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TLR Genes
T SCHIRREN ET AL . 2013
Toll like receptors are a class of proteins that play a key role in the innate
immune system. They recognise invading microbes. The paper looks at how the
variation in TLRs influences disease susceptibility in natural populations. They
assessed the extent of naturally occurring polymorphisms at TLR2 in wild bank
voles. They tested for the associations between the TLR2 variants and Borrelia
afxelii infection (tick-transmitted pathogen, causes human Lyme disease).
They found that voles carrying a certain cluster or TLR2 haplotypes were 3x more
likely to be infected by the pathogen. The first demonstration of an association
between TLR polymorphism and parasitism in wildlife. An example that genetic
variation at innate immune receptors can have a large impact on host resistance.