Things to do in the coming week:

Case 1:

EBM: Bias, Validity and Confounding Variables.

Organogenesis up to 12 weeks. Basic.
Development of CVS, NS, GI and Renal tracts up to 12 weeks. Basic
Ultrasound in pregnancy.
ELISA kits, DIY and Lab kits.
Anatomy & Physiology of normal Pregnancy.
Types of Social Support.
Mode of action of protein and steroid hormones. Basic.
Oogenesis, Fertilization and Cleavage.
Regulation and Function of Female Reproductive System (menstruation).
Adaptations of Fetal lungs at birth & source and role of surfactant.
Uses/effects of oral contraceptives.
Physiology of Labour.
Influence of healthcare system/culture on pregnancy and birth.

Case 2:

Ethics of termination.
Revision of normal development up to 12 weeks as a foetus.
Cell cycle, meiosis and mitosis basics.
Structure of healthcare for pregnancy and birth.
Screening for DS.
Principles of genetic screening.
Abortion Act and Legal Criteria for it, at different stages.
Changing demographics of pregnancy.
Differences between risk and absolute risk
What structural and numerical abnormalities of chromosomes are, how
they arise and their effects.
Physiological changes during pregnancy and risks to the mother and
foetus.
Present risk differently, people understand risk differently. How do you
alter someones perception of risk?
Cultural assumptions about disability influence screening.
Personal experience influences risk.
Effect of major life events on pregnancy outcomes.

Case 3:

Importance of nutrition early in development.

Anatomy of Respiratory System (Mouth, Nose, Trachea, Bronchi, Alveoli)
Effect of infection on Pulmonary System.
GI Tract revision.
Normal patterns of growth in infancy, childhood and puberty. (Tanner
Stages).
Structure and Function of Pancreas.
Tests in the case.

Prenatal Screening, Genetic Counselling and Criteria for Termination in

terms of Decision Making.
How changes in DNA can lead to clinical disease (so mutations like delta
F508).
Ion Transporters
Mendelian Patterns of Inheritance examples and things to remember.
Pseudomonas Aeruginosa and gram staining.
Ethical issues of diagnosis of a serious illness by screening.
Population Genetics.
Genes and Proteins and Protein Synthesis.
Best methods to search electronic literature and recognise best evidence
to answer a question.
Stages of cognitive and psychosocial development (Piagets model)
Specialist healthcare service genetic counselling.

Case 4
GMC document 0-18 guidance for all doctors in care of a 15 year old.
Factors involved in the determination of growth.
Normal patterns of growth revised.
Causes of short stature, treatments and ethical issues.
Spermatogenesis
Male repro anatomy, physiology and endocrinology.
Differences between males and females in terms of patterns of growth.
Steroid and protein hormones revised.
Nature of cell growth division and hypertrophy.
Shared decision making and psychosocial development of adolescents
body image.
Case 5

Limits of confidentiality, when to breach.

Antiviral treatment (not ARVS, instead like interferon e.g).
Antibacterials.
Micro-organisms in the case Candidiasis
Counselling for HIV.
HIV lifecycle and retroviruses in general.
HIV treatment (ARVs).
How antibodies protect against microbiological infection.
Epidemiology of HIV.
Antigen antibody interaction. MHCs etc.
Diagnosis of HIV.
Innate Immune System.
Adaptive Immune System.
Origin and role of T and B cells.
Specificity of such T and B cells and antibodies.
Scope and limits of obligation to harm others.
How GPs maintain confidentiality.
Adherence, compliance and concordance.
Social context on disclosure of sexual health problems.

Why do people engage in health threatening behaviours.

Case 6
Cell mediated and IgE hypersensitivity reactions.
Taking a clinical history.
Staph A
Structure and Function of Skin.
Emotional effects of being a carer.
Adaptive Immune system revision.
Innate Immune system revision.
Treatments used in the case Glucocorticoids, Prednisolone.
Addisons and Cushings Syndrome.
Different types of study, like case and cohort etc.