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Ozcan et al.
Fetal-Neonatal Ovarian Cysts
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Pediatric Imaging
Original Research
OBJECTIVE. Large nonresolving neonatal ovarian cysts may be a risk factor for complications such as torsion, mass effect, rupture, intracystic hemorrhage, and autoamputation.
Torsed cysts and autoamputated cysts can cause a diagnostic dilemma. The objective of our
study was to correlate the imaging findings of intrauterine ovarian torsion and autoamputated
ovaries with their pathologic findings.
MATERIALS AND METHODS. We retrospectively analyzed the pre- and postnatal
medical records, sonographic findings, operation notes, and pathologic reports of 15 patients
with ovarian torsion. All patients had complex cysts noted on postnatal sonographic examination. A complex heterogeneous ovarian cyst was defined by the presence of a fluid-debris
level indicating hemorrhage within the cyst, a retracting clot, septations with or without internal echoes, calcification, and a solid component.
RESULTS. On ultrasound examination, four cysts had solid components, and 11 were
heterogeneous and had a fluid-debris level. Calcifications were seen in two patients. The mean
patient age at the time of surgery was 3.9 months. Exploratory laparotomy was performed on
all patients. Torsed ovaries were identified in five patients. Ten patients had ovaries that were
floating free in the peritoneal cavity at the time of surgery. Histopathologic evaluation revealed that 11 of the cysts consisted of extensive hemorrhagic, necrotic autolytic tissue with
dystrophic calcification. None of the cysts contained any ovarian tissue.
CONCLUSION. A complex heterogeneous ovarian cyst with a fluid-debris level indicating hemorrhage is a significant sonographic hallmark for the diagnosis of ovarian torsion. A
calcified abdominal mass, with or without wandering, can be an autoamputated ovary.
Ozcan et al.
37 weeks). Soon after birth, the infants underwent
surgery performed by a pediatric surgeon.
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Sonography
Prenatal ultrasound examinations were performed by obstetricians according to protocol,
which included routine first-, second-, and thirdtrimester studies. All postnatal ultrasound studies
occurred when patients were between 1 day and
6 months old, and all were performed by radiologists using a sonographic machine with a 7.5-MHz
transducer (Sonoline Elegra, Siemens Healthcare).
Ultrasound studies included a complete evaluation of the abdomen and measurements of the
cyst. A complex heterogeneous ovarian cyst was
defined by the presence of a fluid-debris level indicating hemorrhage within the cyst, cysts with a
retracting clot, septations with or without internal echoes, calcification, and a solid component.
Ultrasound images and reports were reviewed by
three pediatric radiologists.
Results
The demographic characteristics and imaging and pathologic findings of the 15 patients are summarized in Table 1. None of
the patients had a history of maternal diabetes, fetal hypothyroidism, or congenital malformations. All patients had complex ovarian
cysts. Follow-up postnatal ultrasound examinations were performed before surgery and
showed neither spontaneous regression nor
any change in the characteristics of the cysts.
Cyst size ranged from 30 to 70 mm at the
time of prenatal diagnosis and from 25 to 70
mm by the time of surgery.
On follow-up ultrasound examination,
four cysts were found to have solid components (Fig. 1), and the other 11 cysts were
found to have a heterogeneous pattern and
a fluid-debris level (Fig. 2). Color Doppler
imaging showed vascularity in four cysts,
which also had solid components. Calcifications were seen in two patients (Fig. 3).
Intraabdominal free fluid was not identified
in any of the patients. At preoperative ultrasound examination, in addition to evaluation for the presence of complex cysts, the
uterus and contralateral ovaries were also
assessed, and findings were found to be normal for all patients.
One patient underwent MRI examination
before surgery. Ultrasound examination of
that same patient revealed peripheral calcifications in a cyst located in the right side
of the abdomen. The subsequent MR image showed a complex cyst with a fluid-level; however, because the cyst was seen in the
186
Discussion
The majority of fetal-neonatal ovarian
cysts are functional or, less commonly, benign tumors. Hence, it is important to note
that complex cysts in infants are almost
never associated with malignant neoplasm.
However, concern about complications, such
as torsion, plays a significant role in the management of fetal-neonatal ovarian cyst, because such complications can be an indication for surgical intervention [1].
Ovarian torsion and necrosis are followed
by intracystic hemorrhage. Ovarian torsion
can be suggested when ultrasound examination detects changes in the size and characteristic of cysts, resulting in the reclassification of simple cysts as complex cysts.
Ovarian torsion is more commonly seen in
cysts that are 5 cm or greater [7]. Most ovarian torsions occur during and after the antenatal period; they are very rarely seen postnatally [8]. Nussbaum et al. [9] classified the
ultrasound patterns of ovarian cysts as simple or complex on the basis of histopathologic
findings for a series of infants. Simple cysts
are completely anechoic, homogeneous, and
thin walled; are frequently unilocular; and
are located unilaterally. Complex cysts are
typically thick walled, have a solid structure
and septa, and contain blood clots and debris. According to these criteria, all our patients had complex cysts with a fluid-debris
level indicating hemorrhage. Because it was
seen in all our patients, the fluid-debris level
seems to be a significant hallmark for ovarian torsion on ultrasound examination.
Postnatal management of prenatally detected ovarian cysts is controversial. Generally, a wait-and-see policy is preferred
because most cysts resolve spontaneously after birth. On the other hand, early surgery may allow preservation of ovarian tissue if detorsion is possible [1014]. Enrquez
et al. [15] reported involution of 11 clinically
asymptomatic complex fetal-neonatal ovarian cysts, which were conservatively managed and monitored by ultrasound. In their
study, the mean age at which involution of
cysts occurred was 1 year in most cases.
In our series of patients, both symptomatic and asymptomatic complex cysts were
seen. Eight patients had clinical symptoms
caused by the cystic mass, and seven patients
did not have any symptoms before the surgery. The maximum duration of symptoms
during the period from birth to surgery was
Gestational Age
at Time of
Prenatal
Ultrasound (wk)
30
28
32
36
37
34
34
32
34
36
35
32
30
37
27
Patient
10
11
12
13
14
15
0/10
0/2
0/10
0/7
1/0
2/0
6/0
0/4
0/3
5/0
0/10
6/0
0/7
0/1
2/0
Postnatal Age at
Diagnosis (mo/d)
51 37
70 60
68 42
60 50
40 30
63 42
62 45
30 25
47 30
60 40
42 30
48 40
50 44
47 35
40 31
Fluid-debris level
Fluid-debris level
Fluid-debris level
Fluid-debris level
Fluid-debris level,
hemorrhage
Solid component,
septation
Fluid-debris level
Fluid-debris level
Solid component
Fluid-debris level,
calcification
Fluid-debris level,
internal echogenicity
Fluid-debris level,
calcification
Postnatal Sonographic
Features
No
No
No
No
No
No
No
No
Yes
No
No
No
No
Yes
No
Wandering
Abdominal
Mass
Torsed ovary
Torsed ovary
Torsed ovary
Torsed ovary
Torsed ovary
Torsed ovary
Torsed ovary
Dermoid
Autoamputated
ovary
Torsed ovary
Torsed ovary
Dermoid
Teratoma
Autoamputated
ovary
Torsed ovary
Preoperative
Diagnosis
Hemorrhagic
infarct, necrosis,
calcification
Hemorrhagic
infarct
Necrosis and
fibrotic tissue
with calcification
Hemorrhagic
infarct, necrosis,
calcification
Hemorrhagic
necrosis,
calcification
Hemorrhagic
necrosis,
calcification
Necrosis with
calcification
Necrosis with
calcification
Torsed ovary
Hemorrhagic
necrosis
Free-floating ovary
Free-floating ovary
Free-floating ovary
Free-floating ovary
No
No
No
Yes
Yes
Yes
Yes
Yes
Yes
Yes
No
Yes
No
Yes
Yes
Free-floating ovary
Surgical Findings
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Ozcan et al.
188
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toamputation and reimplantation of an ovarian dermoid cyst as the most common causes
of omental teratomas. This finding suggests
that autoamputated ovarian cysts might
evolve into omental masses and have malignant potential in the future. Moreover, there
is some concern that a calcified remnant may
result in an increased risk of bowel obstruction or adhesions. In light of these findings,
surgical removal of an autoamputated ovary is preferable to spontaneous regression, as
observed in our patients.
In conclusion, ovarian torsion is the most
frequent complication of fetal-neonatal ovarian cysts. On ultrasound examination, the
presence of a complex heterogeneous ovarian cyst with a fluid-debris level indicating
hemorrhage is a significant hallmark for the
early diagnosis of ovarian torsion. It should
be kept in mind that, with or without wandering, a calcified abdominal mass might be an
autoamputated ovary.
References
1. Brandt ML, Helmrath MA. Ovarian cysts in infants and children. Semin Pediatr Surg 2005;
14:7885
2. Brandt ML, Luks FI, Filiatrault D, et al. Surgical
indications in antenatally diagnosed ovarian
cysts. J Pediatr Surg 1991; 26:276282
3. Bagolan P, Giorlandino C, Nahom A, et al. The
management of fatal ovarian cysts. J Pediatr Surg
2002; 37:2530
4. Koike Y, Inoure M, Uchida K, et al. Ovarian autoamputation in a neonate: a case report with literature review. Pediatr Surg Int 2009; 25:655658
5. Esposito C, Garipoli V, Di Matteo G, et al. Laparoscopic management of ovarian cysts in newborns. Surg Endosc 1998; 12:11521154
6.
Ozyuncu O, Canpolat FE, Ciftci AO, Yurdakok M, Onderoglu LS, Deren O. Perinatal outcomes of fetal abdominal cysts and comparison of
prenatal and postnatal diagnoses. Fetal Diagn
Ther 2010; 28:153159
7. Chiaramonte C, Piscopo A, Cataliotti F. Ovarian