Scientists develop appetite for escargot due to its skin regeneration prop...

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Scientists develop appetite for escargot due

to its skin regeneration properties
By Andrew McDougall, 06-Jan-2012
Related topics: Skin Care, Formulation & Science
Scientists in Spain have shed light on the molecular mechanisms underlying the regenerative
properties of mollusk Cryptomphalus Aspersa (SCA), more popularly known as escargot, and noted it
could be used for skin regeneration in the future.
Published in the International Journal of Cosmetic Science, the research was based on the regenerative
properties found in escargot, the French word for snail, due to its promoting effect on skin cell migration,
proliferation and survival.
Regenerative properties of skin decrease with age and, thus, the search for substances that minimise cutaneous
ageing has increased in the last few years.
Natural product
The scientists who took part in the Spain-based study explain that secretion of the SCA is a natural product that
bears regenerative properties when applied topically.
Therefore, the researchers studied the in vitro effects of SCA on cell proliferation and migration, as well as on
cell-cell (E-Cadherin, beta-catenin) and cell-substrate (vinculin, beta1-integrin) adhesion proteins expression.
For this, they used a human keratinocyte cell line (HaCaT cells) and primary dermal fibroblasts (HF), derived
from the dermis of normal adult skin.
Different tests for different needs
To test cells proliferation, a colorimetric assay was performed, in which the course of the reaction is followed by
measuring a change in how much light the assay solution absorbs. If this light is in the visible region a change
in the colour of the assay is clearly observed.
Cell migration was also studied using wound healing assays, whereas the study notes that Western Blot and
immunofluorescence microscopy were carried out to test the expression of different cell adhesion protein.
The tests found that SCA promotes proliferation and migration of HaCaT cells in a time- and dose-dependent
manner.
Moreover, treatment with SCA was found to increase the migratory behaviour and the expression of adhesion
molecules in both HaCaT and HF, as well as improving cell survival.
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10/01/2012 10:09