Enzogenol

New Zealand Pine Bark Extract

Enzogenol
History
Production
Composition
Science
Health Benefits

History of Enzogenol
Multi-disciplinary research team
at Canterbury University
discovered and isolated the
most powerful natural
anti-oxidant from New Zealand
grown pine trees in 1997.

History of Enzogenol
ENZO Nutraceuticals Ltd commercialised this discovery,
patented the extraction method internationally, and
optimised and scaled up the production process.

Production of Enzogenol
Raw Material Origin
Only Pinus radiata bark from the sustainable forest
plantations in NZs centre North Island is used.

Production of Enzogenol
Pure Water Extraction
Pinus radiata bark
Purified water only
No solvents
No chemicals
No contaminants
=> 100% Natural Extract

Production of Enzogenol
Comprehensive Quality Control
Chemical Testing
ensuring guaranteed
amount of actives

Microbial
Heavy Metal
Herbicide & Pesticide
ensuring product safety

Composition of Enzogenol
Polyphenols: >80% Procyanidins (OPCs),
other flavonoids, stilbenes, and phenolic
acids
Pinus radiata bark supplies a very concentrated
and powerful mix of anti-oxidant and
anti-inflammatory compounds that are naturally
part of our diet from fruits and vegetables.

Flavonoid Content of Enzogenol

1.4 kg
Fresh Fruit
&
Vegetables

200 mg
Enzogenol

Risk Reduction with

high Flavonoid Intake

Disease Risk

Risk reduction of chronic diseases with high

flavonoid* or OPC# intake

1. Shand B et al, 2003, Phytotherapy Research 17: 4902. 2. Pipingas A et al, 2008, Phytotherapy Research 22: 1168

Science of Enzogenol

Science of Enzogenol

Antioxidant
Health

Superior Antioxidant
Superoxide Scavenging Activity
Comparison1

Clinical trials show reduced

oxidation levels2,3
Reduction in Plasma Reduction in Leukocyte
Protein Oxidation
DNA Damage

Reduced Oxidation => Increased Longevity2,3

1. Wood J E et al, 2002, Food Chemistry 77: 155. 2. Senthilmohan S T, 2003, Nutrition Research 23: 11992
3. Young J M, 2006, Free Radical Research 40: 85

Cardiovascular

Health

Cardiovascular Benefits
Improved Endothelial Function Reduced Blood Pressure2
& Plasma Viscosity1

Reduced Fibrinogen Levels3

Clinical studies show:

Improved Blood Circulation
Improved Blood Vessel Elasticity
Reduced Blood Pressure
1. Shand B et al, 2003, Phytotherapy Research 17: 4902. 2. Pipingas A et al, 2008, Phytotherapy Research 22: 1168
3. Young J M, 2006, Free Radical Research 40: 85

Cardiovascular

Health

Procyanidins and Fat Metabolism

OPCs in Enzogenol
Inhibit pancreatic lipases => Less dietary fat will be
utilised during digestion
Reduce the production of fat storage enzymes in fat
tissue => Less fat storage
Reduce lipid oxidation and accumulation in the blood
vessel walls => reduce atherosclerosis
Reduce body weight gain
References: Int J Obes. 2012. Caimari A et al.; Int J Obes Relat Metab Disord. 2000. 24(3):319. Ardvol A, et al.
Proc Jpn Acad Ser B Phys Biol Sci. 2011. 87(3):104. Nishizuka T, et al.; J Med Food. 2011. 14(11):1298. Okudan N, et al.
J Agric Food Chem. 2007, 55 (11), pp 4604 Hiroshi Sugiyama H, et al.; Nutrition, 2003. 10, p876, Moreno DA, et al.

Skin Health

Antioxidant Protection

UV Protection

=> Enzogenol protects the skin from oxidation and UV damage

Skin Health

Collagen Binding

Collagen Protection

=> Enzogenol binds to and prevents collagen degradation

Enzogenol and Womens Health*

Period pain / dysmenorrhea
Reducing cramps
Reducing pain
Improving ease and efficiency of
the bodies menstrual clearing
Dose: 240mg/day

*Personal communication: Dr. Natalie Wiggins, Avante Medical Center, Anchorage, Alaska, USA

Eye Health
Enzogenol Eye Function Study 2006
Clinical Study on Eye Health in the Elderly
(Publication in progress)

Design:
RCT, 60 Rest-home residents, average age 82,
6 months Treatment: 480mg Enzogenol + 60
mg Vit C/day versus Control: 60mg Vit C
only/day
Parameters measured:
Near and Distant Vision, Change in Acuity Score

Over 6 months the control group showed 5-times greater deterioration in visual
acuity than the Enzogenol group

=> Enzogenol slowed deterioration of eye sight in the elderly

Brain
Health

Brain Benefits

E
N
Z
O
G
E
N
O
L

Brain Function

Enzogenol Brain Function Study 20081

Enzogenol Brain Function Study 20081
Improved Cognitive Performance1

Improved Concentration & Attention

Short-term Memory
Decision Making
1. Pipingas A et al, 2008, Phytotherapy Research 22: 1168

Brain Function
& Age
Enzogenol Brain Function Study 20081

30
s

50
s

70
s

Brain
Health

Enzogenol New Zealand GHQ Study 2010

21 participants: 12 women, 9 men
47-80 years of age, mean 64.6
5 weeks of Enzogenol (480mg/day)
General Health Questionnaire (GHQ):
12 questions to assess brain and general health
Have you recently
1. been able to concentrate on what you are doing?
2. lost much sleep over worry?
0

Better than usual

Same as usual

Less than usual

Much less than usual

Brain
Health

Enzogenol
New
Zealand
Enzo
Professional
Sample
Program 2010
General
Health
Questionnaire
Study
2010
General
Health
Questionnaire
Outcome
10

8
7
6

Before

After 5 weeks

4
3
2
1

GHQ-Results:

67% improved (8F, 6M);

29% no change (3F, 3M);
4% deteriorated (F)

(2)

Average

Participant Number

71

25

22

68

66

59

46

33

31

20

19

18

General Health Questionnaire

Score

Brain
Health

Enzogenol Traumatic Brain Injury Study 20121

60 participants: 36 women, 24 men, avg. age 45
12 weeks of Enzogenol (1000mg/day)
Cognitive Failures:
Short term memory loss
Concentration difficulties
Brain fatigue
Anxiety and Depression

Theodom A et al, 2012, Neurology, pip

Brain
Health

Enzogenol Traumatic Brain Injury Study 20121

Reduced Cognitive Failures
Mean CFQ Score

65
Baseline
60
week 6
55
50
45
40
35

Improved Recovery of Brain Functions

Reduced Fatigue, Anxiety & Depression
1. Theodom A et al, 2012, Neurology, publication in progress

week 12

Migraine
Enzogenol Migraine Study 20091

53% (18 of 34) of patients responded:

79% reduction in headaches
50% reduction in severity
89% reduction in disability
1. Chayasirisobhon, 2009, World Congress of Neurology, Bangkock 2. Chayasirisobhon, 2006, Headache, 46:788

Health Benefits of Enzogenol

Thank You!
Dr. Matt Frevel, Chief Scientist, ENZO Nutraceuticals Ltd, NZ