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Clin Chem Lab Med 2007;45(11):xxx-xxx 2007 by Walter de Gruyter Berlin New York. DOI 10.1515/CCLM.2007.334
2007/287
Larry H. Bernstein*
New York Methodist Hospital Brooklyn, Brooklyn,
NY, USA
Keywords: C-reactive protein; cytokines; hypermetabolism; protein-energy malnutrition; systemic inflammatory response syndrome; transthyretin.
Bernstein: The systemic inflammatory response syndrome C-reactive protein and transthyretin conundrum
tional management and/or successful anti-inflammatory therapy. TTR decline means that the nutritional
support is insufficient or unadapted and/or that the
morbid situation further deteriorates. The TTR
decrease with SIRS, directly influenced by interleukin6 and tumor necrosis factor a, is proportional to the
severity of the inflammatory response, as is the
increase in CRP, and the magnitude of the response
is a cause for delayed return to anabolic status (3).
This knowledge actually ties in with the use of TTR
in managing patients and in the intensive care unit
setting. The increase in TTR with re-feeding can be
delayed several days because of the excessive catabolic response. Nutritional therapy for the intensive
care unit patient has been designed to shorten the
period of hyper-catabolic N losses. This implies that
the serial measurement of TTR gives the direction of
the N balance when all available physiological and
biochemical indicators still remain unresponsive.
Owing to its short half-life, TTR is the sole plasma
protein fulfilling this predictive task, and therefore
being of invaluable help to guide on a daily basis the
clinicians therapeutic decisions with significantly
improved impact on the patients outcome and the
length of hospital stay.
What about the impact of timely nutritional intervention on shortened length of hospital stay and
return to anabolic status? Work going back to 1975 by
Bistrian and coworkers (4) showed the impact of protein-energy malnutrition on hospital morbidity for
surgical and medical patients. The study by Reilly et
al. (5) showed that the direct variable costs for surgical and medical patients associated with malnutrition-related comorbidities is increased by delayed
nutritional intervention associated with a 3- to 5-day
extended length of stay. The Veteran Affairs Cooperative Study (6) showed a benefit for total parenteral
References
1. Johnson AM, Merlini G, Sheldon J, Ichihara K. Clinical
indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition: International
Federation of Clinical Chemistry and Laboratory Medicine
(IFCC): IFCC Scientific Division Committee on Plasma Proteins (C-PP). Clin Chem Lab Med 2007;45:41926.
2. Ingenbleek Y, Carpentier YA. A prognostic and inflammatory and nutritional index scoring critically ill patients.
Int J Vitam Nutr Res 1985;55:91101.
3. Bernstein LH, Ingenbleek Y. Guest editorial: nutrition-disease interactions: malnutrition and stress hypermetabolism. J Clin Ligand Assay 1999;22:2538.
4. Bistrian BR, Blackburn GL, Vitale J, Cochran D, Naylor J.
Prevalence of malnutrition in general medical patients. J
Am Med Assoc 1976;235:156770.
5. Reilly JJ, Hull SF, Albert N, Waller A, Bringardner S. Economic impact of malnutrition: a model system for hospitalized patients. J Parenter Enteral Nutr 1988;12:3716.
6. The Veteran Affairs TPN Cooperative Study Group. Perioperative TPN in surgical patients. N Engl J Med 1991;325:
52532.
7. Brugler L, DiPrinzio MJ, Bernstein L. The five-year evolution of a malnutrition treatment program in a community
hospital. Joint Commission J Quality Improvem 1999;25:
1916.