Killed or Inactivated Vaccines

Devanie Saeteurn
2/24/17
 Vaccine Background/Introductions
This vaccine is used to kill organisms to protect
against future infections
Consists of organisms that cant be replicated and
that cant cause diseases
Inactivated vaccines need a lot of control to
ensure organisms are completely inactivated before
using
This vaccine is created by inactivating a pathogen
by using heat or chemicals (formalin or
formaldehyde)
The formalin or formaldehyde destroys the
pathogens ability to replicate but not enough
to where immune system cant detect it
 Vaccine Production
The steps to creating this vaccine are:

- Weaken the virus (so the virus wont

reproduce in your body)
- Inactivate the virus (when you kill the
virus it wont be able to reproduce and
cause a disease)
- Use part of the virus (this is used when the
immune system is supposed to be protecting
from diseases )
- Use part of the bacteria (It can be given to
people with weakened immune systems)
 Historical Background
Inactivated vaccines were discovered around
the 19th century
The first inactivated vaccine was discovered
by Salmon and Smith (in the US) and by Roux
and Chamberland (in France)
A vaccine was made by Koelle using
heat-inactivated cholera bacilli that was for
general use but it was painful and didnt
give long lasting immunity
It was first used for pathogens like the
plague and cholera bacilli and a form of
hepatitis and viruses
How the vaccine works with the immune
system
The vaccine causes antibodies to
form in the body about 2 weeks after
vaccination
The antibodies protect against
infection with the virus that is in
the vaccine
 Example of vaccine and the disease can fight
An example of the inactivated vaccine is the influenza
vaccine. Theres no other preferred vaccine over this
one. Although it is recommended for children/adults, six
months and older to get the vaccine annually.

Symptoms of influenza:

- Muscle body aches

*Nasal spray does contain live
- Fever viruses but theyre weakend
- Sore throat
- Fatigue
 Interesting Facts
The term inactivated is generally
used more than the killed term
The vaccine cant cause diseases from
an infection even in an immunodeficient
person
Inactivated vaccines are known to be
safer than live vaccines
Every flu season is different and the
infection affects people
differently
 References
- "Different Types of Vaccines." History of Vaccines. N.p.,
29 Jan. 2016. Web. 21 Feb. 2017.
- Health, BIO Ventures for Global. "Current Programs."
Inactivated Vaccines. N.p., n.d. Web. 21 Feb. 2017.
- "Making Vaccines: How Are Vaccines Made?" The Children's
Hospital of Philadelphia. The Children's Hospital of
Philadelphia, 19 Nov. 2014. Web. 21 Feb. 2017.
- "History of Vaccination." Proceedings of the National
Academy of Sciences. N.p., 5 Feb. 2014. Web. 22 Feb.
2017.
- "Key Facts About Seasonal Flu Vaccine." Centers for
Disease Control and Prevention. Centers for Disease
Control and Prevention, 09 Dec. 2016. Web. 24 Feb. 2017.