Page 1 of 24

Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -MARIANNEMarianne
_______________________________________________________________________________________________________________________________________________
APA item 'a'[2]
Time Point/ Method
BASELINE

Cycle 2

Cycle 3

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' 4 = 'very much'

30

15

Subjects who experience hair loss with available APA data on any item point and subjects may be missing one or more APA items and still be
included in the analysis.[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the
introductory sentence Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be
missing one or more APA items and still be included in the analysis.
[2]
APA items includes Iitem a = prevented you from spending time with others including family and friends?; Iitem b = affected your
performance at work? Iitem c = kept you from leaving the house?; Item d = affected yourself-image?; Item e = made you feel embarrassed?.
[3]
The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
[1]

Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)

Page 2 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'a'[2]
Time Point/ Method
Cycle 3

Cycle 4

Cycle 5

Decile

0 = 'not at all'

23

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' 4 = 'very much'

0

11

10

32

14

32

15

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 3 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'a'[2]
Time Point/ Method
Cycle 6

Cycle 7

Cycle 8

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' 4 = 'very much'

0

31

12

26

10

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 4 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'a'[2]
Time Point/ Method
Cycle 8

Study Drug Completion

Visit

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' 4 = 'very much'

0

22

13

12

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 6 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'b'[2]
Time Point/
Method
BASELINE

Cycle 2

Cycle 3

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

0

13

12

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 7 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'b'[2]
Time Point/
Method
Cycle 3

Cycle 4

Cycle 5

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

0

14

18

19

12

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 8 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'b'[2]
Time Point/
Method
Cycle 6

Cycle 7

Cycle 8

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

0

12

15

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 9 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'b'[2]
Time Point/
Method
Cycle 8

Study Drug
Completion Visit

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

0

14

11

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 11 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'c'[2]
Time Point/
Method
BASELINE

Cycle 2

Cycle 3

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' 4 = 'very much'

0

27

17

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 12 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'c'[2]
Time Point/
Method
Cycle 3

Cycle 4

Cycle 5

Decile

0 = 'not at all'

27

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' 4 = 'very much'

0

15

26

16

33

16

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 13 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'c'[2]
Time Point/
Method
Cycle 6

Cycle 7

Cycle 8

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' 4 = 'very much'

0

28

10

25

15

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 14 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'c'[2]
Time Point/
Method
Cycle 8

Study Drug
Completion Visit

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' 4 = 'very much'

0

18

16

15

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 16 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'd'[2]
Time Point/
Method
BASELINE

Cycle 2

Cycle 3

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

0

10

39

23

11

51

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 17 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'd'[2]
Time Point/
Method
Cycle 3

Cycle 4

Cycle 5

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

24

16

46

23

13

43

25

14

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 18 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'd'[2]
Time Point/
Method
Cycle 6

Cycle 7

Cycle 8

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

0

42

23

16

12

33

19

16

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 19 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'd'[2]
Time Point/
Method
Cycle 8

Study Drug
Completion Visit

Decile

0 = 'not at all'

28

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

0

30

12

20

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 21 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'e'[2]
Time Point/
Method
BASELINE

Cycle 2

Cycle 3

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

0

11

40

16

13

44

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 22 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'e'[2]
Time Point/
Method
Cycle 3

Cycle 4

Cycle 5

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

0

24

13

10

47

14

11

11

48

17

13

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 23 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'e'[2]
Time Point/
Method
Cycle 6

Cycle 7

Cycle 8

Decile

0 = 'not at all'

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

0

41

21

10

12

28

15

12

13

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)
Page 24 of 24
Table 5.2.1 Psychometric Analysis on Item Curve Statistics - the Cross-sectional Population (CSP) [1] -Marianne
_______________________________________________________________________________________________________________________________________________
APA item 'e'[2]
Time Point/
Method
Cycle 8

Study Drug
Completion Visit

Decile

0 = 'not at all'

24

1 = 'a little bit' 2 = 'somewhat' 3 = 'quite a bit' ' 4 = 'very much'

0

26

13

15

[1] CSP = cross-sectional population defined as subjects who experience hair loss, patients whoselected Yes on the introductory sentence
Did you have any hair loss in the last 3 months, with available APA data on anyitem at any time point. Subject may be missing one or more
APA items and still be included in the analysis.
[2] APA items includes item a = prevented you from spending time with others including familyand friends?; item b = affected your
performance at work? item c = kept you from leaving the house?; Item d = affected yourself-image? Item e = made you feel embarrassed?
[3] The APA was made available in US English and US Spanish and was collected at baseline andevery 90 days with a 15-day allowable range
until end of study or patient withdrawal.
Program: (t_apa_mar_item_curve_stat.sas) (06AUG15:23:20:27)