Professional Documents
Culture Documents
SNAPSHOTS
IISc: cleaning rivers Spellbound by sound
using a nano-composite H
SHUBASHREE DESIKAN
A
little bit of sun- ic hand, or its ultrasonic
GENE VARIATION shine and a com- equivalent, has been effec-
AND OBESITY pound made out
of rare earth ele-
tively designed now.
A team of researchers,
A single ments may hold
the answers to purifying
Asier Marzo et al, from Uni-
versities of Bristol, Sussex Particles ranging from 0.6 to 3.1 mm diameter are levitated
variation in the polluted rivers criss-cross- and Navarre and Ultrahap- above single-sided arrays. PHOTO: SPECIAL ARRANGEMENT
gene for brain- ing the country. tics Limited have come up
derived neurotropic Scientists from the Indi- with a way to use sound to
Scientists ed the object in a vortex of
factor (BDNF) may an Institute of Science, pick up objects. sound, and nally, the bottles
influence obesity in
Bengaluru have developed In a study published re- have found a were like a cage that trapped
a novel reusable nano- cently in Nature Communi- the object within.
children and adults, composite material, with cations, the team has way to use In a video released by the
says a new study. Cerium being the crucial
compound in it, which can
demonstrated using 64 mini-
ature speakers how high-
sound to group, the scientist brings in
a small ball, a few millime-
degrade microbes and pitch and high-intensity ul- pick up ters across, to a point above
chemical dyes that are
among common effluents
trasonic sound waves can be
used to surround a small ob-
objects the array of loudspeakers. He
then draws away the paper.
in rivers. ject and create a force eld As if a pair of ngers is hold-
Published in the Journal which can then hold the ing it back, the ball is seized
of Industrial and Engineer- object. By manipulating the Marzo and his team achieved and held in place as the paper
ing Chemistry Research re- Researchers managed to degrade methylene blue and methyl orange chemical dyes by 80 per output of the loudspeakers it using a plane array of is pulled away. While at the
cently, the scientists looked cent in an hour. PHOTO: ASHOKE CHAKRABARTY the object can then be loudspeakers. moment they are able to ma-
at ceria (CeO2) a cheap rare moved. The invisible hand that nipulate objects of width
earth oxide with properties catalysis agents, where dyes and bacteria. Within This is interesting because they created was of three about 2 mm only, the scien-
that include a strong ab- chemical reactions are ac- The 60 minutes, nearly all of it differs from earlier at- types tweezers, twisters tists hope to perfect the tech-
sorption of ultraviolet light celerated in the presence of methylene blue and methyl tempts which required that and bottles. The tweezers nique to be able to
(this property also sees it light. composite orange (both common the object that was to be lift- were similar to lifting the ob- manipulate small, cell-sized
ICE SHEET
being widely used for UV- The superior photocata- can speed up chemical dyes) were de- ed be surrounded by loud- ject with a pair of ngers, objects and also much larger
blocking and radiation lytic activity of this nano- graded by the composite. In speakers in all directions. Dr. while the twisters surround- ones.
MOVING SLOWLY shielding agent). composite for the degrada- the comparison, ceria-silver
It is this notion, that the tion chemical dyes is degradation phosphate compound that
In the face of
Vanishing African lions
compound can speed up the attributed to its extended had been synthesized pre-
melting due to degradation of chemical absorption in visible region of chemical viously, researchers man-
global warming,
dyes and the bacterium Es-
cherichia coli (which forms
and enhanced stability of
the catalyst owing to the
dyes and aged to degrade the
chemical dyes by 80 per
the movement of a a large chunk of organic rm adherence of silver E. coli cent in this time frame.
Greenland Ice waste in sewage) led the re- bromide and phosphate to Similarly, for E. coli bac- DIVYA GANDHI
searchers to develop ceria ceria nanoakes, says Nee- terium, colony forming
Sheet that nanoakes, which com- rugatti Krishna Rao Eswar, en cycles of its usage with units (which are responsib-
terminates on land
has been slowing.
bines ceria with silver salts.
In this composite, ceria ab-
sorbs light across the spec-
a researcher with the Cen-
tre for Nanoscience and
Engineering, IISc, who is
polluted uids.
The results show that the
composite material ended
le for the explosion of bac-
terial population) per ml
had reduced from nearly
A frica's lions are fast 'dis-
appearing from vast
swathes of the continent, in-
trum (and not just UV the lead author of the pa- up generating large 200 million units to less cluding from the savannah
light), while the silver salts per. amounts of hydrogen per- than 100 units in 80 min- grasslands, where they are
(silver phosphate, and sil- The compound was to re- oxide (a strong oxidizing utes when exposed to vis- the indisputable agship
ver bromide) form photo- main stable even after sev- agent) that degrades the ible light. species, nds a new scientic
paper. Threatened by habitat
loss, a depleting prey base,
A STEM CELL
SURPRISE
New evidence
More brief, above-normal monsoon QUESTION CORNER
suggests that some
human induced
pluripotent stem
rain spells since 1980 RED EYES
Why do ones eyes become red on consuming
alcohol?
cells are the K.S. RAJGOPAL
Dry and wet Department, Pune, notes: E.S. CHANDRASEKARAN, Chennai
'functional It was found that during Since alcohol causes dilation of blood vessels due to
equivalent' of monsoon the data period, both break release of histamine so increase in blood ow in vessels.
embryonic ones. F or the rst time, a study
published recently has season and active days show signif-
icant variation in rainfall
The tiny blood vessels in sclera , the outermost layer of
our eyes, become dilated causing bloodshot as well as
provided the statistics of
dry and wetter than normal
conditions between each decade of the
study period (1901-2014)
hot eyes. Our cornea is transparent that's why we can
observe the redness of eyes clearly.
monsoon season conditions studied from for the months of July and After some time it disappears. Some people tend to
during July and August over
India for the longest period
1901 to 2014 August. This is natural.
According to him, till
have red eyes very soon after drinking and for longer
duration due to absence of enzyme ALDH2 (aldehyde
(1901-2014) based on a sin- around early 1980s there dehydrogenase) which is responsible for the breaking
gle criterion rainfall. normal rainfall during the was more number of mon- of alcohol into acetic acid and vinegar in liver.
The dry condition, also active (wet) spell and scanty soon depression days lead- This is genetic and very common in people of East
called known as break, oc- or below normal rainfall ing to long duration active Asian descent also known as 'Asian ush'. Persons with
curs when large-scale rain- during the dry spell. spells. Post early 1980s, this this disorder can develop crimson face, headache, nau-
fall over the monsoon During the active spell, The impact of active/break monsoon conditions on the rainfall condition reversed leading sea, hot eyes etc. even by consuming as little as one
trough zone (the zone be- rainfall was signicantly and low level wind circulation patterns is not limited to the to shorter active spells due drink. Besides, heavy drinking depletes body of nutri-
tween which the monsoon above normal particularly Indian region. PHOTO: AP to a sudden decrease in the ents required for the healthy eyes leading to a condition
uctuates north and south over the following areas monsoon depression days.
STAR-BIRTH: ONE wards) is interrupted for monsoon trough zone, monsoon region. no change in the distribu- Post early 1980s, there
termed as alcoholic optic neuritis.
JUNAID ARIF, B.Sc (Biochemistry), Aligarh Muslim University
SIZE FITS ALL several days. On the other along the west coast, along During the study period, tion of the break events. was an increase in the short
hand, the intervals between the foothills of Himalayas both the active and break However, the number of ac- duration active spells. This
A massive star, spells of dry monsoon con- and over southeast Penin- spells of short duration of tive spells showed an in- was caused by the signi- THIS WEEKS QUESTIONS
25 times the mass ditions when the rainfall is sula. 3-6 days were more fre- crease of about 12 per cent cant increase in periods of
higher than normal are The impact of active/ quent than the long dura- during the second half; the less intense low pressure Why do cockroaches have spiky legs?
of the sun, is known as active spells. break monsoon conditions tion (of more than 13 days). increase was mainly in the than the low pressure on Nisha Sharma, Mysuru, Karnataka
forming in a similar The study was published on the rainfall and low level In the case of break spells it short duration (3-6 days) monsoon depression days.
way to low-mass in the journal Climate wind circulation patterns is was 63.4 per cent, while it spells. An increase in periods of Why do celestial objects spin around their own axis?
stars, it is found, Dynamics. not limited to the Indian re- was 94.3 per cent in the case In an email to this Corre- less intense low pressure Do all celestial objects spin?
The study found that the gion. It is felt over a larger of active spells. spondent, the lead author of compensated for the de- Rahul ChanouriaNew Delhi
the final piece in a rainfall anomaly during the spatial scale extending up During both the halves of the paper, Dr. D.S. Pai, who crease in longer duration
long-lasting puzzle. break and active spells was to west Pacic as well as the data period (1901-57 is the Head of Climate Divi- active spells caused by the Readers can send their questions/answers to questioncorner@thehindu.co.in
such that there was above other areas of the Asian and 1958-2014), there was sion, India Meteorological monsoon depression days.
NOIDA/DELHI
SNAPSHOTS
Decoding the colours Novel molecule for
on a butterfly cancer therapy
Y. MALLIKARJUN
MOHIT M. RAO
A
new small molecule
F
or the wildlife enthu- synthesised by scien-
EYE DROPS CLEAR siast, the bright col- tists at the Hydera-
ours, rings, spots and bad-based Indian Institute
CATARACTS stripes on the wing of of Chemical Technology
the buttery repre- has shown to effectively
A chemical that sent the pinnacle of natures control growth of cancer-
could potentially be beauty. However, how does a ous cells by preventing the
used in eye drops to predator a bird or a larger mis-expression of a specif-
insect view the wing col- ic micro RNA involved in
reverse cataracts, a ouration and the rings? Does tumour formation.
laeding cause of it tilt the balance in favour of Micro RNAs or miRNAs
blindness, has been the buttery in this millen- play an important role in Dr. Manika Pal Bhadra, one of the study authors, says that
identified by a nia-old battle of survival in cancer biology. They are the team proposes to conduct experiments on rat models.
the evolutionary war that is non-coding RNAs and are
team of scientists. described by biologist Ri- involved in gene regulation
PHOTO: SPECIAL ARRANGEMENT
chard Dawkins as the Great- and many developmental in vivo experiments. If it goes through effec-
est Show on Earth? Butterflies are under intense natural selection to be very good mimics. processes. Several thou- HDAC inhibitors are tively in pre-clinical and
A study by scientists from PHOTO: SPECIAL ARRANGEMENT sand miRNAs that control known to promote the clinical studies, there is a
the National Centre for Bi- 30-40 per cent of all genes process of programmed denite chance to add a
ological Sciences (NCBS),
Bengaluru and the National
isnt surprising then that the
palatable Danaid Eggy The lower seems to have affected its
ability to mimic, and in many
have been identied in hu-
man and other organisms.
cell death in which un-
wanted cells that pose a
new molecule for cancer
therapeutics and for re-
University of Singapore (Hypolimnas misippus) has surface of species the males look com- Researchers worldwide are threat to the organism are ducing tumours, said Dr.
(NUS) investigate how well evolutionarily learnt to mim- pletely different from fe- targeting miRNAs to nd destroyed. Manika Pal Bhadra, Head
buttery mimics resemble ic the look of the plain tiger in the wing males. Do their offspring better therapeutics for Interestingly, the re- of the Centre for Chemical
their models, and nds the
complexities that drive the
an effort to fool predators in-
to avoiding eating it.
shows better which inherit genes of mim-
icry as well as colours of sex-
cancer.
In studies carried out in
searchers discovered that
the novel molecule speci-
Biology at IICT and one of
the authors of the study.
evolution of mimicry. The predators point of mimicry than ual advantage see their collaboration with the cally acted as a negative She underlined the fact
Researchers studied over
200 specimens from the lush
view was obtained through
the visual modelling of the
the upper offspring struggle to mimic?
Surprisingly, no. The study
Centre for Cellular and
Molecular Biology, Hyde-
regulator for bantam miR-
NA. The mis-expression of
that the molecule was play-
ing a dual role in not only
DISEASE-SPREAD Western Ghats forests of un- avian colour vision (which nds that evolutionary needs rabad the scientists identi- bantam miRNA is respon- controlling cancerous cell
IN WILD BEES palatable butteries that
serve as models to palatable
differs from the colours and
patterns perceived by hu- eggs, which impairs their es-
trump any genetic dilution.
Another surprising result
ed dual functions of the
newly synthesised mole-
sible for diseases of cell
proliferation that inhibit
growth but was also induc-
ing apoptosis.
An entomologist butteries. For instance, the
Danaus chrysippus (plain ti-
mans).
The study, published in the
cape ight when they are at-
tacked by birds and other
thrown up is that the lower
surface of the wing shows
cule, triazole.
It was found that uncon-
programmed cell death.
With the in vivo studies
Dr. Utpal Bhadra of the
Centre for Cellular and
has come to the ger or African monarch but- latest edition of the journal predators. Because of this better mimicry than the up- trolled cell growth was conducted using Drosophi- Molecular Biology said:
conclusion that tery) protects itself from Evolution, quantitatively risk of predation, female but- per surface which is seen in a drastically reduced when la model (the nature of This work is important as
managed bees are predators by injecting unpal- shows that female butteries teries are under intense butterys ight path. This, the molecule was inserted apoptosis is similar to hu- we used Drosophila for
spreading diseases atable alkaloids from plants were better mimics than natural selection to be very says Mr. Kunte, could be be- into cancerous cell lines. mans), the researchers screening of molecules and
during the larval stage. This their male counterparts. good mimics. cause the buttery is more The molecule also acted as now propose to carry out validation of a molecule for
to wild bees, after protection from predators al- Krushnamegh Kunte from For male butteries, the vulnerable at rest (when its HDAC protein inhibitor in experiments in rat models cancer therapy. The study
analysing study lows it to y leisurely with- NCBS explains: Female but- quest for sexual advantage folded wings displays the human tumour cells and and eventually conduct was published recently in
done in this area. out threat of the predator. It teries carry heavy loads of colours that attract mates lower surface) than at ight. Drosophila larvae during clinical studies. Scientic Reports.
For saving Asian vulture from fatal drugs New light on human
blood formation
K.S. SUDHI
Conservation programmes, steps for ban-
ning the veterinary use of Ke- Our ndings show that the
breeding is
T
toprofen and Aceclofenac urning conventional blood system is two-tiered and
A
fter successfully cam- have to be achieved. wisdom on its head, a changes between early human
paigning for the ban on another The veterinary use of Ke- team of Canadian development and adulthood,
multi-dose vials of
painkiller drug diclofenac in
focus point toprofen has already been
banned in three districts of
scientists has discovered a
completely new view of how
says Dick, director of the
cancer stem cell programme at
HOW BIRD WINGS veterinary use, conservation- of the Tamil Nadu, he said. It has human blood is made. the Ontario Institute for
TAKE SHAPE ists have stepped up pressure
for withdrawing two more
campaign been pointed out that the vet-
erinary use of diclofenac was
According to them, the
whole classic textbook view
Cancer Research. For
redening the architecture of
drugs, which they say, are fa- the major cause of the decline we thought we knew about blood development, the
New research tal for Asian vultures. of vulture population. When blood formation doesnt research team mapped the
has found that the It was recently that the au- India in 2007 was estimated vultures which feed on car- actually even exist. lineage potential of nearly
shape of bird wings thorities slapped a ban on the Vultures disposed of millions of tonnes of waste carrion from at one-thousandth of its level cass of animals treated with Through a series of 3,000 single cells from 33
30 ml multi-dose vials of the dead cattle each year. PHOTO: K. V. UTHAMAN in the early 1990s, the docu- the drug, severe kidney experiments, we have been different cell populations of
is influenced more drug, which was largely re- ment said. damage and extensive viscer- able to nally resolve how stem and progenitor cells
by how closely sponsible for the decline of they, and the services they billed vulture (G. tenuiros- In south India, the vulture al gout were observed. different kinds of blood cells obtained from human blood
related species are the vultures, which used to provided, are nearly all gone, tris), are the worst affected populations have been re- The conservation consorti- form quickly from the stem samples taken at various life
to one another than feed on bovine carcasses. The according a publication of and are threatened with glob- ported from Muthumalai and um has also suggested mon- cell the most potent blood stages and ages.
bird conservationists pointed Saving Asias Vultures from al extinction after rapid pop- Sathyamangalam regions of itoring the ban on veterinary cell in the system and not For people with blood
by flight style. out that twenty years ago Extinction (SAVE), a consor- ulation declines, which began Tamil Nadu, Wayanad of diclofenac, surveys on pop- further downstream as has disorders and diseases, the
there were tens of millions of tium of eleven organisations. in the mid-1990s. Kerala and Bandipur and Na- ulations of vultures to assess been traditionally thought, potential clinical utility of the
vultures in the Indian sub- The three species of Gyps They are listed by IUCN as garhole of Karnataka, where its population trends, testing explained stem cell scientist ndings is signicant,
continent. They provided a vultures endemic to South Critically Endangered, the also the bird numbers are fast of vulture-safe veterinary Dr John Dick. unlocking a distinct route to
valuable ecosystem service and Southeast Asia, oriental highest level of endanger- dwindling, pointed out C. drugs and creation of Vulture The research also topples personalising therapy.
by disposing of millions of white-backed vulture (Gyps ment short of extinction in Sashikumar, a leading Safe Zones. Conservation the textbook view that the The ndings were published
tonnes of waste carrion from bengalensis), long-billed vul- the wild. The oriental white- ornithologist. breeding is another focus blood development system is online in the journal Science.
dead cattle each year. Now ture (G. indicus) and slender- backed vulture population in Besides other conservation point of the campaign. stable once formed. IANS
A
s our Institute at Hyderabad The answer comes once we real- lava that began owing still contin-
New data about J. MICHAEL NIRANJAN
Madurai, Tamil Nadu
started constructing a new
building, we found a huge
ize how these rocks and boulders
came about in the rst place. The
ue. This is what led to the steps or
staircase-like arrangement of the
chimps' diet has According to the US National Space Administration (NASA), boulder on the site. Such boulders work of geologists over the last cou- landscape in the Mumbai-Pune
been gained based an astronaut's radiation exposure depends on the structure of and rocks are common place in Hyd- ple of centuries has unveiled the Ghats region. These regular forma-
on teeth remains the spacecraft, the materials used to construct the vehicle, the erabad (and indeed in the Deccan scenario of the area, which show us tions as called the Deccan Traps
altitude and inclination of the spacecraft, the status of outer region) and many builders have sim- that these rocks, boulders and steps (borrowing from the Swedish word
vegetable remains zone electron belts, the interplanetary proton ux, ply blasted them away to make room (of the kind we see in the rocks in trapp for staircase). For some stun-
preserved in the geomagnetic eld conditions, solar cycle position, and Extra for buildings. As Hyderabad ex- Mahabaleshwar or Ajanta area) are ning views of the Deccan Trap, go to
dental calculus or Vehicular Activity (EVA) start time and duration among other panded during the last four decades, the result of the churning of the Asteroid impact led to the Google and ask for images. Cynics
plaque of chimps. factors. The Space Radiation Analysis Group (SRAG) of NASA much of the landscape has been re- earth that went on as early as 65 formation of the Deccan Traps. may ask: what use is this barren
measures radiation levels inside and outside the spacecraft. It markably changed from a series of million years ago. Those were the PHOTO: REUTERS land? For the people who live in the
estimates radiation doses to astronauts after assessing inputs boulders to high-rise buildings. pre-human days when giant dino- area, this is an irrelevant, indeed
such as radiation coming from outer space, radiation trapped This irreversible change in the saurs roamed the Indian landscape 66 million years ago that a giant as- irreverent question. And for under-
in the magnetic eld of the Earth after integrating them with landscape has bothered many, and in Punjab, Rajasthan and Deccan. teroid from space came and barged standing the details of our own his-
information on the altitude and inclination of the spacecraft the conservation group Save the The remains of one such dinosaur on earth. The impact was so huge tory, this is a natural gift. Save the
and location and timing of EVAs. SRAG evaluates radiological Rocks at Hyderabad has canvassed that roamed in the Adilabad area that it led to catastrophic changes Rocks Hyderabad ghts a heroic
safety aspects of radioisotopes and radiation-producing against such thoughtless blasting of have been put together and exhib- on earth. Giant series of earth- battle and we wish them well and
equipment carried on the spacecraft Each crewmember carries these natural gifts and for conserv- ited at the Birla Science Museum quakes erupted and massive res support.
a passive radiation dosimeter. SRAG may ask the astronauts to ing them as much as possible. These (which itself stands on such boul- were ignited, wiping out most life Turning to the boulder in our
remain in the shielded areas of the spacecraft and may demand have borne some fruit as some ar- ders) in Hyderabad. Looking at the forms, plant and animals on land building, we asked the world experts
either the cancellation or revised scheduling of EVAs. SRAG chitects have come out with inge- actual bones of the dinosaurs lying and sea. Dark clouds of poisonous on geo-chronology based in Hydera-
ensures that the exposures received by the astronauts remain nious plans to build houses and there, one wonders what caused dust blocked sunlight, vitiating the bad, Drs. Kunchitapadam Gopalan
below established safety limits and are As Low As Reasonably complexes around the boulders, or their extermination from the Ju- atmosphere and climate. This cata- and Kaigala Venkata Subba Rao.
Achievable (ALARA). More details are available at: http:// making the boulders as part of the rassic Park of India of 65 million strophic event changed the entire They tell us that this boulder is ac-
srag.jsc.nasa.gov/spaceradiation/how/how.cfm plan. We too decided to do so and years ago. landscape and natural history of our tually older than 65 million, perhaps
NEW LIGHT ON K.S. Parthasarathy made the boulder part of the ground Geo-chronologists study such earth. close to 1 billion years old! In re-
HEARING LOSS Former Secretary, AERB
oor of the new building, where it events and estimate their time peri- The collaborative work of Profes- spect, we surrounded it with four
THIS WEEKS QUESTIONS ushers visitors. ods. We have such experts at the sor Paul Renne of UC Berkeley, and walls and the artist Surya Prakash
The function of Why does our body temperature rise when we get
fever?
This is yet another example of the National Geophysical Research In- Professor Pande on Indian geochro- covered the walls with murals- as an
pejvakin, a D. Janani, Chennai
debate between ecology and envi- stitute at Hyderabad, Physical Re- nology shows that the effect of such ode to this priceless gift that Mother
molecule that plays ronment on one hand and devel- search Laboratory at Ahmedabad an asteroid impact was not just a Earth has bestowed on us.
What is dark energy? opment and economic demands on and IIT Bombay. One such, Profes- single bang, but a series of earth- Poets retell the past and foretell
a key role in Rakesh Pandey
the other, but with a different focus. sor Kanchan Pande of IIT Bombay, quakes churning out the Indian land the future. Saint Kabir wrote: The
hearing, has been When we light a lamp it always burns in the upward Boulders of Deccan are not green, has been working on the geo-chro- mass, particularly in the Western clay told the potter: you are churn-
direction. Why?
found. Its absence Indu C.,Thrissur
they play no role in agriculture, wa- nology of the Deccan, and has re- and Central regions of India, an area ing me today. There will come a day
ter or the livelihood of the people in cently co-authored a paper in the almost the size of U. P. and M. P. put when I will be churning you.
causes noise-based any signicant way. While we un- journal Science, which gives us an together. The impact was not just a D. Balasubramanian
Readers can send their questions/answers to
hearing loss. questioncorner@thehindu.co.in derstand the role of other ecosys- insight to the scenario. It was over one-off event but a series of contin- dbala@lvpei.org
CM ND-X
YK
NOIDA/DELHI
SNAPSHOTS
Western Sahara once Robots learning to walk
MOHIT M. RAO
I
f in August 2011 the discovery of dalism, developed through
TIMING IS KEY an underground river in Brazil at evolution, is among the cru-
FOR BIOENERGY a depth of 4 km and stretching for
about 6,000 km made news (The
cial differentiators from our
primate cousins. Scientists are identifying the best possible walking position
Researchers call Hindu, August 31, 2011), scientists
have now discovered evidence of a large
But this simple activity,
oft taken for granted, is quite
for robots that involves minimal energy consumption.
for a rapid shift to river system that once existed in West- complex in reality; and re-
PHOTO: REUTERS
renewable energy,
particularly bio-
ern Sahara.
Based on remote sensing data, the
searchers from the Bengalu-
ru-based Indian Institute of Walking can Engineering, IISc who co-
authored the study.
energy, to avoid existence of a 520 km-long vast ancient Science (IISc) have shown be envisioned The researchers have
river network has been established un- that the uniquely clumsy identied ve physical con-
climate change, der the parched sands of the Mauritania style can be envisioned as a as a straints for instance, mid-
ahead of Climate coast. The river is shallowly buried at sequence of controlled sequence of stance velocity (how fast to
Talks in Paris. present under wind-borne sediments, falls that can be optmised to walk), step angle (how large
says a paper published a few days ago in develop better robots. controlled the steps are) and pushing
the journal Nature Communications.
Water may last have owed through the
Published recently in the
Journal of Bioinspiration
falls capacity (muscles in humans
or motors in robots) to cal-
channels some 5,000 years ago. and Biomimetics, the study culate the optimum con-
Recently, a submarine channel sys- was aimed at identifying the straints for a robot to ensure
tem the Cape Timiris Canyon was constraints of walking and effect on the dynamics of the bi-pedal walking while using
discovered on the Western Sahara mar- so, identifying the best pos- system that is pivoted at the minimal power.
gin off the Mauritania coast. Generally, Evidence of a 520-km long vast ancient river network under the parched sands of sible walking position for ro- hips. A little push is all that is In future, we aim to re-
large-scale submarine channels occur the Mauritania coast has been established. PHOTO: AFP bots that involves minimal needed to move the swinging ne our models to more ac-
off major river mouths. Hence, the Cape energy consumption. The leg forward, and after that, it curately capture the effects
Timiris Canyon must have been linked
to a major river system some time in the Water may last presence of sediments transported by
river were deposited in the Arguin Ba-
work, says the study, can be
used eventually to develop
uses gravity to move for-
ward. The swinging leg then
of the heel striking the
ground, and the energy
recent past. have flowed sin during the mid-Holocene (between bi-pedal robots or even hu- becomes the stance leg, and spent to lift and place legs of
Earlier studies have argued for the 11,000 and 6,500 years ago) suggesting man exoskeletons. the alternative motion con- nite mass, says Mr. Pat-
presence of a large river system in through the that the Tamanrasett River was active Human walking follows tinues. naik. The mechanical under-
BIRDS PREFER Western Sahara. Now, combined with channels some during that period. the inverted pendulum And thus walking be- standing of all the muscles
LOVE TO FOOD geomorphological and sedimentary da- According to the authors, the pres- model. One leg is the stance comes a sequence of con- that goes into walking can
ta already available, the French team 5,000 years ago. ence of the river system during the re- or weight bearing leg, while trolled falls, says Lalit eventually be translated to
Wild birds will suggests that a major river system was cent humid periods provides the the other swings forward. Patnaik from the Depart- motor functions of the ro-
sacrifice access to indeed reactivated during some of the In fact, a fth of the drainage network missing link between the development The swinging leg has little ment of Electronics System bots, he says.
humid periods of the last 245,000 reconstructed matches perfectly with of lakes over Algeria, and Mauritania,
food in order to years, and this river system could have the digital projection model. uvial evidence in Algeria and the river-
stay close to their
partner over the
winter, according
to a new study at
contributed sediments to the Tropical
Atlantic margins during that time.
The authors utilised the data provid-
ed by the Japanese PALSAR radar that
Satellite images reveal that the
course of the ancient river is perfectly
aligned with ancient valleys identied
in the Arguin Basin and proximal trib-
ine signals recorded in the Arguin Ba-
sin. The present study supports the
hypothesis that there was a major drop
in wind-borne sediments to the North-
Now, spider eats a bat
uses L-band frequency to discover the utaries of the Cape Timiris Canyon sys- eastern Tropical Atlantic Western
Oxford. ancient river system. The L-band radar tem. Ocean during the time the river net- K.S. SUDHI
has the potential to see through even The river would have got its water work was active.
metres of loose sand material and can from heavy rainfall in the Western Sah- This nding provides yet another
identify geomorphological features that
are now buried under wind-borne sedi-
aran region during the early Holocene
African humid periods. At that time,
evidence of the extent of the Saharan
wetting during AHPs [African humid A spider feeding on a bat
may sound strange and
taken straight out of science
ments. However, the radar could not equatorial lakes reached their highest periods] and should thus provide valua-
peer through thick sand dunes. level and the present-day Saharan des- ble constraints for numerical simula- ction. But researchers have
But whatever has been reconstructed ert was the location of extensive vegeta- tions of West African climate reported such an event from
perfectly matches with an earlier digital tion, animal life and human throughout the late Quaternary, they Kerala.
projection model of a large river system. settlements, the authors write. The write. It was a giant wood spider
(Nephila pilipes) that
stunned the researchers of
SNAPSHOTS
Chennais new strategy to eliminate TB
R. PRASAD
The 'island of will form the key focus of
the project.
in an accelerated fashion to-
ward the pre-elimination
elimination' For instance, the gaps in phase, which is seen in
T
hanks to the Zero TB ghting the disease have al- wealthy health systems
Cities project, if all strategy does ready been identied by the where TB exists but is no
goes well, Chennai
may drastically re-
not call for Chennai Corporation, and
ruling out TB in HIV positive
longer an urgent public
health problem, Mr. Nichol-
duce TB mortality, any adults using an advanced son said. Realistically we
shrink the number of new
cases annually and impact
breakthrough tool (GeneXpert) has been
going on since June this year.
expect that any city can ex-
pect to reach pre-elimina-
WHEN DID ANDES TB prevalence in the city in a
matter of 3-5 years. municipal authorities in Li-
Actively tracing and testing
people living in the same
tion phase with
comprehensive approach.
the
FORM? Chennai has been chosen ma or Chennai stand up and household as a recently diag- Only after the infrastructure
as one of two cities in the identify TB as a priority pub- nosed TB patient and there- is in place to search, treat
The Andes have world where the Zero TB Ci- lic health menace that needs fore at high risk of and prevent will moving to-
been a mountain ties project will try to create to be tackled, other locations contracting the disease is al- ward the more ambitious
chain for much an island of elimination; may follow suit, and build ready being done. From goals of zero deaths, zero
Lima in Peru is the other their own locally appropriate Stop TB we are already sup- transmission, and ultimately
longer than city. The project will be for- plans to more toward ulti- porting a TB REACH project zero patients be even con-
previously thought. mally launched in Chennai mate elimination of TB.If we in Chennai which among ceptually possible.
It has gone up in a few months time. can help, we will of course The project intends to fight the TB war in Chennai by actively searching for people with TB other things is focussing on Despite the disease being
slowly over at least The project will be imple- nd a way to do so, Mr. Ni- disease. PHOTO: K. MURALI KUMAR how to implement contact airborne and presence of a
mented by the Municipal cholson said. investigation better, said large population infected
the last 30 million Corporation of Chennai with The goal is to help com- ght against tuberculosis as in an email to The Hindu. tools for early and accurate Dr. Sahu. with TB bacteria (latent TB)
years and are the the Chennai-based REACH munities move to zero the global decline in the Making a marked depar- diagnosis and providing ap- The city is planning to go acting as a reservoir, Mr. Ni-
result of gradual and the National Institute deaths from tuberculosis in number of new TB cases ev- ture from the current highly propriate therapy immedi- beyond household contacts cholson is condent that TB
thickening of the for Research in Tuberculosis their own way, and create ery year has been extremely ineffectual methods used to ately, and nally by making to look for hotspots of trans- can be and has been con-
(NIRT) assisting it. islands of elimination, slow in the last 25 years. At tackle the disease, the pro- sure the right supportive mission in slums and poverty trolled in thousands of set-
crust. Our U.S.-based team which will hopefully reverse this rate, it will take another ject envisages a comprehen- programmes are in place to pockets, and to implement tings in the past.
partnered with the Clinton the overall tuberculosis epi- two centuries to eliminate sive tuberculosis keep patients on therapy. active case nding in such While referring to the
Health Access Initiative demic, Pamela Das, Execu- the disease, The Lancet elimination strategy at the Fortunately, the Revised settings, said Dr. Sahu. problems posed by migra-
(CHAI) India, to do exten- tive Editor and Richard notes. community level by using all National Tuberculosis Con- Seamless integration be- tion of people into the city
sive scoping missions across Horton, Editor-in-Chief, The Zero TB Cities project the currently available arse- trol Programme (RNTCP) tween public and private sec- from high-burden settings
major Indian cities starting note in an Editorial in The that began in 2014 and nals. The island of elimina- guidelines are very forward tors for TB care will be less Mr. Nicholson said: The Ze-
in 2014. Over the course of Lancet. launched in active form last tion strategy does not call looking and already advocate challenging in Chennai as ro TB Cities approach needs
several visits, Chennai came The icker of hope shines month has earnestly em- for any breakthroughs but most of the strategies to be the Corporation and REACH to be part of a larger move-
out as the strongest site to brightly amidst the gloomy braced the Zero TB Declara- only requires a change of adopted by the Zero TB Ci- already work closely with the ment and cannot fully suc-
explore a Zero TB City ap- and grim tuberculosis scena- tion in 2012 that calls for a mindset and better use of ties project. private sector to make case ceed in isolation in India in
proach in India, Tom Ni- rio in the country 220,000 new global attitude in the methods and tools that al- Though how soon the ini- notication more effective terms of getting to the nal
cholson associate in research avoidable TB deaths in 2014 ght against TB. ready exist. tial objective will be reached and to address the issue of zeros in Chennai.
at the Duke Center for In- in people who were HIV neg- In India, there is evi- To cut the transmission will depend on how quickly availability of TB medicines The Project is a collabora-
ternational Development ative and 2.2 million new TB dence that transmission of cycle and reduce mortality, and how well the programme to people approaching pri- tive effort between Har-
(DCID), Durham, and who is cases, accounting for 23 per TB is much higher in cities, the project intends to ght is rolled out, Chennai al- vate practitioners. In a small vards Department of Global
CORALS AND heading the new project said cent of the global total. The and cities are often the the TB war in Chennai by ready enjoys a head start. To- way, REACH already has a Health and Social Medicine,
CLIMATE CHANGE in an email to The Hindu.
The very objective of the
country today faces the
world's greatest TB crisis de-
source of infection for rural
communities. So, getting to
actively searching for people
with TB disease, providing
gether with
stakeholders NGOs, pri-
other public-care representative
embedded in private hospi-
Duke Universitys Sanford
School of Public Policy and
New research project is that other cities in
India and elsewhere take the
spite halving TB prevalence
and the mortality rate in the
zero in cities will eliminate
important reservoirs of TB,
preventive therapy to people
infected with TB and belong-
vate practitioners, pharma-
cies, deans of medical
tals to facilitate medicine
availability to poor patients.
Duke Center for Interna-
tional Development. Stop TB
has found that fat initiative in a similar way last 25 years. Dr. Suvanand Sahu, Deputy ing to high-risk groups, con- colleges and NIRT the We see Zero TB as a Partnership provides the op-
helps coral survive and tackle their own TB epi- Business as usual can no Executive Director of Stop trolling TB transmission by Corporation has already ini- long term goal, a catch-all erational and strategic
heat stress over the demics urgently. When the longer be an option in the TB Partnership, Geneva said routinely using efficient tiated some measures that way of saying we are moving collaboration.
short term and
over the long term.
Some corals resist
repeated bouts of
heat stress called
Drinking pie melon juice may counter diabetes REGENERATING
bleaching due to
the presence of fat.
Y. MALLIKARJUN
Juice should
not be
world have been increasingly
consuming processed calo-
rie-rich and energy-dense
BONES
D rink juice of Mother Ma-
ry's Pie Melon (Dosa- consumed if foods and beverages.
He said the study looked at THROUGH
the fruit
kaya in Telugu; Dosaka in
Tamil) and counter the life-
style diseases like diabetes, tastes bitter
nding a traditional dietary
method which would be ben-
ecial in terms of health.
NANOPARTICLES
obesity and cardiovascular Another unique nding
disorders. was that Dosakaya juice re-
With sugar-laden diet and tion, Dosakaya juice boosted duced sucrose feeding in- MOHIT M. RAO
beverages posing a major risk the indigenous anti-oxidant duced hyperlipidemia
factor for lifestyle diseases defence system of the body (excessive amounts of fats
such as diabetes, obesity and by multiple mechanisms. and fatty substances in
A
degradable polymer, with a tinge of a new-age
cardio-vascular disorders, a The results of the research blood), a major risk factor for carbon nanomaterial, can perhaps one day be
NEW EBOLA group of scientists from Indi- work were published in heart diseases. It was also used to mend broken bones.
an Institute of Chemical Pharmacognosy Magazine in found that it reduced trigly- A recent study by scientists at the Indian
VACCINE IS SAFE Technology, Hyderabad has Dosakaya juice also reduced sucrose feeding induced the October-December, 2015 ceride levels in blood. We Institute of Science (IISc), Bengaluru suggests that
studied the effect of Dosa- hyperlipidemia (excessive amounts of fats and fatty issue. are the rst group to work on
A clinical trial of kaya (DK) (Cucumis melo substances in blood) say Dr. Ashok Tiwari (sitting). PHOTO: Lead author of the study Dosakaya. Our highlight is its
3D scaffolds of graphene composites can be used
for bone tissue regeneration as they mimic the
a new Ebola var. chito) juice on sucrose- SPECIAL ARRANGEMENT and senior principal scientist therapeutic effects against environment of the bone.
vaccine found it is induced glucose intolerance at IICT, Dr. Ashok Kumar Ti- diabetes and cardio-vascular The researchers from the department of
well tolerated and and oxidative stress. While diovascular disorders and During the study, the sci- wari, said our literature as risk factors, he added. Materials Engineering went about strengthening
glucose intolerance leads to cancer. entists orally administered well as international litera- Dr. Tiwari cautioned Polycaprolactone (PCL) a biodegradable
stimulates strong more than normal levels of Dosakaya fruit is widely prepared sugar solution to ture over the years has against consuming juice polymer by adding graphene, a two-dimensional
immune responses glucose in the blood stream used in different culinary rats for a month. When the shown that people who ad- when the fruit tastes bitter as hexagonal lattice of carbon atoms.
in adults in Mali (also called pre-diabetes items in South India. It dis- animals were given Dosakaya here to traditional dietary it could be toxic. He said dia- Though PCL is biodegradable, it is considered
and the U.S. Larger state), oxidative stress is plays multiple anti-oxidant juice, it was found that the practices are least prone to betics should consult their too soft to be used as a bone template. However,
caused by free radicals and activities which help in pre- glucose intolerance inducing develop modern-day lifestyle physicians before consuming graphene has a strength that is more than 200
trials of the vaccine associated with many diseas- venting damage to tissues capacity of sucrose was sig- diseases. Since the past 50 as its cumulative effect might times that of steel.
has already begun. es, including diabetes, car- caused by free radicals. nicantly reduced. In addi- years, people around the lead to hypoglycaemia. The addition of graphene dioxide was found to
have increased the strength of PCL by 22 per cent
and its capacity to resist deformation by 44 per
SNAPSHOTS
Alas, topical steroids sold Ramanujans gift: solutions
as over-the-counter drugs to elliptic curves
SHUBASHREE DESIKAN nujans notes, and we figured
R. PRASAD out his secret[Ramanujan]
arrived at the formulae on
C
orticosteroids can be Hardy-Ramanujan much more general identity.
sold in India only on number, is not new to math One which I recognised as a
ANTS' SEX production of a regis- enthusiasts. But now, this K3 surface (a concept that
tered medical practi- number has triggered a ma- mathematician Andrew
DETERMINATION tioners prescription jor discovery on Ramanu- Wiles used for solving Fer-
as they are included in sched-
25 per cent of ule H of the Drugs and Cos-
jan and the theory of what
are known as elliptical
mats last theorem), an ob-
ject that mathematicians did
the progeny metics Rules 1945. However, curves. not discover until the
produced by a footnote in the Rules ex- The anecdote goes that 1960s, notes Dr Ono.
empts eye ointments and once when Hardy visited Ra- Ramanujan died in 1920,
inbreeding in ants topical preparations like skin
Ramanujan arrived at the
manujan who was sick, Har- formulae by producing a long before mathematicians
is sterile. Scientists ointments, creams and lo- dy remarked: I had ridden much more general identity. discovered the K3 surfaces,
discovered that this tions from the list. in taxicab number 1729, and but from research done by
is due to the Thus, topical preparations
presence of two containing steroids, includ-
it seems to me a rather dull
number. I hope it was not an 1729 is the Ono and Trebat Leder, it
transpires that he knew of
separate sex
ing strong corticosteroids,
prescribed by dermatologists
unfavourable omen. To this sum of two these functions long before.
Ramanujan had replied, No, Dr Ono continues, Ramanu-
determination and others can essentially be Steroid cocktails mixed with antifungal and anti-bacterials make the drugs extremely dangerous, it is a very interesting num- cubes in two jan produced so many mys-
regions inants. sold as over-the-counter
(OTC) drugs.
irrational and may lead to emergence of drug resistance. PHOTO: MOHAMMED YOUSUF ber. It is the smallest num-
ber expressible as the sum of
different terious formulas, which can
be misunderstood at first
Even ofloxacin, which is a
Ofloxacin, a drugs extremely dangerous published a few days ago in two cubes in two different ways glance. We have come to
schedule H1 drug, is freely and irrational. Use of irratio- The BMJ. ways. learn that Ramanujan was
used in topical preparations, schedule H1 nal topical steroid combina- Topical steroids can cause Yes, 1729 = 93 + 103 and looked again and found that perhaps the greatest antici-
said Dr. Abir Saraswat, der- tions can lead to drug substantial and permanent
matologist based in Lucknow drug, is resistance. damage, especially to thin
also 1729 = 123 +13
This story is often narrat-
there was another equation
on the same page that indi-
pator of mathematics. His
bizarre methods and formu-
and a member of the Indian
Association of Dermatolo-
freely used in Dermatologists are seeing
increasingly widespread fun-
skin such as on the face and
groin, even if used for a short
ed to explain Ramanujans cated Ramanujan had been las have repeatedly offered
familiarity with numbers but working, even then, on a fa- hints of the future in mathe-
gists, Venereologists and topical gal diseases where the use of period of 15 days. Side effects not more than that. Recent mous seventeenth century matics. In this case, we have
Leprologists.
The schedule H1 category
preparations irrational combination drugs
has been implicated. The fun-
include pigmentation and
atrophy of the skin. Misuse
discoveries have brought to
light that it was far from co-
problem known as Fermats
Last Theorem (proved by
added to Ramanujans leg-
end.
was introduced with an ex- gal diseases do not respond to of steroid combinations can incidence that Ramanujan Andrew Wiles in 1994). Commenting on their own
press intent of preventing register that has details of pa- conventional drugs for con- cause bacterial or fungal re- knew the properties of 1729. I thought I knew all of the work on this, he says, He
any misuse of 46 third and tients and prescribing doc- ventional duration and dose, sistance, which can make in- There are now indications papers there, but to my sur- [Ramanujan] anticipated the
fourth generation drugs and tors. The register has to be said Dr. Shyam B Verma, der- fections difficult to diagnose that he had, in fact, been prise, we found one page theory of K3 surfaces before
CLIMATE CHANGE delaying drug resistance retained for at least three matologist based in Vadoda- and treat, Dr. Verma writes. looking at more general with near misses to the Fer- anyone had the merest
SPEEDS UP from emerging. Since March
1, 2014, the schedule H1 drugs
years.
Worse, steroid cocktails,
ra, Gujarat.
Indian doctors are wit-
According to a 2011 study,
nearly 15 per cent of dermat-
structures of which this mat equation, writes Dr glimpse. These surfaces are
number was but an example. Ono, who is also a Ramanu- now at the forefront of re-
Greenhouse gas could be sold by chemists on-
ly on production of a valid
which are in fixed dose com-
binations, are mixed with
nessing a pandemic of ad-
verse effects induced by
ological patients were found
using topical corticosteroids.
Mathematicians Ken Ono
and Andrew Granville were
jan scholar, in an email to
this correspondent. Having a
search in mathematics and
physics. In addition to add-
emissions that prescription. The chemist various antifungal and anti- topical corticosteroids, Dr. Of the 15 per cent, over 90 per leafing through Ramanujans sneaking suspicion that Ra- ing to Ramanujans legacy,
arise naturally are has to maintain a separate bacterials, thus making the Verma writes in a news piece cent had adverse effects. manuscripts at the Wren Li- manujan had a secret meth- Sarah and I were able to ap-
also affected by brary in Cambridge Univer- od that gave him his amazing ply his formulas to a problem
increased sity, two years ago, when formulas, Dr Ono returned in number theory (finding
they came across the equa- to Emory University and large rank elliptic curves),
temperatures,
concludes a new
study, which
Missing dissolved organic carbon tion 93 + 103 = 123 +13, scrib-
bled in a corner. Recognising
the representations of the
started working on these
leads with his PhD student
Sarah Trebat Leder.
and his formulas immediate-
ly set the record on the prob-
lem. We hardly had any work