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Table 2
BRIEF COMMUNICATIONS
Comparison of perinatal outcome
Perinatal outcome
Nifedipine
Ritodrine
2
0
4
2
1
1
0
1
5.7
11.4
5.6
2.8
2.8
2.8
12
3
8
6
1
5
1
2
34.2
8.5
22.9
17.1
2.8
14.2
2.8
5.6
References
[1] Sirohiwal D, Sachan A, Bano A, Gulati N. Evaluation of ritodrine
for tocolysis in preterm labor. J Obstet Gynaecol India 2001;51:
667.
[2] King JF. Tocolysis for preterm labor using Nifedipine. Aust N Z J
Obstet Gynaecol 2003;43:1928.
[3] Arias F, editor. Practical Guide to High Risk Pregnancy and
Delivery. 2nd edition. New Delhi: Elsevier India Private Ltd;
2004. p. 7195.
KEYWORDS
Nifedipine;
Tocolysis;
Rupture of membranes;
Pulmonary edema
BRIEF COMMUNICATIONS
recruited so far developed PE knowing that ROM and multiple
gestations are exclusion criteria.
The observed clinical symptoms were out of proportion with the
chest X-ray findings. These symptoms might be secondary to some
form of chemical irritation to the lungs which makes them prone to
develop PE particularly after excessive hydration. The second case
had possible pneumonia which might have rendered the lungs
vulnerable to the possible nifedipine-inflicted injury. The
contribution of MgSO4 to the clinical picture cannot be quantified
but is probably marginal in view of the therapeutic Mg level.
In conclusion, nifedipine should be used with caution in the
context of preterm labor and rupture of membranes, considering
149
that most of these patients are candidates for corticosteroids and
generous hydration.
References
[1] King JF, Flenady VJ, Papatsonis DN, Dekker GA, Carbonne B.
Calcium channel blockers for inhibiting preterm labour. Cochrane
Database Syst Rev 2003(1):CD002255.
[2] Abbas OM, Nassar AH, Kanj NA, Usta IM. Acute pulmonary edema
during tocolytic therapy with nifedipine. Am J Obstet Gynecol
2006;195:e34.
KEYWORDS
Heart failure;
Peripartum
cardiomyopathy;
Virus;
Pregnancy