Curriculum Vitae

Name : dr. Nanang Sukmana, SpPD, K-AI

DOB : Pagaden (Subang), August, 3rd 1948
Status : Married, 2 children

Education
Medical Doctor : University of Indonesia, Faculty of Medicine 1974
Internal Medicine : University of Indonesia, Faculty of Medicine, 1987
Consultant for Allergy and Clinical Immunology : University of Indonesia ,
Faculty of Medicine, 1999

Recent activity :
Head of Division of Allergy-Clinical Immunology, Department of Internal
Medicine, FMUI/RSCM
AUTOIMMUNE DISEASE
AND VACCINATION
 Immunization of healthhy individuals is the
most effective way of protecting the public
from infection and epidemics and has proven
to decrease morbidity and mortality.

Autoimmune manifestations following

imunization , though considered
a RARE side effects.
 Immunization of healthhy individuals is the
most effective way of protecting the public
from infection and epidemics and has proven
to decrease morbidity and mortality.

Autoimmune manifestations following

imunization , though considered
a RARE side effects.
 Reported Induction of autoantibodies following various
vaccination in selected patients with autoimune diseases

Vaccine/Ab AN Anti + ds Anti - Anca aCL Anti - LA Anti-SM Anti-Ro Anti- RF

A DNA ENA 2GPI RNP La

Influenza + + + + + + + + + + +
Pneumococcus +

HPV +
Vaccine card recommendation by age for adult patients with
autoimmune rheumatic diseases (ARDs)

Immunization
Non live vaccines (highly recommended)
Influenza, Tetatus diphteria pertusis (Tdap))
HPV

Pneumococcal 23
Conjugated Pneumococcal 13
Conjugated Meningococcal
Hepatitis A
Hepatitis B
Live Vaccine (generally contraindicated)
Yellow Fever
Herpes Zoster
 ASIA
Autoimmune (Autoinflammatory)
induced by Adjuvants
Silicosis
GWS (Gulf War syndrome)
Macrophages myofaciitis (MMF)
Post Vaccination phenomena
 Mechanism of Adjuvanticity
Translocation of antigen to Lymph node
Protection to antigen
Increase capacity to cause local reaction
Induction of the release of Inflamatory
cytokines
Uinteraction with TLRs
 Adjuvants in Human Vaccines

Alum : DPT, DT, HBV, HAV, H influenza,

polio, Strep pneumoinia, HPV ,
meningococcal
 Autoimmune demyeliting disease
associated with AL adjuvanted
Vaccines
Muliple sclerosis : Hepatitis A and B , HPV
Acute Disseminated : Hepatitis B , HPV
encephalomyelitis

GBS : Hepatitis B , HPV

Transverse myelitis : Hepatitis B , DPT
NO : Hepatitis A and B, DPT,
HPV, Tetanus toxoid

Demyelyeliting leukoencephalitis :
Hewpatitis B
 ASIA Syndrome
Major criteria :

Myalgia,myositis, or muscle weaknes

Arthralgia and /or arthritis
Chronic fatigue or sleep disturbances
Sympton neurological : demyelization
Cognotive imnpairment, memory loss
Pyrexia , dry mouth