Rough Estimate for the Number of Questions to Expect on the Step 1 Exam
Broken Down by Section/Chapter
20 Questions Inflammation &
Immunology Section
17 Questions Genetics Section
13 Questions Biochemistry Section
10 Questions Cell Injury & Introduction
to Cancer Section
8 Questions Biostats & Epidemiology
Section
7 Questions Psychiatry Section
4 Questions Vitamins Section
4 Questions Doctoring Section
3 Questions Ethics and Legal Section
Combined High Yield Rating by Topic:
10 Vitamin B12 Deficiency
10 Metastasis
10 B & T Cell Activation
10 Autosomal Recessive Inheritance
10 22 Tables
9 X Linked Recessive Inheritance
9 Toxoid Vaccines
9 Sensitivity & Specificity
9 Prevalence & Incidence
9 Genetic Pedigrees
9 Depression & Suicide
9 Antibody Isotypes
8 Type I Hypersensitivity
8 Reversible vs. Irreversible Cell Injury
8 Types of Necrosis
8 Kartagners Syndrome
8 Free Radicals
7 Tumor Necrosis Factor
7 Tay-Sachs Disease
7 Post Transcriptional Modification
7 Opioid Overdose & Naloxone
7 Interferon
7 Chronic Granulomatous Disease
7 Cellular Adaptions
7 Apoptosis
7 Antidepressant Side Effects
6 Trinucleotide Repeat Expansion
6 DNA Translation
6 Relative Risk and Odds Ratio
6 p-Value and Statistical Significance
6 Prostaglandins, Leukotrienes &
Bradykinin
6 Positive & Negative Predictive Value
6 Cohort Study Design
6 Chronic Organ Transplant Rejection
6 Antipsychotic Side Effects
5 Type IV Hypersensitivity
5 Type III Hypersensitivity
5 Tuberous Sclerosis
5 Schizoid Personality
5 Scar Formation
5 Mitochondrial Inheritance
5 Interleukin 2
5 I Cell Disease
5 DiGeorge Syndrome
5 Cell Cycle
5 Amyloidosis
4 Thiamine Deficiency
4 Standard Deviation
4 Randomized Control Trial
4 p53 Tumor Suppressor
4 Osteogenesis Imperfecta
4 Live/Attenuated Vaccines
4 Lesch Nyhan Syndrome
4 Graft vs. Host
4 Epigenetics
4 Confidence Intervals
4 Complement System
4 Measures of Central Tendency
4 Case-Control Study Design
4 Cardinal Signs of Inflammation
4 Bereavement/Grief
4 Benzo Indications
4 Autosomal Dominant Inheritance
4 Autoantibodies
4 Alcohol Withdrawal/DTs
3 X-Linked Agammaglobinemia
3 Vitamin C Deficiency
3 Vitamin B6
3 Vitamin A
3 Transudate vs. Exudate
3 Mechanism of Stimulant Drugs of
Abuse
3 Statistical Hypothesis Testing

3 Signs and Complications of
Stimulant Intoxication
3 Severe Combined Immunodeficiency
3 Schizophrenia
3 Randomization
3 Polygenic Inheritance
3 Phenylketonuria
3 Opioid Withdrawal
3 Niacin
3 Neutrophil Extravasation
3 Neurofibromatosis
3 Mood Stabilizer Side Effects
3 Methanol Poisoning
3 Marfan Syndrome
3 Killed/Inactivated Vaccines
3 Interleukin 1
3 Imprinting, Angleman & Prader-Willi
3 Histrionic Personality
3 Granulomas
3 Folate Deficiency
3 Down Syndrome
3 DNA Replication
3 Cytoskeleton Basics
3 Collagen and Elastin Basics
3 Borderline Personality
3 Benzo Overdose
3 Bcl-2 Oncogene
2- Mosaicism
2 Von Gierkes Disease
2 Von Hippel-Lindau Disease
2 Variable Expressivity
2 Sampling & Selection Bias
3 Somatization
2 Chediak Higashi
2 Case Fatality Rate
2 Bipolar Disorder
2 Benzo Mechanism of Action
2 Antisocial Personality
2 Antipsychotic Mechanism
2 Antipsychotic Indications
2 Antidepressant Mechanism
2 Alcohol Metabolism
2 Acute Organ Transplant Rejection
1 Type II Hypersensitivity
1 Sorbitol
1 PTSD
1 Passive vs. Active Immunization
1 OTC Deficiency
1 Nieman-Pick
1 Maple Syrup Urine Disease
1 Malingering
1 Hyperacute Organ Transplant
Rejection
1 Hurler
1 HER2/Neu Oncogene
1 Factitious Disorder
1 Fabry
1 E6 & E7 Oncogenes
1 Dependent Personality
1 Buspirone
1 Bulimia Nervosa
1 BRCA 1 & 2 Tumor Suppressor
1 Blinding & Placebo
1 B & T Cell Development
1 Avoidant Personality
2 rb Tumor Suppressor 1 Antidepressant Indications
2 Statistical Power 1 Antibody Structure
2 Pleiotropy 1 Anorexia Nervosa
2 Number Needed to Treat/Harm 1 Absolute Risk Reduction and
2 MYC Oncogene Attributable Risk
2 MPO Deficiency
2 Mood Stabilizer Indications
2 McCardles Disease
2 Incomplete Penetrance
2 IgA Deficiency
2 Hallucinogen Abuse
2 Generalized Anxiety Disorder
2 Gaucher Disease
2 Galactose Disorder
2 Fructose Disorder
2 Ehlers Danlos