Professional Documents
Culture Documents
(CHE 604)
GROUP PROJECT:
SUCCINIC ACID PRODUCTION PLANT
(2010438828)
(2010823606)
(2010427046)
(2010481158)
(2010221172)
(2011817088)
(2011270636)
(2010872226)
(2010825384)
TABLE OF CONTENT
1.
CONTENT
PAGE
Introduction
Process Description
Equipment Design
15
Economic Analysis
48
Environmental Considerations
75
Plant Layout
95
98
References
99
Appendixes
100
INTRODUCTION
2
This plant has been designed to produce succinic acid and focused on all aspects that are
important for the production of succinic acid. The plant is located at Bukit Minyak Free Industrial
Zone, Penang and this report will explain thoroughly on the details about the variation of
methods, process selection, the reaction being generated and the description on the production
of succinic acid based on 1000 kg of raw material supplied. Basically, this project had chosen
the fermentation of Anaerobiospirillum succiniciproducens as the method of operation. This
reaction will consume 100% pure carbon dioxide gas at 39 0C and absolute pressure of 1.013
bars. Product specification has been carried out and the result obtained at the end of the
process is purified succinic acid. The environmental impact assessment, ways to control the
pollution, the characteristics and the behaviour of the populace surrounding are also discussed
in this report. This plant considers full safety of overall plant operations starting from the
handling of raw materials until the recovery of final product. The product will be sold to local and
foreign markets and being used as a raw material for other manufacturing purposes.
1.1
Product Description
Succinic acid is a white, odorless solid which categorized under dicarbolxylic acid and diprotic
acid group. Succinic acid has a chemical formula of C 4H6O4 and molecular weight of 118.088
g/mol. Before this chemical is named as succinic acid, it is known as butanedioic acid. Succinic
acid is under organic acid family and has a melting point of 185-188C. This chemical is soluble
in water, ehanol and diethyl ether while it is insoluble in chloroform and methylene chloride.
Succinic acid could be applied in many different fields, such as chemical, food and medicine
industry. In chemical industry, succinic acid is used in the productions of spray paint, dyes, ion
exchange resin, pesticide and many more. In medicine industry, this chemical is used
in the synthesis of sedative, diuretic, vitamin, contraceptive and cancer drugs. It is also used in
foods as seasoning of wine, candy, feed, buffer, and a neutralizing agent.
1.2
Succinic acid is a component of almost all plant and animal tissues as it is a normal secondary
metabolite and involves in Kreb's cycle. If this chemical released into the atmosphere, succinic
acid may exist in both the particle and vapor phases in the ambient atmosphere. Therefore,
vapor-phase succinic acid will be degraded in the atmosphere by reaction with photochemicallyproduced hydroxyl radicals that has an estimated half-life of about 6 days. Particle phase
succinic acid will be physically removed from the atmosphere by wet and dry deposition. If
succinic acid is exposed to soil, the succinic acid is expected to have very high mobility in soil
while if released into water, succinic acid may not adsorb the suspended solids and sediments
present in the water. Besides, the potential for exposure of succinic acid into aquatic organisms
is low.
Therefore, hydrolysis will not result in crucial environmental effect since this compound lacks
functional group that hydrolyzes under environmental conditions. Occupational exposure to
succinic acid may occur through inhalation and dermal contact with this chemical at workplaces
where succinic acid is produced or applied. Based on data from Hazardous Substance Data
Bank (HSDB), the data indicates that the general population may be exposed to succinic acid
via inhalation of ambient air, ingestion of food and drinking water, and dermal contact with
products containing succinic acid.
1.4
This information is obtained from HDSB where these regulations are set by United States Food
and Drug Administration (FDA).
Succinic acid used as a general purpose food additive in animal drugs, feeds, and
related products is generally recognized as safe when used in accordance with good
manufacturing or feeding practice.
Succinic acid is a food additive permitted for direct addition to food for human
consumption, as long as the quantity of the substance added to food does not exceed
the amount reasonably required to accomplish its intended physical, nutritive, or other
technical effect in food, and any substance intended for use in or on food is of
appropriate food grade and is prepared and handled as a food ingredient.
2.
PROCESS DESCRIPTION
The process start with the medium containing dextrose and corn liquor is charge into the
reactor. Inside this reactor it is mix with the water and also nutrients. The solution is mix to make
sure that the media is homogenized. After that, it is transfer out from the reactor to the heat
sterilization to make sure that the media is no contaminated by other organisms. In this process
as shown from the process design, we can see that the fermentation broth A.
succiniciproducens is grown in a seed fermentor with a temperature of 39 oC and pressure 1 bar
together with a medium containing dextrose, corn liquor, tryptophan, sodium ions, sodium
carbonate and also carbon dioxide to produce succinate and also water. The byproduct and
unreacted material from this seed fermentation is pump to the waste treatment for further
treatment before dispose into the environment.
using microfiltration to removes the succinate. Inside the mircofiltration the filtrate is heated to
80oC to precipitate additional calcium succinate.
hydroxide and also hydrochloric acid is charge in the equipment to get the final product of
succinic acid.
2.1
PROCESS DETAILS
1. Feed Stream
Stream 1: 900 kg/batch fermentation broth
Stream 2, 18, and 27: 100 kg/batch water
Stream 3: 0.01 kg/batch nutrients
Stream 6: 100 kg/ batch microorganisms
Stream 7: 3018 kg/batch Carbon Dioxide
Stream 10: 10 kg/batch Calcium Oxide
Stream 21: 100 kg/ batch Sulfuric Acid
Stream 23: 148.5 kg/batch Calcium Hydroxide
Stream 31: 191.34 kg/batch Sodium Hydroxide
Stream 30: 99.47 kg/batch Hydrochloric Acid
Stream 33: 210.82 kg/batch Succinic Acid
2. Equipments
1. Seed Fermentation (SFR-101)
2. Fermentation (FR-101)
succinate
3. Microfiltration (MF-101)
4. Vessel Procedure (R-101)
(R-102)
(R-103)
Neutralization (V-101)
P&F Filtration (PFF-101)
Ion Exchange (INX-101)
Heat Sterilization (ST-101)
Fluid Flow ( PP-102)
( PM-101,102,103)
10. Mixing (MX-101)
11. Gate Valve ( GTV- 101,102)
5.
6.
7.
8.
9.
2.2
STREAM TABLE
10
11
12
13
14
3.
EQUIPMENT DESIGN
3.1
CHEMICAL DESIGN
In order to develop a commercially succinic acid by the batch fermentation, several
Material Balance
The material balance is fundamental to the control of processing, particularly in the
control yield of the products. It is an important part in the process design. The first material
balances are determined in the exploratory stages of a new process that improved during the
pilot plant experiments. During the succinic acid production A.succiniproducens, were
conducted in a low cost media that contain carbohydrates; dextrose (C 6H12O6), other nutrients,
such as corn steep liquor; trytophan (C11H12N2O2) and water are used as a raw material with
basis of raw material of succinic acid production is 1000 Kg/batch. The carbon dioxide is supply
to ensure that the process in the anaerobically fermentation process.
The law of conservation of mass leads to what is called a mass or a material balance:
Table 3.1.1 below provides a summary of the overall material balances and figure 3.1.1 is the
process flow diagram of our plant in producing succinic acid. Our final product will be the
succinic acid. From the table below, dextrose will represent the fermentable carbohydrates in
molasses. These quantities of these compounds depend on the chemistry of the recovery
process and cannot be reduced without changing the recovery technology. The large amount of
wastewater is worth noting.
15
COMPONENT
A.
succiniprodu
INITIAL
INPUT
OUTPUT
FINAL
0.00
100.00
1.00
0.00
Ca Hydroxide
0.00
148.50
49.50
0.00
0.00
0.00
6.98
0.00
6.98
0.00
10.00
10.00
0.00
Carb. Dioxide
0.00
6164.92
5921.86
1.06
CaSO4
0.00
0.00
214.31
0.00
Corn Liquor
0.00
585.00
35.00
0.00
Dextrose
0.00
315.00
216.00
0.00
0.00
242.000
214.31
550.000
99.000
0.00
99.47
99.47
0.00
0.00
0.00
6.24
1.89
0.00
0.00
0.00
0.00
2.78
0.85
0.00
3.46
1.05
0.00
0.00
0.00
0.00
191.34
191.34
0.00
0.00
0.00
0.00
0.00
0.01
0.00
0.00
0.01
4.40
214.31
0.00
0.00
0.00
Sulfuric Acid
0.00
100.00
1.00
0.00
Tryptophan
Water
TOTAL
0.00
0.00
8.13
0.00
1792.06
9506.29
0.00
2540.06
9508.85
0.00
0.00
5.57
0.00
4.40
214.31
99.000
0.00
748.00
0.00
Calcium
succina
CaOxide
Hydrochloric
ac
Na2CO3
Nitrogen
Oxygen
Sodium
Hydroxide
Sodium ions
Succinate
Succinic Acid
16
OUT-IN
99.000
99.000
6
7
INLET
25
25
25
10.116
1.013
1.013
0
3
3
1000.011
100
3081.723
1002.219 100.532 1713134
Component Flowrates (kg/batch)
585
315
100
100
0.0077
0.0011
0.0022
-
17
3081.723
-
8(a)
39
1.014
3
252
254.28
9
11(a)
OUTLET
20
39
1.013
0.579
19
3
2841.15
1090
1553493
1101.454
35
216
1
-
0.0077
0.0011
650
-
0.0022
2839.141
1.53269
0.46529
-
440
4181.734 kg/batch
4181.734 kg/batch
18
11(b)
Temperature (c)
Pressure (bar)
Vapor fraction
39.01
1.529
3
13
INLET
25
1.013
3
3083.19
4
10
25
1.013
3
12(a)
14
OUTLET
39
20
1.014
1.013
3
19
3094.34
1090
2
1101.45
4
1690594
650
435.6
4.4
19
1.24916
0.37922
3082.71
4
10
-
4182.94 kg/batch
4184.3438 kg/batch
* The mass balance is not equal maybe due to the presence of side reaction inside the
reactor
20
The desired succinic acid product is recovered from the precipitated calcium succinate by the
acidification with the sulphuric acid followed by filtration to remove the calcium sulfate which
precipitate.The fermentation mass stoichiometry (reaction) is as shown below:
Table 3.4 The summary stream for the vessel reactor (acidification process).
Stream Table
20
21
INLET
Temperature (c)
37.81
25
Pressure (bar)
10.605
1.013
Vapor fraction
3
3
Mass flowrate (kg/batch)
1178.99
100
Volumetric Flowrate (L/batch)
1190.856
54.687
Component Flowrates (kg/batch)
succinic acid
Water
746.0422
CaSO4
Sulphuric acid
100
Calcium succinate
432.9477
-
22
OUTLET
37.45
4.319
3
1278.99
1046.394
214.3091
746.0422
214.3091
100
4.3294
21
Water + Calcium succinate + Sulphuric acid Succinic acid + Water + CaSO4 + Calcium
succinate + Sulphuric acid
1278.9899 kg/batch
1278.9899 kg/batch
22
Adding excess of sulfuric acid in the (P-5/R-102) vessel procedure is followed by the
neutralization of the excess acid with 148.5 kg/batch calcium hydroxide. Thus ,the stream, than
goes to the filtration at (P-6/PFF-101) to filtrate any unwanted succinic acid at the filter cake with
the 100 kg/batch of hot water .The succinic acid aqueous also contain some cation and anions
,thus its use ion exchanger to stabilize the charge ions without removing the succinic acid .The
succinic acid production in the ion-exchange (P-9/INX) is 210.819 kg/batch with the volumetric
flow is 152.826 L/batch.The fermentation mass stoichiometry (reaction) in the neutralization
process is as shown below:
Table 3.5 The summary stream for the vessel reactor (Neutralization process)
Stream Table
22
23
24
25
OUTLET
35.68
25
1.013
1.013
3
0
1427.49
0
1212.55
4
0
INLET
Temperature (c)
37.45
25
Pressure (bar)
4.319
1.013
Vapor fraction
3
3
Mass flowrate (kg/batch)
1278.99
148.5
Volumetric Flowrate
1046.39
(L/batch)
4
63747
Component Flowrates (kg/batch)
214.309
214.309
succinic acid
1
1
746.042
944.042
Water
2
2
Calcium succinate
4.3294
4.32948
Succinate
Sulphuric acid
100
1
214.309
214.309
CaSO4
1
1
Calcium Hydroxide
148.95
49.5
23
214.3091 kg/batch + 746.0422 kg/batch + 4.3294 kg/batch + 100 kg/batch + 214.3091 kg/batch
+ 148.95 214.3091 kg/batch + 944.0422 kg/batch + 4.32948 kg/batch + 1 kg/batch +
214.3091 kg/batch + 49.5 kg/batch
1427.9398 kg/batch
1427.9398 kg/batch
24
3.2
3.2.1
Introduction
This chapter covers the mechanical design of the succinic plant production. The purpose of this
chapter is to detail out the design information of major equipment used in the bioproduction of
succinic acid. The summary of the design information of the equipment are tabulated. They
include the parameter of equipment sizing and mechanical design of major equipment.
3.2.2
Sample Calculation
3.2.2.1 Design Pressure
The seed fermentor will designed based on maximum operating pressure. The design pressure
that will be used is in 5%-10% range above the maximum operating pressure. For safety
purpose, the design pressure 10% above the maximum operating pressure was used. The
process flow was designed using SuperPro Designer and equipment report stated that the
design pressure that was used for fermentor is 1.52 bar.
Pdesign = 1.52 bar X 0.1N/mm2 = 0.152 N/mm2
1 bar
3.2.2.2 Design Temperature
The design temperature of the equipment depends on the temperature of the material used in
the process. The design temperature is chosen 10% above the maximum operating temperature
to avoid spurious operation during minor process upsets and for safety reasons.
Operating temperature = 39C
Design temperature = 1.1 x 39C
= 42.9 C
25
3.2:
Mechanical
properties
of
material
used
for
reactors
construction
(Sinnott&Towler,2009).
Design temperature =
42.9C X 9/5 + 32
= 109.22F
The joint efficiency that is chosen was 1.0. The type of welds used for this joint efficiency is
double-welded butt joints. This joint efficiency is selected because the strength of the joint will
be as strong as the virgin plate and the risks can be reduce as any possible defects are cutting
out and reconstructed (Sinnott&Towler, 2009).
3.2.2.6 Corrosion Allowance
Corrosion allowance is defined as the additional thickness of metal added to allow for material
lost by corrosion, erosion or scaling (Sinnott&Towler, 2009). The estimation of corrosion
allowances cannot be specified for all conditions as corrosion itself is a complex phenomenon.
Moreover, corrosion allowances may also be neglected if there is past experience regarding the
same design of reactor that proves or shown no corrosion that occurred.
For this fermentor, there is no corrosion allowance that will be used as Stainless Steel 316 has
superior corrosion resistance.
3.2.2.7 Minimum Wall Thickness
The determination of minimum wall thickness is essential as it will clarify whether the reactor
can withstand its own weight and the weight of additional loads. For a cylindrical shell, the
minimum wall thickness that is required to withstand the internal pressure during the production
of succinic acid can be calculated using the following equation:
From ASME BPV Code Sect. VIII D.I. Part UG-27;
tdesign =
Where;
Pi x Di
2 fJ1.2 Pi
t = Thickness (mm)
f = Maximum Allowable Stress (N/mm2)
J =Joint Efficiency
Di = Diameter (mm)
27
t=
t=
Pi x Di
2 fJ1.2 Pi
1.0mm
2.0mm
3.0mm
4.0mm
5.0mm
The standard torispherical heads was chosen to be used as the head of the fermentor as it is
the most commonly used closure for equipment that operating at pressure less than 15bar. This
28
process only used operating pressure of 1.52bar. The minimum thickness of torispherical head
was calculated as follows:
Flat plates and Hemispherical
Ellipsoidal
formed
heads
flat heads
Torispherical heads
heads
Diagram
Uses
Covers for
manways
The channel
covers of heat
Shape
Strength
exchangers
Flange-only
Domed
heads
Knuckle to crown
ratio = 7/17
radius
Require
plates
for
thick
The
high
shape
Capable
or
pressures
large
diameter
Domed head,
0.06
of Capable
strongest Capable
withstand
withstand
of pressure
twice 15bar.
ratio
of
>
resisting
the pressure of a
reactor.
torispherical
head
Price
of
the
same thickness
Expensive
Cheapest
Cheaper
hemispherical
increased
heads
increase
as
of
the
operating
pressure.
Minimum
thickness
t=De
CPi
fJ
t=
PiDi
4 f 1.2 Pi
29
t=
PiDi
2 fJ0.2 Pi
t=
PiRcCs
2 fJ+ Pi (Cs0.2)
t=
PiRcCs
2 fJ+ Pi (Cs0.2)
0.152 N
)(840 mm)(1.77)
mm 2
t=
0.152 N
2( 136.52 N /mm 2)(1.0)+(
)( 1.770.2)
mm2
(
t=0.83 mm
*Flat plates and formed flat heads;C= a design constant, depends on the edge constraint; De=
nominal plate diameter (L); f= maximum allowable stress (ML -1T-2); J= joint efficiency;
Hemispherical Heads& Ellipsoidal Heads: Pi= internal pressure(ML-1T-2); Di= internal
diameter (L);Torispherical Heads; Rc= crown radius(L); Cs= stress concentration factor for
torispherical heads=1/4(3+Rc/Rk)
3.2.2.9 Total Height of Fermentor
Rk
Rcc
30
Weight loads
According to Sinnott&Towler (2009), there are five major sources of loads. They are:
1.
2.
3.
4.
5.
Pressure
Dead weight of vessel and contents
Wind
Earthquake
External loads due to piping and attached equipment
However, this process will neglect one source of loads that is earthquake. Earthquake loads can
be neglected as there is no earthquake ever occurs in Malaysia.
3.2.2.10.1
Vessel weight
According to Sinnott&Towler (2009), the approximate weight of cylindrical vessel with domed
heads for steel vessel can be calculated by using equation as stated below;
Wv = 240 CvDm(Hv + 0.8Dm)t
Where;
= 130 kg/m3
Thickness
= 50mm (assume)
Total dead weight of the vessel = Vessel weight + Total load due to weight of insulation material
= (2.22 + 0.84)kN
= 3.06kN
3.2.2.10.2
Wind load
The local wind speed at Bukit Minyak Industrial Zone, Penang is 15mph (24.14km/h).
Area of the vessel that projected to wind = 2 r h = 2 (0.42m)(2.51m) = 6.62m2
Wind pressure, Psf=( x air x v2wind x Cd)/A
= [ x 1.25kg/m3 x (6.706m/s)2 x 0.8]
13.25m2
32
= 1.70N/m2
Mean diameter of vessel = 0.84m + 2(0.003m + 0.05m) = 0.946m
Loading per linear meters, Fw = 1.70N/m2 x 0.946m
= 1.61 N/m
Bending moment at the bottom of the vessel;
Mx = Fw Hv2/2 = [1.61N/m x (2.51m)2]/2 = 5.07N.m
3.2.2.10.3
Analysis of stress
Circumferential stress
12.77 N / mm 2
2t
2(5mm)
Longitudinal stress
(0.152 N / mm 2 )(840mm)
6.38 N / mm 2
4(5mm)
PDi
L
4t
=
3.06 10 3 N
0.23 N / mm 2
(840mm 5mm)5mm
Wv
( Di t )t
w
=
Bending stress
Do= 840 mm + 2(5mm) = 850mm
33
M Di
5070 Nmm 840mm
t
5mm 0.0018 N / mm 2
9
4
I 2
2
1.18 10 mm
I = /64 (Do4-Di4) =
Upwind stress
h=6.152
N/mm2
12.77N/mm2
h=6.152 h=6.148
N/mm2
N/mm2
h=6.148
N/mm2
= 6.618N/mm2
= 6.622N/mm2
12.77N/mm2
12.77N/mm2
Criteria 1
The maximum allowable design stress for SS316 at 42.9C is 136.52N/mm 2. Both upwind and
downwind stresses are below the maximum allowable stress for SS316 material. Therefore, it is
safe to specify the wall thickness to be 5mm for the bottom-most part of the vessel.
Criteria 2
34
t
Do
cbs 2 10 4
2 10 4
5mm
2
117.65 N / mm
850
mm
Therefore, maximum compressive stress is less than the critical bending stress. The column will
NOT buckle under wind load and dead loads.
3.2.2.10.3
Vessel support
According to Sinnott &Towler (2009), the notable criteria that must be observe in order to
choose the method to support the vessel are size, shape and weight of the vessel; the design
temperature and pressure; the location and arrangement of the vessel and internal and external
fittings and the accessories of the vessel. Normally, saddle support is used for horizontal vessel
while skirt support is suitable to be used for vertical vessel. The design of the thickness of the
skirt must be sufficient to ensure that the skirt is able to withstand the dead-weight loads and
bending moment with the exclusion of vessel pressure that subjected to the vessel. For the
design of fermentor in this process, the material of construction of the skirt material is plain
carbon steel using straight skirt support for the vessel.
3.2.2.11
35
1
1
Mx Wx 2 (1.62 N / m)( 2.51 0.60) 2 m 2 7.83 Nm
2
2
4M x
( Ds t sR )t sR Ds
Bending stress in the skirt, bs =
4(7.83 10 3 Nmm)
(840mm 5mm)(5mm)(840mm)
=
=
0.0028N/mm2
ws
ws (test )
Wtotal
( Ds t sR )t SR
36
16.71 10 3 N
(840mm 5mm)5mm
= 1.26N/mm
ws (operating )
Wv
( Ds t sR )t SR
3.06 10 3 N
<
fJ sin s
37
It is observed that both criteria are met. The design thickness of the skirt support is 5mm.
3.2.2.12
Agitator design
Agitation provides mixing of the phases in the reactor to keep the cells in perfect homogenous
condition for the microbes to grow and produced desired products (Sakshat Virtual Labs, 2013).
These conditions are met by providing bulk fluid and gas phase mixing, air dispersion, better
oxygen transfer and heat transfer as well as uniform environment inside the vessel (Design of
Fermenter and Kinetics, n.d.). The comparisons between different types of impeller are shown in
Table 3.4.
Pitch-blade Impeller
Gentle Marine-blade
Impellers
Blades
Types of
flow
Axial
Impeller
Diagram
38
Oxygen
mass
transfer
rate
Cells
Example
of cells
Low
High
Not shear-sensitive
Shear-sensitive cells
Filamentous bacteria and
fungi
Shear-sensitive cells
Filamentous bacteria and
fungi
The type of impeller chosen to be used for this fermentor is pitch-blade impeller because it
create better mixing inside the vessel and the mixing process that occur will not damage the
cells.
On the other hand, baffles are essentials as they can prevent vortexing inside the vessel. The
existence of vortex inside the vessel may create unfavourable operating conditions as it may
change the center of gravity of the system thus increase the power consumption of the process
(Sakshat Virtual Labs, 2013). Baffle width is one-tenth the tank diameter. In addition, the
positions of the baffles are offset from the wall at a distance equal to one-sixth the baffle width
because of the presence of heat transfer jacket that is water jacket (Mixing and Agitation,
n.d.).Furthermore, the position baffles from the tangent line at the bottom of liquid level also
extended to one half of impeller diameter.
Dimensions of agitator
39
D/10
Figure 3.4:
The dimentions of vessel.
H=Height of liquid level, Dt= Tank diameter, d=Impeller diameter (Mixing
and Agitation, n.d.).
Dt 0.84m
0.28m
3
3
Impeller diameter
H 2.51m
0.42m
6
6
Dimpeller
4
0.28m
0.07 m
4
Dimpeller
5
0.28m
0.056m
5
Dtan k 0.84m
0.084m
10
10
Width of baffle
Wbuffle
6
0.084m
0.0084m
10
Wbuffle
2
0.084m
0.042m
2
3.2.2.13
Jacket provides the circulation of water of constant temperature to maintain the temperature
inside bioreactor. The maintaining of temperature is done through indirect contact method. The
effective maintaining of temperature inside bioreactor is achieved by providing adequate heat
transfer area at the contact area of jacket and the desired water temperature is constantly
circulated throughout the process (Sakshat Virtual Labs, 2013). There are three types of jackets
that are commonly used in industry. They are spiral baffle jacket, half pipe coil jacket and dimple
jacket. The comparison between these jackets is shown in Table 3.5.
Table 3.5: Comparison of jackets used in bioreactor (Reactor (CSTR) Design Steps and
Calculations, n.d.)
Types of
jackets
41
Dimple jacket
Diagram
Cost
Heat transfer
rate
Pressure
Less expensive
Expensive
High
High
Low
Up to 10 bar
Up to 70 bar
Up to 20 bar
The type of jacket that is used in this fermentor design is spiral baffle jacket because it is
cheaper compared to the other types of jackets and it gives low pressure drop. Furthermore, the
heat transfer rate using this jacket is high thus, the desired temperature inside the fermentor can
be controlled effectively.
MECHANICAL DESIGN SPECIFICATION SHEET
FERMENTOR
Identification:Fermentation process
Item No
: P1/FR-101
No. Required: 1
Vessel length
Domed head
= 2.51 m
= Torispherical heads
Vessel Support
Type
= Skirt
Dimen
sions
(m)
V
0.60
mm
Y
0.15
C
0.74
E
0.31
J
0.245
G
0.095
43
t2
8.8
t1
5.4
Bolt
diam
20
Bolt
holes
25
Function:
Temperature
Throughput
140 C
334.07 L/h
Specification
Material of Construction
Tube length
Tube diameter
44
Function:
Operation:
Material of Construction
Vessel Temperature
Vessel Pressure
Vessel Diameter
Total Height
Vessel Volume
Average wall thickness
Type of insulation
Domed head type
Thickness of head
Total height of fermentor
Dead weight of vessel:
Dead weight of Vessel
Weight of insulation
Total dead weight
Wind load:
Bending moment
Analysis of stress:
Cicumferential stress
Longitudinal stress
Dead weight stress
Bending stress
Vessel support:
45
Type of skirt
Material of construction
Skirt thickness
Skirt height
Straight (s=90)
Plain carbon steel
5 mm
0.63 m
Agitator specifications
Types of impeller
Impeller diameter
Impeller height above vessel floor
Length of impeller blade
Width of impeller blade
Number of impellers
Number of impeller blades
Distance between 2 consecutive impellers
Width of baffles
Position of baffle from wall
Position of baffle from tangent line of
bottom floor
Pitch-blade impeller
0.30 m
0.45 m
0.075 m
0.06 m
3
4
0.30 m
0.09 m
0.015 m
0.045 m
Function:
Material of Construction
Size (Capacity)
Number of available cartridge slots
46
3.2.5
Function:
Operation:
Material of Construction
Vessel Temperature
Vessel Pressure
Vessel Diameter
Total Height
Vessel Volume
Average wall thickness
Type of insulation
Domed head type
Thickness of head
Total height of fermentor
Dead weight of vessel:
Dead weight of Vessel
Weight of insulation
Total dead weight
Wind load:
Bending moment
Analysis of stress:
Cicumferential stress
Longitudinal stress
Dead weight stress
Bending stress
Vessel support:
Type of skirt
Material of construction
Skirt thickness
Skirt height
Straight (s=90)
Plain carbon steel
5 mm
0.625 m
Agitator specifications
Types of impeller
Impeller diameter
Impeller height above vessel floor
Length of impeller blade
Width of impeller blade
Number of impellers
Number of impeller blades
Distance between 2 consecutive impellers
Width of baffles
Position of baffle from wall
Position of baffle from tangent line of
bottom floor
3.2.6
Pitch-blade impeller
0.30 m
0.37 m
0.075 m
0.06 m
3
4
0.30 m
0.089 m
0.015 m
0.0445 m
Neutralizer Specification
MECHANICAL DESIGN SPECIFICATION SHEET
NEUTRALIZER
Identification: Neutralization
Item No
: P-7/V-101
No. Required: 1
Function:
Pressure
Temperature
1.52 bar
25 C
Specification
Material of Construction
Volume
Diameter
Height
Carbon steel
581.33 L
0.67 m
1.67 m
48
3.2.7
Function:
Specification
Material of Construction
Filter area
3.2.8
Function:
Bed height
Column height
Column diameter
Bed volume
Column volume
4.00 m
8.00 m
3.87 m
47, 146.35 L
94, 292.69 L
ECONOMIC ANALYSIS
49
4.1
Introduction
Economic analysis is one parts of the production in order to estimate the economic feasibility.
Succinic acid has a wide range of applications in areas such as pharmaceutical, food and
agricultural and chemical industries. Presently a major share of succinic acid is derived from
petroleum feedstock. Based on the worldwide price index of succinic acid, refer to the demand
of world it has been mentioned that the global succinic acid market going to reach 144.7
thousand tons by 2015, according to New Report by global industry analysts. The objective is to
perform economic analysis to estimate whether that the cost of production is profitable or loss
regarding to world profit. [San Jose, CA (Vocus) August 18, 2010]
4.2
Capital cost is the cost associated with the construction of a new plant or modification to an
existing chemical manufacturing plant.
4.2.1
Module costing technique is a common technique used to estimate the cost of a new chemical
plant and for making preliminary cost estimation. Deviation from these base conditions are
handled by using multiplying factors that depend on the following:
Bare module cost is the sum of the direct and indirect costs:
C BM =C oP F BM
Where CBM = bare module equipment cost: direct and indirect
FBM = bare module cost factor
C oP
50
log
( 10 A )2
C p 0 =K 1+ K 2 log 10 A+ K 3
Where:
K1, K2, K3 can be obtained from appendix table A.1 of Analysis, Synthesis and Design
( P+1 ) D
+ 0.00315
2 [8500.6 ( P+1 ) ]
F P , vessel=
0.0063
For vessel > 0.0063 m
If FP, vessel is less than 1 (corresponding to t
vessel
than -0.5 barg, FP, vessel = 1.25. This equation is strictly true for case when thickness of the vessel
wall is less than D, vessel in the range D= 0.3 to 0.4.
4.2.3
Bare Module and Material Factors for Heat Exchangers, Process Vessels and Pumps
o
C BM =C P F BM =C P (B1 + B2 F M F P )
The value of the constants B1 and B2 are given in Table A.4. in Appendix A in Analysis,
Synthesis, and Design of Chemical Processes, Third Edition, Richard Turton. Table A.5 shows
the Equation for Bare Module Cost for Equipment Not covered by Table A.3 and A.4.
4.2.4
To relate the price of equipment from previous year to the current or present year can be
calculated as follows:
51
C2 =C1
I2
I1
Where:
C = Purchased cost
I = cost index
n
= 1.18
C BM ,i
K1
K2
K3
4.1052
-0.4680
-0.0005
CTM
i=1
Sample calculation:Reactor
Diameter
= 0.88 m
Height
= 2.19 m
Material
Pressure
Equipment
Type
Description
Reactor
Volume
Jacketed
agitated
= ( /4) D2 H
= ( /4) x (0.88)2 x (2.19)
= 1.33 m3
= 1.4 m3
log10 Cp0
Cp0
= $13733.21
52
Capacity,
Min
Max
Units
Size
Size
0.1
35
Volume,
m3
= $13800
Equipment Description
Reactor
Jacketed agitator
3.1
= C1 (I2/I1)
= $108400 (575.4/394)
= $158282.5307
C2
=$158300
C BM ,i
CTM
= 1.18
CTM
=1.18 ($2072648.713)
i=1
= $2445725.481
CTM
= $2446000
Equipment
Capacit
y
Cp ($)
Fp
FM
53
FBM
FBM
CBM ($)
CBM ($)
CE
(2
Pump/Valve
(kW)
PM-101
0.01
PM-102
0.01
PM-103
0.01
Reactor/Ves
sel
(m3)
SFR-101
1.7
FR-101
1.4
R-101
1.4
R-102
1.4
R-103
1.2
ST-101
1.5
V-101
0.6
Tower
(m3)
INX-101
100
Filter
(m2)
MF-101
14
PFF-101
1.5
7892.2348
48
7892.2348
48
7892.2348
48
13733.216
7
12385.953
3
12385.953
3
12385.953
3
11410.936
49
40864.187
3
7891.3600
12
66680.676
92
59269.161
75
21867.448
07
2.3
4.995
2.3
4.995
2.3
4.995
3.1
7.892
3.1
7.892
3.1
7.892
3.1
7.892
3.1
7.892
1.2
3.1
9.0204
4.07
4.07
4.07
4.07
1.65
1.8
75.055
4
8.14
TOTAL
54
39421.713
07
39421.713
07
39421.713
07
*
*
*
3
3942
3942
3942
108382.54
62
97749.943
46
97749.943
46
97749.943
46
90055.110
75
368611.31
52
32117.835
25
32117.835
25
3211
271390.35
51
271390.35
51
2713
97794.116
89
39361.406
52
1419227.6
55
*
*
*
*
*
*
*
*
303508.19
04
1083
9774
9774
9774
9005
3686
9779
3936
1419
4.3
In order to estimate the manufacturing cost, the information that provided on the PFD, an
estimate of the fixed capital investment and an estimate the number of operator required to
operate the plant. There are many factors that will influence the cost manufacturing chemicals.
4.3.1
Fixed Cost
-property taxes
General Expenses
-administration cost
- waste treatment
-insurance
-financing
-utilities
-depreciation
-research
-operating labor
-operating supplies
Table 2: Factors Affecting the Manufacturing Cost
Cost of Manufacturing
1.
2.
3.
4.
5.
With depreciation:
Without depreciation:
COM
CTM =1.18
CBM , i
i=1
CTM = 1.18(2073000)
CTM= $ 2446000
Stream Factor
In order to calculate the yearly cost of raw materials or utilities, the fraction time that the plant is
operating in a year must be known. This fraction known as the stream factor where,
Stream factor, f =
330
Stream Factors, f = 365
56
= 0.9041
4.3.2
In order to estimate the cost operating labor, the average hourly wage of an operator is required.
The cost of labor is broken into direct and indirect costs. Direct costs include wages for the
employees physically making a product, like workers on an assembly line. Indirect costs are
associated with support labor, such as employees that maintain factory equipment but don't
operate the machines themselves. When manufacturers set the price of a good they take the
cost of labor into account. This is because they need to charge more than that good's total cost
of production. If demand for a good drops or the price consumers are willing to pay for the good
falls, companies must adjust their cost of labor to remain profitable. They can reduce the
number of employees, cut back on production, require higher levels of productivity, reduce
indirect labor costs or reduce other factors in the cost of production. The technique used to
estimate operating labor requirements is based on data obtained from five chemical companies
and correlated by Alkayat andGerrard.
Based on the Alkahayat and Gerrard method:
Equipment Type
Vessels
Number of Equipment
1
Nnp
-
Reactors
Pumps
Filter
Valve
Mixing
Heater
1
1
*Pumps, valves and vessels are not counted in evaluating Nnp
Table 3: Estimation of Operating Labor Requirement for Succinic Acid Process
Therefore, the total Nnp= 5 + 3 + 1 + 1
= 10
Number of operator needed for one equipment
Salary Per Month
Operator
= $1500
Manager
= $4500
Assistant Manager
= $3000
Engineer
= $4000
Table 4: Total Salary/Month
Plant operates
Plant running
Operation hour
1 year
1 year
Maintenance
Table 5: Assumptions to Estimate The Cost Operating
58
FOL=
990 shift
year
operater
188 shift
59
4.3.3
Basically, the costs of utilities are directly influenced by cost of a fuel. The cost also related to
the direct impact of fuel gas, oil, coal, electric power, steam, cooling water, process water, boiler
feed water, instrument air, inert gas and refrigeration costs. To determine the utility cost can be
quite complicated and the true cost of such streams is often difficult to estimate in a large
facility. For the approach, assume the capital investment is required to build a facility to supply
the utility. Therefore,the method used to estimate operating labor requirements is based on data
obtained from five chemical companies and correlated by Alkayat andGerrard.
By using Alkahayat and Gerrard method:
Pump utility cost
Electric power=(Output Power)/Efficiency
Once the electrical power is being calculated the yearly cost is being calculated.
Incremental Economic analysis
The calculated overall utilities cost is then must be adjusted to corresponding total operating
cost for the assumed of the life of the plant which in our case is 10 years. This is done through
the incremental economic analysis. This is due to the fact that the utility cost of each year
remains constant even though inflation continues to rise over time. Assume that the discount
rate is 7%. The analysis can be evaluated from:
I = discount rate
n = no. of years
The calculated value is then multiplied by the yearly cost to obtain the accumulated cost over
the 10 years period of time.
60
Pump
Shaft work = 0.01 kW
Utility
Description
Cost $/GJ
Electrical power =
output power
efficiency
Electrical power
= 0.01/ 0.9
= 0.011
61
Slurry Tank
Utility DescriptionCost $/GJ
Ca
Cb
Aa
Ab
Thus,
Cb =
649
100
0.067
Cb = $0.043/1000kg
Hence, the yearly cost for other water =0.043 24 365 0.9041
= $340.56
62
$0.067/1000kg
$2.45/1000kg
$0.26/1000kg
$1.00/1000kg
Mixing
Utility
Description
Cost $/GJ
Waste water
a. primary(filtration) $41/1000m3
treament
$43/1000m 3
sludge
$56/1000m 3
Cb =
293.010
1000
56
Cb = $16.41/1000kg
Hence, the yearly cost for other water =16.41 24 365 0.9041
= $ 129965.82
Therefore, total utility cost, CUT = $ 5.227 + $340.56 + $ 129965.82
= $130311.61
Discount rate for the 10 years period with assumption of 7% discount rate
(1+i)n1
= i(1+i)n
P/A
(1+0.07)101
0.07(1+0.07)10
= 7.0235
63
When dealing with chemical it related to treat the waste and by-product being produced from the
process. As environmental regulations continue to tighten, the problems and costs associated
with the treatment of waste chemical streams will increase. In recent years there has been a
trend to try to reduce or eliminate the volume of these streams through waste minimization
strategies. Nowadays, it has be create a strategies involve utilizing alternative process
technology or using additional recovery steps in order to reduce or eliminate waste streams.
Although waste minimization will become increasingly important in the future, the need to treat
waste streams will continue. The calculation of this cost should be done with extreme caution
Utility Description
Cost $/GJ
$200-2000/tonne
64
4.3.5
It is important to estimate the raw material cost according to the current price in industry. Raw
material cost is a cost of material or substance used in the primary production or manufacturing
of a good. The assessment of raw material cost and the estimation of the potential market size
clearly indicate that thecurrent petroleum-based succinic acid process will be replaced by the
fermentative succinic acid production system in the foreseeable future. The raw materials cost
can be calculated by multiplying the amount produce per year with the cost per unit
weight.Succinic acid could well become an important raw material for the plastics industry if it is
possible to produce the acid biotechnologically and cost-effectively.Succinic acid, an
intermediate product in the metabolism of many organisms, could become an interesting
alternative for the petrol-based production of 1, 4-butanediol. New biotechnological methods
could considerably increase the appeal of this biomolecule if they turn out to be more
economical than traditional methods. Therefore, it is important to determine the cost material to
know the currently price that profitable to the process.
Material
Unit Cost($)
A. Succiniproducens
2.7
259
Calcium Hydroxide
40.1
40
Calcium Oxide
2.7
0.9
Carbon Dioxide
1664.53
12.01(20L-40L)
Corn Liquor
157.95
0.00093
Dextrose
85.05
Hydrochloric acid
26.857
0.095
Na2CO3
0.00059
180
51.66
18.36
0.00210
Sodium Hydroxide
Sodium ions(intermediate)
Sulfuric Acid
27
0.090
Tryptophan
0.0003
Water
483.86
25 per month
65
A.succiniproducens: CRW
= 2.7259 0.9041
= $ 632.24 per year
Calcium Hydroxide:
CRW
= 40.1 40 0.9041
= $ 1450.18 per year
Calcium Oxide:
CRW
Carbon Dioxide:
CRW
Corn Liquor:
CRW
Dextrose:
CRW
= 85.05 2 0.9041
= $ 153.79 per year
Hydrochloric acid:
CRW
Na2CO3:
CRW
Sodium Hydroxide:
CRW
Sodium ions:
CRW
66
Sulfuric Acid:
CRW
= 27 0.090 0.9041
= $ 2.196per year
Tryptophan:
CRW
= 0.0003 1 0.9041
= $ 0.00027 per year
Water:
CRW
67
4.3.6
*With depreciation
COM
*Without depreciation
68
4.4
BREAK-EVEN ANALYSIS
Break even analysis must be determined to get the minimum production of succinic acid that
required to cover back our production cost. Break even analysis is done by calculating fixed
cost, unit selling, price and variable cost with particular reference to the break-even point, to
show the effect on break-even point changes. This requires an estimation of fixed costs (FC),
variable cost (VC) and total revenues (TR).
[Sources: Chemical Engineering Design, Fourth Edition by R.K. Sinnott]
Breakeven Point = Fixed Operating Costs/ (Unit Selling Price - Variable Costs)
4.4.1
Fixed cost (FC) is the costs that do not vary with the production rate. This type of cost is actually
all the bills that need to be paid throughout the entire plant operation. Such examples are:
1
2
3
4
5
6
7
8
9
Maintenance
Operating labor
Supervision
Laboratory cost
Plant overheads
Capital changes
Rates (and any other taxes)
Insurance
License fees & royalty payments
7 operator
shift
1029 shift
year
Total mass flow rate = 2.7 + 40.1+ 2.7 + 1664.53 + 157.95 + 85.05 + 26.857 + 0.00059 + 51.66
+ 0.002 + 1 + 27 + 0.0003 + 483.86
= 2543.41 kg per year
= 2 .5434 tonne per year
year
$ 22085.75
2.5434 tonne
year
Fixed cost, FC =
7203 operator
$ 8683.55
year
year
FC = $ 62547610
70
4.4.2
Variable cost (VC) is the costs that are dependent on the amount of product produced.
Examples of variable cost are:
1
2
3
4
71
4.4.3
Total revenue (TR) is the amount of money generated from the sale of output. The total revenue
can be calculated as follows:
The objective of break-even analysis is mainly to determine, the quantity at which the product at
an assumed price, will generate enough revenue to start earning profit during the plant starts its
operation. Break- even point is to estimate the volume or capacity for the company to reach the
total cost equal to the total revenue and no profit was earned yet. So, it can be defined as:
FC
PVC
Where
Q=210.82 kg /batch
P=$ 100/kg
Total Revenue , TR=P Q
$ 50
270 batch/ year
kg
$ 2846070/ year
72
$ 2850000/ year
BEP=
$ 62547610
50(0.65+ 0.7)
BEP=1285665.16 kg/ yr
BEP=1290000 kg / yr
4.5
4.5.1
There are three criterion of non-discounted profitability which are time criterion, cash criterion
and interest rate criterion.
The term used in time criterion is the payback period (PBP), also known as the payout period,
payoff period and cash recovery period. From the book of Engineering Analysis of Chemical
Processes by Richard Turton/Richard C.Bailie/Wallace B.Whiting/Joseph A.Shaeiwitz, the
definition of payback period is defined as follows:
PBP= time required, after start-up, to recover the fixed capital investment, FCI L, for the
project
As for the cash criterion, there are two types of it which is cumulative cash position (CCP) and
cumulative cash ratio (CCR). CCP is the value of the project at the end of its life.
73
CCR=
Finally for the interest rate criterion, the term used is rate of return on investment (ROROI).
ROROI=
End of
Year
Investme
nt
dk
FCI - total
of dk
COMd
(R-COM-dk)*(1t)+dk
-5280000
2446000
-528000
-1446000
2446000
-144600
-1366900
2446000
-136690
489200
1956800
526276
1406462
140646
782700
1174100
526276
1553212
155321
704468
526276
1396678
139667
526276
1302751.6
1302751
526276
1302751.6
1302751
469632
281779.
2
281779.
2
140909.
6
526276
1232316.8
1232316
526276
1161862
116186
10
526276
1161862
116186
11
526276
1161862
116186
12
5646900
285000
0
285000
0
285000
0
285000
0
285000
0
285000
0
285000
0
285000
0
285000
0
813000
0
526276
3801862
944876
422688.8
140909.6
0
74
Cash Fl
Working
Capital
$1366900
Total Fixed Capital, FCIL =$2446000
COMd =$526276
of 10 years
75
Calculation:PBP
= 3 + (-3736548+5646900) / (-3736548+2433796.4)
= 1.53 Years
CCR
= 21128520/ 8092900
= 2.61
ROROI
4.5.2
End of
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
Non-discounted
Cash Flow
-5280000
-1446000
-1366900
1406462
1553212
1396678
1302751.6
1302751.6
1232316.8
1161862
1161862
1161862
3801862
Discounted cash
flow
-5280000
-1314545.45
-1129669.42
1056695.72
1060864.69
867227.15
735369.32
668517.55
574880.25
492742.9
4479480.09
407225.54
1211390.39
Cumulative discounted
Cash Flow
-5280000
-6594545.45
-7724214.87
-6667519.15
-5606654.46
-4739427.31
-4004057.99
-3335540.44
-2760660.19
-2267917.29
2211562.8
2618788.34
3830178.73
Calculation:DPBP
= 5 + (-3335540.44+5583000) / (-3335540.44+2760660.19)
= 4.63 Years
NPV
= $ 3830178.73
PVR
= [11554393.6 / 7724214.87]
= 1.50
5.
Environmental and safety analysis are crucial aspect to be considered in process and plant
design. The aim of the analysis is to prevent any undesirable scenaria to occur which can be
problem to the process, human and environment.
5.1
Environment Consideration
5.1.1
5.1.1.2 Byproducts
By products of this plant are calcium succinate (CS) and diethyl succinate (DES). The
waste treatment is shown in the appendix section. Properties of these materials are
shown in table 4.2 below:
Table 5.2. Properties of CS and DES.
Properties
Formula
Molecular weight (g/mol)
Boiling point (oC)
Melting point
Density
Flash point
Specific gravity
Vapor pressure
Vapor density
5.1.2
CS
C4H4O4Ca.3H2O
210.15
Decomposes
-
DES
C4H14O4
174.19
2170C
-200C
1.04 g/ml at 250C
910C
1.047 (water=1)
72.8 hPa
6 (air-1)
This plant produced succinic acid with excess calcium succinate as waste. The wastesthat
had been produced from this plant were water, succinate, dextrose, corn liquor, calcium
succinate and last but not least were Anaerobiospirillum succiniciproducens bacteria.
Wastewater that produced can be recycled back and reuse in the plant by undergoes some
modern day water treatment. While for chemical waste such as calcium succinate and
succinate that may be hazardous, the appropriate route of disposal were determine by
chemical treatment such as neutralization, followed by disposal to the sanitary sewer
system. For the non- hazardous wastes including dextrose and corn liquor that can be
disposed in the sanitary sewer or it can be sold to other company as raw materials.
For A.succiniciproducens bacteria waste that was known to infect humans and is
associated with diarrhea, the proper method of disposal this waste is required. This
infectious waste are sterilized and autoclaving at 121oC for 30 minutes before discarding.
5.2
and the public. As shown in Table 4.4, the most common accident that happened in
chemical plant is fire, followed by explosions and toxic release.
Table 5.3. Three types of chemical plant accidents.
Type of accident
Probability of
Potential for
Fire
Explosion
Toxic release
occurrence
High
Intermediate
Low
Low
Intermediate
High
economic loss
Intermediate
High
Low
a)
Flammability
Succinic acid is flammable and has a flash point of 160 0C. It is flammable in air.
There is no upper flammable limit as normally conceived in that exothermic
decomposition replaces combustion at the higher ranges up to 100% succinic acid.
Succinic acid has a boiling point of 2350C which is considered as high. Any leaks of
succinic acid for example from flanges must be avoided because of the high risk of
ignition. The auto-ignition temperature (AIT) of succinic acid in air atmospheric pressure
is 6300C.
b)
Reactivity
Succinic acid reacts exothermically to neutralize bases, both organic and inorganic. It
can also react with active metals to form gaseous hydrogen and metal salt. Such
reactions are slow in the dry but systems may absorb water from the air to allow
corrosion of iron, steel and aluminum parts and containers. Succinic acid reacts slowly
with cyanide salts to generate gaseous hydrogen cyanide. If it reacts with solutions of
cyanides, it can cause the release of gaseous hydrogen cyanide.
It can also generate flammable toxic gases and heat with diazo compounds,
dithiocarbamates, isocyanates, mercaptans, nitrides and sulfides. It may reacts with
sulfites, nitrites, thiosulfates to give out H2S and SO3 and dithionites (SO2) to generate
flammable or toxic gases heat. It can also be oxidized exothermically by strong oxidizing
agents and reduced by strong reducing agents. It may also initiate polymerization
reactions.
c)
Thermal Decompositions
Thermal stability and thermal decomposition of succinic acid and its compounds
were investigated employing simultaneous thermogravimetry and differential thermal
analysis (TG-DTA) in nitrogen and carbon dioxide atmospheres and (TG-FTIR) in
nitrogen atmosphere. On heating, both atmospheres the succinic acid melts and
evaporates. For the transition metal succinate the final residue up to 1180 oC in N,
atmosphere was a mixture of metal and metal oxide in no simple stoichiometry relation.
Routes of Entry
1.
2.
3.
4.
Inhalation
Skin Contact
Eye Contact
Ingestion
Effects of Exposure to
Products
Inhalation:
Inhalation:
symptoms develop,
consults medical
personnel
Wash skin
immediately with
plenty of soap and
water for at least 15
Ingestion:
May be harmful if
swallowed
minutes.
If redness, itching or
a burning sensation
develops, get
medical attention.
Wash contaminated
clothing and
decontaminates
footwear before
reuse.
Eye contact:
Immediately flush
with plenty of water
for at least 15
minutes.
If redness, itching or
a burning sensation
develops, have
eyes examined and
treated by medical
personnel.
Ingestion:
Do not induce
vomiting.
Give one or two
glasses of water to
drink and refer to
medical personnel
or take direction
from either a
physician or a
poison control
center.
Never give anything
by mouth to an
unconscious
person.
Chemical
Diethyl
succinate
Routes of Entry
1.
2.
3.
4.
Eye Contact
Skin Contact
Ingestion
Inhalation
Effects of Exposure to
Products
Eye contact:
Eye contact:
Immediately flush
with plenty of water
for at least 15
Skin contact:
Causes skin irritation
May be harmful if
absorbed through the skin
minutes.
Occasionally lifting
the upper and lower
eyelids
Get medical aid.
Ingestion:
May be harmful if
Skin contact:
swallowed
Wash skin
immediately with
Inhalation:
May be harmful if inhaled
Causes respiratory tract
irritation.
If conscious and
alert, rinse mouth
and drink 2-4 cupful
of milk or water.
Inhalation:
Removes victim to
fresh air.
If not breathing, give
artificial respiration.
If breathing is
difficult, give oxygen
Get medical aid.
Chemical
Calcium
succinate
Routes of Entry
1.
2.
3.
4.
Eye Contact
Skin Contact
Ingestion
Inhalation
Effects of Exposure to
Products
Eye contact:
Eye contact:
Immediately flush
eyes.
Symptoms may include
minutes.
Occasionally
holding eyelids
Skin contact:
apart
Get medical
attention.
normally required.
If symptoms
develop, seek
Inhalation:
medical attention.
Ingestion:
First aid is not
normally required.
If symptoms
develop, seek
medical attention.
Inhalation:
Removes victim to
fresh air.
If breathing is
difficult, call a
physician.
from a gap due to the inclination and thus, ignited by static electricity sparks. The response
taken due to this accident were the operation of the plant was stopped besides, water was used
to sprayed using faucet and the nitrogen gas was introduced to the reaction system.
There were some countermeasures taken after this incident happened included the bolts
should be tightened equally and fully besides, a new support for distributing the weight of piping
is installed and the thorough control of the parts at construction is required. In addition,
thoroughness of checks after construction also required.
In the case of many leak tests after construction, a leak is checked by a soap test after
pressurizing piping and facilities for the test. As a gasket and bolt torque are specified according
to physical properties of a flowing liquid, temperature, long-term use and others. Passing of a
leak test is not guaranteed for long-term use. Moreover, regarding a check of tightness of bolts,
checks in many cases conducted by striking a bolt lightly with a smaller hammer which called as
hammering test. Measurement of torque has been carried out. It is difficult to find a defect from
a general examination after completion of construction. Soap test is one of the leak tests.
Soapsuds are poured at the place to be checked mainly a joint part after pressurizing where if
bubbles are found, that is the evidence of a leak
5.2.6
Duties of Employer:
1. Provide and maintain safe plant and system of work
2. Make arrangement for safe use operation, handling, storage and transportation of
plant and substances.
3. Provide instruction, information, training and supervision.
4. Provide and maintain safe pace of work and means of access to and egress from
any place of work.
5. Provide and maintain safe and healthy working environment and adequate welfare
facilities.
Duties of Employees:
1. Reasonable care for safety and health of himself and others
2. Co-operate with employers and others
3. Wear and use PPE
5.3
Safety analysis
Succinic Acid
a) Handling
Hygiene measures
wash hands and other exposed areas with mild soap and water before
eat, drink, smoke and when leaving work.
b) Storage
II.
Storage conditions
Keep containers tightly closed and in a well-ventilated place
Incompatible materials
Strong oxidizing and reducing agents, strong bases
Storage area
Keep container tightly closed and dry
Keep it cool, well-ventilated place away from acids
CalciumSuccinate
a) Handling
Always keep it away from heat or any souces of ignition. If an empty containers
pose a fire risk, evaporate the residue under a fume hood. It is advisable to
ground all equipment containing material and do not breathe dust
b) Storage
Always keep the containers dry and kept in a cool place. The container must be
III.
Diethyl Succinate
a) Handling
Put on appropriate personal protection equipment. Eating, drinking and smoking
should be prohibited in areas where this material is handled, stored and
processed. Workers should wash hands and face before eating, drinking and
smoking. Do not ingest. Avoid contact with eyes, skin and clothing. Avoid
breathing vapor or mist. Use only with adequate ventilation. Wear appropriate
in
unlabeled
containers.
Use
appropriate
containment
to
avoid
environmental contamination.
5.3.2
Firefighting Measures
The purpose of the Fire Fighting Measures section is to describe any fire hazards
associated with the material. This information, combined with information from the
Handling and Storage and the Stability and Reactivity Data sections, can be used in
determining where a certain material should be stored (e.g. flammable liquids should be
stored in specially designed facilities away from incompatible chemicals).
Information in this section can also be used to plan the appropriate type and
placement of fire extinguishers as well as to plan the best response to a fire for a
particular work site. Much of the information is intended for firefighters and emergency
response personnel.
1. Extinguishing media
The suitable extinguishing media were dry chemical powder, alcoholresistant foam, carbon dioxide (CO2) and water spray.
2. Protection for firefighters
During firefighting, wear self-contained breathing apparatus with full face
piece and full protective clothing. If contact occurs with material or its
solutions, immediately flush with water and remove contaminated
clothing.
Dust can form explosive mixtures with air. Irritating and highly toxic gases
may be generated by thermal decomposition or combustion in a fire.
5.3.3
1. Personal precautions
Wear self-contained breathing apparatus with full facepiece and full
protective clothing. If contact occurs with material or its solutions,
immediately flush with water and remove contaminated clothing.
Use proper personal protective equipment during clean up. Ventilate area
and avoid creating dusty conditions.
2. Environmental precautions
Sweep up dry powder and dispose properly.
Do not let the products get into the drains.
3. Spills or leakage
Clean up spills immediately, observing precautions in the Protective
Equipment section.
Sweep up, then place into a suitable container for disposal. Avoid
generating dusty conditions. Provide ventilation.
4. Methods for containment and clean up
Gather the disposed material without creating dust.
Store in closed containers that are appropriate for disposal.
5.3.4
ventilation
to
minimize
dust
and/or
vapour
concentrations.
2. Personal protective equipment (PPE)
Personal protective equipment
Dust protection, it is better to wear dust mask with filter type P3,
N100
In case of dust production, use dustproof clothing and protective
goggles
Hand protection
Use protective gloves to cover your hands from hazardous
5.3.5
Disposal Considerations
For waste treatment method, first collect all waste in suitable and labelled containers and
dispose according to local legislation. It is recommended the materials and its container
must be disposed of in a safe way and as per local legislation. The waste is not
considered hazardous under US RCRA regulations.
5.3.6
Clear written policies that designate a chain of command, listing names and job titles
of the people (or departments) that are responsible for making decisions, monitoring
ERPs are also the law. The Occupational Safety & Health Administration (OSHA)
requires facilities with over 10 employees to have written emergency plan: in smaller
facilities, the plan can be communicated orally. But whatever the size or type of the
organization, top management support and the involvement of all employees are
essential.
5.4
5.4.1
Comparison of eco-efficiency
The lower eco-efficiency values represent better performance of th system. In the
biorefinery, a large faction of the carbon dioxide (CO 2) emitted by the ethanol fermentation
process is fixed by acid fermentation thus give better performance in global warming potential
(GWP) compared with gasoline refinery. This shows that the combined production of ethanol
and succinic acid is indeed a more promising option. The reason why the eco-efficiency of the
ethanol palnt is significantly worse than that of the gasoline refinery is the contribution of
agriculture realted emissions to the total, which is significantand does not occur in the gasoline
refinery.
The eco-efficiencies of the biorefinery and ethanol plant are better than one of gasoline
refinery in the abiotic resource depletion potential (ADP) and ozone layer depletion potential
(ODP). This is obviously due to the replacement of fossil resources by renewables where crude
oil, natural gas and coal are the main contributors to abiotics resource depletion, while ozone
layer depletion potentiallevel is mainly contributed by emissions from the crude oil production
onshore.
In the rest of the impact categories, biorefining performs worse than gasoline refinery. In
the biorefinery and ethanol plant, although emissions causing photochemical oxidation potential
(POCP) from natural gas production and oil exploitation decreses, the ones from ethanol
production contribute even more photochemical oxidation potential (POCP) level.
In most of the impact categories the biorefinery has a better eco-efficiency than ethanol
plant, which is attributed to the high-value of the succinicacid derived from such a refinery.
The biorefinery designed in this study has clear advantages over the ethanol plant in
terms of eco-efficiency. However, when comparing biorefining to gasoline refinery, the overall
evaluation of the eco-efficiency depends on the importance attached to each impact category.
6.
PLANT LAYOUT
In the production of Succinic Acid, there are many equipment involve in the production process. It can be seen on the PFD diagram
clearly from the beginning of the process until the end of the process. From the PFD, the equipment involves is reactor, filtration,
cation exchanger and etc. in order to make a plant layout several factor must be considered such as economic considerations
(construction and operating costs), process requirements, convenience of the operation and maintenance, safety, future expansion,
and modular construction.(Ray Sinnott, 2009).
SITE LAYOUT
The process units and ancillary building should be laid out to give the most economical flow of materials and personnel around the
site. (Ray Sinnott, 2009) In this production, the site layout was constructed based on a few factors include cost and the layout
construct as seen below:
Based on the layout above we can see that the administration building is far from the plant area
because the plant produce a dangerous and hazardous substances . So, we want to make sure
that the worker are safe to do their work in the administration building because most of the them
are working in that building. Furthermore, from the layout there are two area of car park situated
near the administration building and the plant area. This is done to minimize the time spent by a
worker to travel between the buildings. The administration building is also contain a rest room
and also the canteen.
The assembly area was also provided in case of fire or any other emergency on plant site or
buildings. In this plant aslo provided with fire station in case of anything accident such as fire
occur in that plant can be control quickly to prevent further damaged. Other than that is, the
warehouse and maintenance room is located near the processing plant which allowing the
repair and services of the equipment can be done in that place. The processing plant also has
an expansion area in case of the high demands of the product will require more equipment to be
used.Therefore more space is needed to palce the new equipment.
The laboratory and control room are situated near the plant area because the operation can be
handled easily. The product storage located near the plant processing allowing the product from
the plant processing can be sent to the product storage easily and low cost of transportation.
Raw material storage located near to entrance 2 which is easier for the truck that carry the raw
material to transfer the raw material.
There are three entrance routes in these sites because it is easier to move in and out of the
sites. And these routes situated on three different sides. As you can see on the layout, the
above routes are construct to ensure the travelling distance to transport the waste product are
shorter.
7.
different fields such as chemical, food, and medicine industry. In designing the plant for the
production of succinic acids, several factors have been taken into considerations. The most
important factor is absolutely economic factors. This is because the plant is designed to make
benefit for the investor and the return of investment should be quick. To know this factor, things
such as the price of the raw materials, price of chemicals used, price of equipment used, and
cost of wastewater treatment should be known. All the raw materials and equipment selected
are relatively cheap so that profit can be maximized. To do that, the process should be outlined
and drafted first. After that, process flow diagram (PFD) is constructed using Superpro Designer
software. From there, the most suitable process that should be used is known. Calculations on
mechanical and chemical design are also done to ensure that the equipment used are to know
the maximum temperature used, maximum wind load, maximum pressure, maximum allowable
stress, and tensile strength.
For the site selection, the most suitable site for the plant is in Bukit Minyak Industrial
Area, Penang. This site is selected because of several factors that are not only economically
profitable, but strategic. The plant layout and site layout are also outlined according to the
conduciveness of the workplace and safety issues. Safety issues also should be made as
priority. As one of the industry that involved with majority of potential hazards, it is bound to have
accidents or disaster occurred if the safety issues did not properly considered. The way of
handling the hazardous in this plant which is calcium succinate and diethyl succinate have been
taken as a great deal in order to ensure the safety of employers and employees.
In designing chemical plant, safety issues have to be taken as number priority. As one of
the industry that involved with majorly potential hazards, it is bound to have accidents or
disaster occurred if the safety issues did not properly considered. The way of handling the
hazardous in this plant which is calcium succinate and diethyl succinate have been taken as a
great deal in order to ensure the safety of employers and employees. A safer and healthier
workplace environment are desirable not only because the welfare of the workers but also
minimize the cost and improves the plant productivity. In other words, this succinic acid plant
has the safe working environment and healthier working area.
8.
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9.
APPENDIX