Effect of Modifiable Risk Factors on Hypertension and Coronary Heart

Disease in the City of Padang: A Hospital-Based Matched Case Control

Study
Mona Lisa1, Defriman Djafri1, Ratno Widoyo1
1

Department of Epidemiology & Biostatistics

Faculty of Public Health, Andalas University, West Sumatra, 25128, INDONESIA

Epidemiological studies have established a strong association between hypertension

and coronary heart disease. hypertension, diabetes mellitus, dyslipidemia, obesity and
hyperuricemia are risk factors for coronary heart disease. The aim this study is examining the
role of modifiable risk factors association between hypertension and coronary heart disease in
the central general hospital Dr. M. Djamil Padang, in 2013. from Desember 2014 to April
2015, we conducted A hospital-based matched case control study among a randomly selected
sample by matching the age and sex of medical record (secondary data). We studied 171
samples with 1:2 ratio between the case and the control. Data were analyzed using
McNemars test and conditional logistic regression for multivariate modeling. Result this
study show that the variables associated with coronary heart disease are hypertension
(OR=16,04, 95%CI 5.705-45.12), obesitas (OR=2.53 ,95%CI 1.321-4.844), and
hyperusrisemia (OR 2.41 ,95%CI 1.292-4.516). Multivariate modeling identification
hyperurisemia as a confounder for the causal hypertension and coronary heart disease. The
adjusted risk factor hypertension on coronary heart disease after controlling hyperuricemia is
15.86. The magnitude of the effect of hypertension on coronary heart disease was 15.68.
People are expected to manage their blood pressure to decrease the risk of coronary heart
disease
Keywords: Coronary Heart Disease, Hypertension, Modifiable Risk Factors, Case Control