Professional Documents
Culture Documents
Name
Nationality
Date of Birth
Place of Birth
Academic Career
1988-1990
1991-1995
1990-1991
December 1996
November 2003
October 2008
Professional Training
1/96-6/1997
7/1998-6/1999
7/98-12/1998
1/99-10/2000
10/2000-05/2004
05/2004-06/2006
07/2006-09/2008
Since 10/2008
November 1997
Friedrich-Wilhelm-Award of Rheinisch-Westflischen
Technical University of Aachen, Germany
October 2002
since 2002
Patents
Research Training
1990-1991
01/96-06/1997
7/98-12/1998
1/99-10/2000
Since 10/2001
2.
3.
4.
5.
6.
2.
Cooperation with Matthias A. Clauss, MD, Indiana Center for Vascular Biology &
Medicine, Indianapolis, USA regarding the role of the CXCR3 chemokine EMAPII in cardiovascular disease, particular in the recruitment and differentiation of
endothelial progenitor cells
Multiple cooperation within the WP7 of the Cardiogenics Proposal FP6-2005th
LIFESCIHEALTH-6 (LSH-2005-2.1.1-1)(No. 037593) of the 6 Framework
Programme on Research, Technological Development and Demostration of the
European Commision
Major Achievements
First transcriptome analyses in human restenosis, hibernating myocardium and
ruptured plaques
Identification of interferon and the TH1 immune response as culprit in restenosis
Identification of new therapeutic options for the treatment of restenosis (sirolimus)
First proof that stem cell mobilization with G-CSF does not have any benefit in
patients with acute myocardial infarction
1.
2.
3.
4.
Publications
1.
2.
3.
5.
6.
7.
8.
9.
10. Klein CA, Zohlnhfer D, Petat-Dutter K, Wendler N (2003). Gene expression analysis of a single or
few cells. Curr Protoc Mol Biol. 2003 Feb ;Chapter 25:Unit 25B.8.
11. Zohlnhfer D, Nhrenberg TG, Neumann FJ, Richter T, May AE, Schmidt R, Denker K, Clauss MA,
Schomig A, Baeuerle PA (2004). Rapamycin effects transcriptional programs in smooth muscle cells
controlling proliferative and inflammatory properties. Mol Pharm 65(4):880-9.
12. Hausleiter J, Kastrati A, Mehilli J, Vogeser M, Zohlnhfer D, Schuhlen H, Goos C, Pache J, Dotzer F,
Pogatsa-Murray G, Dirschinger J, Heemann U, Schmig A (2004). Randomized, double-blind, placebocontrolled trial of oral sirolimus for restenosis prevention in patients with in-stent restenosis: the Oral
Sirolimus to Inhibit Recurrent In-stent Stenosis (OSIRIS) trial. Circulation 17;110(7):790-5
13. Nhrenberg TG, Voisard R, Fahlisch F, Rudelius M, Braun J, Gschwend J, Kountides M, Herter T,
Baur R, Hombach V, Baeuerle PA, Zohlnhfer D (2005). Rapamycin Attenuates Vascular Wall
Inflammation and Progenitor Cell Promoters after Angioplasty. FASEB J. 19(2):246-8
14. Gick M, Jander N, Bestehorn H-P, Kienzle R-P, Ferenc M, Werner K, Comberg T, Peitz K, Zohlnhfer
D, Bassignana V, Buettner HJ, Neumann F-J (2005). A Randomized Evaluation of the Effects of FilterBased Distal Protection on Myocardial Perfusion and Infarct Size After Primary Percutaneous Catheter
Intervention in Myocardial Infarction With and Without ST-Elevation. Circulation 6;112(10):1462-9.
15. Ott I, Michaelis C, Schuermann M, Steppich B, Seitz I, Dewerchin M, Zohlnhfer D, Wessely R,
Rudelius M, Schmig A, Carmeliet P. (2005). Vascular remodeling in mice lacking the cytoplasmic
domain of tissue factor. Circ Res. 5;97(3):293-8.
16. Zohlnhfer D, Hausleiter J, Kastrati A, Mehilli J, Goos C, Schhlen H, Pache J, Pogatsa-Murray G,
Dirschinger J, Schmig A (2005). A Randomized, Double-blind, Placebo-controlled Trial on Restenosis
Prevention by the Receptor Tyrosine Kinase Inhibitor Imatinib. J Am Coll Cardiol. 46(11):1999-2003.
17. Klein CA, Zohlnhfer D, Petat-Dutter K, Wendler N.(2005). Gene expression analysis of a single or
few cells.Curr Protoc Hum Genet;Chapter 11:Unit 11.8.
Reviews
1. Zohlnhfer D, Kastrati A, Schmig A (2007). Stem cell mobilization by granulocyte-colony-stimulating
factor in acute myocardial infarction: Lessons from the REVIVAL-2 trial. Nature Clinical PracticeCardiovascular Medicine. Vol 4 Suppl 1
Books
1. Klein CA, Zohlnhfer D, Petat-Dutter K, Wendler N (2003). Gene expression analysis of a single or
few cells.Curr Protoc Mol Biol.;Chapter 25:Unit 25B.8.
2.
Klein CA, Zohlnhfer D, Petat-Dutter K, Wendler N (2005).Gene expression analysis of a single or few
cells.Curr Protoc Hum Genet. Chapter 11:Unit 11.8.
3.
4.
Zohlnhfer D, Neumann FJ (2007). Gene Expression Profiling and Restenosis in: Essentials of
Restenosis: For the Interventional Cardiologist. Edited by H-J- Duckers, P.W. Serruys, and E.G. Nabel.
Humana Press, ISBN 1588294919, 9781588294913
5.
External funding
1.
2.
3.
4.
5.
6.
Research grant by Deutsche Forschungsgemeinschaft, Bonn, Germany (Zo 104/21); Jan. 2002- Dec. 2005
Research grant by Deutsche Forschungsgemeinschaft, Bonn, Germany (Zo 104/22); Jan 2005 - Dec. 2006
Research
grant
within
the
Graduiertenkolleg
438
of
Deutsche
Forschungsgemeinschaft, Bonn, Germany; Jan 2002-Dec 2007
Project in Working Package 7 des Cardiogenics-Antrags FP6-2005LIFESCIHEALTH-6 (LSH-2005-2.1.1-1)
Ongoing funding within the Klinische Kommission fr Forschung (KKF) of the
Technische Universitt Mnchen since 2001 (KKF 8732194, KKF 8732151, KKF
7-05)
Rolle des CXCR-3-Systems fr die Rekrutierung und Differenzierung
zirkulierender Vorluferzellen im Rahmen der Th-1-Antwort nach
Gefwandverletzung: DFG Zo 104/4-1
Teaching
1.
2.
3.
4.
Teaching experience within the scope of lectures, weekly bedside teaching, weekly
seminars, conferences, practical training of the students since 1997.
Participation in innovative teaching approaches such as supervision of students for
a week at the beginning of the term and mentorship for students for the duration of
their studies.
Annual lecture within the Intensivkurs Innere Medizin (subject: heart failure) at
Munich since 2004.
Supervision of doctoral candidates (n= 9) partly within the Graduiertenkolleg 438
of the DFG (n=2).
Memberships
1.
Deutsche Gesellschaft fr Kardiologie (DGK)
2.
Europische Gesellschaft fr Kardiologie (ESC)
3.
Gesellschaft fr Mikrozirkulation und Vaskulre Biologie