BDA Master on Bioinformatics 2016

To deliver best before December 15th , 2016 send by email to juan<.>rodriguez<at>upf<dot>edu

1- The new guy in the lab went out in the field. He randomly sampled 254 flowers from the wild. He
classified it into four categories on the basis of seed type (red plain, red striped, green plain and
green striped).
TYPE

COUNT

Red Plain
Red Striped
Green Plain
Green Striped

153
40
54
67

a) Test the hypothesis that the collected sample was derived from a population with loci segregating
under independent assortment.

2- The average adult height in Spain is 160.3 cm with a standard deviation of 7.11 cm for females
and 173 cm with an standard deviation of 7.42 cm for males. The official Spanish population size is
of 46,007,655 with a 50.6% of females.
- Perform a formal statistical test to check if height really depends on the gender in the Spanish
population.
- I am an adult Spanish female of height 159 cm. How many people (both females and males) do you
expect to be taller than me in Spain?
- Above which height do we find the tallest 10% Spanish females?

3- Sheena, who is a super-smart cancer researcher, suspects that cells have differential growth
during day and night. So, she treats the cells differentially during day and night with two anticancer
drugs: Staurosporine (STS) and Oncostatin-M (OSM).
After 10 days and nights, she hands you the results because she doesn't know how to interpret them.
These are her results.
Time Treatment

Growth

Day

STS

15

Day

STS

25

Day

STS

20

Day

STS

21

Day

STS

20

Day

OSM

33

Day

OSM

19

Day

OSM

24

Day

OSM

28

Day

OSM

16

Night OSM

15

Night OSM

21

Night OSM

25

Night OSM

18

Night OSM

19

Night STS

25

Night STS

25

Night STS

17

Night STS

26

Night STS

16

a) Check that the data fulfil expectations/assumptions required by the test you will use.
b) Could you inform her if there is a significant interaction effect between factors?
c) In case there is not any, repeat the analysis without interaction.
d) Play with boxplot() function to confirm your observations.
BONUS: At the lights of the results/data, do you think its worth repeating the experiment with more data points, or is it OK
just with that? What could you do to gain more statistical POWER? Propose at least a method. (It is enough if you can just
explain it, but awesome if you can do it!) ;)

5- Sheena and her dog want to ride in a bus located 20 metres further on the opposite sidewalk.
Because of the herds of tourists walking along the sidewalk, Sheena walks at different speed on the
sidewalk and in the road, where cars are passing.
The time taken for Sheena to reach the bus can be minimised if she crosses the street to a particular
point, P, x metres upstream on the other sidewalk, as shown in the diagram.
The time taken , T, measured in tenths of a second, is given by the following equation:

a) How many meters should Sheena walk through the sidewalk, before crossing, to minimise the
time until catching the bus? Solve it graphically using R and show the graph.