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The AGID test has been used in eradication programs, but the cELISA test provides a direct
quantification of serum antibodies to the OPP virus, while AGID does not. Blood samples are needed for
both of these tests. Lambs should not be tested until after six months of age due to the tests detecting
circulating antibodies to the virus and colostrum can interfere. The cELISA test is more sensitive than the
AGID test at identifying true positive animals. A necropsy is needed for a definitive diagnosis. Your
veterinarian can help choose the appropriate tests to run for your flock.
LITERATURE CITED
Gerstner, S., Adamovicz, J., Duncan, J., Laegreid, W., Marshall, K., Logan, J., & Schumaker, B. (2015).
Prevalence of and risk factors associated with ovine progressive pneumonia in Wyoming sheep flocks.
Journal of the American Veterinary Medical Association, 247(8), 932-937
Leymaster, K., Chitko-McKown, C., & Heaton, M. (n.d.). Incidence of infection in 39-month-old ewes
with TMEM154 diplotypes "1 1," "1 3," and "3 3" after natural exposure to ovine progressive pneumonia
virus. Journal of Animal Science, 93(1), 41-45.
Wolf, C. (2010). Ovine Progressive Pneumonia General Fact Sheet. OPP Concerned Sheep Breeders
Society. Retrieved from <http://www.oppsociety.org/About_OPP_files/OPP_General_Fact_Sheet.pdf>
Animal and Plant Health Inspection Service. (2003). Ovine Progressive Pneumonia: Awareness,
Management and Seroprevalence. Veterinary Services Centers for Epidemiology and Animal Health.
Retrieved from <https://ahdc.vet.cornell.edu/docs/OvineProgressivePneumonia.pdf>