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Protoplasm
refers to the substance associated
with life.
the substance out of which cells and
organisms are made.
a mixture of substances composed
essentially of water, organic
substances and inorganic substances.
Water
Living organisms are absolutely
dependent upon water for their
existence.
Chemical and physical processes of
life requires water to move about,
encounter one another and change
partners frequently in the complicated
process of metabolism and synthesis.
The fluid environment that allows
molecular mobility in living system is
provided by water.
The medium in which transport of
nutrients, enzyme-catalysed reaction
of metabolism and the transfer of
chemical energy occur.
The nutrients which a cell consumes
the oxygen it uses in oxidation of
those nutrients and the waste
products it produces are all
transported by water.
70% - 90% of the weight of most
forms of life is made up of water.
Also represents the continuous phase
of living organisms.
Often regarded as bland, inert liquid
and a mere space filler in organisms.
Structure of Water
Made up of two (2) hydrogen and one
oxygen covalently bonded with each
other.
Carbohydrates Synthesis
Carbohydrates are initially synthesized
in plants from a complex series of
reactions involving photosynthesis.
Structure of cell
membranes
cushion
Precursors of hormones
(steroids and prostaglandins)
Trp niacin
Gly, Arg, Met creatine
Gly, Cys bile salts
Glu, Cys, Gly glutathione
Gly heme and tripeptides
Some AA such as gly and cys are used
as detoxicants
Met transfers methyl group to various
substances by transmethylation
Cys and Met are sources of sulfur
Essential & Nonessential Amino Acids
Nine amino acids
Cannot be made (synthesized) by the
body from other amino acids
Protein foods must be eaten daily that
contain these amino acids
11 amino acids
Can be made from other parts
Conditionally essential
Proteins
Derived from the Greek word Proteios
which means first or primary. The
name is given because they are the
first among natural polymers essential
for growth and maintenance of life
Complex nitrogenous polymers
present in all forms of living matter
Contains carbon, hydrogen, oxygen
and nitrogen. (may also contain sulfur
and phosphorus)
Peptides
Composed of amino acids linked
together but they possess much
smaller molecules than proteins and
contain much fewer amino acids.
2 AA dipeptide
3 AA tripeptide
4 -10 AA oligopeptide
>10 AA polypeptide
C. Hormones
Some hormones, but not all, are
proteins
Hormones signal the appropriate
enzymes to act.
E. Fluid Balance
Proteins help regulate the quantity of
fluids to help maintain fluid balance.
Nucleotide
A nucleotide is a chemical compound
that consists of 3 portions: a
heterocyclic base, a sugar, and one or
more phosphate groups.
In the most common nucleotides the
base is a derivative of purine or
pyrimidine, and the sugar is the
pentose (five-carbon sugar)
deoxyribose or ribose.
Structural protein
Collagen connective tissues
Elastin ligaments
Fibroin silk of cocoon, spiderwebs
Keratin skin, feathers, nails, hoofs
Toxins
Diptheria toxin bacterial toxin
Nucleotide
Nucleotides are the monomers of
nucleic acids, with three or more
bonding together in order to form a
nucleic acid.
A tour of
THE CELL
THE CELL THEORY
All living things are made of cells
Smallest living unit of structure and
function of all organisms is the cell
All cells arise from preexisting
cells(this principle discarded the idea
of spontaneous generation).
Two (2) types of cell
1) Eukaryotic cell
2) Prokaryotic cell
PEROXISOMES: Oxidation
Types:
1. Diffusion
2. Facilitated Diffusion
3. Osmosis
Active Transport
Types:
1. Protein Pumps
2. Endocytosis
3. Exocytosis
Passive Transport
Into cell
Out of cell
FACILITATED DIFFUSION
Diffusion of specific particles through
transport proteins found in the
membrane
a) Transport Proteins are specific
they select only certain
molecules to cross the membrane.
b) Transports larger or charged
molecules.
Transporters are of two general
classes: carriers and channels.
Receptor-mediated endocytosis.
PROCESS OF ENDOCYTOSIS
Plasma membrane surrounds material
Edges of membrane meet
Membranes fuse to form vesicle
ENERGY TRANSFORMATION
IN CELL
Respiration includes all of the
processes used continuously by cells
to produce usable energy.
Energy enables cells to do work of
building up some molecules
(synthesis) and taking others apart.
Synthesis is a process that consumes
energy, while decomposition (taking
molecules apart) releases energy.
Cellular respiration is a pathway of
decomposition: it is a series of
reactions that break down sugars,
releasing energy along the way.
(nicotinamide adenine
dinucleotide) producing NADH and a
carbon is lost, forming carbon dioxide
(CO2).
KREBS CYCLE
Also known as the Citric acid cycle
and Tricarboxylic acid cycle (TCA).
In this process, the acetyl-CoA will
bind with starting compound called
oxaloacetate, and through a series of
enzymatic redox reactions, all
carbons, hydrogen and oxygen in
pyruvate ultimately end up as carbon
dioxide and water.
The pathway is called a cycle because
oxaloacetate is the starting and
ending compound of the pathway.
For every glucose enters glycolysis,
the cycle completes twice, once for
each molecule of pyruvate that
entered the mitochondria.
During pyruvate oxidation and the
Krebs cycle a net of 8 NADH, 2
FADH2, 2 ATP and 6 CO2 are
produced for each glucose molecule.
ELECTRON TRANSPORT CHAIN (ETC)
In order to understand how the
majority of the energy is produced by
aerobic respiration (with oxygen),
we need to follow the NADH and
FADH2 molecules in the next stage of
cellular respiration.
The electron transport chain (ETC)
is a series of membrane-bound
carriers in the mitochondria that pass
electrons from one to another.