Professional Documents
Culture Documents
Summary
Challenges in Preservation
Manufacturing processes
Parabens
Formaldehyde releasers
Isothiazolinones
Quaternary ammonium
Trichlosan
Parabens Chlorxylenol
Formaldehyde Releasers
Imidazolidinyl urea
DMDM Hydantoin Diazolidinyl urea
Isothiazolinones
Chlorhexidine
Organic Acids
Sorbic acid
IPBC
Trichlosan
Phenoxy ethanol
Parabens & Formaldehyde
Releasers
Parabens are implicated in disrupting endocrine
system, ultimately linked to breast cancer [(Pharmacology
& Toxicology (Vol. 86(3), pp 110-13, March 2000, Toxicology
and Applied Pharmacology (Vol. 153(1), pp. 12-19 (Nov. 1998),
Journal of Veterinary Medical Science (Vol. 64(3), pp227-35
(March 2002, Journal of Applied Toxicology, 24 (3): 167-176, (2004)]
CAS No 122-99-6
Occurs in nature (Green Tea)
Used as antiseptic in olden time
Preferred antimicrobial for preserving vaccines
Broad spectrum activity, more active against Gram -ve bacteria
Non-controversial, most widely used (produced), safe, popular with leave-on
Cosmetic and Drug Preservation, Principles and Practice, Vol I, Ed Jon Kabara,
Marcel Dekker
N-Capryloyl glycine
CAS No 14246-53-8
N-octanoyl glycine
CAS No 54301-26-7
Undecylenoyl amino acids for the
treatment of skin disorders
JP 49093521 (1974)
Thermodynamically stable
Chemical instability addressed
Delivery of other antimicrobials into microbes body
Microemulsion : nano-structure and easy fusion with the lipids of cell membrane
and delivering the surfactants to disrupt the membrane
Peptide type surfactants (lipidated glycines) are good at breaching the cell
membrane
James Baker and team , Microbiol. Res. 2001, 156, 1 (Univ of Michigan)
Kyle Vanderelick, Langmuir, 2003, 19, 591(Princeton Univ)
HPLC analysis of Galguard Trident
N-Undecylenoyl glycine: NMR
Antimicrobial Efficacy
of
Galguard Trident
Galguard Trident MICs