ABSTRACT

AN ANALGETIC STUDY ON PHARMACODYNAMIC INTERACTION

BETWEEN MENGKUDU JUICE (Morinda citrifolia) AND ASPIRIN
The study on the onset of pain by using hot plate method within mice (Mus
musculus)
Akhmad Setyo Rahman
Aspirin has been known to have an analgesic effect and mengkudu juice
contains alkaloids, flavonoids, and scopoletin alleged to have analgesic effects
too. The aims of this were to determine the pharmacodynamic interaction of
analgesic effect between mengkudu juice and aspirin in mice induced by hot plate.
This was an experimental study conducted in 6 groups. Group I were given 0.5 ml
of distilled water (negative control), group II were given given mengkudu juice
with dose of 0.042 mg/g BW (positive control I), group III were given aspirin at a
dose of 0.065 mg/gBW (positive control II), and group IV-VI were given a
combination of mengkudu juice at a dose of 0.042 mg/g and aspirin at a dose of
0.01625 mg/grBW, 0.0325 mg/grBW, and 0.065 mg/gBW. The treatment was given
for 7 days. The results showed an average onset of pain were 5.36 seconds, 8.28
seconds, 8.74 seconds, 10.16 seconds, 11.09 seconds, and 14.92 seconds for
group I, II, III, IV, V and VI, respectively. Statistical anaysis using Kruskal-Wallis
showed that that there were significant differences between groups with p =
0.000, with the most potential analgesic effect is dose aspirin group with 0.065
mg/ gBW. It can be concluded that there is a synergistic interaction between
mengkudu fruit juice combination with aspirin in mice.
Keywords: mengkudu juice, analgesics, aspirin, pharmacodynamic interaction