Professional Documents
Culture Documents
Prolonged aPTT
Other studies normal
PT 1:1 mix
Full correction
Partial
correction
Factor VII
Deficiency
Lupus
anticoagulant
workup
Factor levels,
if needed
No correction
Factor
inhibitor
workup
Coumadin
Full correction
vWD
Factor
Deficiency
vWD
workup, if
needed
Factor
levels, if
needed
Partial
correction
No correction
Full correction
Partial
correction
Lupus
anticoagulant
workup
Factor inhibitor
workup
Factor
Deficiency
Lupus
anticoagulant
workup
Factor levels,
if needed
No correction
Factor
inhibitor
workup
Coumadin
Prolonged aPTT, TT
Other studies normal
Normal Studies /
Bleeding Patient
Diffuse or joint
bleeding
Hepzyme treatment
D-dimer
Factor VIII
Correction
Heparin
contamination
Normal
Low
Normal
Antibody to
bovine
thrombin
Dysfibrinogen
DIC
FDP
Low or
normal
High
Dysfibrinogen
DIC
Factor XI
Mild
hemophilia B
vWD workup
Mild
hemophilia C
Abnormal
vWD
Normal
Low
Fibrinolytic
workup
Factor XIII
deficiency
PAI-1
deficiency
Low
Low
Factor XIII
Alpha-2-antiplasmin
deficiency
Normal
Normal
Normal
TPA
excess
Abnormal
Mild
hemophilia
A
Factor IX
Prolonged
Recommend workup
for Thrombocytopenia
High
Reptilase time
Normal
Petechiae or
Mucosal bleeding
No correction
Low or
normal
Low Plt Ct
Other studies normal
Platelet
dysfunction
vWD workup
Normal
Abnormal
vWD
Factor V
Leiden
Abnormal
Normal
APC resistance
Protein C Ag &
activity
Factor II
G20210A
MTHFR
Prothrombin
Antiphospholipid
antibodies
Factor VIII, XI
levels
? elevated
Anticardiolipin
antibodies
Anti-B2glycoprotein
antibodies
Abnormal
Normal
Protein C
deficiency
Protein S Ag &
activity
Lupus
anticoagulant
workup
Abnormal
Normal
Protein S
deficiency
AT III Ag &
activity
Abnormal
Normal
AT III
deficiency
Fibrinogen
level & activity
Normal
Abnormal
Homocysteine
levels
Dysfibrinogen
? high
Hyperhomocysteinemia
Screening
Tests
Mixing Studies
aPTT
Normal
DRVVT
Abnormal
Confirmatory
Testing
Failure to correct
Corrects
Incubated 1:1
mixing study
Hexagonal
platelet
neutralization
study
Negative
Corrects
Factor assays
Normal
Specific factor
deficiency or
inhibitor
Negative
Positive
Lupus
anticoagulant