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Available software packages are either only intended for gamma camera imaging or
include only methods for one or several working steps and/or are only commercially
available. To address this unmet need of standardisation and reproducibility and to
increase the acceptance of dosimetry, the goal of this work was developing a user-
friendly software including state of the art methods which allows seamless workflow
from the entry of patient specific data with (quantitative and coregistered) images, over
image processing and data fitting to therapy planning. Furthermore, a rigorous
assessment of the overall uncertainty (error) as demanded by the EANM dosimetry
committee is included in the software.

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Please refer to the publications provided.

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On the left side, you see the navigator which shows you where you are, what you have
done and through which steps you still have to go.
From this GUI, you can load a new workspace or start an new case.

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Here, you can enter counter data of you blood samples. This is necessary to determine
the red marrow dose.

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Explanation functionality.
Draw ROIS in SPECT or in CT image.
What do you need to enter?
Organ activities can be corrected by entering the more accurate organ volume from MRI
or high resolution CT or by entering the recovery coefficient.

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The 2D image processing methods are implemented according to MIRD pamphlet 16.
List of organs can be modified in the settings. Organ parameters such as thickness can
also be edited in the settings.
Using the first total body image and the urine acitivty, the calibration factor can be
estimated. If a 3D image is available, an accurate value of the 2D calibration factor is not
required. However, if only 2D data are available an accurate estimation of the 2D
calibration factor is needed.

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The most sophisticated part of the software is the modeling and fitting tool.
Please refer to the publications provided.

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Model selection.

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You can visually check the fit. You can check the parameter values and the standard
deviations, the correlation matrix and the residuals.

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In addtion to this quality tests, functions can be compared using the Akaike information
criterion.
All functions which are selected are used for model inferences.
The time-integrated activity coefficient of each function is analytically calculated based
on the fitted parameters.
The TIACS are then averaged using the Akaike weights.

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Please refer to the publications provided.

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Here, the dose for the limiting organ can be entered.
The acitivity and the absorbed doses are then calculated.
Both the BED and the absorbed doses can be calculated.
The histogram shows whether the distrubution is homogenous or heterogenous.

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PET/CT-based dosimetry in NUKDOS requires either generation of 2D data from 3D Data
sets (works in progress at Marburg) or calculation of kinetics using 3D data in NUKDOS.
Import of registered images from standalone SPECT and CT requires third party data
processing because of restrictions in NUKDOS when importing image data (works in
progress at Marburg).
ROI analysis to be done by using advanced available on the market (PMOD, inviCRO,
HERMES, Siemens, Philips, GE and many others) would be much more convenient and
and much more powerful than it is actually in NUKDOS itself (works in progress at Ulm).

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Please refer to the publications provided.
Stabin and Siegel, Health Phys. 85(3):294-310, 2003 (abstract).
Stabin MG_INTERNAL DOSIMETRY IN NUCLEAR MEDICINE_Braz. J. Rad. Sci. 2013

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Video: HERMES Hybrid Dosimetry Module.

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