Paper I

Write short notes on:

1.
a) Adrenal steroid hormone synthesis

5+(2+3)

b) Outline the biochemical consequences of defects in the classical 21-hydroxylase

deficiency and its management.

2.
a) Structure of glomerulus with diagrammatic representation. (6+4)
b) What are the glomerular changes in rapidly progressive glomerulonephritis.

3. Enumerate the five high impact activities under RMNCH+A programme.

2+2+2+2+2

4. How is plasma osmolality calculated? Discuss its determinants. What are the
diagnostic criteria of SIADH (Syndrome of inappropriate ADH secretion) (3+4)+3

5.
a) Steps to curb female infanticide. (5+5)
b) Role of micronutrients in pediatric health and disease.

6.
a) Virology and epidemiology of Swine-flu. (1+2)+3+(2+2)
b) How is the disease categorized according to Govt. of India guidelines.

c) Mention which children need to be immunized and who need to be given

medication for the disease.

7.
a) EVidence based medlcine. (6+4)
b) Forest plot in meta-analysis.

8.
a) Clinical trials - Phase I, Phase II, Phase III & Phase IV. (5+5)
b) Ethics in biomedical research.

9.
a) Laws of adoption in India Define translocation. Write the Inheritance pattern for
translocations. Describe clinical features of anyone translocation disorder. (4+6)
b) Enumerate 4 common neuronal migration disorders and their clinical features in
brief.

10. Millennium Development Goals (MDG). (6+4)

Paper II

1.
(a) Causes of neonatal anaemia. 5+5
(b) Cyanosis in newborn.

2. Aetiology, pathogenesis, linical features and management of

hypophosphataemia. 2+3+2+3

3.
(a) What is Severe Acute Malnutrition (SAM)? 2+2+6
(b) What are the clinical signs of SAM?
(c) Management of SAM in an one year old child weighing 5 kg.

4. An 8 year old child is brought with history of convulsions and altered sensorium,
his BP is 180/110 mmHg . Discuss the differential diagnosis, laboratory
investigations and management of this patient. 3+3+4

5.
(a) Apnoea of prematurity 5+5
(b) Retinopathy of prematurity.

6. Management of steroid resistant and steroid dependent nephritic syndrome. 5+5

7. Management of

5+5

(a )Acute myeloid leukaemia

(b) Aplastic anaemia .

8.
(a) Diagnosis and management of pertussis 5+5

(b) VAPP (Vaccine Associated Paralytic PoliomyelitiS).

9.
(a) Fluoride and disease 2+4+4
(b) Hypervitaminosis

(c) Hypervitaminosis

10.
(a) CSF formation and CSF circulation. 4+(3+3)
(b) Enumarate the causes and management of
1. Communicating

hydrocephalus

2. Non-communicating hydrocephalus

Paper III

1. Pathcphysioloqy

and management of

(a) Organophosphorus

5+5

poisoning.

(b) Scorpion bite.

2. What are the biochemical criteria for the diagnosis of Diabetic Ketacidosis
(DKA)? What are the goals of therapy? How will you manage a 7 year child with
DKA? 3+3+4

3. Etiology,

pathogenesis,

shock? 2+3+2+3

clinical features and management

of cardigenic

4. Describe the symbols used in pedigree chart. Draw pedigree charts over
four generation depicting. 4+(3+3)
(a) X-linked dominant disease
(b) X linked recessive disease.

5. Define severe dengue

Describe the WHO guidelines for Its

management. Enumerate the complications of severe dengue. 2+4+4

6.
(a) Bioterrorism

3+3+4

(b) Radiation sickness

(c) Congenital cataract

7.
(a) Modified Glasgow Coma Scale for children and Infants. 5+2+3
(b) Its advantages and disadvantages.

(c) What is AVPU Pediatric Response Scale?

8. Define fulminant Hepatic

failure.

Write

stages Hepatic

Encephalopathy. Outline steps of Its management. 2+3+5

9.
(a) Autistic spectrum disorders 3+3+4
(b) Wiskott-Aldrich

syndrome .

(c) Graft versus host disease

10.
(a) Hypernatrerma. 3+3+4
(b) Hyperkalemia.
(c) Non-pharmacoglogic strategies for pain management.