THE OXFORD COLLEGE OF ENGINEERING

Hosur road , Bommanahalli, Bangalore-560 068

Department of Engineering Mathematics

LESSON PLAN
Faculty Name
K Palanivel
Academic Year 2013-2014
Course/Branch MTECH/Biology
Semester
III SEM
Subject Title
Statistical Methods for Biology
Subject Code
10BI32
Objective of
To get the basic knowledge of Statistics in field of Bioinformatics
Course
engineering
PREREQUISITE Basic Mathematics, Statistics, Permutations & combinations
Uni
t
I

II

III

Date
29/09/20
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30/09/20
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01/10/20
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01/10/20
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04/10/20
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07/10/20
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10/10/20
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12/10/20
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13/10/20
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14/10/20
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15/10/20
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17/10/20
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20/10/20
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21/10/20
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21/10/20
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22/10/20

Perio
d
2nd

TOPIC
UNIT I-BASICS OF STATISTICS
Descriptive statistics-frequency distributions

Books Referred
& Pages
Warren J. &
Gregory Grant,

Data presentation

3rd

Diagrammatic representation of frequency

distribution

1st

Histogram, Frequency polygon, frequency curve

4th

Measures of central tendency

5th

Inferential Statistics

3rd

UNIT II-FREQUENCY DISTIBUTION FUNCTIONS

Binomial Distribution, Poisson Distribution

1st

Warren J. &
Gregory Grant

Uniform Distribution

4th

p. no. 80-105

Normal distribution

5th

Distribution functions of more than one RV

2nd

Joint Distributions

7th

Conditional Distributions

3rd

Marginal Distribution and Independent RV

3rd

UNIT III- STATISTICAL INFERENCE

and Bayesian methods

1st

S P Gupta

Classical Estimation Methods

1st

p.no.76-89

Classical Hypothesis testing

4th

Classical

p.no. 9-34

IV

VI

VII

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28/10/20
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28/10/20
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02/11/20
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03/11/20
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04/11/20
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04/11/20
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08/11/20
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09/11/20
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15/11/20
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17/11/20
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18/11/20
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19/11/20
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21/11/20
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22/11/20
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23/11/20
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25/11/20
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26/11/20
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28/11/20
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30/11/20
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01/12/20
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02/12/20
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03/12/20
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05/12/20
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08/12/20
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Likelihood ratios few examples

3rd

Hypothesis testing using Maximum as Test Statistics

5th

UNIT IV-STOCHASTIC PROCESSES

Introduction to Random Process

3rd

S P Gupta
Warren J.

st

Poisson and Binomial distribution

p.no.89-166
&
115-134

Poisson and Gamma distribution

4th

Pure Birth Test

5th

Markov Chains

1st

Transition Probabilities TPM

1st

Absorbing non-absorbing states

6th

Criteria for Good Estimators

3rd

UNIT-V ESTIMATION AND HYPOTHESIS TESTING

THEORY Introduction

4th

Gibson & S.V. Muse

Maximum Likelihood Estimation

1st

p.no. 356-390

Multiple Regression

1st

Hypothesis testing

2nd

Confidence limits, t-distribution

1st

2 -Test

3rd

ANNOVA - One Way Classification

3rd

Two Way Classification

1st

UNIT VI ANALYSIS OF DNA SEQUENCES

Analysis of single DNA sequence

4th

Warren J. &
Gregory Grant

Analysis of pattern.

5th

p.no.185-205

Frequency comparison, Sequence alignment

3rd

Alignment algorithms

1st

Protein sequences & Substitution matrices

4th

UNIT VII STATISTICAL APPROACH FOR

SEQUENCE ALIGNMENT & SEQUQNCE SEARCH
Comparison of two Aligned sequences

5th

Gibson & S.V. Muse

VIII

IX

09/12/20 Query sequence against a database

11
10/12/20 Minimum Significance lengths
11
12/12/20 Gapped BLAST and PSI-BLAST
11
18/12/20 UNIT-VIII HIDDEN MORKOV MODELS:
Introduction, Algorithms
11
20/12/20 Forward and Backward algorithm
11
21/12/20 Verterbi and estimation Algorithms
11
25/12/20 Applications of HMM. C
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27/12/20 UNIT-IX CASE STUDY IN PROTEOMIC MASSSPECTROMETRY: Coronary artery disease data
11
30/12/20 Phenotypic characterization of Yersinia pestis,
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30/12/20 Detecting lineage-specific evolution of DNA
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01/01/20 UNIT-X Evolutionary Models of Nucleotide substitution
12
03/01/20 Discrete Time Models Phylogenic tree estimation
11
04/01/20 Tree building methods
12

Signature of the Faculty

HOD

3rd

P.no.109

1st
4th
5th

e-Book

3rd
1st
4th
5th

T. Hastie, R.
Tibsirani

6th

p.no 68

3rd
1st

R. Gentlema

4th

p.no. 345

5th