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CALORIE RESTRICTION DISPLAYS CONSERVED EXPRESSION PATTERNS

OF SEVERAL DISEASES PATHWAYS IN EUKARYOTIC ORGANISMS RELATED


TO MITOCHONDRIA FUNCTION
Priscilla Mercado-Salgado1, Emmanuel Salazar2, Lourdes Anzures2, Rebeca Martinez2, Joivier
Vichi2, Veronica Jimenez-Jacinto3 and Armando Hernandez-Mendoza2.
1
Facultad de Medicina. Universidad Autnoma del Estado de Morelos. Leeros s/n Col. Volcanes,
C.P. 62350. Cuernavaca Morelos, Mxico.
2
Unidad de Bioinformtica y Genmica Funcional. Centro de Investigacin en Dinmica Celular.
Universidad Autnoma del Estado de Morelos. Av. Universidad 1001 Col. Chamilpa, C.P. 62209.
Cuernavaca Morelos, Mxico (+52) 777 329 7000 ext. 3687.
3
Universitaria de Secuenciacin Masiva de ADN. Instituto de Biotecnologa. Universidad Nacional
Autnoma de Mxico.
Email: 2ahm@uaem.mx, 1priscilla.mersal@gmail.com

Since life style has changed, particularly in urban settings, the lack of physical
activity and an unhealthy diet has jeopardized human welfare. The adverse health
consequences of excessive body fat are especially correlated to the dysfunctional
deposition of adipose tissue (obesity), which contributes to metabolic comorbidities
including high blood pressure, dyslipidemia, insulin resistance, hyperglycemia and
inflammation; that can develop chronic disorders like metabolic syndrome,
diabetes, cardiovascular diseases and cancer, directly and significantly associated
with mortality. Abdominal obesity and insulin resistance are the main risk factors for
oxidative metabolism failure, suggesting that mitochondria and probably other
signaling and metabolic pathways related to oxidative phosphorylation could be
involved in these disorders. Otherwise, Caloric Restriction (CR) has a beneficial
effect in the activity of nutrient sensing pathways, mostly seen in different species,
but mainly for prolonging life span and improving quality of life.
As we have previously reported, through bioinformatics and appropriate statistical
analyses in different organisms, it is possible to study specific behaviors of
enriched gene expression data sets in response to dietary restriction as a stimulus,
whose results allowed us to propose that the same regulatory elements are
conserved throughout evolution. Previously, our group showed that a comparison
of conserved human orthologues genes among four eukaryotic organisms such as
Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans and
Mus musculus subjected to CR connected a potential enrichment of common
signaling pathways shared with neurodegenerative human diseases like Alzheimer,
Huntington and Parkinson, as well as other metabolic pathways such as the
oxidative phosphorylation, the TCA cycle, etc. By extrapolation, these expression
changes lead us to predict that these conserved evolutionary mechanisms are
conserved in humans, but this comparison has not been analyzed yet. In this work
we used the same pipeline of bioinformatical and statistical analysis previously
used in above mentioned organisms in the study of different experiments of
humans subjected to CR. This information will generate a high impact on the
exploration of new complex disease processes, which can be targeted by new
therapeutic treatments to control and reverse these problems.