Professional Documents
Culture Documents
CASE
A 46 y.o, 60 kg woman was struck by angkot. She
was transported to hospital and received 1 liter of
crystalloids for blood pressure support.
In the next few hour, patient was noted to be
hypotensive, tachycardic with abdominal distention and
a bloody abdominal tap.
A type and crossmatch for 6 units of packed red blood
cells (PRC) was drawn and she was rushed to the OR
for an exploratory laparotomy.
C. Cryoprecipitate
D. Fresh whole blood
E. Platelets concentrate
CASE
A 30 year-old pregnant woman presents to the
emergency room with third trimester vaginal bleeding
and the sudden onset of marked pelvic pain.
She is quickly admitted to the labor and delivery floor,
where fetal monitoring shows severe fetal distress and
ultrasound reveals placental abruption.
An emergent cesarean section is performed, a few
minutes later the vaginal bleeding increases notably.
1.
2.
3.
4.
Cryoprecipitate.
Platelets concentrate
Antithrombin III
Heparin
CASE
A 28-year-old man was admitted to the hospital
because of fever.
The patient had been in excellent health until two weeks
earlier, when fever developed. The next day he had
fatigue, anorexia, and malaise, which waxed and waned.
He frequently had meals at warteg.
On admission, his temperature was 40.6C, with severe
headache. The pulse was 86 bpm, and the respirations
were 24. The blood pressure was 105/80 mm Hg.
endotoxin
(LPS)
CD14
TNF-
ProIL-1, IL-6
inflammatory
PAF
mediators
MAP-1
Inflamation
Proinflamatory
mediators
Anti-inflamatory
mediators
INFECTION
Endothelial injury
TF
Tissue
factor
Coagulation
cascade
TNF-
IL-1
Tissue
factor
Tissue
factor
Microvascular
thrombosis
Thrombin
TNF-
IL-1
IL-6
Tissue
factor
Inflammation
Endothelial cell
dysfunction
P-selectin
Severe Sepsis:
The Final Common Pathway
Endothelial Dysfunction and
Microvascular Thrombosis
Hypoperfusion/Ischemia
Clinical manifestation
Altered
Consciousness
Confusion
Psychosis
Tachypnea
PaO2 <70 mm Hg
SaO2 <90%
PaO2/FiO2 300
Jaundice
Enzymes
(LDH)
Albumin
PT
Tachycardia
Hypotension
CVP
PAOP
Oliguria
Anuria
Creatinine
Platelets
PT/APTT
Protein C
D-dimer
Symptoms of bleeding
Organ failure due to thrombosis
Values
score
1.25-1.66
>1.67
1.00-1.50
<1.00
500-1000
>1000
80-120
50-80
<50
Positive
Positive
2
1
2
1
2
1
2
3
1
1
aPTT
PT
Platelets count
Fibrinogen
AT III
d-Dimer
Compensated
Decompensated
N or
N or
N or
N or
N or