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Specific immune
- Preface
Specific immune defenses require the recognition of antigens.
Key Concepts of Specific Immunity is an antigen is a molecule that
provokes a specific immune response. Antigens are large, complex
molecules such as proteins; they are generally foreign to the body,
usually present of the surface of pathogens. A large antigen may
have several parts, and each stimulate a different specific immune
response. In this case, the different parts are known as antigenic
determinant sites, and each serves as a different antigen. Particular
lymphocytes have receptor proteins on their surfaces that recognize
an antigen and direct a specific immune response against either the
antigen or the cell that carries the antigen.
The specific immune responses protect the body in two ways.
First, an individual can gain immunity by being exposed to a
pathogen (disease-causing agent) and perhaps getting the disease.
This is acquired immunity, such as the resistance to the chicken pox
that you acquire after having the disease in childhood. Another term
for this process is active immunity. Second, an individual can gain
immunity by obtaining the antibodies from another individual. This
happened to you before you were born, with antibodies made by
your mother being transferred to you across the placenta. Immunity
gained in this way is called passive immunity.
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- T cell
After their origin in the bone marrow, T cells migrate to the
thymus (hence the designation T), a gland just above the heart.
There they develop the ability to identify microorganisms and
viruses by the antigens exposed on their surfaces. Tens of millions
of different T cells are made, each specializing in the recognition of
one particular antigen. No invader can escape being recognized by
at least a few T cells. There are four principal kinds of T cells.
1. inducer T cells oversee the development of T cells in the
thymus;
2. helper T cells (often symbolized TH) initiate the immune
response;
3. cytotoxic (cell-poisoning) T cells (often symbolized TC)
lyse cells that have been infected by viruses;
4. suppressor T cells terminate he immune response.
B cell