ducted terminal HEPA filters are
most common

Sensible Only Cooling

Direct Drive Fan with VFD
Humidifier
Pre-filter

TEAO

Motor
Minimize Pressure Drop
Direct Digital Controls
Control Valves

HVAC systems for cleanrooms are expensive

and consume high amount of energy
Optimize air change rates and differential
pressures
Maximize life of HEPA filters
Design for good maintenance and testing

ASHRAE HVAC Applications - Clean Spaces

IEST Recommended Practices
ISPE Pharma Engineering Guides
US FDA Center for Drug Evaluation and
Research http://www.fda.gov/cder/