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(2) (3)
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@@
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:::
::
: Syntex: Monsant
(2) Linezolid
500-700
"learn-before-doing" "learn-whi1e-doing"
(Process Analytical Technology)
(4) Irinotecan HCl
High- Throughput Screening
Quality by Design Process Analytical
Technology Continuous Process
Irinotecan HCl
(1)
(5) Docetaxel Microreactor '
TeriparatidePEGylation
(continuous ozonolysis process)
PEGylation
RPC
; pH
(on line monitoring)
(solubi1ity parameters)
offline HPLC
(baseline separation)
(3) (Quality by Design)
226
20146
65
:
:
:::
::
: Syntex: Monsant
(2) Linezolid
500-700
"learn-before-doing" "learn-whi1e-doing"
(Process Analytical Technology)
(4) Irinotecan HCl
High- Throughput Screening
Quality by Design Process Analytical
Technology Continuous Process
Irinotecan HCl
(1)
(5) Docetaxel Microreactor '
TeriparatidePEGylation
(continuous ozonolysis process)
PEGylation
RPC
; pH
(on line monitoring)
(solubi1ity parameters)
offline HPLC
(3) (Quality by Design)
226
20146
65
.....................................................
I Pharmacy and Chemical Technol?
..
|
|
: Teriparatide
Octreotide
PEG' N ;
lysine[6] ( acetonitrile ,
(polyethylene glycol ,
ACN) 0.1%(trifluoroacetic
PEG) PEGylation
acid , TFA)
mono- PEGy lated
Octreotides [7] 2011 Cai and Yue
cation-IEC PEGylation
biobetters (
Exenatidecation-IEC
biosuperiors) PEG
mono-PEGylated multiple-PEGylated
Exenatide
[1 2]
[8]
PEGylation ;
IEC
PEGylation
RPC [9] PEGylation
PEG N
Lysine Glutamic
acid
PEGylation(post-grafting)
(PEGylation)
Cysteine
biobetters
(diastereomers) (osteoporosis) Teriparatide
PEGylation
PEGylated peptide
(solubility parameters)
PEGylated peptide
PEGylation
[10]
(size
exclusion
(solubility parameter)
chromatography, SEC)
(like dissolves like principle)
(ion-exchanged chromatography, IEC)
()
(reversed-phase chromatogr
(l iposome)
RPC) Octreotide PEGylation
(peptide drug)
66
226
20146
1936 Hildebrand
67
.....................................................
I Pharmacy and Chemical Technol?
..
|
|
: Teriparatide
Octreotide
PEG' N ;
lysine[6] ( acetonitrile ,
(polyethylene glycol ,
ACN) 0.1%(trifluoroacetic
PEG) PEGylation
acid , TFA)
mono- PEGy lated
Octreotides [7] 2011 Cai and Yue
cation-IEC PEGylation
biobetters (
Exenatidecation-IEC
biosuperiors) PEG
mono-PEGylated multiple-PEGylated
Exenatide
[1 2]
[8]
PEGylation ;
IEC
PEGylation
RPC [9] PEGylation
PEG N
Lysine Glutamic
acid
PEGylation(post-grafting)
(PEGylation)
Cysteine
biobetters
(diastereomers) (osteoporosis) Teriparatide
PEGylation
PEGylated peptide
PEGylated peptide
PEGylation
[10]
(size
exclusion
(solubility parameter)
chromatography, SEC)
(like dissolves like principle)
(ion-exchanged chromatography, IEC)
()
(reversed-phase chromatogr
(l iposome)
RPC) Octreotide PEGylation
(peptide drug)
66
226
20146
1936 Hildebrand
67
\,}(-)'
_?
HII
...
...1
1.....
.......... ................ .......... ........
.....................................................
1 Pharmacy and Chemical Technolg
[11]
PEGylated
PEGylation
1m (Raoult's
(2)
PEGylation
law) (negative deviation)
"\
PEGylatedH
RPC
pH
1966 Hansen
AB =J~~AA + Oi~BB
: (dispersion force)
(2)
: d
(polarity force) (hydrogen bonding
rce )l 12] (i1 8)
:A
"\
:B
A1=R:
=4(A -Od,B)2 + (Op ,A-Op ,B)2 + (O" ,A-Oh ,B)2
(1)
(d L p L
(baseline
separation)
dAB 5pd
(isocratic elution)
AB(3) :
(l nk')
PEGylated
Teriparatide
4AB=J;JB+5;AB+5:8(3)
lnk'= [( y ( -n2]+ln
RT
Solubility parameter o (MPa')

Solvent
(4)
ACE : L = 14.76
Teriparatide 5000 g/mole PEG
~L = 14.18h.L =9.78 [10]
SPA (succinimide propionate methoxylate)
0,
Od
Op
Oh
n-Hexane
15.30
15.30
0.00
0.00
Toluene
18.20
18.00
1.4 0
2.00
2002
PEGylation
Tetrahydrofuran (THF)
19.40
16.80
5.70
8.00
Teriparatide
pH 6.0 8.0 PEG-SAP
Acetone (ACE)
20.00
15.50
10 .40
7.00
Teriparatide
monoPEGylation
2 'J Propanol
(IPA)
23.50
15.80
6.10
16 .40
Teriparatide N lysine13
Acetonitrile (ACN)
24 .40
18.00
6.10
15.30
ACE CI8-RPC (4.5 mmX 150 mm ,
24.80
17 .40
13.70
11.30
5m) ACN/
Ethanol (EtOH)
Teriparatide
HP(O.I%TFA)
26.50
15.80
8.80
19.4 0
Dimethylsulphoxide (DMSO)
26.70
18 .4 0
16 .40
10.20
[13 14] Teriparatide
co-elution
22.30
PEGylation Teriparatide
N N Dimethylformamide
68
".J (4)
1971 Hansen 2S C
8; 8; 8;) 1
Teriparatide
(DMF)
Methanol (MeOH)
29.60
15.10
12.30
Ethylene glycol (EG)
32.90
17.00
11.00
26.00
Water(Hp)
47.80
15.60
16.00
42.30
226
20146
69
\,}(-)'
_?
HII
...
...1
1.....
.......... ................ .......... ........
.....................................................
1 Pharmacy and Chemical Technolg
[11]
PEGylated
PEGylation
1m (Raoult's
(2)
PEGylation
law) (negative deviation)
"\
PEGylatedH
RPC
pH
1966 Hansen
AB =J~~AA + Oi~BB
: (dispersion force)
(2)
: d
(polarity force) (hydrogen bonding
rce )l 12] (i1 8)
:A
"\
:B
A1=R:
=4(A -Od,B)2 + (Op ,A-Op ,B)2 + (O" ,A-Oh ,B)2
(1)
(d L p L
(baseline
separation)
dAB 5pd
(isocratic elution)
AB(3) :
(l nk')
PEGylated
Teriparatide
4AB=J;JB+5;AB+5:8(3)
lnk'= [( y ( -n2]+ln
RT
Solubility parameter o (MPa')

Solvent
(4)
ACE : L = 14.76
Teriparatide 5000 g/mole PEG
~L = 14.18h.L =9.78 [10]
SPA (succinimide propionate methoxylate)
0,
Od
Op
Oh
n-Hexane
15.30
15.30
0.00
0.00
Toluene
18.20
18.00
1.4 0
2.00
2002
PEGylation
Tetrahydrofuran (THF)
19.40
16.80
5.70
8.00
Teriparatide
pH 6.0 8.0 PEG-SAP
Acetone (ACE)
20.00
15.50
10 .40
7.00
Teriparatide
monoPEGylation
2 'J Propanol
(IPA)
23.50
15.80
6.10
16 .40
Teriparatide N lysine13
Acetonitrile (ACN)
24 .40
18.00
6.10
15.30
ACE CI8-RPC (4.5 mmX 150 mm ,
24.80
17 .40
13.70
11.30
5m) ACN/
Ethanol (EtOH)
Teriparatide
HP(O.I%TFA)
26.50
15.80
8.80
19.4 0
Dimethylsulphoxide (DMSO)
26.70
18 .4 0
16 .40
10.20
[13 14] Teriparatide
co-elution
22.30
N N Dimethylformamide
68
".J (4)
1971 Hansen 2S C
8; 8; 8;) 1
Teriparatide
(DMF)
Methanol (MeOH)
29.60
15.10
12.30
Ethylene glycol (EG)
32.90
17.00
11.00
26.00
Water(Hp)
47.80
15.60
16.00
42.30
226
20146
69
lii.. .1
1.
.......... ....... .... ...... ....... ......... .....
20 K13-
K13-PEGylated TeriparatideNter
PEGylated TeriparatideNter-PEGylated
PEGylated Teriparatide
Teriparatide
1 3.61 4.20
.....................................................
1 Pharmacy and Chemical Technom
15
Isocratic elution: 15% THF +15% ACN +70% H20
Nter.+ K13-PEGylated Teriparatide
[C,l = 222ug/mL
10
Nter
A 22 m(mV)
K13-PEGylated Teriparatide
Nter-PEGylated(d.L
Nter-PEGylated Teriparatide (36 .4 0
p.L ) (4)
MPa l/2 )Kl3-PEGylated Teriparatide
(37.20 MPa l 12 )Nter-PEGylated
(isocratic elution)
Teriparatide K13-
(l nk')
Nter EGylated Teriparatide
l (t = 4.20 min)
Nter-PEGylated Teriparatide ;
pH
K13-
(t
PEGylated
Kl3-PEGylated Teriparatide Nter
Teriparatide
PEGylated Teriparatide K13-PEGylated
Teriparatide
Nter-PEGylated Teriparatide (t R =
(polarity)
20.04 min)
8P
Park
(baseline separation) Park
15%
CI8-RPCpH
15% 0
PEGylated octreotide
pH 8.0 9.0
34.25 MPa isocratic
K13-Nter
pH=8.0
Kl3-PEGylated Teriparatide
ACE CI8-RPC(4.5mmXI50mm ,
Nter-PEGylated Teriparatide
5m) pH7.0
pH
8.0 9.0 10mM
-5
R = 3.61
min)
Nter-PEGylated Teriparatide K13-PEGylated Teriparatide
Peptide
Elution time (min)

1
Nter-PEGylated Teriparatide 3-PEGylated Teriparatide 15% THF

+15% ACN + 70%
HP
Solubility parameter of PEGylated peptide , (Mpa '12 )
70
Teriparatide
pH
= 7.0
K13-
PEGylated Teriparatide (t R = 19.36 min)
(PB) A' 100% ACN
Nter
14.10
14.50
30.30
36 .4 0
B' 20 20% 60%
(L'1tR)0.04 min 0.68 min
K13
14 .40
16.00
30.30
37.20
ACN/PB
2.63 min
22 6
20146
71
lii.. .1
1.
.......... ....... .... ...... ....... ......... .....
20 K13-
K13-PEGylated TeriparatideNter
Teriparatide
1 3.61 4.20
.....................................................
1 Pharmacy and Chemical Technom
15
Isocratic elution: 15% THF +15% ACN +70% H20
Nter.+ K13-PEGylated Teriparatide
[C,l = 222ug/mL
10
Nter
A 22 m(mV)
Nter-PEGylated(d.L
Nter-PEGylated Teriparatide (36 .4 0
p.L ) (4)
MPa l/2 )Kl3-PEGylated Teriparatide
(37.20 MPa l 12 )Nter-PEGylated
(isocratic elution)
Teriparatide K13-
(l nk')
Nter EGylated Teriparatide
l (t = 4.20 min)
Nter-PEGylated Teriparatide ;
pH
K13-
(t
PEGylated
Teriparatide
PEGylated Teriparatide K13-PEGylated
Teriparatide
Nter-PEGylated Teriparatide (t R =
(polarity)
20.04 min)
8P
Park
(baseline separation) Park
15%
CI8-RPCpH
15% 0
PEGylated octreotide
pH 8.0 9.0
34.25 MPa isocratic
K13-Nter
pH=8.0
Kl3-PEGylated Teriparatide
ACE CI8-RPC(4.5mmXI50mm ,
5m) pH7.0
pH
8.0 9.0 10mM
-5
R = 3.61
min)
Nter-PEGylated Teriparatide K13-PEGylated Teriparatide
Peptide
Elution time (min)

1
Nter-PEGylated Teriparatide 3-PEGylated Teriparatide 15% THF

+15% ACN + 70%
HP
Solubility parameter of PEGylated peptide , (Mpa '12 )
70
Teriparatide
pH
= 7.0
K13-
PEGylated Teriparatide (t R = 19.36 min)
(PB) A' 100% ACN
Nter
14.10
14.50
30.30
36 .4 0
B' 20 20% 60%
(L'1tR)0.04 min 0.68 min
K13
14 .40
16.00
30.30
37.20
ACN/PB
2.63 min
22 6
20146
71
...1
1...
........... ........... ....... ......... ........
............ ........ ............ .....................
1 Pharmacy and Chemical Techn.1'fj?
Adv Drug Deliv Rev 54 (2002) 459.

[2] F. M. Veronese , Biomaterials 22 (2001)
100
~
A220nm
pH 7.0
(mV)
[3] Y.
P. Yue , Journal of Chromato-
15
10
Ruaan , W. Y. Chen , Analytical and
Journal of Applied Polymer Science 116
Bioanalytical Chemistry 404 (2012)
(2010) 3220.
2437.
[5] M. Stromqvist , Journal of Chromato-
[6] D.H. Na , P.P. DeLuca , Pharmaceutical
pH8.0pH 9.0
[7] E.J. Park, K. C. Lee , D.H. Na , Journal of
[8] H. Dou , M. Zhang , Y. Zhang , C. Yin ,
Chem Biol Drug Des 69 (2007) 132.
PEG
Teriparatide
-amine(pKa= 10.1)' pH 7.0~pH
mono-PEGylated Teriparatide
9.0 amine (NH 3 +)
pH ;
PEG
pH
-amine (pKa = 7.8) pH 7.0
-amine pH
8.0 9.0 (NH )
PEGylation
Engineering Chemistry Product

Research 8 (1 966) 2.
Chromatography A 1216 (2009) 7793.
[11] J.H. Hildebrand, Science 83 (1936) 2 1.

[12] C.M. Hansen , Industrial and
graphy A 667 (1 994) 304.
20
Elulion time (min)
mono-PEGylated Teriparatide pH7.0
L. C. Chang , R. C.
H.S. Lin, L. Q. Zang ,
Research 22 (2005) 736.

2
Kao
::
K13
Ti
(1996) 996.
[10] C.W. Tsai , W.
graphy A 1218 (2011) 6953.

[4]X.F. Wang , Y.
pH 9.0
A.G. Paige , J.B. Hamburger , M.J.

Treuheit , Pharmaceutical Research 13
405.
_)l
[9] O.B. Kinstler, D.N. Brems, S. L. Lauren ,
[1 M.
Shiraki, T. Sugimoto , T. Nakamura ,
Osteoporos Int 24 (2013) 219.

[14] H. Sowa, E. Hamaya , T. Yamamoto ,
Clin Calcium 21 (2011) 9.
:
:
Nter-PEGylated
Teriparatide
72
[l]M.J. Roberts , M.D. Bentley, J.M. Harris ,
22 6
Analytical Chemistry
20146
Physical
Chemistry
73
...1
1...
........... ........... ....... ......... ........
............ ........ ............ .....................
1 Pharmacy and Chemical Techn.1'fj?
Adv Drug Deliv Rev 54 (2002) 459.

[2] F. M. Veronese , Biomaterials 22 (2001)
100
~
A220nm
pH 7.0
(mV)
[3] Y.
P. Yue , Journal of Chromato-
15
10
Ruaan , W. Y. Chen , Analytical and
Journal of Applied Polymer Science 116
Bioanalytical Chemistry 404 (2012)
(2010) 3220.
2437.
[5] M. Stromqvist , Journal of Chromato-
[6] D.H. Na , P.P. DeLuca , Pharmaceutical
pH8.0pH 9.0
[7] E.J. Park, K. C. Lee , D.H. Na , Journal of
[8] H. Dou , M. Zhang , Y. Zhang , C. Yin ,
Chem Biol Drug Des 69 (2007) 132.
PEG
Teriparatide
-amine(pKa= 10.1)' pH 7.0~pH
mono-PEGylated Teriparatide
9.0 amine (NH 3 +)
pH ;
PEG
pH
-amine (pKa = 7.8) pH 7.0
-amine pH
8.0 9.0 (NH )
PEGylation
Engineering Chemistry Product

Research 8 (1 966) 2.
Chromatography A 1216 (2009) 7793.
[11] J.H. Hildebrand, Science 83 (1936) 2 1.

[12] C.M. Hansen , Industrial and
graphy A 667 (1 994) 304.
20
Elulion time (min)
mono-PEGylated Teriparatide pH7.0
L. C. Chang , R. C.
H.S. Lin, L. Q. Zang ,
Research 22 (2005) 736.

2
Kao
::
K13
Ti
(1996) 996.
[10] C.W. Tsai , W.
graphy A 1218 (2011) 6953.

[4]X.F. Wang , Y.
pH 9.0
A.G. Paige , J.B. Hamburger , M.J.

Treuheit , Pharmaceutical Research 13
405.
_)l
[9] O.B. Kinstler, D.N. Brems, S. L. Lauren ,
[1 M.
Shiraki, T. Sugimoto , T. Nakamura ,
Osteoporos Int 24 (2013) 219.

[14] H. Sowa, E. Hamaya , T. Yamamoto ,
Clin Calcium 21 (2011) 9.
:
:
Nter-PEGylated
Teriparatide
72
[l]M.J. Roberts , M.D. Bentley, J.M. Harris ,
22 6
Analytical Chemistry
20146
Physical
Chemistry
73
.....................................................
I Pharmacy and Chemical Techn ly
..
:(Li nezolid)
-78 0 C (R)
50S
((R)-glycidyl
butyrate)
5-1H( 1
mRNA 70S
(1 b)
(1 c)
50S
(1 b)
1999 Br B. Lohray
3382
(Tetrahedron Letters ,
1990, 40 , 4885-4886)
(streptococcuspyogenes 'A
3- -4-
(MRSA) (MRSE) (PRSP)
MIC50 0.5~4/
(VER)
2(2a)) H (2b)
(2c)
5-1H (2d)
(2e)
Pharmacia & Upjohn 5-(S)-

(linezolid) N -[[3-(3-fluoro-4-
morpholinophenyl)-2-oxooxazolidin-5-yl]methyl]acetamide '
2000FDA(G+)
MRSA(HAP) (CAP)
(SSTI) (VRE)2001 3
2004 (Zyvox) ,
74
(la)) ,
226
2
2007
1994
US 5688792 'N- =f -3- -4-
20146
75
.....................................................
I Pharmacy and Chemical Techn ly
..
:(Li nezolid)
-78 0 C (R)
50S
((R)-glycidyl
butyrate)
5-1H( 1
mRNA 70S
(1 b)
(1 c)
50S
(1 b)
1999 Br B. Lohray
3382
(Tetrahedron Letters ,
1990, 40 , 4885-4886)
(streptococcuspyogenes 'A
3- -4-
(MRSA) (MRSE) (PRSP)
MIC50 0.5~4/
(VER)
2(2a)) H (2b)
(2c)
5-1H (2d)
(2e)
Pharmacia & Upjohn 5-(S)-

(linezolid) N -[[3-(3-fluoro-4-
morpholinophenyl)-2-oxooxazolidin-5-yl]methyl]acetamide '
2000FDA(G+)
MRSA(HAP) (CAP)
(SSTI) (VRE)2001 3
2004 (Zyvox) ,
74
(la)) ,
226
2
2007
1994
US 5688792 'N- =f -3- -4-
20146
75
31
...1
1........
.................... ........ ....... ......
.....................................................
1 Pharmacy and Chemical Techn6
obh)
~CI
obhp 1
(S)-epichlorohydrin
Ac20
AcNH
-4- -4-)-- (3b)
(3- -4-4.)-
- (3b)
(S)-5-{[(4- .)-
3 .4--4
} -3-(3- -4- -4-)- -2-
(3c)
.t
Ar-d
.,
(ii) NaBH MeOH
___loH ...OH
._.....-
(i)MeSOpl!
(ii)NaNiDMSO. 80 0 C
(2d)
(i)LTAfTHF
Ar-0NH
(2e)
A?
--
(3b)
Li nezolid
2
76
Lilhium I-Buloxide
acetic acid
(3a)
AN3
-7HI<
)- -2-( 4(3a)) (3-
> H
CI
)-
-o-
(S)-l- -3-[(4- -E-
y :1v
X=
Chlbh
Li nezolid
L v._/N~X
(3c)
W02007116284Al (S)-(+)-
(S)-l- -3-[(4- -E-)-]- -2-
4-
(3'3
226
X=
-o-
CI
R=
\....Q
4
20146
77
31
...1
1........
.................... ........ ....... ......
.....................................................
1 Pharmacy and Chemical Techn6
obh)
~CI
obhp 1
(S)-epichlorohydrin
Ac20
AcNH
-4- -4-)-- (3b)
(3- -4-4.)-
- (3b)
(S)-5-{[(4- .)-
3 .4--4
} -3-(3- -4- -4-)- -2-
(3c)
.t
Ar-d
.,
(ii) NaBH MeOH
___loH ...OH
._.....-
(i)MeSOpl!
(ii)NaNiDMSO. 80 0 C
(2d)
(i)LTAfTHF
Ar-0NH
(2e)
A?
--
(3b)
Li nezolid
2
76
Lilhium I-Buloxide
acetic acid
(3a)
AN3
-7HI<
)- -2-( 4(3a)) (3-
> H
CI
)-
-o-
(S)-l- -3-[(4- -E-
y :1v
X=
Chlbh
Li nezolid
L v._/N~X
(3c)
W02007116284Al (S)-(+)-
(S)-l- -3-[(4- -E-)-]- -2-
4-
(3'3
226
X=
-o-
CI
R=
\....Q
4
20146
77
...1
1...........
....... .... ....... ......... ........ ...

.)-]- }-3-(3- -4-
-4--)- H 2- (3c)
.....................................................
1 Pharmacy and Chemical Techn Jy
2011 James R.
McCarthy
(S)-N-{[3-[3-
US61389534
US61389534 (S)-(+)
-4-( ) -5- H
4-
} (4c)
( 500~700 )
( 6(3c))
(S)-I- -3-[(4- -)-]- -2-
(3a)
(in process control , IPC)
(S)-N-(4- .)-1-(
(3c)
: -2-)( 5(4a)) 3- -4-
N-4- -
(4b)
(S)-N {[3-[3- -4-(
) -5- } (4c)
(S)-5-{[(4-
(4c)
(4c)
(4c)
b-F|+clH
NH.OH
,
CLbft=
4b
Clf2
[
RHI0
)(
(4c)
( 50~100 )
5-10
( 5~10)
pH=7.0~8.0 (4c)
Y
4c
Yo
n
o
+UN f
:l
)\)
Fb
CH 2CI 2
1N HCI
n-Bu 3 P=O , Li Br,
Fb
78
5~10
FC
22 6
2014 6
79
...1
1...........
....... .... ....... ......... ........ ...

.)-]- }-3-(3- -4-
-4--)- H 2- (3c)
.....................................................
1 Pharmacy and Chemical Techn Jy
2011 James R.
McCarthy
(S)-N-{[3-[3-
US61389534
US61389534 (S)-(+)
-4-( ) -5- H
4-
} (4c)
( 500~700 )
( 6(3c))
(S)-I- -3-[(4- -)-]- -2-
(3a)
(in process control , IPC)
(S)-N-(4- .)-1-(
(3c)
: -2-)( 5(4a)) 3- -4-
N-4- -
(4b)
(S)-N {[3-[3- -4-(
) -5- } (4c)
(S)-5-{[(4-
(4c)
(4c)
(4c)
b-F|+clH
NH.OH
,
CLbft=
4b
Clf2
[
RHI0
)(
(4c)
( 50~100 )
5-10
( 5~10)
pH=7.0~8.0 (4c)
Y
4c
Yo
n
o
+UN f
:l
)\)
Fb
CH 2CI 2
1N HCI
n-Bu 3 P=O , Li Br,
Fb
78
5~10
FC
22 6
2014 6
79
;?
1
.. .1
1 . ...................... . ... . .....................0
pH control for acylation reaction

1 hour IPC(HP (I_C area% )
Batch No
Acp (eq.)
Reaction
.....................................................
1 Pharmacy and Chemical Techntg
(S)-l- -3-[(4 - -)- -2-
(IPC criteria)
(3a) GC
75% 'Loss on ying(LOD)
pH ntrol
Li ne-4
(l_ inezolid
Total impurity
539R04o
3.0
NA
12.20
86.61
1.10
507R093
3.0
7.0-8.0
ND
96 .44
3.56
1. (S)-1- -3-[(4- ")
507R095
3.0
8.0-8.5
ND
95.29
4.71
]--2-(3a)
507R1o7
3.0
9.0-10 .0
8.82
90 .1
1.08
507R098
3.0
6.5-7.0
2.41
95.22
2.37
1. 05 4-
95%
2.(S)-N (4- -)-1-( -2- ) (4a)
1. 0
1. 5part 2.0part
(4c) ( 539R131)
(S)-(+)- 2.0
30-40
pH>9.0
3 . 0-5.0
25%
1.0part (S)-l- -3-[(4- .)-]- -2-
403 0 C
(3a) 20-25 0 C 6-7 2
6-7 2
GC (S)-I- -3-[(4- .
pH=7.0-8.0
3.0
GC
)-]- -2- (3a) 3a 3%
(S)-(+)-
5part
l 2
(3c)
(S)-(+)- 3%
5% 5part
pH=7.0-8.0 3.0
1.5-2.0
40 0 C'
45 0 C'
GC 72%'
ROE
539R127) 3.0
Batch No
80
Molar ratio of acetic anhydride vs. (3c)

Reaction
Acp
(eq.) I Temp. ("C)
1 hour IPC(HPLC area% )
40 C'
pH ntrol
Reaction Ti me
(h)
Li ne-4
Linezolid
Total impurity
2/3
Reaction
539R127
6.0
20 - 30
7.0-8 .0
1.0
ND
97.64
2.35
539R129
5.0
20 - 30
7.0-8.0
1.0
ND
98 .80
1.22
539R13o
3.0
20 - 30
7.0-8.0
1.5
ND
98.54
1.4 5
539R131
2.0
20 30
7.0-8 .0
2.0
2.21
96.0 2
1.77
20-25 0C
22 6
20146
Lot No
3a
(GC area%)
3a (Kg)
(%)
F2ooC1 12002
97.2
114.3
59.2
F2ooC1 12004
97 .4
123.2
61.4
60.3
81
;?
1
.. .1
1 . ...................... . ... . .....................0
pH control for acylation reaction

1 hour IPC(HP (I_C area% )
Batch No
Acp (eq.)
Reaction
.....................................................
1 Pharmacy and Chemical Techntg
(S)-l- -3-[(4 - -)- -2-
(IPC criteria)
(3a) GC
75% 'Loss on ying(LOD)
pH ntrol
Li ne-4
(l_ inezolid
Total impurity
539R04o
3.0
NA
12.20
86.61
1.10
507R093
3.0
7.0-8.0
ND
96 .44
3.56
1. (S)-1- -3-[(4- ")
507R095
3.0
8.0-8.5
ND
95.29
4.71
]--2-(3a)
507R1o7
3.0
9.0-10 .0
8.82
90 .1
1.08
507R098
3.0
6.5-7.0
2.41
95.22
2.37
1. 05 4-
95%
2.(S)-N (4- -)-1-( -2- ) (4a)
1. 0
1. 5part 2.0part
(4c) ( 539R131)
(S)-(+)- 2.0
30-40
pH>9.0
3 . 0-5.0
25%
1.0part (S)-l- -3-[(4- .)-]- -2-
403 0 C
(3a) 20-25 0 C 6-7 2
6-7 2
GC (S)-I- -3-[(4- .
pH=7.0-8.0
3.0
GC
)-]- -2- (3a) 3a 3%
(S)-(+)-
5part
l 2
(3c)
(S)-(+)- 3%
5% 5part
pH=7.0-8.0 3.0
1.5-2.0
40 0 C'
45 0 C'
GC 72%'
ROE
539R127) 3.0
Batch No
80
Molar ratio of acetic anhydride vs. (3c)

Reaction
Acp
(eq.) I Temp. ("C)
1 hour IPC(HPLC area% )
40 C'
pH ntrol
Reaction Ti me
(h)
Li ne-4
Linezolid
Total impurity
2/3
Reaction
539R127
6.0
20 - 30
7.0-8 .0
1.0
ND
97.64
2.35
539R129
5.0
20 - 30
7.0-8.0
1.0
ND
98 .80
1.22
539R13o
3.0
20 - 30
7.0-8.0
1.5
ND
98.54
1.4 5
539R131
2.0
20 30
7.0-8 .0
2.0
2.21
96.0 2
1.77
20-25 0C
22 6
20146
Lot No
3a
(GC area%)
3a (Kg)
(%)
F2ooC1 12002
97.2
114.3
59.2
F2ooC1 12004
97 .4
123.2
61.4
60.3
81
YJ
.. .1
1..
......... ...... .... ..... ...... ........ .........
.....................................................
1 Pharmacy and Chemical Technog
4
3a
4a
(Kg)
(GC area%)
F200C211001
69 .4
78 , 7
50.1
F200C2 11002
74 .4
80 .4
F200C2 11003
79.3
75.5
Lot No
4a(kg)
(%)
7.5~8.0 0.75parts
20-
(S)-(+)-
85.6
30 0 C l
53.4
85 , 2
3c 3c 1.0%
57.7
86 .4
20%
1) 35%
85.7
3%
50
8 . 0~9 . 0
1500
3.(S)-5-{[(4- .)-]- }-3-
(S)-5-{[(4- -)
(3- -4- -4- -)- H -2-
}-3-(3--4--4-.)--2-
(3c)
(3c)
35 0 C'
99.0% '
1.6parts
2 20-
lpart 3- -4- "

(4b'
) 7parts
30 0 C 1
0.027parts
O.13C part
4. H
99.5% '
1part
5.6parts 3%
12
0.97part (S)-N-(4-
8parts
99.5% '
)-1-(-2- ) (4a)
1parts (S)-5-{[(4- .
1.6parts
)-} -3-(3- -4-~ -4--
2 20-30 0 C
4b 4b
)-H-2-(3c)
1 H
1%
20-30 0 C 2-3
() 20%
:
:
5
4b
LotNo
3c
3c
3c
(Linezolid. 1) (HPLC
(Kg)
area%)
F200C411001
78.4
78.2
F200C4 11002
86.8
F200C4 11003
(%)
LotNo
78 .4
81.8
99.9
75.0
99 , 6
83 , 2
(kg)
(HPLC area%)
(kg)
F200C3 11001
51
99.9
F200C3 11002
51
F200C311003
51
82
(%)
99.93
53.5
84.5
75.0
99.95
48.8
80.7
83.2
99.98
53.1
79.0
82.3
226
1 (kg)
20146
81 .4
83
YJ
.. .1
1..
......... ...... .... ..... ...... ........ .........
.....................................................
1 Pharmacy and Chemical Technog
4
3a
4a
(Kg)
(GC area%)
F200C211001
69 .4
78 , 7
50.1
F200C2 11002
74 .4
80 .4
F200C2 11003
79.3
75.5
Lot No
4a(kg)
(%)
7.5~8.0 0.75parts
20-
(S)-(+)-
85.6
30 0 C l
53.4
85 , 2
3c 3c 1.0%
57.7
86 .4
20%
1) 35%
85.7
3%
50
8 . 0~9 . 0
1500
3.(S)-5-{[(4- .)-]- }-3-
(S)-5-{[(4- -)
(3- -4- -4- -)- H -2-
}-3-(3--4--4-.)--2-
(3c)
(3c)
35 0 C'
99.0% '
1.6parts
2 20-
lpart 3- -4- "

(4b'
) 7parts
30 0 C 1
0.027parts
O.13C part
4. H
99.5% '
1part
5.6parts 3%
12
0.97part (S)-N-(4-
8parts
99.5% '
)-1-(-2- ) (4a)
1parts (S)-5-{[(4- .
1.6parts
)-} -3-(3- -4-~ -4--
2 20-30 0 C
4b 4b
)-H-2-(3c)
1 H
1%
20-30 0 C 2-3
() 20%
:
:
5
4b
LotNo
3c
3c
3c
(Linezolid. 1) (HPLC
(Kg)
area%)
F200C411001
78.4
78.2
F200C4 11002
86.8
F200C4 11003
(%)
LotNo
78 .4
81.8
99.9
75.0
99 , 6
83 , 2
(kg)
(HPLC area%)
(kg)
F200C3 11001
51
99.9
F200C3 11002
51
F200C311003
51
82
(%)
99.93
53.5
84.5
75.0
99.95
48.8
80.7
83.2
99.98
53.1
79.0
82.3
226
1 (kg)
20146
81 .4
83
2014 |||||||
lii ...1
1....
...... ....... .... ...... ..... ...... ....... ....
- --1
: 1.
FORMOSA LABORATORIES , INC.
2.
36, Hoplng Street, Louchu County,

Taoyuan , Ta Nva n, 33642
Tel : 886-3-3240895 . Fax: 886-3-3240923
Intern~t : wv.w.formosalab.com E-mall: info@fonmosal.com
3.
Certificate of Analysis
Produc!:

........g.u . -.......33232
4. (
)
@
@
5.
6.
Li nezolid
Lo! No.: F20013004
Amoun!: 85.12 kg
Whlteto ihlte powder
O.
< 10ppm
< 10 ppm
0.0%
0.0%
()
Notdetted
101.3%
Not detecled
Notdeteted
Not detecled
Not detected
Not detected
Not detected
247ppm
Not detecled
<0.2 EU/mg
: 1.
2.
46 11m
95m
3.
molsture.
84
L :l
~3m
QC Approved by:
-- -;-- ;-
TesUng Method: F200.E7.TS
Da!e:
g.b . Z.bl~
Date:
etJ.-01 "
4.
5.
6.
@
@
@
:
:
22 6
2014 |||||||
lii ...1
1....
...... ....... .... ...... ..... ...... ....... ....
- --1
: 1.
FORMOSA LABORATORIES , INC.
2.
36, Hoplng Street, Louchu County,

Taoyuan , Ta Nva n, 33642
Tel : 886-3-3240895 . Fax: 886-3-3240923
Intern~t : wv.w.formosalab.com E-mall: info@fonmosal.com
3.
Certificate of Analysis
Produc!:

........g.u . -.......33232
4. (
)
@
@
5.
6.
Li nezolid
Lo! No.: F20013004
Amoun!: 85.12 kg
Whlteto ihlte powder
O.
< 10ppm
< 10 ppm
0.0%
0.0%
()
Notdetted
101.3%
Not detecled
Notdeteted
Not detecled
Not detected
Not detected
Not detected
247ppm
Not detecled
<0.2 EU/mg
: 1.
2.
46 11m
95m
3.
molsture.
84
L :l
~3m
QC Approved by:
-- -;-- ;-
TesUng Method: F200.E7.TS
Da!e:
g.b . Z.bl~
Date:
etJ.-01 "
4.
5.
6.
@
@
@
:
:
22 6
)./ l
/Ll
|
(Quality
86
..
practice , cGMP)
(Intemational
19
Society for Pharmaceutical
Engineering, ISPE)
Bayer
(Interlational
Hoffman
of technical requirements for registration of
pharmaceuticals for human use , ICH)
Bayer
(Pharmaceutical
[1]
Inspection Convention and Pharmaceutical
1940
Inspection Co-operation Scheme , PIC/S)
(Good
1928 Fleming
manufacturing practice , GAMP)
(Code of federal regulation, CFR)21
. "
Florey
Heatley
conference on harmonization
automated
by testing)
Pfizer...
(Critical quality attribute , CQA)(Critical process parameter, CPP)
[2]
1964 GMP
(Quality
19
QbD)
(Target product profile , TPP) (Target
(FDA) 1987
product quality pro:file, TPQP)
cGMP
by design ,
(Quality risk management , QRM)
1960
(Design space) (Control
strategy)
[4]
(Chemometric)
(Computer
1960
validation)
(Quality
by design)
[1 3] : (Good
(Process analytical technology)
manufacturing practice)
(Current
226
20146
good manufacturing
system
f[3]
21
87
)./ l
/Ll
|
(Quality
86
..
practice , cGMP)
(Intemational
19
Society for Pharmaceutical
Engineering, ISPE)
Bayer
(Interlational
Hoffman
of technical requirements for registration of
pharmaceuticals for human use , ICH)
Bayer
(Pharmaceutical
[1]
Inspection Convention and Pharmaceutical
1940
Inspection Co-operation Scheme , PIC/S)
(Good
1928 Fleming
manufacturing practice , GAMP)
(Code of federal regulation, CFR)21
. "
Florey
Heatley
conference on harmonization
automated
by testing)
Pfizer...
(Critical quality attribute , CQA)(Critical process parameter, CPP)
[2]
1964 GMP
(Quality
19
QbD)
(Target product profile , TPP) (Target
(FDA) 1987
product quality pro:file, TPQP)
cGMP
by design ,
(Quality risk management , QRM)
1960
(Design space) (Control
strategy)
[4]
(Chemometric)
(Computer
1960
validation)
(Quality
by design)
[1 3] : (Good
(Process analytical technology)
manufacturing practice)
(Current
226
20146
good manufacturing
system
f[3]
21
87
. ..1
......
..... ................... ........ ..........
2002 8 'FDA
(Quality
.....................................................
1 Pharmacy and Chemical Techn _(gy
by design)
1000
; 2004 9 'FDA
FDA ICH
Employees
E8600
w
<
U3
400
[ QbD
ICH 2003 GMP
(Harmonized pharmaceutical quality
system) Q8 :
FDA 1990
(Pharmaceutical development)
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Harmonization, "Guidance for Industry,
[8]Internationa1 Conference of
Q9 Qua1ity Risk Management" , http://
'
www.fda.gov/down1oads/Drugs/.. ./
(2004)
[2]Barreiro , C.; Martin , J. F.; Estrada , C.
FDA
G. , "Proteomics Shows New Faces for
the Old Penicillin Producer Penicillium
Q10 Pharmaceutica1 Qua1ity System" ,
chrysogenum" , J. Biomed. Biotech. ,
http://www.fda. gov / down1oads/Drugs/
2012 , 1-15(2012).
Guidances/ucm073517. pdf, (2009).
[3]
'
Harmonization , "Guidance for
(2009)
[4]"Facts about Current Good
Manufacture of Drug Substances" ,
... 15
Manufacturing Practices (cGMPs)" ,
http:// www.fda.gov/down1oadslDrugs/
http://www.fda.gov/drugs/
GuidanceComp1ianceRegu1atoryInfo
deve 1opme n ta pp rov a1 pro c e s s/
rmation/Guidances/UCM261078.p
manufacturing/ucm 1691 05.h1.
(2012).
[5]US FDA , "Pharmaceutica1 cGMPs
; [27J
A. S.; Wink1e , H. , "Qua1ity by
Approach" Fina1 report, hp://www.fda.
Biotech. , 27 , 26-34(2009).
[1 Yu
L. X.; Raw , A.; Li onberger ,
[6]
r21 GMP
R.; Rajagopa1an , R.; Lee ,L. M.;
'
Ho1combe , F.; Pate1 , R.; Fang , F.;

Sayeed,
v.;
Schwar P.;
Adams , R.;
Bueh1er, G. , "US FDA Question-based
Review for Generic Drugs: A New
Q8 Pharmaceutica1 Deve1opment" ,
Pharmaceutica1 Qua1ity Assessment
http://www . fda. gov / down1oads/
System" , J. Gen. Med. , 4 , 239-
Regu1atory Information/Guidances/
248(2007).
ucm128029.pdf, (2006).
226
[11]Ratho
Design for Biopharmaceutica1s" , Nat.
317 (2007)
15
Industry , Q 11 Deve10pment and
for the 21 st Century: A Risk-based
gov/oc/guidance/gmp.htm1, (2004).
104
Guidances/ucm07 351 1. P~ (2006).
20146
[1 Nasr
M. , "FDA's Qua1ity Initiatives:
105
.. .1
................................................0
Karl-Fischer
0.3% '
.....................................................
1 Pharmacy and Chemical Techno ly
Q9 Qua1ity Risk Management" , http://
'
www.fda.gov/down1oads/Drugs/.. ./
(2004)
[2]Barreiro , C.; Martin , J. F.; Estrada , C.
FDA
G. , "Proteomics Shows New Faces for
the Old Penicillin Producer Penicillium
Q10 Pharmaceutica1 Qua1ity System" ,
chrysogenum" , J. Biomed. Biotech. ,
http://www.fda. gov / down1oads/Drugs/
2012 , 1-15(2012).
Guidances/ucm073517. pdf, (2009).
[3]
'
Harmonization , "Guidance for
(2009)
[4]"Facts about Current Good
Manufacture of Drug Substances" ,
... 15
Manufacturing Practices (cGMPs)" ,
http:// www.fda.gov/down1oadslDrugs/
http://www.fda.gov/drugs/
GuidanceComp1ianceRegu1atoryInfo
deve 1opme n ta pp rov a1 pro c e s s/
rmation/Guidances/UCM261078.p
manufacturing/ucm 1691 05.h1.
(2012).
[5]US FDA , "Pharmaceutica1 cGMPs
; [27J
A. S.; Wink1e , H. , "Qua1ity by
Approach" Fina1 report, hp://www.fda.
Biotech. , 27 , 26-34(2009).
[1 Yu
L. X.; Raw , A.; Li onberger ,
[6]
r21 GMP
R.; Rajagopa1an , R.; Lee ,L. M.;
'
Ho1combe , F.; Pate1 , R.; Fang , F.;

Sayeed,
v.;
Schwar P.;
Adams , R.;
Bueh1er, G. , "US FDA Question-based
Review for Generic Drugs: A New
Q8 Pharmaceutica1 Deve1opment" ,
Pharmaceutica1 Qua1ity Assessment
http://www . fda. gov / down1oads/
System" , J. Gen. Med. , 4 , 239-
Regu1atory Information/Guidances/
248(2007).
ucm128029.pdf, (2006).
226
[11]Ratho
Design for Biopharmaceutica1s" , Nat.
317 (2007)
15
Industry , Q 11 Deve10pment and
for the 21 st Century: A Risk-based
gov/oc/guidance/gmp.htm1, (2004).
104
Guidances/ucm07 351 1. P~ (2006).
20146
[1 Nasr
M. , "FDA's Qua1ity Initiatives:
105
- ".
. ..
~'
\ ,_ ?
.;/
. ..1
........
........ .... ..................... .......
[20]Ratho A.
Mhat
..
.......... .
R. , "Quality
Pharm. Dev. Tech. , 14, 567-587(2009).
compliance. coml datenl downloadl
by Design for Biopharmaceuticals ,
[26]"Lyo f1 ux@ 200 TDLAS Water Vapor
FDAs_ Quality_ Initiative. pdf.
Principles and Case Studies" , John
Mass Flow Monitor" , http://www.
Wiley & Sons, Inc., 10-11, 24(2009).
gilyos.com/k:ey-technologies/lyo f1 ux-
An Update" , http://www.gmp-
[14]Robert, A. L.; Lee, S. L.; Lee, L.
S.;
M.; Raw, A.; Yu, L. X. , "Quality by
[21 ]US FDA office in Department of
Design: Concepts for ANDAs" , AAPS
Health and Human Services, "Study
J., 10, 268-276(2008).
on the Development of Quality
[2 7]Romero- Torres , S. , "Practical
[15]Mehta, B. , "Understanding ICH Q11-
by Design (QbD) for Lyophilized
Considerations on PAT Analyzer
FDA's Guidance on the Development
Protein Parenteral Manufacturing
Selection-Raman v s. NIR
and Manufacture ofDrug Substances" ,
Processes" , https:llwww.fbo.gov/
Spectroscopy" , http://www.aaps.org/
Pharm. Tech., 37, 64-68(2013).
index?s=oppunity&mode=
form&id
uploadedFiles/Contentl Sections_ and
=836593b9dl fD 89468b9c8fbOf68a8
GroupslRegional_Discussion_Groupsl
d&tab=core&_ cview=O , (2009).
Romero-TorresMar20 1O.pdf, (2010).
by Design in Development and
Scale-Up ofFreeze-Dried Parenterals" ,

Biopharm. Inter. , 21 , 44-52(2008).
[2 Mockt
L.; LeBlond, D.; Basu, P. K.;
Control" , Pharm. Res. , 25 , 781-
Shah R. B.; Khan, M. A. , "A QbD
791(2007).
Case Study: Bayesian Prediction of

R.; Ghare,
Lyophilization Cycle Parameters" ,
"Process Analytical Technology
AAPS Pharm. Sci. Tech. , 12 , 442-
[18]Rathore, A. S.;
v.,
Bhambu
(PAT) for Biopharmaceutical

Products", Anal. Bioanal. Chem., 398,
137-154(2010).
448(2011).
[24]Sundaram, J.; Shay, Y. H. M.; Hsu,

C. C.; Sane , S. U. , "Design Space
L X.; Lionberger, R. A.; Raw, A.
Development for Lyophilization
S.; D'Costa, R.; Wu, H.; Hussain, A.
U sing DoE and Process Modeling" ,
S. , "Application of Process Analytical
Biopharm. Inter., 23, 26-36(2010).
[1 Yu
Development, Understanding, and
J. A.; "Elements of
by Design: Product and Process
Qualir
Searl
[17]Yu , L. X. , "Pharmaceutical Quality
S. L.;
Biomed. Res. , 3, 100-108(2012).
[2Nail
in Pharmaceuticals" , In t. J. Pharm.
Holistic Concept of Building Quality
monitor/.
[16]Roy , S. , "Quality by Design: A
200 dlas-water-vapor-mass-flow-
:
:
Technology to Crystallization
[25]Patel, S. M.; Pikal , M. , "Process
Processes", Adv. Drug De l. Rev. , 56,
Analytical Technologies (PAT) in
349-369(2004).
Freeze-Drying ofParenteral Products",
| E-mail|
|in5
7@mmm c.com.tw
:
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106
226
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- ".
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Mhat
..
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R. , "Quality
Pharm. Dev. Tech. , 14, 567-587(2009).
Wiley & Sons, Inc., 10-11, 24(2009).
S.;
J., 10, 268-276(2008).
Pharm. Tech., 37, 64-68(2013).
form&id
=836593b9dl fD 89468b9c8fbOf68a8

Biopharm. Inter. , 21 , 44-52(2008).
[2 Mockt
791(2007).

R.; Ghare,
[18]Rathore, A. S.;
v.,
Bhambu

137-154(2010).
448(2011).

Biopharm. Inter., 23, 26-36(2010).
[1 Yu
J. A.; "Elements of
Qualir
Searl
S. L.;
Biomed. Res. , 3, 100-108(2012).
[2Nail
monitor/.
:
:
349-369(2004).
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R. , "Quality
Pharm. Dev. Tech. , 14, 567-587(2009).
Wiley & Sons, Inc., 10-11, 24(2009).
S.;
J., 10, 268-276(2008).
Pharm. Tech., 37, 64-68(2013).
form&id
=836593b9dl fD 89468b9c8fbOf68a8

Biopharm. Inter. , 21 , 44-52(2008).
[2 Mockt
791(2007).

R.; Ghare,
[18]Rathore, A. S.;
v.,
Bhambu

137-154(2010).
448(2011).

Biopharm. Inter., 23, 26-36(2010).
[1 Yu
J. A.; "Elements of
Qualir
Searl
S. L.;
Biomed. Res. , 3, 100-108(2012).
[2Nail
monitor/.
:
:
349-369(2004).
| E-mail|
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(virtual energy state)
Smekal(9)
(electromagnetic radiation , EMR)
(Stokes shift)
(Raleigh
(Stokes
scattering) (Raman
scattering)
Gardiner( 1989)[10) Long(1977)[II) ,
scattering)
(Anti-Stokes Raman scattering)
Nakamoto(1986)[12) Stoicheff( 1959)[13)
(Anti-Stokes shift)l l 1
scattering)
Raman
qd -4
==--
MVUVW
dum
ees
Er
puv
V
Ae
v =0
Anti-Stokes Raman Scattering

--r
-..-
Eas
=h ( +
E =hv_
E = hv_
^^V^ 1I1!II.
A^
^ ^ ^ ^V ~
VVVVVV. Rayleigh Scattering
VVVVVV'fIi.
v=3
ground
.._
eleclronic . state
v =1
=0
IR
Es
Raleigh Stokes
antiscattering radiation Stokes
radiation
NIR
=h( - v)
Raman e'ect
Stokes Raman Scattering

1
110
(8J
22 6
Fluorescence
20146
(9J
111
".1
1...........
..... ........ ......... ....... .........
(8)
(532 nm)(785 nm and
1064
nm)
)()
()
(Raleigh
()
Lord Rayleigh[I4)
Sir C. v. Raman
and Krishnan 1928
(virtual energy state)
Smekal(9)
(electromagnetic radiation , EMR)
(Stokes shift)
(Raleigh
(Stokes
scattering) (Raman
scattering)
Gardiner( 1989)[10) Long(1977)[II) ,
scattering)
(Anti-Stokes Raman scattering)
Nakamoto(1986)[12) Stoicheff( 1959)[13)
(Anti-Stokes shift)l l 1
scattering)
Raman
qd -4
==--
MVUVW
dum
ees
Er
puv
V
Ae
v =0
Anti-Stokes Raman Scattering

--r
-..-
Eas
=h ( +
E =hv_
E = hv_
^^V^ 1I1!II.
A^
^ ^ ^ ^V ~
VVVVVV. Rayleigh Scattering
VVVVVV'fIi.
v=3
ground
.._
eleclronic . state
v =1
=0
IR
Es
Raleigh Stokes
antiscattering radiation Stokes
radiation
NIR
=h( - v)
Raman e'ect
Stokes Raman Scattering

1
110
(8J
22 6
Fluorescence
20146
(9J
111
...1
..........
...... ............... ........ ...... ...
4.
.....................................................
1 Pharmacy and Chemical Technrog)
(1 200 grooves/mm) -75 0 C

(Princeton) 785
()
nm 50
5.
785 nm
(ethyl acetate,
400 mW
1.
EA) 99 . 5% (ethanol EtOH)
22
500
LSI RamanSoft
2.
Dimension Pl Raman system '
Lambda Solutions, Inc. (LSI)
3. O-H
1
3300 cm-
H-O-H
1
1560 cm-
O-H-
(photon-molecule)
H O-H
1
3100 cm-
[15]
112
Syringe pump
226
()
20146
113
...1
..........
...... ............... ........ ...... ...
4.
.....................................................
1 Pharmacy and Chemical Technrog)
(1 200 grooves/mm) -75 0 C

(Princeton) 785
()
nm 50
5.
785 nm
(ethyl acetate,
400 mW
1.
EA) 99 . 5% (ethanol EtOH)
22
500
LSI RamanSoft
2.
Dimension Pl Raman system '
Lambda Solutions, Inc. (LSI)
3. O-H
1
3300 cm-
H-O-H
1
1560 cm-
O-H-
(photon-molecule)
H O-H
1
3100 cm-
[15]
112
Syringe pump
226
()
20146
113
...1
1....
...... .......... .... .... ....... ..............
: 10 56.3
(1100 to 1800 cm
4(b)
(2N)
1535 to 1595 cm. 1
.....................................................
100
solvents showing strong signals
-1
Technoly
A -
Form 1
B ........ Form 11
C EA
l.-D
80
EtOH
E -
Solution
89.5
....
Q)
1568.8 cm- I 1557 .4 cm- I
5 C
40
20
400
800
1000
1200
Raman shift (cm")
1400
1600
1800
(a)
120
Solution
A-Forml
B Form 11
100
C - -EA
EtOH
E -Solution
80
5(a)
600
()
0::
b
Q)
()
1560
40
cm- I
1557 .4
cm- I
4(a)
20
1450
1500
1550
Raman shift
1600
1650
(cm)
(b)
30
(200
cm' l )
:(b) (a)
5(b)
(normalized)
to 1100
114
226
(a)
Xj
20146
115
...1
1....
...... .......... .... .... ....... ..............
: 10 56.3
(1100 to 1800 cm
4(b)
(2N)
1535 to 1595 cm. 1
.....................................................
100
solvents showing strong signals
-1
Technoly
A -
Form 1
B ........ Form 11
C EA
l.-D
80
EtOH
E -
Solution
89.5
....
Q)
1568.8 cm- I 1557 .4 cm- I
5 C
40
20
400
800
1000
1200
Raman shift (cm")
1400
1600
1800
(a)
120
Solution
A-Forml
B Form 11
100
C - -EA
EtOH
E -Solution
80
5(a)
600
()
0::
b
Q)
()
1560
40
cm- I
1557 .4
cm- I
4(a)
20
1450
1500
1550
Raman shift
1600
1650
(cm)
(b)
30
(200
cm' l )
:(b) (a)
5(b)
(normalized)
to 1100
114
226
(a)
Xj
20146
115
...1
140
i l:
1.....
..... ........... .... .... . . ....... ...........
A--
(a)
.....................................................
1 Pharmacy and Chemical Techn
6 sec
min
140
B--8
A--
(c)
B -
c 27
120
min
min
224 min
D -133
E
51 min
min
F - 225 min
100
D --
E -137
c- 34min
120
100
11 sec
24 min
0::
lJl
80
60
60
40
40
20
20
1520
1500
1540
1560
1500
1600
1580
1520
A 22
(b)
sec
B -4min
1580
1600
D -28
(a) 5 (b) 30 (c) 60
C--22min
100
1560
Raman shift (cm-')
Raman shift (cm)

120
1540
min
E - 55min
F -
110 min
80
1560
5(a) 30
0::
b
lJl
cm- 1
1557 .4
60
cm- 1
5(b)
40
20
1500
1520
1540
1560
1580
1600
Raman shift (cm-')

5
(a) 5 (b) 30 (c) 60

116
226
(1568.8 cm-')
1560 cm 1557 .4
cm- 1 30
(1568.8 cm-')
30
1568.8 cm- 1
60
20146
117
...1
140
i l:
1.....
..... ........... .... .... . . ....... ...........
A--
(a)
.....................................................
1 Pharmacy and Chemical Techn
6 sec
min
140
B--8
A--
(c)
B -
c 27
120
min
min
224 min
D -133
E
51 min
min
F - 225 min
100
D --
E -137
c- 34min
120
100
11 sec
24 min
0::
lJl
80
60
60
40
40
20
20
1520
1500
1540
1560
1500
1600
1580
1520
A 22
(b)
sec
B -4min
1580
1600
D -28
(a) 5 (b) 30 (c) 60
C--22min
100
1560
Raman shift (cm-')
Raman shift (cm)

120
1540
min
E - 55min
F -
110 min
80
1560
5(a) 30
0::
b
lJl
cm- 1
1557 .4
60
cm- 1
5(b)
40
20
1500
1520
1540
1560
1580
1600
Raman shift (cm-')

5
(a) 5 (b) 30 (c) 60

116
226
(1568.8 cm-')
1560 cm 1557 .4
cm- 1 30
(1568.8 cm-')
30
1568.8 cm- 1
60
20146
117
::
.. .1
1.... . ...
()
...... ... . . ........ .... ....... .... .......
.....................................................
1 Pharmacy and Chemical Technoog
(1 568.8 cm- I )
(1557 .4 cm
6(a) 5(a)
6
(b)
1568.8 cm- I 1557 .4 cm
L()
l 1
<Il
"'"
,'
O
H
1568.8 cm- I
1557 .4 cm- I
5(c)
5(b) 1568.8 cm- I 1557 .4 cm- I
6(a)
1557 .4
&.
2
c
EA
Q)
1568.8 cm- I
cm
50
100
150
Time , min
250
200
300
6
2.0
EA Charge
1.8
1.2
1.0
0. 8
EACharae
6j/
Cooling
Holding
t--
0 .4
0.2
0.0
100
200
300
400
500
600
Ti me , min
700
800
900
1000
1100
(a) 5 (b) 30 (c) 60

1568.8 cm- 1 1557 .4 cm
118
L()
L()
AH
WLKAZmcHZ h
F=
214
Cooling
1.6
Holding
(a)
50
100
150
200
250
300
350
Ti me , min
(a) 5 (b) 30 (c) 60 Z
1568.8 cm- 1 1557 .4 cm- 1
226
20146
119
::
.. .1
1.... . ...
()
...... ... . . ........ .... ....... .... .......
.....................................................
1 Pharmacy and Chemical Technoog
(1 568.8 cm- I )
(1557 .4 cm
6(a) 5(a)
6
(b)
1568.8 cm- I 1557 .4 cm
L()
l 1
<Il
"'"
,'
O
H
1568.8 cm- I
1557 .4 cm- I
5(c)
5(b) 1568.8 cm- I 1557 .4 cm- I
6(a)
1557 .4
&.
2
c
EA
Q)
1568.8 cm- I
cm
50
100
150
Time , min
250
200
300
6
2.0
EA Charge
1.8
1.2
1.0
0. 8
EACharae
6j/
Cooling
Holding
t--
0 .4
0.2
0.0
100
200
300
400
500
600
Ti me , min
700
800
900
1000
1100
(a) 5 (b) 30 (c) 60

1568.8 cm- 1 1557 .4 cm
118
L()
L()
AH
WLKAZmcHZ h
F=
214
Cooling
1.6
Holding
(a)
50
100
150
200
250
300
350
Ti me , min
(a) 5 (b) 30 (c) 60 Z
1568.8 cm- 1 1557 .4 cm- 1
226
20146
119
...1
H:
1...
........... ........... ...... ........ ..........
.....................................................
1 Pharmacy and Chemical Techno]y
1 5
6(b) 6(c) 5 6
Merschae
"On-line near infrared spectroscopy as
a Process Analytical Technology (PAT)
tool to control an industrial seeded API
()
[1 ]http://www.fda.gov/drugs/developmentapprovalprocess/manufacturing
[2]Schaefer, C. , Lecomte , C. , Clicq , D. ,
A. , Norrant , E. ,Fotiadu , F. ,
crystallization" , J. Pharm. Biomed. Ana1.,
83 ,
[3]Rosas , J.G. , Blanco , M. , Gonzalez , J.M. ,
Alcala , M. , "Real-time determination
of critical quality attributes using near-
infrared spectroscopy: A contribution for
Process Analytical Technology (PAT) " ,
TALANTA , 97 ,
Form I
Mixture
78 .C
Form I
a
Form I
reglon
Mixture
72.C
.
Form I
6S'C
Transition
reglon
..
h
Smin
Form I
Mixture
h
."
30 min
.. - 60' min
90min
Form 11
reglon
120
226
(2013).
163~ 170
(2012).
[4] Li n , ZH. , Zhou , LL., Mah an A. , Song,
S. , Wang , T. , Ge , ZH. , Ellison , D. ,
"Real-time endpoint monitoring and
determination for a pharmaceutical salt
formation process with in-line FT-IR
speco-scopy"
41 , 99~ 104 (2006).
J. Pharm. Biomed. Ana1.,
[5]Wirges , M. , Funke , A. , Serno , P. , Knop ,
K., Kleinebudde , P. , "Development and
in-line validation of a Process Analytical
Technology to facilitate the scale up of
coating processes" , J. Pharm. Biomed.
Ana1., 78~79
194~201
20146
57~64
(2013).
[6]Pataki , H. ,Csontos , 1., Nagy, Z.K. , Vajna ,
121
...1
H:
1...
........... ........... ...... ........ ..........
.....................................................
1 Pharmacy and Chemical Techno]y
1 5
6(b) 6(c) 5 6
Merschae
"On-line near infrared spectroscopy as
a Process Analytical Technology (PAT)
tool to control an industrial seeded API
()
[1 ]http://www.fda.gov/drugs/developmentapprovalprocess/manufacturing
[2]Schaefer, C. , Lecomte , C. , Clicq , D. ,
A. , Norrant , E. ,Fotiadu , F. ,
crystallization" , J. Pharm. Biomed. Ana1.,
83 ,
[3]Rosas , J.G. , Blanco , M. , Gonzalez , J.M. ,
Alcala , M. , "Real-time determination
of critical quality attributes using near-
infrared spectroscopy: A contribution for
Process Analytical Technology (PAT) " ,
TALANTA , 97 ,
Form I
Mixture
78 .C
Form I
a
Form I
reglon
Mixture
72.C
.
Form I
6S'C
Transition
reglon
..
h
Smin
Form I
Mixture
h
."
30 min
.. - 60' min
90min
Form 11
reglon
120
226
(2013).
163~ 170
(2012).
[4] Li n , ZH. , Zhou , LL., Mah an A. , Song,
S. , Wang , T. , Ge , ZH. , Ellison , D. ,
"Real-time endpoint monitoring and
determination for a pharmaceutical salt
formation process with in-line FT-IR
speco-scopy"
41 , 99~ 104 (2006).
J. Pharm. Biomed. Ana1.,
[5]Wirges , M. , Funke , A. , Serno , P. , Knop ,
K., Kleinebudde , P. , "Development and
in-line validation of a Process Analytical
Technology to facilitate the scale up of
coating processes" , J. Pharm. Biomed.
Ana1., 78~79
194~201
20146
57~64
(2013).
[6]Pataki , H. ,Csontos , 1., Nagy, Z.K. , Vajna ,
121
201
~
. '
E
.. .1 1..
M01n M. , Katona , L. , Marosi ,
New York (1959).
G. , "Imp1ementation of Raman Signa1

Feedback to Perform Controlled
of Raman spectroscopy" , John Wi1ey
Crystallization of Carvedi101" , Org.
& Sons , New Jersey (2008).
[7]Bodson , C. , Dewe , W. , Hubert , P. ,

De1attre , L., "Comparison of FT-NIR
4. (ICP)
M. , Saere L., Remon , J.P. , Verva
and to assay 10w-dose tab1ets contaimng
C. , "Near inared and Raman spectro-
riboflavin" , J. Pharm. Biomed. Ana 1.,
scopy for the inprocess monitoring of
:(
(PLA) : (cone
pharmaceutica1 production processes" ,
417 , 32~47 (2011).
ucm128029.pdf
[9]Smeka1 , A. , "On the quantum theory
- - -1
of diversification and dispersion" , Die
Naturwissenschaften , 11 , 873~875
: 1.
(1928).
[10]Gardiner , D.J. , "Practica1 Raman
:
Spectroscopy" , Springer-Ver1 ag , New
[l1 ]Long , D.A. , "Raman Spectroscopy" ,

McGraw-Hill Intemationa1 , New York
Compounds" , John W i1 ey & Sons ,

New York (1 986).
[13]Stoicheff, B.P. , "Advances in Spectroscopy" , Interscience Pub1ishers Lt d. ,
5.
1;1
3. .
6.
: API Process R&D

Engineering Nanotechnology
Electrochemistry
[1 Nakamoto K. , "Infrared and Raman
2.
Manager
Particle
4 @
: project
(1 977).
Spectra of Inorganic and Coordination
calorimeter)
(ICP)
Regu1atorylnformation/Guidances/
York (1989).
@
@
5. - (photo-DSC)
@ :
photomeY to follow the mixing kinetics
[ 8]http://www. fda. gov/ down10ads/
3. (cone calorimeter)
(1871).
[16]De Beer Burggraeve A. , Fonteyne ,
41 , 783~ 790 (2006).
2. (PLA)
p01arization and c010ur" , 41 , 107~ 120,
transmission and UV- VIS spectro-
: 1. (PLA)
[1 Stru J. , "On the 1ight om the s its
274~279
[14]Sasic, S. , "Pharmaceutica1 app1ications
Process Res. Dev. , 17 , 493-499 (2013).
..
4 |||||| |

..........g.u.-.......33333

.
:
DCS PLC
226
122
201
~
. '
E
.. .1 1..
M01n M. , Katona , L. , Marosi ,
New York (1959).
G. , "Imp1ementation of Raman Signa1

Feedback to Perform Controlled
of Raman spectroscopy" , John Wi1ey
Crystallization of Carvedi101" , Org.
& Sons , New Jersey (2008).
[7]Bodson , C. , Dewe , W. , Hubert , P. ,

De1attre , L., "Comparison of FT-NIR
4. (ICP)
M. , Saere L., Remon , J.P. , Verva
and to assay 10w-dose tab1ets contaimng
C. , "Near inared and Raman spectro-
riboflavin" , J. Pharm. Biomed. Ana 1.,
scopy for the inprocess monitoring of
:(
(PLA) : (cone
pharmaceutica1 production processes" ,
417 , 32~47 (2011).
ucm128029.pdf
[9]Smeka1 , A. , "On the quantum theory
- - -1
of diversification and dispersion" , Die
Naturwissenschaften , 11 , 873~875
: 1.
(1928).
[10]Gardiner , D.J. , "Practica1 Raman
:
Spectroscopy" , Springer-Ver1 ag , New
[l1 ]Long , D.A. , "Raman Spectroscopy" ,

McGraw-Hill Intemationa1 , New York
Compounds" , John W i1 ey & Sons ,

New York (1 986).
[13]Stoicheff, B.P. , "Advances in Spectroscopy" , Interscience Pub1ishers Lt d. ,
5.
1;1
3. .
6.
: API Process R&D

Engineering Nanotechnology
Electrochemistry
[1 Nakamoto K. , "Infrared and Raman
2.
Manager
Particle
4 @
: project
(1 977).
Spectra of Inorganic and Coordination
calorimeter)
(ICP)
Regu1atorylnformation/Guidances/
York (1989).
@
@
5. - (photo-DSC)
@ :
photomeY to follow the mixing kinetics
[ 8]http://www. fda. gov/ down10ads/
3. (cone calorimeter)
(1871).
[16]De Beer Burggraeve A. , Fonteyne ,
41 , 783~ 790 (2006).
2. (PLA)
p01arization and c010ur" , 41 , 107~ 120,
transmission and UV- VIS spectro-
: 1. (PLA)
[1 Stru J. , "On the 1ight om the s its
274~279
[14]Sasic, S. , "Pharmaceutica1 app1ications
Process Res. Dev. , 17 , 493-499 (2013).
..
4 |||||| |

..........g.u.-.......33333

.
:
DCS PLC
226
122
(batch) (semis-batch)
(production campaigns)
(2)B : 1
20
(flexibility) (versatility)E l]
(3) C : 20
(liquid-liquid
extraction)
50%
(microreactor technology)
70%
50%(ozonolysis)
(space-time
yield)
[1]
DocetaxelSPT1 141M6
-70~-600C
-20 0 C'
70%
SPT1 141M6
124
(1) A :
226
Roberge [2]
20146
125
(batch) (semis-batch)
(production campaigns)
(2)B : 1
20
(flexibility) (versatility)E l]
(3) C : 20
(liquid-liquid
extraction)
50%
(microreactor technology)
70%
50%(ozonolysis)
(space-time
yield)
[1]
DocetaxelSPT1 141M6
-70~-600C
-20 0 C'
70%
SPT1 141M6
124
(1) A :
226
Roberge [2]
20146
125
\y@/
...1
f l:
1.....
....................... . ...... ... ... ..... ...
[18 19]
(surface to volume ratio)
[2021]
(polydimethyl siloxane , PDMS)
[34]
g
u-2
OME
126
100m
(a)
Ego-2
Oego-2
: (a) Syrris's
Institut
fr Mikrotechnik Mainz
Africa Flow Chemistry
System;
(b)
GmbH; (c)(22(
; (d) Institut fr Mikrotechnik Mainz GmbH; (e)

; (f) (23( ; (g)[(
(h)
(interdigitated multilamellae)
(chaotic advection)[7 ,8]
(1) 1000
[9 10]
[11 12]
[]
[13 14] [15]
[29-32]
(2)
[16 17]
226
(24( ; (i)
20146
[43]
127
\y@/
...1
f l:
1.....
....................... . ...... ... ... ..... ...
[18 19]
(surface to volume ratio)
[2021]
(polydimethyl siloxane , PDMS)
[34]
g
u-2
OME
126
100m
(a)
Ego-2
Oego-2
: (a) Syrris's
Institut
fr Mikrotechnik Mainz
Africa Flow Chemistry
System;
(b)
GmbH; (c)(22(
; (d) Institut fr Mikrotechnik Mainz GmbH; (e)

; (f) (23( ; (g)[(
(h)
(interdigitated multilamellae)
(chaotic advection)[7 ,8]
(1) 1000
[9 10]
[11 12]
[]
[13 14] [15]
[29-32]
(2)
[16 17]
226
(24( ; (i)
20146
[43]
127
y
1
.. .1
1............
...... ...... ..... ....... .......... ...
(stereolithography) ; (powder
molding)
; (electrodischarge
machining) ;
(Iaser machining)
iE
I:
[33 ,34]
(powder blasting) ; (wet etching) ;

(ultrasonic machining)
[35 ,36]
(soft
molding)
lithography)
; (injection
; (hot
embossing)
.jE
[37 ,38]
:;
[39 ,4 0]
(Iithography) ; (electroplating)
(molding) ; (stamping) ;
(micromachining)
128
1 Pharmacy and Chemical TechnoJy
0.05M SPT1141M51 /
0.2M
.....................................................
(photolithography) ;
[41 ,42]
SPTl141M5
O-Cube ThalesN ano N ano-
technology Inc. 2
O-Cube
Docetaxel '
-70~-600C
SPTl141M6
O-Cube
SPTl141M6
SPTl141M6
-70 60 0 C
(3)
-20 0 C
[47]
()
()
(4)
[ 24/J
(acetic acid)
O-Cube
(dimethyl sul DMSO)
20
SPTl141M5 '
(SPTl141M5 )
(5)
(6)
226
20146
129
y
1
.. .1
1............
...... ...... ..... ....... .......... ...
(stereolithography) ; (powder
molding)
; (electrodischarge
machining) ;
(Iaser machining)
iE
I:
[33 ,34]
(powder blasting) ; (wet etching) ;

(ultrasonic machining)
[35 ,36]
(soft
molding)
lithography)
; (injection
; (hot
embossing)
.jE
[37 ,38]
:;
[39 ,4 0]
(Iithography) ; (electroplating)
(molding) ; (stamping) ;
(micromachining)
128
1 Pharmacy and Chemical TechnoJy
0.05M SPT1141M51 /
0.2M
.....................................................
(photolithography) ;
[41 ,42]
SPTl141M5
O-Cube ThalesN ano N ano-
technology Inc. 2
O-Cube
Docetaxel '
-70~-600C
SPTl141M6
O-Cube
SPTl141M6
SPTl141M6
-70 60 0 C
(3)
-20 0 C
[47]
()
()
(4)
[ 24/J
(acetic acid)
O-Cube
(dimethyl sul DMSO)
20
SPTl141M5 '
(SPTl141M5 )
(5)
(6)
226
20146
129
...1
1......
......... ...... ..... ...... ........ .........
BNO
UU3
Cryo-Compact
Circulator
O-Cube
SPT1141M5: (1); (2) :(3):
(4); (5)SPT1141M5; (6) SPT1141M6;(7)
()
(: E2695 , Waters)
120
110
100
(polytetrafluoroethylene , PTFE)
()
(ozonides)
SPT1141M5 SPT1141M6
(SPT1 141M6)
SPT1141M5 51 1. 2
589.6 1215.9 1649.0cm- 1 , SP T1 141M6
226
90
80
70
5c
60
50
40
quqL4
nunununu
,.
200 300 400 500 600 700 800 900 1000 110012001300140015001600170018001900
Raman Shift (cm-')
4
20146
SPT1141M5SPT1141M6
131
...1
1......
......... ...... ..... ...... ........ .........
BNO
UU3
Cryo-Compact
Circulator
O-Cube
SPT1141M5: (1); (2) :(3):
(4); (5)SPT1141M5; (6) SPT1141M6;(7)
()
(: E2695 , Waters)
120
110
100
(polytetrafluoroethylene , PTFE)
()
(ozonides)
SPT1141M5 SPT1141M6
(SPT1 141M6)
SPT1141M5 51 1. 2
589.6 1215.9 1649.0cm- 1 , SP T1 141M6
226
90
80
70
5c
60
50
40
quqL4
nunununu
,.
200 300 400 500 600 700 800 900 1000 110012001300140015001600170018001900
Raman Shift (cm-')
4
20146
SPT1141M5SPT1141M6
131
!
. ..1
...........
....... ......... ..... ..... ...... .....
.....................................................
1 Pharmacy and Chemical Technoly
() SPT 41M6
789.3 1628.8cm- 1
" (selectivity) SPT1141M6 '
SPT1141M7
SPT1141M5 (
SPT1 141M5
SPT1 141M6
SPT1 141M6
SPT1 141M6
SPT1 141M7
SP T1 141M5 SPT1141M6
33
SPTl 141M6
SPTl141M7 SP T1 141M6
SPT1141M5
( )SPT1141 M5
O-Cube
(conversion)
-60-70 C '
2 SP T1 141M5
-20 0 C '
100% 94%
SPT1141M5
;. (1111)
0_05
0.05
0.025
(ml/min)
1.2
1.2
2.0
(%)
14
14
(eq.)
1.08
(ml/min)
15.6
(OC)
SPT1141M5
SPT1141M6
SPT1141M6
SPT1141M7
15
j(M)
0.050
NA
1.08
1.08
(ml/min)
1.2
NA
15.6
12.1
j(%)
15
NA
( 4 )
(eq . )
1.08
1.0
(mllmin)
14.5
NA
(OC)
-20
-60
-20
-20
-20
ND*
ND
ND
94.21%
94.50%
94.37%
SPt1 141M7 (assay)
: ND
132
22 6
20146
(%)
77. 00
69.96
133
!
. ..1
...........
....... ......... ..... ..... ...... .....
.....................................................
1 Pharmacy and Chemical Technoly
() SPT 41M6
789.3 1628.8cm- 1
" (selectivity) SPT1141M6 '
SPT1141M7
SPT1141M5 (
SPT1 141M5
SPT1 141M6
SPT1 141M6
SPT1 141M6
SPT1 141M7
SP T1 141M5 SPT1141M6
33
SPTl 141M6
SPTl141M7 SP T1 141M6
SPT1141M5
( )SPT1141 M5
O-Cube
(conversion)
-60-70 C '
2 SP T1 141M5
-20 0 C '
100% 94%
SPT1141M5
;. (1111)
0_05
0.05
0.025
(ml/min)
1.2
1.2
2.0
(%)
14
14
(eq.)
1.08
(ml/min)
15.6
(OC)
SPT1141M5
SPT1141M6
SPT1141M6
SPT1141M7
15
j(M)
0.050
NA
1.08
1.08
(ml/min)
1.2
NA
15.6
12.1
j(%)
15
NA
( 4 )
(eq . )
1.08
1.0
(mllmin)
14.5
NA
(OC)
-20
-60
-20
-20
-20
ND*
ND
ND
94.21%
94.50%
94.37%
SPt1 141M7 (assay)
: ND
132
22 6
20146
(%)
77. 00
69.96
133

.. .1
1.
... ....... . .. .... .... ... . .. ....... ........ ......
SPT1141M5
c)
-60
-20
Chim. Oggi-Chem. Today, 21 , 8-11
(2009).
[5]Pennemann , H. ,
Forster
Kinkel ,
Alfa Laval IMMEfeld BTS
J. ,
"Improvement of dye properties of
Hessel
Lwe , H. , Wu , L. ,
[9] Kh an , S.A. , Gunther, A. , Schmidt M.A. ,
K.F. , "Micromixing of miscible
Jensen , K. F. , "Microfluidic synthesis
liquids in segmented gas-liquid flow" ,
of colloidal silica" , Langmuir , 20 ,
Langmuir, 21 , 1547-1555 (2005).
Jens
[17]Gnther, A. ,
K.F., "Microfluidic
Jens
microfiuidics: om
K. F. , "Multiphase
flow characteristics
synthesis of titania shells on colloidal
to chemical and materials synthesis" ,
silica" , Adv. Mater. , 19 , 2556-2560
Lab Chip, 6, 1487-1503 (2006).
(2007).
[18]Muhy
[ll]Hessel , V. , Lowe , H. ,
Schonfe
E. R., Inoue , T. , Sahoo , H. R.'
F. ,
Zaborenko , N. , Jensen , K. F., "Solder-
"Micromixers-a review on passive
based chip-to-tube and chipto- chip
and active mixing principles" , Chem.
packaging for microfluidic devices" ,
Eng. Sci., 60, 2479-2501 (2005).
Lab Chip, 7, 1309-1314 (2007).
[12]Nguyen , N.T. , Wu, Z. , "Micromixers-a
the azo pigment yellow 12 using a
review" , J. Micromech.
micromixer-based process" , Org.
RI-16 (2005).
Process Res. Dev. , 9, 188-92 (2005).
Park, J. , Rempel , J. , Guan ,
J. , Bawendi M.G. , Jensen , K.F. ,

"S upercri ti cal continuous-microflow
R.C.
synthesis of narrow size distribution
[6]Hessel V , Hardt S , Lwe H ,
"Continuous laminar evaporation:
quantum dots" , Adv. Mate r., 20 ,
Schonfeld F. , "Laminar mixing in
micron-scale distillation" , Chem.
4830-4834 (2008).
[2]Ainsworth , D. , Brocklebank , M. ,
different interdigital micromixers. I.
Commun. , 3, 266-267 (2004).
"Multiproduct plant design" , Chem.
Experimental characterization" , AIChE
Eng. , 110, 42-49 (2003).
J. , 49 , 566-77(2003).
articles/2002/6/
[13]Wootton ,
Microeng.
[1 Mae
deMello , A.J. ,
[1]http://www.pharmamanufacturing.com/
[20]Baxendale , I.R., Ley,
S.
Mansfield ,
[14]Hartman , R.L. , Sahoo , H.R. , Yen ,
A.C. , Smith , C.D. , "Multistep
B.C. , Jensen , K.F. , "Distillation
synthesis usingmodular fiow reactors:
inmicrochemical systems using
Bestmann-Ohira reagent for the

formation of alkynes and triazo les 13" ,
[3]Roberge , D .M . , Ducry , L., Bieler ,
[7]Song , H. , Bringer , M.R. , Tice ,
N. , Cretton , P. , Zimmermann , B. ,
J.D. , Gerdts , C.J. , Ismagilov , R.F. ,
capilla forces
"Microreactor technology: A revolution
"Experimental test of scaling of mixing
Lab Chip , 9, 1843-1849 (2009).
for the fine chemical and pharmaceutical
by chaotic advection in droplets moving
[15]Zheng, B. , Gerdts , C.J. , Ismagilov, R.F.,
industries" , Chem. Eng. Techno l., 28 ,
through microfluidic channels." , App l.
"Using nanoliter plugs in microfiuidics
318-323 (2005).
Phys. Lett. , 83 ,4664-4666 (2003).
to facilitate and understand protein
H. , Tokeshi , M. , Kitamori , T. ,
crystallization" , Curr. Opin. Struct.
"Continuous-flow chemical processing
Bio l., 15 , 548-555 (2005).
in three-dimensional microchannel
[4]Roberge , DM(Roberge , Dominique M.)
[8]Song , H. , Tice , J.D. , Ismagilov, R.F. ,
M(Gottsponer, Michael)
"A microfluidic system for controlling
[1];Eyholzer, M (Eyholzer, Markus)
reaction networks in time" , Angew.
[1];Kockmann , N , "Industrial design ,
Chem. In t. Ed. , 42 ,768-772 (2003).
[1];Gosponer
134
1 Pharmacy and Chemical Techn~g
[10] Kh an , S. A.,
scale-up , and use of microreactors" ,
Karlsruhe
.....................................................
8604-8611 (2004).
SPT1141M5
Corring F orschungzentrum
226
and segmented flow" ,
Angew. Chem. Int. Ed. , 48 , 4017-4021

(2009).
[21]Kikuta
Y. , Ueno , M. , Hisamoto ,
[16]Gnther , A. , Jhunjhunwala , M. ,
network for on-chip integration of
Thalmann , M. , Schmidt, M.A. , Jer
multiple reactions in a combinatorial
20146
135

.. .1
1.
... ....... . .. .... .... ... . .. ....... ........ ......
SPT1141M5
c)
-60
-20
Chim. Oggi-Chem. Today, 21 , 8-11
(2009).
[5]Pennemann , H. ,
Forster
Kinkel ,
Alfa Laval IMMEfeld BTS
J. ,
"Improvement of dye properties of
Hessel
Lwe , H. , Wu , L. ,
[9] Kh an , S.A. , Gunther, A. , Schmidt M.A. ,
K.F. , "Micromixing of miscible
Jensen , K. F. , "Microfluidic synthesis
liquids in segmented gas-liquid flow" ,
of colloidal silica" , Langmuir , 20 ,
Langmuir, 21 , 1547-1555 (2005).
Jens
[17]Gnther, A. ,
K.F., "Microfluidic
Jens
microfiuidics: om
K. F. , "Multiphase
flow characteristics
synthesis of titania shells on colloidal
to chemical and materials synthesis" ,
silica" , Adv. Mater. , 19 , 2556-2560
Lab Chip, 6, 1487-1503 (2006).
(2007).
[18]Muhy
[ll]Hessel , V. , Lowe , H. ,
Schonfe
E. R., Inoue , T. , Sahoo , H. R.'
F. ,
Zaborenko , N. , Jensen , K. F., "Solder-
"Micromixers-a review on passive
based chip-to-tube and chipto- chip
and active mixing principles" , Chem.
packaging for microfluidic devices" ,
Eng. Sci., 60, 2479-2501 (2005).
Lab Chip, 7, 1309-1314 (2007).
[12]Nguyen , N.T. , Wu, Z. , "Micromixers-a
the azo pigment yellow 12 using a
review" , J. Micromech.
micromixer-based process" , Org.
RI-16 (2005).
Process Res. Dev. , 9, 188-92 (2005).
Park, J. , Rempel , J. , Guan ,
J. , Bawendi M.G. , Jensen , K.F. ,

"S upercri ti cal continuous-microflow
R.C.
synthesis of narrow size distribution
[6]Hessel V , Hardt S , Lwe H ,
"Continuous laminar evaporation:
quantum dots" , Adv. Mate r., 20 ,
Schonfeld F. , "Laminar mixing in
micron-scale distillation" , Chem.
4830-4834 (2008).
[2]Ainsworth , D. , Brocklebank , M. ,
different interdigital micromixers. I.
Commun. , 3, 266-267 (2004).
"Multiproduct plant design" , Chem.
Experimental characterization" , AIChE
Eng. , 110, 42-49 (2003).
J. , 49 , 566-77(2003).
articles/2002/6/
[13]Wootton ,
Microeng.
[1 Mae
deMello , A.J. ,
[1]http://www.pharmamanufacturing.com/
[20]Baxendale , I.R., Ley,
S.
Mansfield ,
[14]Hartman , R.L. , Sahoo , H.R. , Yen ,
A.C. , Smith , C.D. , "Multistep
B.C. , Jensen , K.F. , "Distillation
synthesis usingmodular fiow reactors:
inmicrochemical systems using
Bestmann-Ohira reagent for the

formation of alkynes and triazo les 13" ,
[3]Roberge , D .M . , Ducry , L., Bieler ,
[7]Song , H. , Bringer , M.R. , Tice ,
N. , Cretton , P. , Zimmermann , B. ,
J.D. , Gerdts , C.J. , Ismagilov , R.F. ,
capilla forces
"Microreactor technology: A revolution
"Experimental test of scaling of mixing
Lab Chip , 9, 1843-1849 (2009).
for the fine chemical and pharmaceutical
by chaotic advection in droplets moving
[15]Zheng, B. , Gerdts , C.J. , Ismagilov, R.F.,
industries" , Chem. Eng. Techno l., 28 ,
through microfluidic channels." , App l.
"Using nanoliter plugs in microfiuidics
318-323 (2005).
Phys. Lett. , 83 ,4664-4666 (2003).
to facilitate and understand protein
H. , Tokeshi , M. , Kitamori , T. ,
crystallization" , Curr. Opin. Struct.
"Continuous-flow chemical processing
Bio l., 15 , 548-555 (2005).
in three-dimensional microchannel
[4]Roberge , DM(Roberge , Dominique M.)
[8]Song , H. , Tice , J.D. , Ismagilov, R.F. ,
M(Gottsponer, Michael)
"A microfluidic system for controlling
[1];Eyholzer, M (Eyholzer, Markus)
reaction networks in time" , Angew.
[1];Kockmann , N , "Industrial design ,
Chem. In t. Ed. , 42 ,768-772 (2003).
[1];Gosponer
134
1 Pharmacy and Chemical Techn~g
[10] Kh an , S. A.,
scale-up , and use of microreactors" ,
Karlsruhe
.....................................................
8604-8611 (2004).
SPT1141M5
Corring F orschungzentrum
226
and segmented flow" ,
Angew. Chem. Int. Ed. , 48 , 4017-4021

(2009).
[21]Kikuta
Y. , Ueno , M. , Hisamoto ,
[16]Gnther , A. , Jhunjhunwala , M. ,
network for on-chip integration of
Thalmann , M. , Schmidt, M.A. , Jer
multiple reactions in a combinatorial
20146
135
...1
1..............
mode" , QSAR Comb. Sci. ,
[28]Nagaki , A. , Takabayashi , N. , Tomida, Y. ,
of nanoparticles in high temperature
[40]Yen , B.K. , Gnther A. , Thalmann ,
Yoshida , J. , "Selective monolithiation
ceramic microreactors: design ,
M. , Bawendi , M.G. , Jensen , K.F. ,
of dibromobiaryls using microflow
fabrication and testing" , In t. J. App l.
"A microfabricated segmented-flow
Ceram. Techno l., 6,41 0~419 (2009).
reactor for the synthesis of CdSe
[34]Knitter, R. , Li auw, M.A. , "Ceramic
quantum dots" , Presented at In t.
F. J. ,
microreactors for heterogeneously
Conf. Miniaturized Syst. Chem. Li fe
for multiphase mixing and reaction",
"Application ofmicroreactor technology
catalysed gas-phase reactions" , Lab
Sci. , 8 Malmo , Swed. (2004).
J. Microelectromech. Syst. , 11 ,
in process development" , Org. Process
Chip, 4 378~383 (2004).
709~ 717
Res. Dev. , 8, 455~460 (2004).
24742~757
[2 Losey
(2005).
M.W. , Jackman , R. J.,
Firebaugh , S.L. , Schmidt ,
systems" , Org. Lett. , 10 ,
M.A. , Jensen , K.F. , "Design and
(2008).
fabrication of microfluidic devices
(2002).
[2 Zhang
X.N. ,
3937~3940
Stefanick Villa
[41]Hessel , V. , Hardt , S. , Lwe ,
[35]Woolley A.T. , Mathies R.A. , "Ultra-
H. , "Chemical Micro Process
[2 Lbbecke S. , Ferstl , W. , Pani' c ,
[30] Li u S. F., Fukuyama , T. , Sato , M. , Ryu ,
high-speed DNA fragment separations
Engineering: Fundamen tals ,
S. , Turcke , T. , "Concepts for
1., "Continuous microflow synthesis
using microfabricated capillary array
Modelling and Reactions" ,
modularization and automation of
of butyl cinnamate by a Mizoroki-
electrophoresis chips", Proc. Natl. Acad.
Weinheim, Ger.: Wiley (2004).
microreaction technology" , Chem.
Heck reaction using a low-viscosity
Sci. USA, 91 , 11348~11352 (1 994).
Eng. Technol., 28 , 484~493 (2005).
ionic liquid as the recycling reaction
[24] Kra
J. G. , Sahoo, H.R. , Jensen , K. F.,
medium" , Org. Process Res. Dev. , 8 ,

(2004).
"Integrated continuous microfluidic
477~481
liquid-liquid extraction", Lab Chip,
[31]Ehrfeld , W. ,
[36]Mellors ,
R.
J.
Hessel Lwe
H. ,
Gorbounov, v., Ramsey,
"Microreactors: New Technology
Ramsey, J.M. , "Fully integrated
for Modern Chemistry" , Weinheim ,
glass microfluidic device for performing
Golbig Hessel
[42]Ehrfe W. ,
Ger.:Wiley (2000).
capilla electrophoresis
[43]Wiles , C. , Watts , P. , "Continuous
Lowe , H. , Richter, T. , "Characterization
and electrospray ionization mass
flow reactors, a tool for the modern
of mixing in micromixers by a test
spectrometry" , Ana l. Chem. , 80 ,
synthetic chemist" , Eu r. J. Org.
G. , Papautsky,
reaction: single mixing units and mixer
6881 ~6887 (2008).
Chem. , 10,
1., "Inertial microfluidics for
arrays" , Ind. Eng. Chem. Res. , 38 ,
continuous particle separation in
1075~1082
7, 256~263 (2007).
[2 Kuntaegowdanahalli S. Bhag
A.A.S. ,
Kum
spiral microchannels" , Lab Chip , 9,

2973~2980
(1999).
[32]Vankayala B.K. , Lob , P. , Hessel , V. ,

Menges , G. , Hoffman , C. Metzke ,
(2009).
Ko
1655~1671
(2008).
[37]Becker, H. , Grtner, C. , "Polymer based
[44]Sudarsan , A. P. , Ugaz , V. M. ,
microreactors" , Rev. Mo l. Biotechno l.,
"Fluid mixing in planar spiral
82, 89~99 (2001).
microchannels" , Lab Chip , 6,
[38]Becker, H. , Grtner , C. , "Polymer
74~82
(2006).
microfabrication methods for
[45]Zhang , X. , Haswell , S.J. , "Micro-
The Science of
up of process intensifying falling film
microfluidic analytical applications" ,
Fluidic and Lab-on-a-Chip
Miniaturization" , Boca Raton , CRC
microreactor to pilot production scale",
Electrophoresis , 21 ,
(2002).
Int. J. Chem. Reac t. Eng. , 5, A91 (2007).
icrofabrication:
[27]Whitesides , G.M. , "The origins and
D. , Krtschil , U. ,
high-e:fficiency
H.J. , "Scale-
[26]Madou , M.J. , "Fundamentals of
136
........ ...... ........ ......... ....
[33]Jain
Wu , C. , Atre , S. v., Jovanovic ,
the future of microfluidics" , Nature ,
Narayanan Kimura
442, 368~373 (2006).
v., Canfield , N. , Roy, S. , "Synthesis
Sprenkle,
226
12~26
(2000).
Technology" , Ernst Schering
[39]Geyer , K. , Seeberger , P.H. ,

"Optimization of glycosylation reactions
in a microreactor" , Helv. Chim.
90, 395~403 (2007).
20146
Ac
Foundation Symposium Proceedings,

3, 21~37 (2007).
[46]Schwalbe T. ,
Autz
Wille ,
G. , "Chemical synthesis in
137
...1
1..............
mode" , QSAR Comb. Sci. ,
[28]Nagaki , A. , Takabayashi , N. , Tomida, Y. ,
of nanoparticles in high temperature
[40]Yen , B.K. , Gnther A. , Thalmann ,
Yoshida , J. , "Selective monolithiation
ceramic microreactors: design ,
M. , Bawendi , M.G. , Jensen , K.F. ,
of dibromobiaryls using microflow
fabrication and testing" , In t. J. App l.
"A microfabricated segmented-flow
Ceram. Techno l., 6,41 0~419 (2009).
reactor for the synthesis of CdSe
[34]Knitter, R. , Li auw, M.A. , "Ceramic
quantum dots" , Presented at In t.
F. J. ,
microreactors for heterogeneously
Conf. Miniaturized Syst. Chem. Li fe
for multiphase mixing and reaction",
"Application ofmicroreactor technology
catalysed gas-phase reactions" , Lab
Sci. , 8 Malmo , Swed. (2004).
J. Microelectromech. Syst. , 11 ,
in process development" , Org. Process
Chip, 4 378~383 (2004).
709~ 717
Res. Dev. , 8, 455~460 (2004).
24742~757
[2 Losey
(2005).
M.W. , Jackman , R. J.,
Firebaugh , S.L. , Schmidt ,
systems" , Org. Lett. , 10 ,
M.A. , Jensen , K.F. , "Design and
(2008).
fabrication of microfluidic devices
(2002).
[2 Zhang
X.N. ,
3937~3940
Stefanick Villa
[41]Hessel , V. , Hardt , S. , Lwe ,
[35]Woolley A.T. , Mathies R.A. , "Ultra-
H. , "Chemical Micro Process
[2 Lbbecke S. , Ferstl , W. , Pani' c ,
[30] Li u S. F., Fukuyama , T. , Sato , M. , Ryu ,
high-speed DNA fragment separations
Engineering: Fundamen tals ,
S. , Turcke , T. , "Concepts for
1., "Continuous microflow synthesis
using microfabricated capillary array
Modelling and Reactions" ,
modularization and automation of
of butyl cinnamate by a Mizoroki-
electrophoresis chips", Proc. Natl. Acad.
Weinheim, Ger.: Wiley (2004).
microreaction technology" , Chem.
Heck reaction using a low-viscosity
Sci. USA, 91 , 11348~11352 (1 994).
Eng. Technol., 28 , 484~493 (2005).
ionic liquid as the recycling reaction
[24] Kra
J. G. , Sahoo, H.R. , Jensen , K. F.,
medium" , Org. Process Res. Dev. , 8 ,

(2004).
"Integrated continuous microfluidic
477~481
liquid-liquid extraction", Lab Chip,
[31]Ehrfeld , W. ,
[36]Mellors ,
R.
J.
Hessel Lwe
H. ,
Gorbounov, v., Ramsey,
Ramsey, J.M. , "Fully integrated
for Modern Chemistry" , Weinheim ,
glass microfluidic device for performing
Golbig Hessel
[42]Ehrfe W. ,
Ger.:Wiley (2000).
capilla electrophoresis
[43]Wiles , C. , Watts , P. , "Continuous
Lowe , H. , Richter, T. , "Characterization
and electrospray ionization mass
flow reactors, a tool for the modern
of mixing in micromixers by a test
spectrometry" , Ana l. Chem. , 80 ,
synthetic chemist" , Eu r. J. Org.
G. , Papautsky,
reaction: single mixing units and mixer
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Chem. , 10,
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arrays" , Ind. Eng. Chem. Res. , 38 ,
continuous particle separation in
1075~1082
7, 256~263 (2007).
[2 Kuntaegowdanahalli S. Bhag
A.A.S. ,
Kum
spiral microchannels" , Lab Chip , 9,

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(1999).
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Menges , G. , Hoffman , C. Metzke ,
(2009).
Ko
1655~1671
(2008).
[37]Becker, H. , Grtner, C. , "Polymer based
[44]Sudarsan , A. P. , Ugaz , V. M. ,
microreactors" , Rev. Mo l. Biotechno l.,
"Fluid mixing in planar spiral
82, 89~99 (2001).
microchannels" , Lab Chip , 6,
[38]Becker, H. , Grtner , C. , "Polymer
74~82
(2006).
microfabrication methods for
[45]Zhang , X. , Haswell , S.J. , "Micro-
The Science of
up of process intensifying falling film
microfluidic analytical applications" ,
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Miniaturization" , Boca Raton , CRC
microreactor to pilot production scale",
Electrophoresis , 21 ,
(2002).
Int. J. Chem. Reac t. Eng. , 5, A91 (2007).
icrofabrication:
[27]Whitesides , G.M. , "The origins and
D. , Krtschil , U. ,
high-e:fficiency
H.J. , "Scale-
[26]Madou , M.J. , "Fundamentals of
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[33]Jain
Wu , C. , Atre , S. v., Jovanovic ,
the future of microfluidics" , Nature ,
Narayanan Kimura
442, 368~373 (2006).
v., Canfield , N. , Roy, S. , "Synthesis
Sprenkle,
226
12~26
(2000).
Technology" , Ernst Schering
[39]Geyer , K. , Seeberger , P.H. ,

"Optimization of glycosylation reactions
in a microreactor" , Helv. Chim.
90, 395~403 (2007).
20146
Ac
Foundation Symposium Proceedings,

3, 21~37 (2007).
[46]Schwalbe T. ,
Autz
Wille ,
G. , "Chemical synthesis in
137
...1
1..........
........ ..... ..... ........ ......... ....
BP
microreactors" , Chimia , 56 , 636~646
(2002).
[47]Murphy , E. R. , Martinelli , J. R ,
L
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12
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with microreactors at elevated
| '< 1 ..
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| Automotive
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12
12
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12
for Modern Chemists" , Wiley-VCH
| ;t ~
26
(2000).
14
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12
| :1 1) _/ 3 /
24
| :1 7 7
12
Jensen , K. F., "Accelerating reactions
1734~1737
(2007).
[48]Wong-Hawkes , S. Y. F. , Matteo , J.
: (1)
: Project
Manager
API Process
17
18
Schering Foundation Symposium

Proceedings , 3 , 39~55 (2007).
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Number of samples
256
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256
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256
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256
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226
20146
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290
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20146
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20146
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l lIItI&l
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,.
.. ..~ 11m
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-,
lLtzfgF3fvpm_WJ 1-'-'.
" ..
18
19
PET/ITO FESEM
0.0015
WOC y ..u++-+u
u
g
e
PET/lTO/WOXCy FESEM
0.0005
1.
WOXC u+
y
u WO C
ITO
e- ....
nU nUnUnUn
U
ITO
u+
u+
u+
u+
u+
u+
.0.0005
e-
E-OO010
C
e-
.0.0015
.0.0020
ju++e'+WO u a
Anode(+)
.0.0025
.1.0
.0.5
0.0
0.5
20
Anode(+)
d Li ~atriX +d WS+d W6++d e -+d U +
1.0
bleaching
Potential (Volts)
150
WO.C"
21
u+
0.0010
EEE
u+
1'" ,'_' "'"....~" '!~ 1

11 - ."- |
_~J
u+
22
WOXC y
226
20146
WOXC y u+
151
FLVaLV
T ea men TB
-Hno
FUV
opbvd
-UH
ri
", VT ",
-u
H
E
-E
J"
. .
::. ...
2014 April ~
WO Cy'
[3]Shakin M. M. , "Reaction under plasma
conditions" , p.298. Wiley, New York ,
1971.
( 2.5V)
[4]Yasuda H. , Yasuda T. , "The competitive
WO CY
ablation and polymerization (CAP)
principle and the plasma sensitivity of
elements in plasma polymerization and
( 2.5V) 23
PET/ITO/WOJy 1.5cm y 1. 5cm
1. 5cm x 1. 5cm ~T(%) ,
PET/ITO/WO CY1. 5cm
[1]Langmuir , I., "The Interaction of
y 1. 5cm1. 5cm x 1.5cm
El ectron and Positive Ion Space
~T(%) 550nm
Charges in Cathode Sheaths" , Phys.
57+2(%)
Rev. , 33 , 954-989 (1929).
0.3cm'
[2]Be l1, A. , "The application of plasmas to
lcm
SiO Cy
chemical processing" , MIT Press, 1967.
eatment"
J. Polym. Sci. Part A: Polym
Chem. , 38 , 943-953 (1 999).

[5]Yasuda H. , "Plasma polymerization" ,
p. 180, Academic Press Inc. , Orlando ,
Florida, 1985.
[6]Merche D. , Vandencasteele N. , Renier
F., "Atmospheric plasmas for thin film
deposition: a critical review" , Thin Solid

Films 520, 3219-4236 (2012).
100
80
60
1.0
0.5
0.0
yaxis(cm) -0.5
-1.0
-1.5~1.5
23
WOXC yO.5cmS y O.5cm-1.5cmS
x S1.5cm550nm
LH(%)
152
226
20146
153
FLVaLV
T ea men TB
-Hno
FUV
opbvd
-UH
ri
", VT ",
-u
H
E
-E
J"
. .
::. ...
2014 April ~
WO Cy'
[3]Shakin M. M. , "Reaction under plasma
conditions" , p.298. Wiley, New York ,
1971.
( 2.5V)
[4]Yasuda H. , Yasuda T. , "The competitive
WO CY
ablation and polymerization (CAP)
principle and the plasma sensitivity of
elements in plasma polymerization and
( 2.5V) 23
PET/ITO/WOJy 1.5cm y 1. 5cm
1. 5cm x 1. 5cm ~T(%) ,
PET/ITO/WO CY1. 5cm
[1]Langmuir , I., "The Interaction of
y 1. 5cm1. 5cm x 1.5cm
El ectron and Positive Ion Space
~T(%) 550nm
Charges in Cathode Sheaths" , Phys.
57+2(%)
Rev. , 33 , 954-989 (1929).
0.3cm'
[2]Be l1, A. , "The application of plasmas to
lcm
SiO Cy
chemical processing" , MIT Press, 1967.
eatment"
J. Polym. Sci. Part A: Polym
Chem. , 38 , 943-953 (1 999).

[5]Yasuda H. , "Plasma polymerization" ,
p. 180, Academic Press Inc. , Orlando ,
Florida, 1985.
[6]Merche D. , Vandencasteele N. , Renier
F., "Atmospheric plasmas for thin film
deposition: a critical review" , Thin Solid

Films 520, 3219-4236 (2012).
100
80
60
1.0
0.5
0.0
yaxis(cm) -0.5
-1.0
-1.5~1.5
23
WOXC yO.5cmS y O.5cm-1.5cmS
x S1.5cm550nm
LH(%)
152
226
20146
153
2014
(:;:?|
!ffl .8U.
Bio-Medical Materials I |
molding) (Qualification)
2070
70%
5%
: (Process validation) (Injection
600
1%
2010 30
PET
10%
7.5%
cGMP FDA
pH
2~3
() (polyethyleneterephthalates PET)
226
20146
155
2014
(:;:?|
!ffl .8U.
Bio-Medical Materials I |
molding) (Qualification)
2070
70%
5%
: (Process validation) (Injection
600
1%
2010 30
PET
10%
7.5%
cGMP FDA
pH
2~3
() (polyethyleneterephthalates PET)
226
20146
155
2014
16| h
_6:El
Bio-Medical Materials i
Special Planning
1.
8 PET
_20 C
PET
...
(shot
rate , cm 3 /s) (3) (injection pressure,
kgf/cm 2 ) (4) (plastication
(1)
size, cm2/s) (2)(injection

rate , g/s) ,
()
156
226
20146
157
2014
16| h
_6:El
Special Planning
1.
8 PET
_20 C
PET
...
(shot
rate , cm 3 /s) (3) (injection pressure,
kgf/cm 2 ) (4) (plastication
(1)
size, cm2/s) (2)(injection

rate , g/s) ,
()
156
226
20146
157
tid
mw
4mE
16 | h
Bio-Medical Materials
Ei= .d .PH.S
4.10 2 .2. t
Ei (KW) ; d
(m) ; PH 114
3/4(MPa) ; S
...
(m) ; t S
: Gp( )
(sec)
lb/h;
g/
(1):
=K
O.7~O.8
PS
S : D :
(2):
PVC
(4):
= Sx
4
(cm 3 /s)
(:
2.
(cm 3 )
(s) ; (g/s)
(g) (s)
158
(3):
1O~30%
--
--
< 1 11
226
20146
tid
mw
4mE
16 | h
Ei= .d .PH.S
4.10 2 .2. t
Ei (KW) ; d
(m) ; PH 114
3/4(MPa) ; S
...
(m) ; t S
: Gp( )
(sec)
lb/h;
g/
(1):
=K
O.7~O.8
PS
S : D :
(2):
PVC
(4):
= Sx
4
(cm 3 /s)
(:
2.
(cm 3 )
(s) ; (g/s)
(g) (s)
158
(3):
1O~30%
--
--
< 1 11
226
20146
16 l h
3 4
[6]
(
)
()
161
160
226
20146
16 11
3
JJ
2046
()
2014
16| h
SR_ec Planning
-l
.-
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()
()
3.
input/output
+ A/D&D/A +
+ keyboard
'
'
PC
USB SAVE/
LOAD
(European
[1]
PLC
(Food
Administration , FDA)
'
(Minist ofhealth Labour, and Welfare ,
20%
MHLW)
162
226
20146
Medicines Agency,
EMA)
and Drug
163
2014
16| h
SR_ec Planning
-l
.-
.Ii_.
()
()
3.
input/output
+ A/D&D/A +
+ keyboard
'
'
PC
USB SAVE/
LOAD
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[1]
PLC
(Food
Administration , FDA)
'
(Minist ofhealth Labour, and Welfare ,
20%
MHLW)
162
226
20146
Medicines Agency,
EMA)
and Drug
163
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EA
mw
16| h
[2]
[4]
J [3]
(1)
(process design) (2)
(process qualification) (3)
(process
validation)
()
[2]
design)
()
(2)(process
qualification)
'
.)
164
(1)(process
226
20146
165
--
EA
mw
16| h
[2]
[4]
J [3]
(1)
(process design) (2)
(process qualification) (3)
(process
validation)
()
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design)
()
(2)(process
qualification)
'
.)
164
(1)(process
226
20146
165
2014
5! Pl8:lg
16| h
-l
(b. )
(3)(process
validation)
: (i)OQ
OQ
(c.
OQ
OQ (iii)OQ
: (i)IQ
PQ
(ii)IQ
3. (Performance
1.(Installation
Qualification '
:
:
(ii)OQ OQ
IQ)
Qualification '
PQ)
IQ
IQ (iii)IQ
OQ
OQ
2. (Operational
OQ)
1.
2.
Qualification '
A.
OQ
166
226
20146
167
2014
5! Pl8:lg
16| h
-l
(b. )
(3)(process
validation)
: (i)OQ
OQ
(c.
OQ
OQ (iii)OQ
: (i)IQ
PQ
(ii)IQ
3. (Performance
1.(Installation
Qualification '
:
:
(ii)OQ OQ
IQ)
Qualification '
PQ)
IQ
IQ (iii)IQ
OQ
OQ
2. (Operational
OQ)
1.
2.
Qualification '
A.
OQ
166
226
20146
167
2014
Special Planning
16 | h
-El
7. QA
IQ OQ PQ
OP /
IQ
IQ
(IQ)
'
1.
IQ/
(//)
3.
4.
5. :
IQ
IQ-A
380V
IQ-8
ON
IQ-C
IQ-O
6.
IQ-E
7. QA
IQ-F
PQ
IQ-G
270'C
1.
IQ-H
180'C-220'C
IQ
IQ-I
177'C-182'C ' PET0 . 05%
OQ
IQ-J
20'C
1.
IQ-K
(/)
2.
IQ-L
3.
IQ-M
2.
3. /
4 .
5 . :
6.
168
2.
4.
5. :
() :
6.
7. QA
226
20146
169
2014
Special Planning
16 | h
-El
7. QA
IQ OQ PQ
OP /
IQ
IQ
(IQ)
'
1.
IQ/
(//)
3.
4.
5. :
IQ
IQ-A
380V
IQ-8
ON
IQ-C
IQ-O
6.
IQ-E
7. QA
IQ-F
PQ
IQ-G
270'C
1.
IQ-H
180'C-220'C
IQ
IQ-I
177'C-182'C ' PET0 . 05%
OQ
IQ-J
20'C
1.
IQ-K
(/)
2.
IQ-L
3.
IQ-M
2.
3. /
4 .
5 . :
6.
168
2.
4.
5. :
() :
6.
7. QA
226
20146
169
2014
16| 1-
Specia:l Planning
-~l
PQ
PQ
OQ IQ
PQ
6 'IQ
(FDA cGMP) ,
~84%
75%~83%
74%
8 PQ
OQ-a
1400bar
OQ-b
300mm/s
150rpm
OQ-d
100bar
OQ-e
300T
270 C
OQ-9
180 C-220 C
OQ-h
17rC-182 C ' PET0.05%
OQ-i
20 C
_29 C_ -4 0 C
OQ
170
: 0.6mm
<0.6
0.6-0.8
<0.8
: 0.05mm'
0.05
0.05-1
0.3
>0.1
>0.35
:0.05mm
20146
10mm 0.3mm
226
OQ-f
.2mm
OQ-c
O Q
PQ
100%
:t 0.05
0.05- :t 0.1
>
:t 0.1
171
2014
16| 1-
Specia:l Planning
-~l
PQ
PQ
OQ IQ
PQ
6 'IQ
(FDA cGMP) ,
~84%
75%~83%
74%
8 PQ
OQ-a
1400bar
OQ-b
300mm/s
150rpm
OQ-d
100bar
OQ-e
300T
270 C
OQ-9
180 C-220 C
OQ-h
17rC-182 C ' PET0.05%
OQ-i
20 C
_29 C_ -4 0 C
OQ
170
: 0.6mm
<0.6
0.6-0.8
<0.8
: 0.05mm'
0.05
0.05-1
0.3
>0.1
>0.35
:0.05mm
20146
10mm 0.3mm
226
OQ-f
.2mm
OQ-c
O Q
PQ
100%
:t 0.05
0.05- :t 0.1
>
:t 0.1
171
2014
16| h
Special Pllning
-I~J
PQ
Series Motion Controller Utilized in
Full Electric Plastic Injection Molding
Machine" , Springer-Verlag (2011).
0.1mm
[8]Catherine A. Petretich, "Development of
0.1
0.1-0.2
>0.2
: 2mm'
a validation method for thermoplastic
injection molding processes for the
[1]
'
contract medical device manufacturer" ,

Master of industrial technology (2005).
(2005)
1mm
100%
[2]
- cGMP
' 19 6
(2011)
' 19 6
[4]
5'
' Vo l.
No.
[5]
r .
[6]Ming-Shyan Huang , Tsung- Yen
Lin , Rong-Fong Fung , "Key design
22 6
:
:
(2008)
(2011)
172
[3]
' 21 (2003)
parameters and optimal design of a
:
:
:-
:
:
five-point double-toggle c1 amping
mechanism" , Elsevier Inc 35 , 4304
4320 (2011).
[7]Hang-wei Zhang, Chan-juan Chen, and
Ji-xian Dong "Development of GE
20146
:
:
173
2014
16| h
Special Pllning
-I~J
PQ
Series Motion Controller Utilized in
Full Electric Plastic Injection Molding
Machine" , Springer-Verlag (2011).
0.1mm
[8]Catherine A. Petretich, "Development of
0.1
0.1-0.2
>0.2
: 2mm'
a validation method for thermoplastic
injection molding processes for the
[1]
'
contract medical device manufacturer" ,

Master of industrial technology (2005).
(2005)
1mm
100%
[2]
- cGMP
' 19 6
(2011)
' 19 6
[4]
5'
' Vo l.
No.
[5]
r .
[6]Ming-Shyan Huang , Tsung- Yen
Lin , Rong-Fong Fung , "Key design
22 6
:
:
(2008)
(2011)
172
[3]
' 21 (2003)
parameters and optimal design of a
:
:
:-
:
:
five-point double-toggle c1 amping
mechanism" , Elsevier Inc 35 , 4304
4320 (2011).
[7]Hang-wei Zhang, Chan-juan Chen, and
Ji-xian Dong "Development of GE
20146
:
:
173
;?
GDP
174
226
20146
(
)
175
;?
GDP
174
226
20146
(
)
175
T~L : 02-87125539686 688
( 3)
(A Real-Time Approach to Process Control , 3
Ed.)
(Science and Technology of Crystal Growth)
: William Y. Svrc Donald P. Mahoney Brent R. Young
: J.P. van der EerdenO.S. L. Bruinsma
(ISBN) :
(ISBN)
978-1119993872
: 978-9401040624
: Wiley
: 20142 10
: 2013 12 31
: 360
391
Springer
(Copper-Catalyzed Asymmetric Synthesis)
(Environmental Risk Assessment)
: Alexandre Alexakis , Norbert KrauseSimon Woodward
(ISBN) :
(ISBN)
978-3527332045
Ted Simon
: 978-1466598294
: Wiley-VCH
: 20142 10
: 20142 18
: 472
: 406
CRC Press
(Multisensor Systems for Chemical Analysis)
<<~......~ 117__
(Electromembrane Desalination Processes for Production of Low Conductivity Water)
: Larisa Lvova , Dmitry Kirsanov, Corrado Di NataleAudrey Legin
(ISBN) :
(ISBN) :
978-9814411158
Andrej Grabowski
978-3832527143
: Pan Stanford Publishing
: 20142 15
: 20142 19
: 408
: 237
(Fourier Transform Rheology on Dispersions Based on Newtonian Fluids)
(Polymer Processing , 2 nd Ed.)

: Donald G. Baird Dimitris
(ISBN) :
Logos Berlin
(2)
1. Collias
Kathrin Reinheimer
(ISBN) :
978-0470930588
978-3832531386
: Wiley
: Logos Berlin
: 20142 17
: 20142 19
: 408
: 179
IntrodllctioD lo
Chernical
EngineeFing
Kinetics&
Reactor Design
(Nanotechnology in Electrocatalysis for Energy)

: Alessandro Lavacchi , Hamish Miller Francesco Vizza
(ISBN) :
176
978-1489980588
.\~t.""
(2)
(Introduction to Chemical Engineering Kinetics and Reactor Design , 2
(ISBN)
: 978-1118368251
2013 12 31
: 20142 24
: 430
: 560
20146
Ed.)
: Charles G. HillThatcher W. Root
: Springer
226
nd
Wiley
177
T~L : 02-87125539686 688
( 3)
(A Real-Time Approach to Process Control , 3
Ed.)
(Science and Technology of Crystal Growth)
: William Y. Svrc Donald P. Mahoney Brent R. Young
: J.P. van der EerdenO.S. L. Bruinsma
(ISBN) :
(ISBN)
978-1119993872
: 978-9401040624
: Wiley
: 20142 10
: 2013 12 31
: 360
391
Springer
(Copper-Catalyzed Asymmetric Synthesis)
(Environmental Risk Assessment)
: Alexandre Alexakis , Norbert KrauseSimon Woodward
(ISBN) :
(ISBN)
978-3527332045
Ted Simon
: 978-1466598294
: Wiley-VCH
: 20142 10
: 20142 18
: 472
: 406
CRC Press
(Multisensor Systems for Chemical Analysis)
<<~......~ 117__
(Electromembrane Desalination Processes for Production of Low Conductivity Water)
: Larisa Lvova , Dmitry Kirsanov, Corrado Di NataleAudrey Legin
(ISBN) :
(ISBN) :
978-9814411158
Andrej Grabowski
978-3832527143
: Pan Stanford Publishing
: 20142 15
: 20142 19
: 408
: 237
(Fourier Transform Rheology on Dispersions Based on Newtonian Fluids)
(Polymer Processing , 2 nd Ed.)

: Donald G. Baird Dimitris
(ISBN) :
Logos Berlin
(2)
1. Collias
Kathrin Reinheimer
(ISBN) :
978-0470930588
978-3832531386
: Wiley
: Logos Berlin
: 20142 17
: 20142 19
: 408
: 179
IntrodllctioD lo
Chernical
EngineeFing
Kinetics&
Reactor Design
(Nanotechnology in Electrocatalysis for Energy)

: Alessandro Lavacchi , Hamish Miller Francesco Vizza
(ISBN) :
176
978-1489980588
.\~t.""
(2)
(Introduction to Chemical Engineering Kinetics and Reactor Design , 2
(ISBN)
: 978-1118368251
2013 12 31
: 20142 24
: 430
: 560
20146
Ed.)
: Charles G. HillThatcher W. Root
: Springer
226
nd
Wiley
177
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SOFC
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10
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SOFC
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SOFC
SOFC'
SOFC
(NEDO) SOFC rSOFC
rSOFC J
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178
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L(P)D
(Li nezolid)
86
LWL/
...
(PAT)
24
Tel:+886.7.6295086 F
15
No.8 , Ln. 15 , Gangrong Rd. Gangsh a; O ist.

Ka e hsiung 6 it y- 820 , Taiwan
Cell: -:!:, 886-.Ji) 39-73 7 926_ E-mail: fung.hong@msa.hi 4 .p el
3

CONENs
2014 6 255
139
37
138 BP
181
Pin MiII
Turbo MiII
Rotary Cone Mixer
Ribbon Mixer
.......
...
....
..
..
..
154
174 ?
38
63
2014 7-8
20149-10
107
123
2014 11-12
180
"
78
Foodstuff,Milk Powder,Spices ,Seasoning ,

Mixing , Conveying & Packing System
176
....
Agar,Soybean,Oat,Buckwheat,Grains ,Beans ,
Spices & Healthy Food Turbo Grinding System
@mill~~
E A"ilE
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POWDER CH
aadhm - Tel: 6-6-2545566
~ |
L r 11 ~ 1 .| h
Fax: +886-6-2538697
Mill Powder Tech Solutions
E-mail: mill@mill.com.tw
2014
ISO/IEC 17025:2005
6 255
ISO/IEC 17025:2005 (AMC Analysis)
~.11m
/
/
cGMP CIP SIP
ASME - BPE - PIC I S iti

;J!
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"
(Head Space)
lon Science
/-
100
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IJ:
- PhotoCheck ppbVOC (PID)

PhoCheck &Tiger Series
-TVOC PID Analyzer
(Zirconia
0.01
EBl
: Br CI' CIO
F 0 NH CO H 0
COCI HCI HCN HF NO
flt;
:( 533)
(Fuel
ATI
Oxide)
.:(Paramagnetic)
Cell)
ppm - 100 %
MesaLa bs
HS NO SO AsH PH
BH HSe HO 1 ETO
HCOH ...
TVA-1000
FID VOCf!
. NDIR , TCD , EC
: E
:( 855)
Denuder
( 821)
A A A

A
CIP/SIP/ASME
- BPE-PIC/S IQ OQ
&
(WFI SYSTEM)
A
(PFW SYSTEM)
SHANG YUH MACHINE CO.. L TO.

: 389 46
/105 51 3 ()
TE L!(02)871 25539()
FAX!(02)87126567
http://www.mmmpc.com.tw
E-mail: mmmpc11@mmmpc.com.tw()
Extrel
AMC
TGA + MS.
(PM2.5
::: Environics
I PM10)
@CU'rAn
:
-/
PIC L\ RRO
/~I!42569
TE(04)22511670
ReU byOn
FAX!(04)22521315
: 50261920
1385
/
Head Office : 3F. , No.51 , Sec. 4, Nanjing E. Rd. , Songshan Dist.,

Taipei City 105, Taiwan
Welcome to contact with us by the above address.
/()
1st etect
10Hzm
.GPS
3D
lonTrap it
CH"CO"NO
: 14
MS/MS
TEL:(886-2)8601-4966 (REP)
ppb
FAX:(886-2)8601-2866
250 5
TEL:
CO H S C H 13C 15N
G81 OX0003
(010)68433147
: 108-4 9
:(02)
2219-5511
:www.jusun.com.tw
:0800-000501
7
Clean Utilities
made simple.
Brkert - ELEMENT
ELEMENT diaphragm valves:
We make ideas flow.

www.burkert.com
API 610 ,API 671
d:J, I ~
JJJ I~psl I ~OKrA I
?@
8
ct)
r
Burkert Contromatic Taiwan Lt d.

115 32 9
38 17 1
JJI gS.o~1
Saudi Aromcl
http://www.ktrtaiwan.com.tw/
http://www.ktr.com
9F , No. 32 , Chenggong Rd. , Sec. 1, Nangang District ,

Taipei 115 ,Taiwan
TEL:(02)2653-7868
FAX: (02)2653-7968
E-mai: info.rc@burkert.com
http://www.burkert.com
9
Clean Utilities
made simple.
Brkert - ELEMENT
ELEMENT diaphragm valves:
We make ideas flow.

www.burkert.com
API 610 ,API 671
d:J, I ~
JJJ I~psl I ~OKrA I
?@
8
ct)
r
Burkert Contromatic Taiwan Lt d.

115 32 9
38 17 1
JJI gS.o~1
Saudi Aromcl
http://www.ktrtaiwan.com.tw/
http://www.ktr.com
9F , No. 32 , Chenggong Rd. , Sec. 1, Nangang District ,

Taipei 115 ,Taiwan
TEL:(02)2653-7868
FAX: (02)2653-7968
E-mai: info.rc@burkert.com
http://www.burkert.com
9

KNF
114 6 123 249 2
TEL: (02) 2794-1011

FAX: (02) 8792-1648
Email: info@knftwn.com.tw

KNF
114 6 123 249 2
TEL: (02) 2794-1011

FAX: (02) 8792-1648
Email: info@knftwn.com.tw
llh
SAINT..GOBAIN
P&T1
13MMXO.1MMX15M
10 l;
100 l
P&T8
13MMXO.1MMX15M
10 I#.
100 l
P&T6
13MMXO.1MMX15M
10 /
100 l
P&T 4-1
12MMXO.076MMX10M
12 l:
100:/
P&T4 -2
12MMXO.076MMX6M
12 /;
100 l
P&T3
12MMXO.076MMX10M
200 l
6 l
P&T11
1OMMXO.1 MMX30M
10 l
50 l
P&T12
20MMXO.15MMX10M
5 l:
100 l
P&T18
25MMXO.2MMX10M
10 /;
50 /
m'n'iiSeal@
Spring-Energized SeaLs
::
j/:
600
UNASCO
UNASCO
:
1 ...

2 ' 3000Psi
(260'C +260'C)
3 () () UL
()
4.
LEAK-SEE~ and LEAK-DETEX

(r T
;)
) 0 LEAK-SEEK@ ( ethylene glycol )

2005 n Ii
;:
;
:
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3. (-23'C~930C )
I Omni Seal@
4. :Ij
5. :
6. ( Z )
(ASTM) D-1693
7.
8. "
405 4
: (02)2752-0355
: (02)2721-9662
E-mail: topprim e@seed.net.tw
llh
SAINT..GOBAIN
P&T1
13MMXO.1MMX15M
10 l;
100 l
P&T8
13MMXO.1MMX15M
10 I#.
100 l
P&T6
13MMXO.1MMX15M
10 /
100 l
P&T 4-1
12MMXO.076MMX10M
12 l:
100:/
P&T4 -2
12MMXO.076MMX6M
12 /;
100 l
P&T3
12MMXO.076MMX10M
200 l
6 l
P&T11
1OMMXO.1 MMX30M
10 l
50 l
P&T12
20MMXO.15MMX10M
5 l:
100 l
P&T18
25MMXO.2MMX10M
10 /;
50 /
m'n'iiSeal@
Spring-Energized SeaLs
::
j/:
600
UNASCO
UNASCO
:
1 ...

2 ' 3000Psi
(260'C +260'C)
3 () () UL
()
4.
LEAK-SEE~ and LEAK-DETEX

(r T
;)
) 0 LEAK-SEEK@ ( ethylene glycol )

2005 n Ii
;:
;
:
1. '5
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3. (-23'C~930C )
I Omni Seal@
4. :Ij
5. :
6. ( Z )
(ASTM) D-1693
7.
8. "
405 4
: (02)2752-0355
: (02)2721-9662
E-mail: topprim e@seed.net.tw
..x .
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HEPA ( 50 "C)

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..

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COOLER 8EL T CONVEYING FLAKES
13500 Li ter
13500Liter PLOUGHSHARE MIXER
ATOMIZER PULVERIZER
TUV
AIR CLASSIFY PULVERIZER
HORIBA PRECISA;~~
powder handling
hEMqp
established in 1982

: 37 11 14
http:// www.rnill-rnachine.com.tw
:7
14
http:// www.rnill-rnachine.net.cn
* Preci
SHE HUI MACHINERY CO. , LTD.

SHENZHEN XIEHONG MACHINE CO. , LTD.
TEL:+886.2.2988.2475
FAX:+886.2.2984'5891
E-mail:shehui99@ms32.hine t. net
TEL:+86.755.28073275-6
FAX:+86'755.28073277
E-mail: xiehongzh@mill-machine.net.cn
powder handling
@FEHJ!!~
established in 1982
: 37 11 14
:7
* tlb

TEL:+886.2.2988.2475
FAX:+886.2.2984.5891
E-mail: shehui99@ms32.hine t. net
TEL:+86.755.28073275-6
FAX:+86.755.28073277
15
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~B;t
.. H

..

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HEPA ( 50 "C)

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..

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9
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11'.'
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. .11

HEPA( 500 "C)
COOLER 8EL T CONVEYING FLAKES
13500 Li ter
13500Liter PLOUGHSHARE MIXER
ATOMIZER PULVERIZER
TUV
AIR CLASSIFY PULVERIZER
HORIBA PRECISA;~~
powder handling
hEMqp
established in 1982

: 37 11 14
:7
14
* Preci

TEL:+886.2.2988.2475
FAX:+886.2.2984'5891
E-mail:shehui99@ms32.hine t. net
TEL:+86.755.28073275-6
FAX:+86'755.28073277
powder handling
@FEHJ!!~
established in 1982
: 37 11 14
:7
* tlb

TEL:+886.2.2988.2475
FAX:+886.2.2984.5891
E-mail: shehui99@ms32.hine t. net
TEL:+86.755.28073275-6
FAX:+86.755.28073277
15
' :
RC--
RC-44
:G)
@@
@@
: ABS
PVC ()
PET ...
C02
()
1861
TE L: 05-3421 [(j)'&~;.3421 057
http://www.renchen.com.tw
16
FAX; 05-34211:e;~~
E-mail: renchen.a1122@msa.hine t. net
@)..~ ~
FC
TEL:02-2932-7828
94 2
FAX:02-2935-2180
http://www.pneumtech.com.tw/
22862115
17
' :
RC--
RC-44
:G)
@@
@@
: ABS
PVC ()
PET ...
C02
()
1861
TE L: 05-3421 [(j)'&~;.3421 057
http://www.renchen.com.tw
16
FAX; 05-34211:e;~~
E-mail: renchen.a1122@msa.hine t. net
@)..~ ~
FC
TEL:02-2932-7828
94 2
FAX:02-2935-2180
http://www.pneumtech.com.tw/
22862115
17
Rt
__
~_
FILAD
434~ < mfli 3= 15
TEL:'4~2636161 FX: 4-2636i163
B~TK@
Si 985
AFV
.
.
BV
PLC
SPS
CjS
FAB
HEF
i j
.80 l-l m
./
BTE
-
.
BSF

i j
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The Be~t FIL1'1lA fI ON SOLUTIONS
BLO TEK ELECTRIC MACHINERY CO. , LTD
BPA
111 53 8 49 1
49, LANE 8, TIEN-MOU E. R TAIPEI , TAIWAN, 11153

TEL:(02)2873-4729 Rep.
FAX:(02)2875-1068
19
Rt
__
~_
FILAD
434~ < mfli 3= 15
TEL:'4~2636161 FX: 4-2636i163
B~TK@
Si 985
AFV
.
.
BV
PLC
SPS
CjS
FAB
HEF
i j
.80 l-l m
./
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-
.
BSF

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The Be~t FIL1'1lA fI ON SOLUTIONS
BLO TEK ELECTRIC MACHINERY CO. , LTD
BPA
111 53 8 49 1
49, LANE 8, TIEN-MOU E. R TAIPEI , TAIWAN, 11153

TEL:(02)2873-4729 Rep.
FAX:(02)2875-1068
19
EYElA
FD-1000.FDU-1200.2200
100 CGMP( ) CIP SIP
; (OQ) (IQ) (OQ) ASME-BPE PIC/S

GMP
FDU-2200
FDU-1200
FD 1000
FDU-1110 10
...
SY-PM
HIGH SPEED POWDER MIXER
...
S~y/-~ RM
S~-RBT
S R~~
ROCKING MIXER
TRIPLICITY CONE MIXER
.V.TYPE MIXER
.
.
FDU-2110
FDU-111 0
__0#1'"
MB1Mi
DRC-1000.1100 (RE C)
...
SY-HME
SY-SS
SY-KMV
MULTIBLEND iMACHINE
VACUUM EMULSIFY MIXER
MAGNETIC MIXING TANK
VACUUM KNEADING MACHINE
24
cm x 24 cm
10mL
270
DRC-ll00 DRC-ll00REC
DRC-REC
SHANG YUH MACHINE CO. , LTD.
: 242 389 46
:244 14
(886-2)8601-4966
(886-2)8601-2866
()
COMPANY:N0 .46 , LN.389 , HUACHENG RD. , XINZHUANG DIST. ,

NEW TAIPEI CITY 242 , TAIWAN
FACTORY: NO.14 , GONG 8th RD. , GONG 2 INDUSTRIAL DIST. ,
L1 NKOU DIST, NEW TAIPEI CITY 244 , TAIWAN.
TEL: (886-2)8601-4966 (REP.) FAX: (886-2)8601-2866
E-mail: shang-yuh@shang-yuh.com
DRC-ll00( )
Q !531
FDU-21l 0( )
: 02-27718337
: 03-5525300
: 04-2206 13
: 07 -5552355
EYElA
FD-1000.FDU-1200.2200
100 CGMP( ) CIP SIP
; (OQ) (IQ) (OQ) ASME-BPE PIC/S

GMP
FDU-2200
FDU-1200
FD 1000
FDU-1110 10
...
SY-PM
HIGH SPEED POWDER MIXER
...
S~y/-~ RM
S~-RBT
S R~~
ROCKING MIXER
TRIPLICITY CONE MIXER
.V.TYPE MIXER
.
.
FDU-2110
FDU-111 0
__0#1'"
MB1Mi
DRC-1000.1100 (RE C)
...
SY-HME
SY-SS
SY-KMV
MULTIBLEND iMACHINE
VACUUM EMULSIFY MIXER
MAGNETIC MIXING TANK
VACUUM KNEADING MACHINE
24
cm x 24 cm
10mL
270
DRC-ll00 DRC-ll00REC
DRC-REC
SHANG YUH MACHINE CO. , LTD.
: 242 389 46
:244 14
(886-2)8601-4966
(886-2)8601-2866
()
COMPANY:N0 .46 , LN.389 , HUACHENG RD. , XINZHUANG DIST. ,

NEW TAIPEI CITY 242 , TAIWAN
FACTORY: NO.14 , GONG 8th RD. , GONG 2 INDUSTRIAL DIST. ,
L1 NKOU DIST, NEW TAIPEI CITY 244 , TAIWAN.
TEL: (886-2)8601-4966 (REP.) FAX: (886-2)8601-2866
E-mail: shang-yuh@shang-yuh.com
DRC-ll00( )
Q !531
FDU-21l 0( )
: 02-27718337
: 03-5525300
: 04-2206 13
: 07 -5552355
VAISALA
~~
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HM40
-10 60 o ( (::t 0.2 o (l
0-100% RH (::t 1.5% RHl
NtA "
HMM100/ HMPll0
0-100% RH
-40--20 0 ( / +40 +180 0 (
HMD
HMW
82/83
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0 100%
0-100%RH
RH
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0 360
0 60m/s
--
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0-100%
HM T3 60
h-
GMW90
MM T3 308
RH
0 200mm/h
600-1100hpa
Jet A 1
BA(net / Modbus
LR
DICK
OPUS20
0
1TO
ZMHAM
EJ
cJnu
'
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PSI , 0 - 1000 PSI
dzyd
0 200
DM T1 43
SF6
(02
3 200 000
nuo rL
USB
1030-2
Pt100
-200 400
0.001
1036-2
E sensor
'~i ~
ALMEMO MA710
5.7
10 8
700 1100mbar
90
o(
!I
::t <1% RH
SEKONIC
PH
8MB 150
I
THERMAX
: 700 1100bar
TC5
~tp:// www.airpower.com.tw o/\
2tgv
407 39 1
TEL:03-4340-836
TEL:04-2359-7300
FAX:04-2359-7305 TEL:06-2719-900
http://www.airpower.com.tw
E-mail :email@airpower.com.tw
1 OL / 8L
j
ST-50A
-20 - +80 0 (
0 100% RH
ST-50M
S xi8mm
(1 Ql.
mml
( 1 : F )
(o(l
lf
39x 1I
( 1 !J 1 l )
5L
cf3\
77
99J '110! 110
D 1 121 127 1132 138
l' }
1 1 5
il n t 0 P . ei O m
TEL: (02)2598-1199
www x
FAX: (02)2596-2331
E-mail: info@xintop.com
-231
VAISALA
~~
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HM40
-10 60 o ( (::t 0.2 o (l
0-100% RH (::t 1.5% RHl
NtA "
HMM100/ HMPll0
0-100% RH
-40--20 0 ( / +40 +180 0 (
HMD
HMW
82/83
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RH
0 200mm/h
600-1100hpa
Jet A 1
BA(net / Modbus
LR
DICK
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0
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3 200 000
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USB
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-200 400
0.001
1036-2
E sensor
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ALMEMO MA710
5.7
10 8
700 1100mbar
90
o(
!I
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SEKONIC
PH
8MB 150
I
THERMAX
: 700 1100bar
TC5
~tp:// www.airpower.com.tw o/\
2tgv
407 39 1
TEL:03-4340-836
TEL:04-2359-7300
FAX:04-2359-7305 TEL:06-2719-900
http://www.airpower.com.tw
E-mail :email@airpower.com.tw
1 OL / 8L
j
ST-50A
-20 - +80 0 (
0 100% RH
ST-50M
S xi8mm
(1 Ql.
mml
( 1 : F )
(o(l
lf
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77
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D 1 121 127 1132 138
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TEL: (02)2598-1199
www x
FAX: (02)2596-2331
E-mail: info@xintop.com
-231
?JRRKAL
--
10microns()
2microns (PE)
:
ABF Filter
:8" -14"
: a~.1 ~ ooOm3/hr
EBS ~ Fllter
:"
-14"
2.
3.
..
Prodynamic K-Mate Corp.
806 296 29
TEL:(07)821-7128 http://www.kmate.com.tw
FAX:(07)821-4659 E-mail:kmate@ms31.hine t. net
-4
8.
hr
TOC
7. '1
TA --
6 .
5.
7.
-
=
-
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4.
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d.-4.E FEz -- =
= R
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:
.3
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:max. 400m3/hr
qJV
oseBPZUH
41
=
=
=
SAF Filter
: 2" -10"
LONGTECH MACHINERY INDUSTRY CO. , LTD.
=-
--
:max. 4000m3/hr
?JRRKAL
--
10microns()
2microns (PE)
:
ABF Filter
:8" -14"
: a~.1 ~ ooOm3/hr
EBS ~ Fllter
:"
-14"
2.
3.
..
Prodynamic K-Mate Corp.
806 296 29
TEL:(07)821-7128 http://www.kmate.com.tw
FAX:(07)821-4659 E-mail:kmate@ms31.hine t. net
-4
8.
hr
TOC
7. '1
TA --
6 .
5.
7.
-
=
-
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M
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...-....1
:
.3
A = kd=
:max. 400m3/hr
qJV
oseBPZUH
41
=
=
=
SAF Filter
: 2" -10"
LONGTECH MACHINERY INDUSTRY CO. , LTD.
=-
--
:max. 4000m3/hr
ARI
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11
IKEUCHI TAIWAN CO. , LTD.
J
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Tempe controller tho
H.IKEUCHI&CO. LTD. 1954
auxiliary power TEMPTRO L.:.
Bellows valve
FABA.-Plus , FABA.-Sup I/C
Stop valves with gland seal

STOBU
{}
Safety valves (DIN)

SAFE
Safety valves (DIN)

SAFE P
Safety.valves: (API 526)

SAFE FN (Full nozzle)
Safety valves
SAFE TCP
1-7.1<
AlI-in-One"
Manifolds
COD I"
Steam ap
Steam aps (mechani1
ballfloatl
thermostatic 1 bimetallic and
membrane 1 thermodynamic)
CONA'
FAX (04)2350122
FAX: ~)270.2797
(1.)270.2798
TEL:
m-w
TEL:()2350.88
TEL: (02)2511.6289
FAX: (02)2541.6392
58
23 5
rEpe
....
-'
27 11.1
26
Steam apwith
monltoring system
CONA.-Con01
with multi-valving
technology(incl. stop valve ,
strainer, check valve, drain valve)
CONAO Al I.in.One"
286-9 4F-1
TEL:(07)822-2918( )
FAX:(07)812-3938
E-mail:fengguh@ms8.hine t. net
www.ari-armaturen.com
27
ARI
L tt .;
11
IKEUCHI TAIWAN CO. , LTD.
J
il:i
Tempe controller tho
H.IKEUCHI&CO. LTD. 1954
auxiliary power TEMPTRO L.:.
Bellows valve
FABA.-Plus , FABA.-Sup I/C
Stop valves with gland seal

STOBU
{}
Safety valves (DIN)

SAFE
Safety valves (DIN)

SAFE P
Safety.valves: (API 526)

SAFE FN (Full nozzle)
Safety valves
SAFE TCP
1-7.1<
AlI-in-One"
Manifolds
COD I"
Steam ap
Steam aps (mechani1
ballfloatl
thermostatic 1 bimetallic and
membrane 1 thermodynamic)
CONA'
FAX (04)2350122
FAX: ~)270.2797
(1.)270.2798
TEL:
m-w
TEL:()2350.88
TEL: (02)2511.6289
FAX: (02)2541.6392
58
23 5
rEpe
....
-'
27 11.1
26
Steam apwith
monltoring system
CONA.-Con01
with multi-valving
technology(incl. stop valve ,
strainer, check valve, drain valve)
CONAO Al I.in.One"
286-9 4F-1
TEL:(07)822-2918( )
FAX:(07)812-3938
E-mail:fengguh@ms8.hine t. net
www.ari-armaturen.com
27
* ***
:
1.
2.
3.
4.
5. SCS14
6.
7.
8.
Ipme
CERTIFICATE OF
AUTHORIZATION
.. .....
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126 6
CHIEN MACHINERY CO. , LTD.
: (02) 09-1100
E-mail:magic.pum p@msa.hinet.net
http://www.magicpump.com.tw
NO.6. Ln. 126. Dtong Rd.. Donshui Dist.. New Tipei City 25 l.Toiwn
: (02) 09-1005
29
* ***
:
1.
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4.
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126 6
CHIEN MACHINERY CO. , LTD.
: (02) 09-1100
E-mail:magic.pum p@msa.hinet.net
http://www.magicpump.com.tw
NO.6. Ln. 126. Dtong Rd.. Donshui Dist.. New Tipei City 25 l.Toiwn
: (02) 09-1005
29
E
BB
Globe Valves
FABA . I
FABA90
A R MATUREN
Control valves
Supra I <lI
STEVI
STEVI
s'
4
-MIm
i--t1
u-X
E-H
m-o
Safety valves
SAFE
SAFE
Pressure reduclng
valves
Steamtraps
PREDU
CONA<lI B
.
.6
.100L
Control valves
RANGER QCT
S'
Model 520/521
. TFE
I ive-Ioaded"
304SST
. cv 710
S'
' 1440psig
-198'C 400'C
bellow
))ft
: . /
: y j
)
.m
Croesus
lndustrial Corporation
: 144 5 5 9 3
: 256 9
TEL:(02)2557-9955
TEL:(07)312-1609 FAX:(07)312-1664
E-mail:croesus.ka@msa.hine t. net
FAX:(02)2557-9959 , 2557-9653
mail:croesus9@ms35.hine t. net
E-mail:croesus_tpe@yahoo.com.tw
30
: 18-23
:(02) 2908-6129
:(02) 2904-2474
http://ton-long_com/0229086129.com.tw
about-us.html
E-mail: n008009492@so-net. ne t. tw
31
E
BB
Globe Valves
FABA . I
FABA90
A R MATUREN
Control valves
Supra I <lI
STEVI
STEVI
s'
4
-MIm
i--t1
u-X
E-H
m-o
Safety valves
SAFE
SAFE
Pressure reduclng
valves
Steamtraps
PREDU
CONA<lI B
.
.6
.100L
Control valves
RANGER QCT
S'
Model 520/521
. TFE
I ive-Ioaded"
304SST
. cv 710
S'
' 1440psig
-198'C 400'C
bellow
))ft
: . /
: y j
)
.m
Croesus
lndustrial Corporation
: 144 5 5 9 3
: 256 9
TEL:(02)2557-9955
TEL:(07)312-1609 FAX:(07)312-1664
E-mail:croesus.ka@msa.hine t. net
FAX:(02)2557-9959 , 2557-9653
mail:croesus9@ms35.hine t. net
E-mail:croesus_tpe@yahoo.com.tw
30
: 18-23
:(02) 2908-6129
:(02) 2904-2474
http://ton-long_com/0229086129.com.tw
about-us.html
E-mail: n008009492@so-net. ne t. tw
31
TAlBONG
rJ2014 2014/7/24 -7/27
4 SHUN-YI MACHINERY
TX
: SUS304 , SUS316 , SUS316L , SUS904 , SUS904L , SM0254 , Titanium ,
Titanium-Paladium , Nickel , Nickel alloy, Hastelloy-C , Hastelloy-B

: NBR , EPDM , CR , Butyl , Vito Teflon , Silicon , Reflon l!il
MODEL:TX-1-3
110
: 43-1080m l./min
SPIRAL
PLASTIC
PLAIN PLATE
Max .45kg/cm
450.C
: PVDF PP PE
: -30 .C~+ 140.C
: Max.1000mmaq
: 900.C
GAB Neumann GmbH

Graphite Annular-groove
Silicon Carbide SiC
TANTALUM HEAT EXCHANGER
227
. 231 . 233
TEL:
(07)226-9896
32
TEL: 592-710-9991 3
FAX: 592-710-9996
http://www.shun-yi.com.cn
E-mail: shun-yj@shun-yi.com.cn
TEL: 86-512-6257-0717
FAX: (02)2995-7458
E-mail: shunyimc@ms15.hinet. net
ALL WELDED WIDE GAP

:
13917176462
TEL: 20-8551 -2161
FAX: 20-8758-3416
: 3mm-30mm
: 700 0 C
E BI
SERU INTERNATIONAL CO. ,LTD.
(Ta)
201 6
(02)2702-0199
E-mail:seru@ms37.hine t. net
: (02)2708-7272
http://www.seru.com.tw
33
TAlBONG
rJ2014 2014/7/24 -7/27
4 SHUN-YI MACHINERY
TX
: SUS304 , SUS316 , SUS316L , SUS904 , SUS904L , SM0254 , Titanium ,
Titanium-Paladium , Nickel , Nickel alloy, Hastelloy-C , Hastelloy-B

: NBR , EPDM , CR , Butyl , Vito Teflon , Silicon , Reflon l!il
MODEL:TX-1-3
110
: 43-1080m l./min
SPIRAL
PLASTIC
PLAIN PLATE
Max .45kg/cm
450.C
: PVDF PP PE
: -30 .C~+ 140.C
: Max.1000mmaq
: 900.C
GAB Neumann GmbH

Graphite Annular-groove
Silicon Carbide SiC
TANTALUM HEAT EXCHANGER
227
. 231 . 233
TEL:
(07)226-9896
32
TEL: 592-710-9991 3
FAX: 592-710-9996
http://www.shun-yi.com.cn
E-mail: shun-yj@shun-yi.com.cn
TEL: 86-512-6257-0717
FAX: (02)2995-7458
E-mail: shunyimc@ms15.hinet. net
ALL WELDED WIDE GAP

:
13917176462
TEL: 20-8551 -2161
FAX: 20-8758-3416
: 3mm-30mm
: 700 0 C
E BI
SERU INTERNATIONAL CO. ,LTD.
(Ta)
201 6
(02)2702-0199
E-mail:seru@ms37.hine t. net
: (02)2708-7272
http://www.seru.com.tw
33
EWl El / Products
1 250 C 1100 C
2. ;97% 99% 100%
3. SUS304 SUS316
4.
5.
6. ISO (5cm-40cm)
(5cm-500cm)
7.100%
8. 75
TH
THV
THD
THV ()
BFM
THL
TMD ()
TSW
TS
TMD ()
THS
DISC
. 3A USDA , FDA , CE
TUBE

43441 43-1
TEL: 04-24636566 FAX: 04-24636527

MAIL: li.jin8@msa.hinet. net
Websiste: www.actuator-valve.com.tw
35
EWl El / Products
1 250 C 1100 C
2. ;97% 99% 100%
3. SUS304 SUS316
4.
5.
6. ISO (5cm-40cm)
(5cm-500cm)
7.100%
8. 75
TH
THV
THD
THV ()
BFM
THL
TMD ()
TSW
TS
TMD ()
THS
DISC
. 3A USDA , FDA , CE
TUBE

43441 43-1
TEL: 04-24636566 FAX: 04-24636527

MAIL: li.jin8@msa.hinet. net
Websiste: www.actuator-valve.com.tw
35
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CHEMICAL MONTHLY
___.
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02-87126567
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3. ?
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90-100-90 70-80 6070 60
90-100 80-90 70-80 60-70 60
90-100 80-90 70-80-70 60
90-100 80-90 70-80 60-70 60
90-100 80-90 70-80 60-70 60
TEL: 02 23656107( .
EE~~~
?:
?:
NEDERMAN FIL TERBOX
NEDERMAN
99%
D .O.P.TEST 99.97%
~I~.
.
:::
::
:
()
E mail:
39
8;2132:1:1

www.taiwah.com.twinfo@taiwah.com.tw
--. ~ ~|
/
(KIMO@)
MP 120
:1: 1000
2 - 40 m/s
Pa
0.15 - 30 m/s
HD 100
AMI300
-20 - +70 0 C
CO...
- 100 %RH
* Data Logger
Vacuu'ml. p
TH 110
-20 - +80 0 C
(:1: 0 .4%)
KH 210
-20
DBM 610
- +70 C
0
( 1.5%)
3500 m3 /h
5 - 95 %RH
5 - 95 %RH
3%
KTT 310
:1: 10
-200 - +1000'C
-2500
K J T
:1: 0.2%
KTH 350-P
:1:2
* ;~tl
II!
- +2,500 Pa
(:1: 1.5%)
:l: 100Pa :l:2 000mbar
:1: 100
mA
CP 2 10
CPE 310-8
:1: 100 Pa - :1: 2 ,000 mbar
2 4-20 mA
.-
~CS ENTS
:1: 2 , 000
mbar
s ()
0 - 50 C
D () -20 - +80 o C
5 - 95%RH
DP 520
-80 - +20 Ctd
-30 - +50 0 C
-0.1 - 1.5 MPa
OEM
5.0 MPa(VA 400)

1.6MPa (VA420)
ISUZU
40
BUSCH
VA 400/420
:
B180-0N
(KIMO')
BUSCH
H8T
Pa
Pa -
"H
P8T
CP 1 10
@
7
lfl
(:1: 0.3%)
5 - 95 %RH
Pa
I ~
~IB
4 20
-40 - +180 0 C
2 4 - 20 mA
TH 210
m3 /h
(180mm)
HTC-8
5098
930 - 1,070 hPa
: -50-+70 o C
(:1: 1.5
:
:
hPa)
()
C_'UM
' " CS INSTRUMENTS
10-99%RH
ISUZU
-10-+50 o C
0-100%RH
Tel (02)2662-0775 I Fax (02)2662-0796
info@busch.com.tw I www.busch.com.tw
41
8;2132:1:1

www.taiwah.com.twinfo@taiwah.com.tw
--. ~ ~|
/
(KIMO@)
MP 120
:1: 1000
2 - 40 m/s
Pa
0.15 - 30 m/s
HD 100
AMI300
-20 - +70 0 C
CO...
- 100 %RH
* Data Logger
Vacuu'ml. p
TH 110
-20 - +80 0 C
(:1: 0 .4%)
KH 210
-20
DBM 610
- +70 C
0
( 1.5%)
3500 m3 /h
5 - 95 %RH
5 - 95 %RH
3%
KTT 310
:1: 10
-200 - +1000'C
-2500
K J T
:1: 0.2%
KTH 350-P
:1:2
* ;~tl
II!
- +2,500 Pa
(:1: 1.5%)
:l: 100Pa :l:2 000mbar
:1: 100
mA
CP 2 10
CPE 310-8
:1: 100 Pa - :1: 2 ,000 mbar
2 4-20 mA
.-
~CS ENTS
:1: 2 , 000
mbar
s ()
0 - 50 C
D () -20 - +80 o C
5 - 95%RH
DP 520
-80 - +20 Ctd
-30 - +50 0 C
-0.1 - 1.5 MPa
OEM
5.0 MPa(VA 400)

1.6MPa (VA420)
ISUZU
40
BUSCH
VA 400/420
:
B180-0N
(KIMO')
BUSCH
H8T
Pa
Pa -
"H
P8T
CP 1 10
@
7
lfl
(:1: 0.3%)
5 - 95 %RH
Pa
I ~
~IB
4 20
-40 - +180 0 C
2 4 - 20 mA
TH 210
m3 /h
(180mm)
HTC-8
5098
930 - 1,070 hPa
: -50-+70 o C
(:1: 1.5
:
:
hPa)
()
C_'UM
' " CS INSTRUMENTS
10-99%RH
ISUZU
-10-+50 o C
0-100%RH
Tel (02)2662-0775 I Fax (02)2662-0796
info@busch.com.tw I www.busch.com.tw
41
(stripper)
1 IPA()
GMMP
GMB
~;\ :-800C-+2800C
:-20 C-+130 C
:316
:60W
:8M
:20 L/ min
:316
:90W.200W.400W. 550W
:31M
:95 L/ min
GMP
GMSW
~;\ :-800C -+280
~;\ :-30oC -+230
o
C
:316
:1-7.5HP
60M
600 L/ min
o
C
:316
:1-5HP
:91M
:56 L/ min
~.()
GMPL
%!!I :-80 C-+280 C
o
:316
:7.5HP-25HP
:133M
:1400 L/ min
TEL: 07-3720913
FAX: 07-3720923
: 8 395 -17
http://www.ricopump.com.tw
A P ...
B.
A S
11
quld mi-automatic
High scosity liquid sem

aulomatic filling mac/ine
ftll
Tubemuln
Desktop liquid sem

filling machine
Hig h-eff1
emulsion pump
aomatic
0.7
2MW
2 an-
AM
HSc
m XO
anau nF
111.
nM
?dm
khm
hm
aRM
m
ft
machine
hW
filling machine
&
DA JING HEATTE(. MACHINERY CO. ,

TEL : (02)8630-6666
1 '11 ,
1
FAX: (02)2619-6299
:0938-066698
E-mail: heatec@ms24.hinet.net
1,11111' I
(stripper)
1 IPA()
GMMP
GMB
~;\ :-800C-+2800C
:-20 C-+130 C
:316
:60W
:8M
:20 L/ min
:316
:90W.200W.400W. 550W
:31M
:95 L/ min
GMP
GMSW
~;\ :-800C -+280
~;\ :-30oC -+230
o
C
:316
:1-7.5HP
60M
600 L/ min
o
C
:316
:1-5HP
:91M
:56 L/ min
~.()
GMPL
%!!I :-80 C-+280 C
o
:316
:7.5HP-25HP
:133M
:1400 L/ min
TEL: 07-3720913
FAX: 07-3720923
: 8 395 -17
http://www.ricopump.com.tw
A P ...
B.
A S
11
quld mi-automatic
High scosity liquid sem

aulomatic filling mac/ine
ftll
Tubemuln
Desktop liquid sem

filling machine
Hig h-eff1
emulsion pump
aomatic
0.7
2MW
2 an-
AM
HSc
m XO
anau nF
111.
nM
?dm
khm
hm
aRM
m
ft
machine
hW
filling machine
&
DA JING HEATTE(. MACHINERY CO. ,

TEL : (02)8630-6666
1 '11 ,
1
FAX: (02)2619-6299
:0938-066698
E-mail: heatec@ms24.hinet.net
1,11111' I
'VAIIl
-- . .
DE-DIETRICH
[)e Dl8lrlcn .; *tttzr

PROCESS SYSTEMS
* ri DEDIETRICH
( 5)
..
IS09001
1L"""'1 r-----11"'"""""":" "'_"n!
Therm al S h ock 220 C
(GLASLOCK ANCHOR IMPELLER)
PTI MIX 13% ' Vortex 80% '

4 250%

. :
_ QVF Borosilicate 3.3 vessels and stirrers

_ De Dietrich Process System Filter/Dryer
*
W IL E N
PUMP
ENGINEERING
~ : 1 " 1/2"
, 1" , 11/2" ,2" ,3" 4"

ALUMINUM ,CAST IRON 316S.S()
HASTELLOY C PP ACETAL PVDF PFA(TEFLON).....
IU:
360
' IU '
:
U. L. CODE
79 FDA USDA 3A.
: .
GE 2 GEA
Cl:nori Ptnt'h l
mi
GEA-ECQFLEX -
.VARI THERM

.NT(New Ser)$ 25Bar
LWC Laser Welded Casse

Free
.BPH E ES

TypeAE
* AJ LONE
- _.-
I LJ.
Graphilor@ 3 a decisive step against corrosionVessels
_..
Pr$ure
~;
II~~FT
( CARBONE LORRAINE }=
Fully Welded GEAShell GEAF! 'GEABloc'

REKULUVO/REKUGAVO ': 1m'-250 000m'
TypeDWN
Flow
12mm
: (02)2786-7221
FAX: (02)2786-6009
(1 1
EY
-..
--"""
~
- -
HEAT EXCHANGERS:BlocklPlate(welded);Shell & Tube;Columns;Piping Fittings

MATERIALS:Graphite , SiC ,Tantalum ,Zirconium ,Titanium , Nickel alloys , Stainless steel , Carbon steel.
(~c;rL &HERM (O..LlD.
103 144 6 12 1
P.O.BOX68-651 TAIPEI 103 , TAIWAN.

TEL:(02)25570299(6Iines)
FAX: 886-2-25531328 886-2-25535816
45
'VAIIl
-- . .
DE-DIETRICH
[)e Dl8lrlcn .; *tttzr

PROCESS SYSTEMS
* ri DEDIETRICH
( 5)
..
IS09001
1L"""'1 r-----11"'"""""":" "'_"n!
Therm al S h ock 220 C
(GLASLOCK ANCHOR IMPELLER)
PTI MIX 13% ' Vortex 80% '

4 250%

. :
_ QVF Borosilicate 3.3 vessels and stirrers

_ De Dietrich Process System Filter/Dryer
*
W IL E N
PUMP
ENGINEERING
~ : 1 " 1/2"
, 1" , 11/2" ,2" ,3" 4"

ALUMINUM ,CAST IRON 316S.S()
HASTELLOY C PP ACETAL PVDF PFA(TEFLON).....
IU:
360
' IU '
:
U. L. CODE
79 FDA USDA 3A.
: .
GE 2 GEA
Cl:nori Ptnt'h l
mi
GEA-ECQFLEX -
.VARI THERM

.NT(New Ser)$ 25Bar
LWC Laser Welded Casse

Free
.BPH E ES

TypeAE
* AJ LONE
- _.-
I LJ.
Graphilor@ 3 a decisive step against corrosionVessels
_..
Pr$ure
~;
II~~FT
( CARBONE LORRAINE }=
Fully Welded GEAShell GEAF! 'GEABloc'

REKULUVO/REKUGAVO ': 1m'-250 000m'
TypeDWN
Flow
12mm
: (02)2786-7221
FAX: (02)2786-6009
(1 1
EY
-..
--"""
~
- -
HEAT EXCHANGERS:BlocklPlate(welded);Shell & Tube;Columns;Piping Fittings

MATERIALS:Graphite , SiC ,Tantalum ,Zirconium ,Titanium , Nickel alloys , Stainless steel , Carbon steel.
(~c;rL &HERM (O..LlD.
103 144 6 12 1
P.O.BOX68-651 TAIPEI 103 , TAIWAN.

TEL:(02)25570299(6Iines)
FAX: 886-2-25531328 886-2-25535816
45
8 55
@
@'lj @-UL-EX-CAS
@-~f- iJ - f @
f:~{B 00 ~@il tm -~ 8
FC20-WCB-304 304L-316-316L
,.
TEL:(07)8214538
FAX:(07)8232238
-ITAP-
47
8 55
@
@'lj @-UL-EX-CAS
@-~f- iJ - f @
f:~{B 00 ~@il tm -~ 8
FC20-WCB-304 304L-316-316L
,.
TEL:(07)8214538
FAX:(07)8232238
-ITAP-
47
CE62
. ECONO TYPE
* 1/2.~48.
* ANSI150LB~1 500LB
* -240~800
: 906
(07)699-8385
* 3
*
0 4
(07)699-8063
PVC
:
*
* ANSI150LB, JIS10K, PN16

*
*
Control Valve
X-Stream Trim
.30 flow cont to

reduce noise
cavitation ,
erosion , vibration
zajl
J I,ItI("_
L!Il".
~~
11
;
ANSI 4500 LB
CONTROLTEK INT'L CO. , LTD.

48
114 478 18 20 4
TEL : 02-26277671
FAX: 02-26277673
I kevln@ctk1980.com
http://www.ctk1980.com
E-mail:jon j;l ctk1980.com
49
CE62
. ECONO TYPE
* 1/2.~48.
* ANSI150LB~1 500LB
* -240~800
: 906
(07)699-8385
* 3
*
0 4
(07)699-8063
PVC
:
*
* ANSI150LB, JIS10K, PN16

*
*
Control Valve
X-Stream Trim
.30 flow cont to

reduce noise
cavitation ,
erosion , vibration
zajl
J I,ItI("_
L!Il".
~~
11
;
ANSI 4500 LB
CONTROLTEK INT'L CO. , LTD.

48
114 478 18 20 4
TEL : 02-26277671
FAX: 02-26277673
I kevln@ctk1980.com
http://www.ctk1980.com
E-mail:jon j;l ctk1980.com
49
:lJj
Pumps ard Blending System
LCD/PDP
EHEDG
?74
@
@
1.N
2.T
3.CS
4.
CS
wa
Jl
3-AEHEDG
. E

.:
1. Gasketed PHE
2. AII Welded PHE
3. Evaporator
4. UHT& HTST System
5. Maintenance & Construction
419 7
Wide Shine Co. , Ltd.

7F NO.419 KUANG-FU S.RD.TAIPEI
-Et;p..!lERE-Eaii-
TEL: 886-2-2723-0977
FAX: 886-2-2722-5923
http://www.wideshine.com.tw/
E-mail:wideshine@wideshine.com.tw
51
:lJj
Pumps ard Blending System
LCD/PDP
EHEDG
?74
@
@
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4.
CS
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. E

.:
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2. AII Welded PHE
3. Evaporator
4. UHT& HTST System
5. Maintenance & Construction
419 7
Wide Shine Co. , Ltd.

7F NO.419 KUANG-FU S.RD.TAIPEI
-Et;p..!lERE-Eaii-
TEL: 886-2-2723-0977
FAX: 886-2-2722-5923
http://www.wideshine.com.tw/
E-mail:wideshine@wideshine.com.tw
51
s;eep ex"com
,
Progressive Cavity Pump
CGM8
5tandard Pumps
IN
seepex N seepex

lI'I
TJCW
500m3/h
48bar(720PSI)
1111
Metering Pumps
ID
seepex D

JCPT
1000 I/h
24bar (360PSI)
Food Grade Pumps
CS
seepex cs CIP() SIP(

;
1Il111
)
FDA
EHEDG 130m3/h 24bar

()
(360PSI)
Open Hopper Pumps
IT
seepex T
N
'T
130m3/h 36bar
(540PSI)
Semi-Submersible Pumps
IE
seepex E
300m3/h 12bar (180PSI)
Uaceratr I M
seepex "
150m3/h
s ele l pex~ com
I[ 1 37820F2
20F-2 ,378 Wunsin Rd. ,Sec.1 ,Taichung ,Taiwan 408

TEL:04-23208766 FAX:04-23204815
E-mail: uln.ikem.inc@msa.hinet.net
http://www.unikem.~Jm.tw
all things fl ~: w
Asia Pacific Head Office

seepex (M) Sdn. Bhd.
59-1 , Jalan PJU 1/37 Dataran Prima
47301 Petaling Jaya Selangor D. E., Malaysia
Tel +60 3 7880 6951
Fax +60 3 7880 6959
E-mail: seepex.m@seep com
Webpage: www.seepex.m
Taiwan Contact
10663 237 13
Tel 02771078621 Fax 0277107868

Mobile 09285183011 E-mail: tliu@seepex.com
53
s;eep ex"com
,
Progressive Cavity Pump
CGM8
5tandard Pumps
IN
seepex N seepex

lI'I
TJCW
500m3/h
48bar(720PSI)
1111
Metering Pumps
ID
seepex D

JCPT
1000 I/h
24bar (360PSI)
Food Grade Pumps
CS
seepex cs CIP() SIP(

;
1Il111
)
FDA
EHEDG 130m3/h 24bar

()
(360PSI)
Open Hopper Pumps
IT
seepex T
N
'T
130m3/h 36bar
(540PSI)
Semi-Submersible Pumps
IE
seepex E
300m3/h 12bar (180PSI)
Uaceratr I M
seepex "
150m3/h
s ele l pex~ com
I[ 1 37820F2
20F-2 ,378 Wunsin Rd. ,Sec.1 ,Taichung ,Taiwan 408

TEL:04-23208766 FAX:04-23204815
E-mail: uln.ikem.inc@msa.hinet.net
http://www.unikem.~Jm.tw
all things fl ~: w
Asia Pacific Head Office

seepex (M) Sdn. Bhd.
59-1 , Jalan PJU 1/37 Dataran Prima
47301 Petaling Jaya Selangor D. E., Malaysia
Tel +60 3 7880 6951
Fax +60 3 7880 6959
E-mail: seepex.m@seep com
Webpage: www.seepex.m
Taiwan Contact
10663 237 13
Tel 02771078621 Fax 0277107868

Mobile 09285183011 E-mail: tliu@seepex.com
53
ES
/ (3Y
/ 6Y / 8Y)
:0.05m 0.1mm
0.2mm
:O.3mm 0.4mm
0.5m 0.65mm
0.8mm 1.0mm
HIP
~ 105 * 105 * 20mm

o
" HIP
:2mm-15mm :
0 - 300mm
: 273
TEL : 03-2123328 . 033125869

E-mail: service@oc-tec.com
E-m ail: srvice@ee-tec.com
FAX: 03-3228651
http://www.oc-tec.com
http://www.ee-tec.com
55
ES
/ (3Y
/ 6Y / 8Y)
:0.05m 0.1mm
0.2mm
:O.3mm 0.4mm
0.5m 0.65mm
0.8mm 1.0mm
HIP
~ 105 * 105 * 20mm

o
" HIP
:2mm-15mm :
0 - 300mm
: 273
TEL : 03-2123328 . 033125869

E-mail: service@oc-tec.com
E-m ail: srvice@ee-tec.com
FAX: 03-3228651
http://www.oc-tec.com
http://www.ee-tec.com
55
95%

()
illW
: (200.C-400.C) ,
: 1. l
2 . -99%
3.Thermal Nox
b0c4:
: 1.
2 .
2 95%
3 99%
~ill
@EPZTZITEFE!
99 2
TEL : 886-2-29384848()
http://www.geto.tw
E-mail:geto@ms17.hinet.net
FAX:886-2-29384864
7 -
95%

()
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2 . -99%
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: 1.
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3 99%
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@EPZTZITEFE!
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TEL : 886-2-29384848()
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E-mail:geto@ms17.hinet.net
FAX:886-2-29384864
7 -
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MAGNETIC DRIVE PUMP IN CATEGORY OF LARGE FLOW OR FILTER
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2HP-3HP-5HP ;
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KXH/KX. RIES
700IDOOL/Min
58
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MAGNETIC DRIVE PUMP IN CATEGORY OF LARGE FLOW OR FILTER
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19
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21
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12
24
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12
NT$ 560
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27
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12
11
Chemical Engineering
12
12
Chemical Week
50
13
Modem Plastics World Wide
12
14
Industry Week
12
15
Occupational Hazards
12
16
Forging
17
FoundrManagement
12
18
Govemment Procurement
19
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13
21
Business Week
51
22
Harvard Business Review
12
24
Aviation Week & Space Technology
52
25
Business &Commercial Aviation
12
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27
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12
28
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12
NT$ 1000
41
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51
47
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12
NT$ 300
NT$ 500
N$
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NT~
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53
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: 114 513269 1
: 886-2-87973324
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886-2-87974381
: kyle.hsu@spx.com
>APV

化工月刊 14年06月

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化工月刊 14年06月

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06

Butterfly Twin Shafts High Vi ssi

Three Shafts High Vi scosity Mlxer

High Speed Mixer

Incllned Fully Hydraulic Three RolI MiII

Four Shafls High Vsity

DURAWELL/DIRDWELL Taipei CD LTD

E-mail: rowell@ms1.hine t. net

Horlzontal Type Sa nd MIII

DURAWELL/DEROWELL Taiching CD LTD

Type Bead Mill

E-mail: Sales@saideli. com

No.8 , Ln. 15 , Gangrong Rd. Gangsh a; O ist.

Rotary Cone Mixer

Foodstuff,Milk Powder,Spices ,Seasoning ,

aadhm - Tel: 6-6-2545566

Mill Powder Tech Solutions

ISO/IEC 17025:2005 (AMC Analysis)

cGMP CIP SIP

ASME - BPE - PIC I S iti

- PhotoCheck ppbVOC (PID)

COCI HCI HCN HF NO

SHANG YUH MACHINE CO.. L TO.

Head Office : 3F. , No.51 , Sec. 4, Nanjing E. Rd. , Songshan Dist.,

90-100-90 70-80 6070 60

90-100 80-90 70-80 60-70 60

90-100 80-90 70-80-70 60

90-100 80-90 70-80 60-70 60

90-100 80-90 70-80 60-70 60

NEDERMAN FIL TERBOX

(Process Analytical Technology)

(4) Irinotecan HCl

High- Throughput Screening

Quality by Design Process Analytical

Technology Continuous Process

(5) Docetaxel Microreactor '

(continuous ozonolysis process)

(on line monitoring)

(3) (Quality by Design)

(Process Analytical Technology)

(4) Irinotecan HCl

High- Throughput Screening

Quality by Design Process Analytical

Technology Continuous Process

(5) Docetaxel Microreactor '

(continuous ozonolysis process)

(on line monitoring)

(3) (Quality by Design)

I Pharmacy and Chemical Technol?

mono- PEGy lated

Octreotides [7] 2011 Cai and Yue

RPC [9] PEGylation

(diastereomers) (osteoporosis) Teriparatide

(like dissolves like principle)

(ion-exchanged chromatography, IEC)

RPC) Octreotide PEGylation

I Pharmacy and Chemical Technol?

mono- PEGy lated

Octreotides [7] 2011 Cai and Yue

RPC [9] PEGylation

(diastereomers) (osteoporosis) Teriparatide

(like dissolves like principle)

(ion-exchanged chromatography, IEC)