Professional Documents
Culture Documents
Radioactivity
Phenomenon by which one nuclide is
spontaneously transformed into another nuclide
with the emission of energy in the form of
radiation
During decay/spontaneous transformation, ratio
of neutrons to protons changes
After one or more decay, a NEW nucleus is
formed
Concepts on Radiopharmacy
Half-life
Time required for number of
radioactivity to decrease to onehalf the original number
t1/2 = 0.693/k
Atoms of a particular
radioisotope will ALWAYS
disintegrate in the same way and
rate
The amount of radioisotopes will
decrease with time at a constant
rate of disintegration
Radioactive isotope
Non-reactive complex (ligand)
Affinity to organ of choice
General use
Diagnostic application
For treatment
Production of Radioisotopes
Nuclear Reactor
Accelerator Produced Isotopes with the use
of cyclotron
Generator Produced Isotopes
Methods of Measurement
Ionization chamber (electroscope)
The Geiger-Muller counter
The Scintillation Counter
Autoradiograph method
Forms of Radiation
Alpha Decay
Least penetrating
Can be blocked by paper
Beta Decay
Medium penetrating
Can be blocked by aluminum
Units of Measurements
Nuclear Medicine
Aim
Technicium - 99m
Metastable isomer of Technecium 99
Gamma emitter
Short phsyical half life - 6hrs
Short biological half life - 1 day
Tc-99m
Generator
Examples of Radioactive
Isotopes
Tc99m-HMPAO
(hexamethyl propylene amine oxime)
Must be injected
Bone scan
Sodium
Pertechnetate
Tc99m-medronate
Myocardial perfusion
Tc99m-sestamibi or Tc99m-tetrofosmin
Tc99m-isosulfan
blue
Immuno-scintigraphy
Tc99m-monoclonal
antibody
Tc99m-Sn
Heart Scan
Tc99m-pyrophosphate
Spleen Scan
Tc99m-sulfur colloid
Meckel's Scan
Tc99m-technetate
Half-life
1. Ga67
2. Au198
3. Kr81m
4. K42
K43
Generic Name
Use
Gallium citrate
Ga67 inj
Lesions of lungs,
breast, sinuses,
liver tumor bones
For neoplastic
suppressant and
liver scanning
13 seconds
Krypton Kr81m
Lung function,
ventilation and
perfusion;
radiocardiology
12.4 hours
Tumor
Potassium
localization and
Chloride K42 inj
renal blood flow
22 hours
Potassium
Heart imaging
Chloride K43 inj
78 hours
2.7 days
5. Se75
6. Na22
7. F18
8. Sr85
9. Tl201
10. Xe127
Xe133
120days
Selenomethionine
Se75 inj
Scintigraphy of
pancreas and
parathyroid glands
2.6 years
Sodium Na22
inj
Detection of circulatory
time, Na space and total
exchangeable Na
1.7 hours
Sodium
Fluoride F18 inj
Bone
metabolism
64 days
Strontium Sr85
inj
Bone
metabolism
73 hours
Thallium Tl201
Myocardial
Chloride inj perfusion imaging
36.4hours
Xenon Xe127
gas
5.27days
Xenon Xe133
inj
BRAIN
BLOOD
BONES
Hg197/203
In113m
Tc99m
In113m
F18
Sr85
Tc99m
Ga67