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Mallory bodies. Hyaline (eosinophilic) inclusions (arrow)

are present in the cytosol of hepatocytes.
.

A and B, Right-sided Bell's palsy showing inability to

fully close the eye and drooping of the corner of the
.
mouth

Acid-fast stain of a lung biopsy in a patient with

reactivation tuberculosis due to Mycobacterium
.
tuberculosis

Acoustic neuroma showing spindle-shaped cells with

alternating dark and light areas
.

Bronchopneumonia showing patchy areas of

consolidation
.

Cerebellum in a patient with rabies showing Purkinje

cells with intracytoplasmic, eosinophilic inclusions
(arrows) called Negri bodies
.
 Common systemic fungal infections. The yeast form of
Cryptococcus neoformans (A) produces a narrow-
based bud (arrow). Coccidioides immitis (B) has
.
spherules containing endospores (arrows).
Multinucleated giant cells

Dependent pitting edema showing depressions in the

skin around the ankle. Pitting edema is due to an
increase in vascular hydrostatic pressure or a decrease
.
in vascular oncotic pressure (hypoalbuminemia)

Dermatographism
.

Diffuse membranous glomerulonephritis. The H[amp ]E

(hematoxylin [amp ] eosin)-stained biopsy (A) shows
glomerular basement membranes that are uniformly
thickened. There is no proliferative component. The
. silver stain

Diffuse type of gastric adenocarcinoma with signet-ring

carcinoma cells (arrows)
.

Electron micrograph of a type II pneumocyte showing

lamellar body (arrow) containing surfactant
.

Embryonated eggs of Enterobius vermicularis

.
 Metastatic renal cell carcinoma showing multiple
nodular lesions scattered throughout the lung
parenchyma
.

Fibroadenoma
.

Mallory bodies. Hyaline (eosinophilic) inclusions (arrow)

are present in the cytosol of hepatocytes
.

Fatty change of the liver

.

Hydronephrosis of the kidney. There is marked dilation

of the renal pelvis and calyces with thinning of the
overlying cortex and medulla due to compression
.
atrophy

. Left ventricular hypertrophy

.Benign prostatic hyperplasia

.
 Intestinal metaplasia of the gastric mucosal epithelium
in chronic gastritis
.

Squamous dysplasia of the cervix, a precursor of

squamous cell carcinoma..jpg
.

Acute myocardial infarction (MI) showing coagulation

necrosis.
.

Acute myocardial infarction (MI) showing a pale

infarction of the posterior wall of the left ventricle
. (bottom left)

Hemorrhagic infarction of the lung. There is a roughly

wedge-shaped area of hemorrhage.jpg
.

Dry gangrene of the toes

.

Cerebral infarction showing liquefactive necrosis

.
 Caseous granuloma showing a central area of acellular,
necrotic material surrounded by activated macrophages
(epithelioid cells), lymphocytes, and multiple
. multinucleated Langhans-type giant cells

Enzymatic fat necrosis in acute pancreatitis

.

Apoptosis in the epidermis. The arrow shows a clear

space in the epidermis containing an intensely
eosinophilic staining cell with a small, dense nucleus.
.

Signs of acute inflammation. The patient has erysipelas

of the face due to group A streptococcus. Signs of
acute inflammation that are present in the photograph
.
include redness (rubor) and swelling (tumor)

Acute inflammation. Histologic section of lung in

bronchopneumonia showing sheets of neutrophils with
.
multilobed nuclei.

Purulent (suppurative) inflammation. The photograph

shows a skin abscess (furuncle) due to Staphylococcus
aureus. Abscesses are pus-filled nodules located in the
.
dermis.

Fibrinous inflammation. The epicardial surface of the

heart is covered by a shaggy layer of fibrin material
.
 Pseudomembranous inflammation. There is necrosis
and a yellow-colored exudate covering the mucosal
surface of the colon due to a toxin produced by
. Clostridium difficile.

Chronic inflammation. This tissue shows an infiltrate of

predominantly plasma cells (cells with eccentric
.
nucleus and perinuclear clearing) and lymphocytes

Ehlers-Danlos syndrome
.

Keloid formation
.

Absolute leukocytosis with left shift. Arrows point to

band (stab) neutrophils, which exhibit prominence of
the azurophilic granules (toxic granulation). Vacuoles in
.
the cytoplasm represent phagolysosomes

Malar rash in systemic lupus erythematosus showing

the butterfly-wing distribution
.

Systemic sclerosis. The tightening of the skin around

the mouth is caused by excess collagen.
.
 Kaposi's sarcoma in HIV. Skin lesions are raised, red,
and nonpruritic
.

Patient with signs of volume the mucosal surface of the

tongue is dry. Additional findings on examination were
hypotension, tachycardia, and decreased skin turgor.
.
(From Forbes C, depletion

Electrocardiogram showing hyperkalemia. Arrows show

peaked T waves, which are a sign of hyperkalemia.
.

Coronary artery thrombosis. In this specially stained

cross-section of a coronary artery, collagen is blue and
the thrombus is red
.

Pulmonary embolus. The main branches of the

pulmonary artery are occluded with large-caliber
.
thromboemboli (saddle emboli)

Down syndrome. The facial profile (A) shows a short

stature, small head with small nose and ears. The hand
(B) shows a single palmar (simian) crease
.

Turner's syndrome is characterized by a webbed neck

.
 Klinefelter's syndrome

Prader-Willi syndrome

Angelman syndrome

Testicular feminization. The patient is genotypically

male, but phenotypically female
.

Black widow spider

.

Brown recluse spider

Kwashiorkor and marasmus. Left, Child with

kwashiorkor, showing dependent pitting edema
involving the lower legs. Right, Child with marasmus,
showing broomstick extremities with loss of muscle
. mass and sub
 Anorexia nervosa

Gums showing the effects of scurvy

.

Tubular adenoma (adenomatous polyp) of the colon

showing a fibrovascular stalk
.

Lipoma showing a well-circumscribed yellow tumor (A)

containing benign adipose cells (B)
.

Cystic teratoma of the ovary,

.Figure 8-4 Squamous cell carcinoma. The many well-

differentiated foci of eosinophilic-staining neoplastic
.
cells produce keratin in layers (keratin pearls)..jpg

Adenocarcinoma. Irregular glands infiltrate the stroma

.
 Osteogenic sarcoma of the distal femur. The light-
colored mass of tumor in the metaphysis abuts the
epiphyseal plate (arrow)
.

Metastasis to the liver. The liver contains multiple

nodules that have a depressed central area
. (umbilicated)

Basal cell carcinoma (invasive tumor that does not

metastasize)
.

Malignant melanoma. The lesion on the patient's

forearm is black, is multinodular, and has an irregular
border with areas of pale-gray discoloration
.

Xanthelasma. Yellow, raised lesions are noted on the

eyelids in both eyes
.

Hyaline arteriolosclerosis
.

Abdominal aortic aneurysm

.
 Henoch-Schnlein purpura
.

Acute myocardial infarction (day 7) in the posterior wall

of the left ventricle
.

Fibrinous pericarditis. The surface of the heart is

covered by a shaggy, fibrinous exudate
.

Left ventricular aneurysm. The bulging aneurysm has a

thin wall of scar tissue
.

Acute rheumatic fever. Uniform, verrucoid-appearing

sterile vegetations appear along the line of closure of
.
the mitral valve

Mitral valve prolapse. The arrow shows prolapse of the

posterior mitral leaflet into the left atrium
.

Aortic stenosis
.
 Acute bacterial endocarditis
.

Myocarditis. The biopsy shows a lymphocytic infiltrate

with dissolution of myocardial fibers
.

Peripheral blood reticulocytes with supravital stain (new

methylene blueView drug information). Red blood cells
with thread-like material in the cytosol represent
.
residual RNA filaments and protein (arrow

Peripheral blood smear in iron deficiency anemia. The

enlarged central area of pallor in the red blood cell
(arrow) indicates a decrease in hemoglobin synthesis,
.

Ringed sideroblasts in a bone marrow aspirate. Dark

blue iron granules around the nucleus of developing
normoblasts (arrows) represent iron trapped within
. mitochondria and indicate a defect in mitochondri

Peripheral blood with coarse basophilic stippling of

RBCs in lead poisoning. Note the mature RBC
containing numerous dots representing ribosomes
. (arrow)

Peripheral blood in megaloblastic anemia showing the

hypersegmented neutrophil (arrow) with nine lobes
.
 Peripheral blood with spherocytes in hereditary
spherocytosis. Numerous, round, dense red blood cells
(RBCs) without central areas of pallor represent
.
spherocytes (arrows). The mean corpuscular
hemoglobi

Peripheral blood with sickle cells and target cells,

showing the dense, boat-shaped sickle cells. Cells with
a bull's-eye appearance are target cells (arrows), which
. have excess RBC membrane that bulges

Peripheral blood with sickle cells and Howell-Jolly

bodies. The three dense boat-shaped sickle cells and
the two cells containing a single dark, round inclusion
. (arrows) represent nuclear remnants. Howel

Peripheral blood with schistocytes. The fragmented red

blood cells (RBCs) with absence of central pallor,
schistocytes, are produced when RBCs are
mechanically injured by calcium deposits in an aortic
.
valve

Plasmodium falciparum ring forms in red blood cells

(RBCs). This RBC has two ring forms. Multiple
infestation of an RBC is characteristic of P. falciparum
. malaria

Leukoerythroblastic reaction. Numerous bone marrow

reticulocytes with a blue discoloration
.

Peripheral blood with atypical lymphocyte. The cell

shows prominent nucleoli and coarse nuclear
chromatin. The cytoplasm is abundant and is indented
.
by adjacent red blood cells
 Peripheral blood in chronic myelogenous leukemia.
Marked leukocytosis shows neutrophils at different
stages of development (segmented and band
. neutrophils, metamyelocytes and myelocytes)

Peripheral blood with promyelocyte filled with Auer rods

in acute promyelocytic leukemia
.

Peripheral blood in chronic lymphocytic leukemia

Gaucher disease
.

Niemann-Pick disease
.

Senile purpura
.

Laryngeal squamous cell carcinoma

.
 Asbestos body
.

Malignant mesothelioma

Sarcoid granuloma
.

Chest radiograph in emphysema

Primary lung cancer

Small cell carcinoma of the lung

.

Oral thrush
.
 Hairy leukoplakia along the lateral.

Leukoplakia of the tongue

.Barrett's esophagus
.

. Esophageal varices

. Gastric adenocarcinoma
.

.Entamoeba histolytica trophozoites

.

. Celiac disease
.
 .Dermatitis herpetiformis
.

Hemorrhagic infarction
.

. Meckel diverticulum
.

. Sigmoid diverticulosis

. Ulcerative colitis.
.

. Crohn's disease
.

Tubular adenoma
.
 . Familial polyposis
.

. Acute appendicitis

. Centrilobular hemorrhagic necrosis

Alcoholic cirrhosis
.

. Spider angioma (telangiectasia)

.

.Kayser-Fleischer ring.
.

.Hepatocellular carcinoma
.
 . Yellow cholesterol stones
.

.Black pigmented stones

.

. Adult polycystic kidney disease

.

Normal glomerulus
.

.Subepithelial immunocomplex
.

.Red blood cell cast in the urine

. Crescentic glomerulonephritis
.
 . Fatty cast under polarization
.

. Diabetic glomerulosclerosis
.

.Acute pyelonephritis.
.

.Waxy cast in the urine sediment

.

. Benign nephrosclerosis

.Renal cell carcinoma

.

Benign prostatic hyperplasia

.
 .Prostate cancer. Arrow
.

A, Candida.
B, Chlamydia trachomatis. C, Gardnerella vaginalis. D,
Herpes type
E, Herpes type 2.
. F, Human papillomavirus.

G, Neisseria gonorrhoeae.
H, Treponema pallidum.
I, Treponema pallidum.
. J, Trichomonas vaginalis.

.Extramammary Paget's disease

.

.Squamous cell carcinoma of cervix

.

.Polycystic ovarian syndrome

.

.Simple hyperplasia of endometria.jpg

.
 . Endometrial carcinoma
.

.Leiomyomas.
.

. Ruptured ectopic tubal pregnancy

.

.Complete hydatidiform mole

.

.Ductal carcinoma in situ (DCIS)

.

.Lobular carcinoma in situ

.

.Infiltrating ductal carcinoma.

.
 .Paget's disease of the breast
.

.Acromegaly showing the patient

.

. Primary hypothyroidism

Graves' disease

Papillary carcinoma of thyroid.

.Patient with Cushing syndrome

.Osteoporosis of vertebral column

.
 .Rheumatoid arthritis
.

.Tophi (arrows)
.

.Erythema chronicum migrans

.

.Verruca vulgaris (common wart)

.

.Molluscum contagiosum
.

.Erythema infectiosum

.Varicella infection of skin

.
 Impetigo of the face

. Patient with severe facial acne

.

.Acne rosacea
.

. Tinea versicolor.
.

. Lymphocutaneous sporotrichosis

.Contact dermatitis.

.Actinic (solar) keratosis

.
 Lichen planus showing flat-topped
.

.Psoriasis involving the elbow

.Nail changes in psoriasis

.

. Pityriasis rosea
.

. Erythema multiforme
.

. Erythema nodosum
.

. Granuloma annulare.
.
 . Acanthosis nigricans

.Solar lentigo
.

. Seborrheic keratosis on the breast

. Compound nevus
.

.Lentigo maligna melanoma

.Anencephaly

. Neurofibromatosis
.
 .Epidural hematoma
.

.Subdural hematoma
.

.Atherosclerotic stroke.

.Embolic stroke
.

. Intracerebral hemorrhage
.

.Bacterial meningitis

. Cerebral abscess

.
 .Fusion of the podocytes. Arrowheads show fusion of
the podocytes, which should be separated by slit pores.
This finding occurs in all glomerular diseases that
present with the nephrotic syndrome (e.g., minimal
. change

.Gram stain of Streptococcus pneumoniae. The sputum

stain shows numerous lancet-shaped diplococci
.

.Granular immunofluorescence. Granular irregular

deposits in the capillaries are caused by
immunocomplex deposition (e.g., poststreptococcal
. glomerulonephritis

. brain of a newborn with kernicterus. Arrows depict

yellow bilirubin pigment deposited in the basal ganglia
.

.Herpes zoster
.

.Huntington disease. Coronal section (A) shows a

dilated lateral ventricle and atrophy of the caudate,
putamen, and globus pallidus when compared with a
. normal coronal section (B)

.If the crystal is blue when parallel to the slow ray, the
crystal demonstrates positive birefringence.
.
 .Normal peripheral blood smear showing RBCs. The
RBCs are uniform in size, and the central areas of
pallor are slightly less than half the total diameter of an
.
RBC. The four dark objects (arrows) outside

. Giardia lamblia with two nuclei

.

. Man with ankylosing spondylitis

.Keratoacanthoma

classic Reed-Sternberg (RS) cell. The large, multilobed

cell with prominent nucleoli is surrounded by a halo of
clear nucleoplasm. Classic RS cells are more easily
. found in mixed-cellularity Hodgkin's lymphoma

.Linear immunofluorescence. The uninterrupted smooth

immunofluorescence along the glomerular basement
membrane is caused by deposition of IgG antibodies
directed against the membrane (e.g., Goodpasture
.
syndrome)

.Liver biopsy stained with Prussian blue in a patient

with hereditary hemochromatosis
.
 .Lung biopsy stained with Gomori methenamine-silver
showing septated hyphae and fruiting body (inset) of
. Aspergillus fumigatus

.Malignant plasma cells in multiple myeloma. The

majority of malignant plasma cells show a gray-blue
cytoplasm, peripherally located nuclei, and perinuclear
. clearing

.Multiple sclerosis showing multiple areas of

demyelinated white matter (arrows pointing to brown
plaques)
.

analgesic nephropathy showing multiple brownish

necrotic papillae (arrows)
.

.Neonatal respiratory distress syndrome

.

.Neurocysticercosis showing multiple cysts between the

gray and white matter
.

.Optic disk with papilledema showing loss of the disk

margin and hard exudates (white streaks
.
 .Osteoarthritis. Bony protuberances (Heberden's
nodes)
.

.Patient with myasthenia gravis showing ptosis of the

left eye (A) followed by opening of the eye (B) after
intravenous injection of Tensilon.
.

.Petechiae in idiopathic thrombocytopenic purpura

showing pinpoint hemorrhages, a sign of platelet
. dysfunction

.Pneumocystis jiroveci pneumonia. This silver-

impregnated cytologic smear
.

.Poststreptococcal diffuse proliferative

glomerulonephritis
.

.Potassium hydroxide preparation of skin scrapings

showing hyphae and yeasts
.

.Prostate cancer metastatic to the vertebral column.

Multiple white foci of metastatic prostate cancer
produce an osteoblastic response in the bone.
.
 .Radiograph of a skull showing multiple punched out
lytic lesions in multiple myeloma
.

.Radiograph showing small bowel obstruction.

.Saddle embolus occluding the main branches of the

pulmonary artery
.

.Senile plaque (arrow) shows an eosinophilic center

with peripherally located distended neuronal processes
.
(neurites).

.Silver stain showing Helicobacter pylori organisms.

.Spongiform encephalopathy in Creutzfeldt-Jakob

disease showing classic bubbles and holes of the
.
neuropil cell bodies

.Subendothelial immunocomplex deposits viewed with

electron microscopy.
.
 .Substantia nigra in a patient with Parkinson disease
. (A) and a normal individual (B)

.Tinea capitis due to Trichophyton tonsurans

.

.Tinea corporis showing annular lesions with

erythematous margins and clear centers
.

.subnuclear vacuoles (arrows) containing mucin push

the nuclei of the endometrial cells toward the apex of
the cell
.

Wernicke's encephalopathy showing hemorrhage and

discoloration of mamillary bodies and the wall of the
third ventricle
.

Wilson's disease showing cavitary necrosis of the

putamen on both sides of the brain
.

cytomegalovirus. The enlarged nuclei of many of the

type I pneumocytes contain large inclusions
.