PERBANDINGAN FORMULA ANTARA FAST DISSOLVING FILM ORTHOSIPHON

STAMINEUS DAN FAST DISSOLVING FILM APIUM GRAVIOLAMS

(COMPARISON OF FORMULATION BETWEEN ORTHOSIPHON STAMINEUS FAST DISSOLVING
FILM AND APIUM GRAVIOLAMS FAST DISSOLVING FILM)
Diva Yulanri, Dyah Ayu Setyarini, Herny, Isabella Putri S, Rachman Rizky, Sheni Herdina, Silvia
Anggraini, Tiara Rani, Umi Hanik, Yuni Fitriani
Program Studi Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam
Universitas Sriwijaya Inderalaya
email: farmasiunsri2014@gmail.com

ABSTRACT
A practice of the comparative between the formulation of Orthosiphon stamineus Fast
Dissolving Film and Apium graviolams Fast Dissolving Film has been done. This practice aims to
compare the Fast Dissolving Films formulatios using a variation of type and concentration of the
plasticizer, whereas in Orthosiphon stamineus Fast Dissolving Film, two plasticizer are used, namely
2% of Propylene Glycol and 5% of Polyethylene Glycol 400, whilst Apium graviolams Fast Dissolving
Film uses one plasticizer, that is 2% of Polyethylene Glycol 400. This practice also aims to compare the
mechanical properties, the swelling property, and the disintegration time of the two different
formulations of Fast Dissolving Film. Both formulations also use a variation of type and concentration
of the sweetener-plasticizer, whereas in Orthosiphon stamineus Fast Dissolving Film, 7% of Sorbitol is
used, and in Apium graviolams Fast Dissolving Film, 4% of Mannitol is used. Fast Dissolving Films
that have been cut were being analized, including the weight and size uniformity, the mechanical
properties, the swelling property, and the disintegration time. Apium graviolams Fast Dissolving Film
has a better result in the weight uniformity test with the %CV of 0,9%, whilst Orthosiphon stamineus
Fast Dissolving Film has the %CV of 0,23%. Whereas for the disintegration time test, Orthosiphon
stamineus Fast Dissolving Film is better with the %CV of 0,06% compares to Apium graviolams Fast
Dissolving Film that has the %CV of 0,095%.

Keywords: Fast Dissolving Film, solvent casting, polyethylene glycol, Sodium-CMC, HPMC

ABSTRAK
Telah dilakukan praktikum mengenai perbandingan antara formula Fast Dissolving Film
Orthosiphon stamineus dan Fast Dissolving Film Apium graviolams. Praktikum ini bertujuan untuk
membandingkan formula Fast Dissolving Film dengan menggunakan variasi jenis dan konsentrasi
pemlastis, dimana pada Fast Dissolving Film Orthosiphon stamineus, digunakan dua pemlastis yakni
Propilen Glikol 2% dan Polietilen Glikol 400 5%, sedangkan Fast Dissolving Film Apium graviolams
menggunakan satu pemlastis yakni Polietilen Glikol 400 2%. Praktikum ini bertujuan untuk
membandingkan sifat mekanik, sifat pengembangan, dan waktu hancur antara kedua formulasi Fast
Dissolving Film. Kedua formulasi juga menggunakan variasi jenis dan konsentrasi pemanis-pemlastis,
dimana pada Fast Dissolving Film Orthosiphon stamineus digunakan Sorbitol 7% dan pada Fast
Dissolving Film Apium graviolams digunakan Manitol 4%. Fast Dissolving Film yang telah dicetak
dievaluasi keseragaman bobot dan ukuran, sifat mekanik, sifat pengembangan, dan waktu hancurnya.
Fast Dissolving Film Apium graviolams memiliki hasil lebih baik dalam uji keseragaman bobot yakni
dengan %CV 0,9%, sedangkan Fast Dissolving Film Orthosiphon stamineus memiliki %CV 0,23%.
Sedangkan untuk uji waktu hancur, Fast Dissolving Film Orthosiphon stamineus lebih baik dengan
%CV 0,06% dibandingkan dengan Fast Dissolving Film Apium graviolams yang memiliki %CV
0,095%.

Kata kunci: Fast Dissolving Film, solvent casting, polietilen glikol, Na-CMC, HPMC