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Breast
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Poster Exhibition
Annual Congress of KSS 2015 [67th Congress of the Korean Surgical Society]
PE-226
PE-227
F284
PE-228
Expression of CD73 is associated
associated with the molecular
subtypes of breast cancer
Department of Surgery, 1Pathology, Catholic
University of Daegu School of Medicine,
2
Department of Surgery, Raphael Hospital, Korea
(Purpose) CD73 is a glycosyl phosphatidylinositol-anchored membrane protein defined as the lymphocyte differentiation antigen, and a negative regulator of inflammation. CD73 was highly expressed
in many human solid tumors including breast cancer and is known to promote cancer progression.
The aims of this study were to analyze whether
the expression of CD73 is associated with a particular molecular subtype of breast cancer and to
F285
Annual Congress of KSS 2015 [67th Congress of the Korean Surgical Society]
PE-229
PE-230
F286
PE-231
Impact of immunotherapy using
viscum album as an adjuvant
treatment in invasive breast cancer
Division of Breast and Endocrine Surgery, Hallym
University Sacred Heart Hospital, Department of
Surgery, Hallym University College of Medicine,
Korea
F287
Annual Congress of KSS 2015 [67th Congress of the Korean Surgical Society]
PE-232
Synergistic effect with the
combination of selenium with
eribulin in breast cancer cell lines
and synergic pattern were found between the combination treatment groups and the eribulin without
selenium treatment group. (Conclusion) The current study showed that combination of selenium
with eribulin could increase cytotoxicity and this
might be through apoptosis in MDA-MB-231 breast
cancer cells.
PE-233
(Purpose) Eribulin, a non-taxane microtubule dynamics inhibitor, is used to treat patients with
metastatic breast cancers. Even if it is proved to be
an effective drug in the metastatic disease, various
adverse events negatively affect quality of life of
the patients who have previously received multiple
lines of chemotherapy. The cytoprotective role of
selenium that has been reported could be helpful
in this clinical situation. However, the combination
effects of selenium on chemotherapy have not yet
been clearly defined. Considering anticancer property of selenium, authors designed this study to investigate the combined effects of selenium on chemotherapy using eribulin on breast cancer cell
lines. (Methods) Under adherent culture conditions, three breast cancer cell lines, MDA-MB-231,
MCF-7 and SK-BR-3 were treated with eribulin at
0.6 nM and selenium at 2M, 4M, or 8M.
Changes in cytotoxicity and degree of apoptosis after 24 hours or 48 hours in each treated group
were evaluated and analyzed. (Results) In the
MDA-MB-231 cells, there was a significant difference in cytotoxicity according to concentration of
selenium (P=0.022). The combination treatment
group (eribulin at 0.6nM plus selenium at 4M)
showed a significantly increased percentage of cell
death (5.9% vs. 48.2%; P=0.05) and a tendency toward increased early apoptosis (27.8% vs. 43.9%;
P=0.083), compared with the eribulin without selenium treatment group. Isobologram analysis demonstrated the synergistic effect of the combination
treatment in the MDA-MB-231 cells. However, in
the MCF-7 or SK-BR-3 cells, no significant differences in cytotoxicity, the percentage of apoptosis,
F288
PE-234
Vacuum-assisted breast biopsy
using a single circumareolar
incision
Department of Surgery, Damsoyu Hospital, Korea
PE-235
Effect of marine brown alga on
two human breast cancer cell lines
: Apoptosis and cell-cycle arrest
Department of Surgery, College of Medicine,
Uijeongbu St. Marys Hospital, The Catholic
University of Korea, Korea
F289
Annual Congress of KSS 2015 [67th Congress of the Korean Surgical Society]
was assayed via Annexin V-flourescein isothiocyanate and propidium iodide staining followed
by flow cytometric analysis. Immunoblotting analysis was also performed using BAX/Bcl-2, CDK2,
CDK4, and cyclin D3. (Results) Dieckol and Seanol
Seanol were cytotoxic to SK-BR-3, and MCF-7 human breast cancer cells via induction of apoptosis
and cell-cycle arrest. Therefore, we suggest that
PE-236
PE-237
Cumulative sum analysis for
learning curve for breast mass
excision using an
ultrasound-guided vacuum-assisted
biopsy system
Department of Surgery, Yonsei University College of
1
Medicine, Department of Surgery, Dongnam
Institution of Radiological & Medical Sciences, Korea
F290
PE-238
Dermatofibrosarcoma protuberans
in breast
Department of Breast-Endocrine Surgery, Korea
University Medical Center, Korea
mass of approximately 37 mm x 30 mm in diameter in the upper central part of the right breast.
The mass of right breast was demonstrated DFPS
by pathologic examination. Computerized tomography
(CT)
scan
of
the
chest
and
2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron-emission tomography (PET) showed only primary lesion in subcutaneous layer and no enlarged
lymph node. The patient underwent excision of the
tumor widely. (Conclusion) DFSP in breast is extremely uncommon and can mimic a primary
breast tumor. Surgical excision with adequate resection margins is recommended to ensure local
control of the disease.
PE-239
Signet ring cell carcinoma in breast
Department of Breast-Endocrine Surgery, Korea
University Medical Center, Korea
F291
Annual Congress of KSS 2015 [67th Congress of the Korean Surgical Society]
upper outer quadrant of the right breast, with enlarged lymph node in right axilla. On ultrasonography, a lesion appeared as hypoechoic, irregular mass of approximately 13 mm x 10 mm in diameter in the upper outer quadrant of the right
breast. Another hypoechoic, irregular mass of approximately 12 mm x 6 mm in diameter was noticed just beside previous mentioned mass. The
mass of right breast was demonstrated SRCC by
pathologic examination, and the mass of right
breast was demonstrated invasive carcinoma. On
esophagogastroduodenoscopy, atrophic mucosa of
stomach suggestive of chronic atrophic gastritis was
shown. On colposcopy, a polyp was detected in
rectum and demonstrated tubular adenoma with
high grade dysplasia. CT scan of the chest and abdomen showed several enlarged lymph nodes in
the right axilla. 18F-FDG PET showed also only
primary lesion and right axillary lymph nodes. The
patient underwent both conserving surgery and axillary lymph node dissection. After surgery, the patient received four cycles of docetaxel followed by
four cycles of anthracycline and cyclophosphamide.
Chest wall irradiation were performed. Since May
2015, she was given 2.5 mg of letrozole once daily.
Following 11 months follow-up, the patient showed
neither the evidence of progressive disease, nor
metastasis in other parts of the body. (Conclusion)
Primary SRCC of the breast is a very rare malignant tumor and must be distinguished from metastases of SRCCs to the breast. The prognosis of this
tumor is usually poor but early detection may provide a good result. It is important to differentiate
this type of tumor according to the pathological
and clinical characteristics.
F292
PE-240
Maximum standardized uptake
value of tumor on 18-FDG PET CT
after neoadjuvant chemotherapy
can predict the pathologic
response in locally advanced breast
cancer
Department of Surgery, 1Nuclear Medicine, 2Internal
3
Medicine, Pathology, Keimyung University School of
Medicine, Korea
PE-241
Prognositc effect of sentinel lymph
node biopsy after neoadjuvant
chemotherapy
Division of Breast and Endocrine Surgery,
Department of Surgery, Samsung Medical Center,
Sungkyunkwan University School of Medicine, Korea
PE-242
Juvenile gynecomastia
Department of Surgery, Damsoyu Hospital, Korea
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Annual Congress of KSS 2015 [67th Congress of the Korean Surgical Society]
testosterone. In most cases, it regressed naturally
after puberty, but juvenile gynecomastia without regression gives psychological damage to patients
having it. (Methods) A thousand and eighty six
patients who have been treated with gynecomastia
from January 2013 to August 2015 at the Damsoyu
Hospital
were
analyzed
retrospectively.
Subcutaneous mastectomy and liposuction were
performed on all cases by two surgeons (Dr.
Hwang and Dr. Lee). (Results) Juvenile gynecomastia was found in 40 patients (3.7%). The chief reason for their surgery was psychosocial problem and
all patients underwent surgery with the consent of
their parents. The mean age was 17.1 years old.
According to type of gynecomastia, fibro-glandular
type was in 35 patients (87.5%), pseudo-type in 4
patients (10%), and mixed type in one patient
(2.5%). Symmetric type of gynecomastia was in 37
patients (92.5%) and asymmetric type in three patients (7.5%). In our study, all patients enjoyed cosmetically
satisfying
outcomes.
(Conclusion)
Juvenile gynecomastia sometimes makes patients
having it embarrassed psychologically in their social life. The surgical intervention can be an useful
option for them.
in 45 patients (4.3%). According to type of gynecomastia, fibro-glandular type was most in both symmetric and asymmetric group (56% VS 62%). The
mean age was 28.0 years in symmetric group and
26.3 years in asymmetric group. The most frequent
age group in asymmetric gynecomastia was twenties (57.7%). The body mass index (BMI) was 27.4
kg/m2 in symmetric group and 24.8 kg/m2 in
asymmetric group. The both superficial mastectomies with liposuction was performed on patients
having symmetric gynecomastia. In operation method of asymmetric gynecomastia, both superficial
mastectomies with liposuction was performed in 39
patients (87%) and unilateral mastectomy with liposuction in 6 patients (13%). In our study, 96.4% of
patients enjoyed cosmetically satisfying outcomes.
(Conclusion) Asymmetric gynecomastia is more
observed in patients who are older or have lower
body mass index than in patients with symmetric
gynecomastia.
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F294
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PE-245
The differences according to
marriage status in accessory
breast patients
Department of Surgery, Damsoyu Hospital, Korea
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Annual Congress of KSS 2015 [67th Congress of the Korean Surgical Society]
18F-FDG PET/CT before first treatment for invasive
breast carcinoma between January 2007 and
November 2011. The patient underwent curative
treatment for breast carcinoma without systemic
metastasis, and had confirmed axillary node metastasis on pathologically. The clinicopathological features that were recorded included the patients age,
histology, tumor size, metastatic node, stage, hormonal receptor status, human epidermal growth
factor receptor 2 (HER2) status, primary tumor
SUVmax, metastatic nodal SUVmax and ratio of
nodal SUVmax to tumor SUVmax. There were assessed significant difference in predicting recurrence
by univariate and multivariate analysis. (Results)
All patients were women and mean age of patients
was 52 years (range, 30-84). Median follow up period of total patients was 58 months (range 11-95),
and 23 patients had recurrence (median follow-up,
21 months). 5 years overall survival (OS) rate was
90.9% and 5 years disease free survival (DFS) rate
was 72.8%. The mean value of tumor SUVmax, nodal SUVmax and ratio of nodal SUVmax to tumor
SUVmax were 8.15 (range, 1.0-26.5), 5.06 (range,
0.9-27.8) and 0.77 (range, 0.06-12.0). The tumor
SUVmax had more a significant difference from T
stage (p=0.021) and nodal SUVmax had more a significant difference from N stage (p<0.0001). The advanced breast stage, ER negative, triple negative
breast carcinoma (TNBC) and recurrence groups
had
higher
SUVmax.
The
receiver-operating-characteristic (ROC) curve determined a tumor
SUVmax of 8.3 (sensitivity, 65%; specificity, 68%;
area under the curve 0.659) and nodal SUVmax of
4.4 (sensitivity, 69%; specificity, 68%; area under
the curve 0.672) to identify the optimal cutoff value
about predicting recurrence. Univariate analysis
demonstrated that stage (p=0.017), cut off value of
tumor SUVmax (p=0.009) and nodal SUVmax
(p=0.003) had significant difference with recurrence.
In these 3 factors, there was no significant difference with recurrence by multivariate analysis.
(Conclusion) The tumor and nodal SUVmax on
18F-FDG PET/CT may be prognostic factors for
predicting recurrence in female breast cancer patients with nodal involvement.
F296
PE-247
Optimal concentration of
indocyanine green in near-infrared
fluorescence guided sentinel lymph
node biopsy in breast cancer
Division of Breast and Endocrine Surgery,
Department of Surgery, Samsung Medical Center,
Sungkyunkwan University School of Medicine, Korea
PE-248
Multi-modality imaging evaluation
in preoperative assessment of risk
for false-negative results of sentinel
node biopsy for patients with
breast cancer
FNR: false negative rate of sentinel lymph node biopsy, FN patients/Total patients
Fig. Venn diagram of patients group
(Purpose) Understaging and omitting adjuvant chemotherapy caused by a false negative (FN) in a
sentinel lymph node biopsy (SLNB) can adversely
influence survival outcome of breast cancer
patients. The aim of this study was to evaluate the
value of multi-modality imaging studies in pre-
F297
Annual Congress of KSS 2015 [67th Congress of the Korean Surgical Society]
PE-249
PE-250
F298
PE-251
Associations of physical activity and
metabolic syndrome with
comparison between breast cancer
survivors and non-breast cancer
participants : Findings from
KNHANES (2009-2013)
women. We would like to know whether the prevalence of metabolic syndrome according to the degree of physical activity is different between the
cancer survivors and non-cancer participants.
(Methods) We investigated physical activity pattern
and biomarkers related to the metabolic syndrome
of cancer survivors using data from the Korean
National Health and Nutrition Examination Survey
(KNHANES) 2009-2013 and compared with that of
non-cancer participants. The physical activity classified as severe activity, moderate activity, light activity like walking. And the prevalence was obtained from the data after adjustment for age and
after adjustment for age, BMI, smoke, drink, income, education respectively. (Results) The cancer
survivor group showed nearly half prevalence of
metabolic syndrome compared with non- cancer
participants group with light activity [odds ratio
(OR)=0.429; 95% confidence interval (CI)=0.205,
0.897 and OR=0.9; 95% CI=0.776, 1.044] in age-adjusted model and age, BMI, smoke, drink, income,
education - adjusted model [OR=0.433; 95%
CI=0.188, 0.997 and OR=0.887; 95% CI=0.759, 1.037].
However the OR was not different between two
groups with severe activity or moderate activity.
(Conclusion) This analysis showed that the light
intensity exercise like walking may reduce the metabolic syndrome in cancer survivor group compared with non-cancer participants. But the association between moderate to severe physical activity
and metabolic syndrome was not clear. In conclusion, light activity like walking, not the moderate to severe physical activity might guarantee reducing metabolic syndrome in cancer survivor compared with non-cancer group.
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Annual Congress of KSS 2015 [67th Congress of the Korean Surgical Society]
PE-252
PE-253
F300
Total
(N=358)
ER/PR+
Low Ki-67
(N=102)
ER/PR+
High Ki-67
(N=113)
HER2 +
(N=70)
ER/PR
HER2
(N=73)
P value
52.211.2
2.371.53
51.611.7
2.031.4
53.511.3
2.361.48
51.110.3
2.721.76
52.111.1
2.501.43
0.611
0.041
1.854.81
1.263.47
1.613.55
2.466.18
2.456.34
0.151
4.083.39
0.952.00
2.82.08
0.862.35
3.83.03
0.561.3
4.393.18
1.322.43
5.954.56
1.331.79
<0.0001
0.015
0.33
0.180.48
0.120.28
0.230.37
0.942.77
0.103
Sensitivity
Specificity
PPV
NPV
Accuracy
AUC
Total
(N=358)
ER/PR+
Low Ki-67
(N=102)
ER/PR+
High Ki-67
(N=113)
HER2 +
(N=70)
ER/PR
HER2
(N=73)
0.565
0.853
0.688
0.775
0.749
0.72
0.411
0.924
0.736
0.753
0.75
0.671
0.439
0.930
0.782
0.744
0.752
0.685
0.667
0.825
0.740
0.767
0.757
0.761
0.875
0.667
0.567
0.914
0.736
0.797
PE-254
Oncological safety and cosmetic
satisfaction of oncoplastic breast
conservation surgery-compare with
conventional breast conserving
surgery and total mastectomy
1
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Annual Congress of KSS 2015 [67th Congress of the Korean Surgical Society]
ment of breast cancer has steadily and considerably
improved. Now oncoplastic techniques applied to
breast-conserving surgery (BCS) allow large-volume
resections without compromising oncological safety.
A satisfactory cosmetic result could be difficult to
obtain due to high tumor to breast size ratio, unfavorable location, close to the nipple and contralateral ptosis. Oncoplastic techniques allows the
performance of wide excision, conserving an excellent breast shape, may be helpful in many cases.
This study was aimed to evaluate the oncological
safety of OPS. (Methods) Between January 2012
and December 2014, 1995 patients were identified,
who underwent mastectomy at Seoul National
University Hospital by one experienced breast
surgeon. Retrospectively medical chart review was
done and patients divide into three groups. Among
them 28.22% (n=563) underwent oncoplastic surgery
F302