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An Integrative Review
Melissa Alfaro
On my honor, I have neither given nor received aid on this assignment, and I pledge that I am in
Abstract
The purpose of this integrative review is to assess the literature concerning the effectiveness of
posttraumatic stress disorder and comorbid symptoms in the pediatric population. Posttraumatic
stress disorder and depression following traumatic events can lead to maladaptive behaviors in
youth; prompt and time-effective treatment is necessary in order to mitigate the illness. Trauma-
focused cognitive behavioral therapy, augmented from usual cognitive behavioral therapy by
direct addressment trauma symptoms, may reduce the morbidity of the illnesses. The following
research follows an integrative review design. Literature was collected using the online
databases, PubMed, EBSCO Discover, and psycNET. The search yielded 563 research articles. 5
met inclusion criteria. The findings analysis demonstrated inconclusive results pertaining to the
use of trauma-focused cognitive behavioral therapy for traumatized youth with PTSD. All
studies were effective in reducing posttraumatic stress symptoms; however, some were not
superior to the control group in doing so. Research limitations include the lack of research in the
past 5 years and a lack of experience on behalf of the researcher. Additional limitations include
the discrepancies in the delivery of trauma-focused cognitive behavioral therapy; time allotted
for treatment; the involvement of the caregiver in therapy; and inclusion of articles that may
contain bias. Implications for practice cannot be deduced from the integrative review due to the
inconsistencies across the research findings. There is an indication for future research that would
An Integrative Review
The purpose of this integrative review is to appraise literature pertaining to the use of
with posttraumatic stress disorder (PTSD). Cognitive behavioral therapy (CBT) has been used
with great remission rate with depressed children and adolescents; however, the history of
trauma in the adolescent tends to convolute the success of CBT (Shirk, DePrince, Cristostomo, &
Labus, 2013). Although children may create coping mechanisms in order to foster a sense of
normalcy, those coping mechanisms may lend themselves to unhealthy patterns, giving rise to
anxiety and depression (Konanur, Muller, Cinamon, Thornback & Zorzella, 2015). The aim of
this integrative review is to explore the literature pertaining to the researchers PICOT question:
In the pediatric population diagnosed with posttraumatic stress disorder (PTSD), what is the
effect of TF-CBT versus control in reducing PTSD and comorbid anxiety and depression? While
research is abundant in regards to the implementation of CBT for youth with posttraumatic
symptoms, there is limited evidence on TF-CBT that works specifically to address the trauma.
The researchers personal experience sparked interest in this topic; as a victim of intimate abuse
and violence, regular course of CBT was not effective for her.
This integrative review focuses on five research articles. Three databases, PubMed,
EBSCO Discover, and psycNET, were used to search for articles. The terms included PTSD,
children, adolescents, trauma, and CBT. The research yielded 107 results from PubMed,
326 results from EBSCOhost and 130 articles from psycNET. To obtain recent articles, the
search was limited from 2011 to 2016. Filters were used to narrow down the articles to peer-
reviewed quantitative and qualitative nursing research articles in English, published in academic
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journals with full text. It was imperative that the articles pertained to the researchers PICO
question, In the pediatric population diagnosed with posttraumatic stress disorder (PTSD), what
is the effect of TF-CBT versus control in reducing PTSD and comorbid anxiety and depression?
The articles were then selected based on the following inclusion criteria: TF-CBT, and
examination of anxiety and depression. The research articles were screen based on inclusion
criteria and PICO question significance. Articles that did not meet the criteria were excluded
from the review. The screening produced 5 TF-CBT articles, all of which were quantitative.
Findings/Results
The results and findings of the research showed mixed results; 3 of the 5 articles
demonstrated a greater reduction in signs and symptoms of PTSD and associated comorbidities
compared to the controls (Jensen et al., 2014; Goldbeck et al., 2016; Konanur et al., 2015). Two
articles (Nixon et al., 2012; Shirk et al., 2014) did not, as TF-CBT did not outperform the
controls in that population in reducing symptoms of PTSD and comorbidities. A summary of the
research articles are in Table 1. This review is structured around the following themes in order to
categorize findings: use of TF-CBT as an intervention; differing dependent variables used for
TF-CBT Interventions
Among all 5 studies, there was a consensus that the use of TF-CBT was effective in
reducing symptoms of PTSD (Jensen et al., 2014; Goldbeck et al., 2016; Konanur et al., 2015;
Nixon et al., 2012; Shirk et al., 2014). However, 2 of the studies did not outperform the control
group (Nixon et al., 2012, Shirk et al., 2014). In the quantitative study conducted by Konanur et
al. (2015), researchers examined the PTSD status outcomes of a randomized, controlled trial
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involving the use of TF-CBT versus a waitlist among 6 to 12-year-old Canadian children.
Employing a convenience sampling method, 113 children recruited from mental health clinics in
Canada were randomly assigned to a non-waitlist or waitlist (WL) condition. The non-waitlist
group completed a pre-waitlist data collection then immediately started receiving TF-CBT
treatment, whereas the waitlist group completed pre-waitlist collection data, waited three months,
then started TF-CBT treatment. For both WL and TF-CBT groups, data was collected pre-
therapy, post-therapy and six months following therapy using the Trauma Symptom Checklist for
Children or Trauma Symptom Checklist for Young Children. Data was analyzed with T scores
using raw scores obtained from child and caregiver reports of childrens PTS. A linear, mixed
model one-way ANOVA was used for repeated measures for statistical analyses. Significant
decreases in childrens PTS from pre-assessment to the six-month follow up were indicated in
the TF-CBT group versus WL condition. There was also a reduction in childrens and
caregivers report of associated arousal symptoms and intrusion symptoms. The effectiveness of
the study and statistical significant decrease in clinical variables among school-age children
terms of reducing posttraumatic stress syndromes (PTSS) assessed at 4 months. Also, additional
hypotheses sought to explore the following outcomes: remission of PTSD diagnosis, remission
reported and caregiver reported PTSS, posttraumatic cognitions, general behavioral and
emotional symptoms, symptoms of anxiety and depression, and improvement of quality of life.
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Utilizing convenience sampling, 159 children and adolescents between the ages of 7-17 years old
who were symptomatic of PTSD per the Clinician-Administered PTSD Scale for Children and
received no treatment. Data was collected at baseline, 2 months and 4 months for both groups.
Data analysis was performed using raw data from the database and imported into the Statistical
Package for the Social Sciences, version 21 for Windows. The primary hypothesis was tested by
were also performed by ANOVAs. Significant data was found in the number of youth receiving
treatment who had fulfilled the diagnostic criteria of PTSD at baseline who were no longer
diagnosed as having PTSD. Furthermore, there was a significant number of patients among the
treatment group who no longer filled the criteria for any comorbid mental disorder after 4
months. The significant data found in this study contributes to the body of literature.
The experimental trial conducted by Jensen et al. (2014) sought to evaluate whether TF-
CBT was superior to therapy as usual (TAU) in eight community clinics in Norway. Using
convenience sampling, 156 youth in between the ages of 10 and 18 were randomized to either
TF-CBT or TAU. Data collection occurred at baseline, mid-treatment after the 6th session, and
post-treatment after 15 sessions. Data collection included the measurement of PTSS using
CAPS-CA and Child Posttraumatic Symptom Scale (CPSS). Secondary outcomes were
measured using a battery of tests, assessing comorbid disorders, anxiety and depression. Data
analysis was performed using a mixed effects model on each of the outcome measures and
utilized the statistics program R and SPSS version 17. The study demonstrated a significant
decrease in PTSS values and depressive symptoms in the TF-CBT group than those in TAU
group. All groups showed significant reductions in PTSS between pre- and post-therapy
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assessments. There was no significant effect of treatment condition on child anxiety symptoms
in either group. In terms of diagnostic remission, significantly more participants in the TF-CBT
group lost their PTSD diagnosis. The significant data found in this article contributes to the
body of literature.
The randomized control trial conducted by Shirk et al. (2014) studied the initial
feasibility, acceptability, and treatment impact of modified CBT (m-CBT). The m-CBT was the
core CBT therapy augmented with mindfulness exercises targeted directly at trauma-related
emotions and cognitions. Adolescents were referred for outpatient treatment at a large mental
health center in the Rocky Mountains. The study followed 43 adolescents between the ages of
13 and 17. The m-CBT was a 12-session, manual-guided individual weekly therapy for
adolescents with a diagnosis of PTSD and a history of at least one interpersonal trauma. Data
was collected at sessions 1, 4, 8, 12 and at post-treatment at 16 weeks and for the primary
outcome, included Beck Depression Inventory II (BDI-II) scores. A battery of tests was used for
the secondary outcomes of feasibility and acceptability. Data analyses included assessing for
differences using t-tests for continuous variables and chi-squared for categorical variables. A
repeated measures linear mixed-effects model was applied to all outcomes. Results indicated
that results from both CBT and m-CBT indicated a significant reduction in PTSS and depressive
symptoms, though m-CBT did not outperform CBT. Diagnostic statuses did not differ between
groups. The contrasting outcome of this study drives the need for amelioration of research in this
The experimental study by Nixon et al. (2012) examined the outcomes of a randomized,
controlled trial involving TF-CBT versus trauma focused cognitive therapy (CT) in the reduction
of PTSD in child following single-incident trauma. The researchers were also interested in the
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effects of caregiver pretreatment levels of PTS, unhelpful posttraumatic beliefs, and depression.
Using convenience sampling, 34 child and adolescent victims were referred from mental health
clinics, hospital and police in Australia. Children and adolescents were randomized to either TF-
CBT or CT. TF-CBT comprised of 9 sessions, pretreatment, posttreatment and a 6-month follow-
up; and included CAPS-CA as the measurement of the primary outcome. Secondary outcomes
were measured using participants self-reports of: The Child PTSD Symptom Scale (CPSS), the
(CPTCI), and the Revised Childrens Manifest Anxiety Scale (RCMAS). Mothers rated their
children on the Child Behavior Check List (CBCL), and rated their own responses to their childs
trauma using the Posttraumatic Stress Diagnostic Scale (PDS), Post-Traumatic Cognitions
Inventory (PTCI), and the BDI-II. Repeated measures ANOVAs were used to determine
symptom change. X2 or Fisher exact test was used to determine differences in diagnosis, in
conjunction with Reliable Change Index (RCI), used to assess good end-state functioning.
Significant decreases in PTSD symptoms, associated trauma cognitions, and general anxiety
were reduced across both groups. Mothers of both groups reported significant reductions of their
own PTSD and depressive symptoms. Both youth across the two groups showed a significant
remission in their status of PTSD. The findings connote a need for further development in the
All five of the research studies utilized quantitative variables to measure the effectiveness
of TF-CBT and compared the results with the control group (Jensen et al., 2014; Goldbeck et al.,
2016; Konanur et al., 2015; Nixon et al., 2012; Shirk et al., 2014). Albeit the tools chosen are
effective at measuring the intended variable, the consistency of measurements for every primary
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and secondary outcome is not the same tool. Thus, is difficult to extrapolate the true impact of
TF-CBT on PTSD and comorbidities. BDI-II was used for the primary outcome of reduction of
PTSD symptoms in the study conducted by Shirk et al. (2014). BDI-II was used as a
measurement in the secondary outcome of maternal PTSD of the child victimized (Nixon et al.,
2012).
Two of the studies used CAPS-CA and CPSS as a measurement of PTSD (Jensen et al.,
2014; Nixon et al., 2012); Goldbeck et al. (2016) only used CAPS-CA to measure PTSD. For
the primary outcome of PTSD symptoms, Konanur et al. (2015) used Trauma Symptom
Checklist for Children (TSCC) to measure trauma-related symptoms among children 8-16.
Trauma Symptom Checklist for Young Children (TSCYC) was used for caregivers to report the
involvement and therapeutic treatment in conjunction with the child victim as part of the TF-
CBT protocol (Goldbeck et al., 2016; Jensen et al., 2014; Konanur et al., 2015; Nixon et al.,
2011). The differing variables highlight the need for consistency throughout the research.
Across the studies, there was not one definitive amount of time allotted for amount of
sessions, nor was there a consensus on the definition of TF-CBT. All 5 studies explored the
benefit of addressing the trauma, which is the cornerstone of TF-CBT (Jensen et al., 2014;
Goldbeck et al., 2016; Konanur et al., 2015; Nixon et al., 2012; Shirk et al., 2014). The
execution of the core idea deviates among the studies. Shirk et al. (2014) enhanced CBT with
mindfulness techniques and targeting trauma-related beliefs over 12 individual therapy sessions,
and each session was not time limited. For 4 of the other studies, TF-CBT focused on
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narrative, cognitive errors and restructuring, and involved the caregiver or the parents to varying
degrees; the parents received parenting skills aimed at managing the childs illness (Jensen et al.,
2014; Goldbeck et al., 2016; Konanur et al., 2015; Nixon et al., 2012). In the study conducted by
Nixon et al. (2012), children received one and-a-half hour weekly sessions provided over nine
weeks, with two thirds of the session time dedicated to the children and the rest of the time
dedicated to the parents. TF-CBT sessions provided by Jensen et al. (2014) included 12 to 15
sessions, with sessions offered to the child and parent in either parallel and co-joint sessions.
Konanur et al. (2015) provided weekly therapy sessions that consisted of 45 minutes allotted to
the child and 45 minutes allotted to the caregivers. In the study conducted by Goldbeck et al.
(2016), 12 weekly 90-minute parallel or co-joint therapy sessions with the caregiver were spread
over 4 months.
Discussion/Implications
The findings of the integrative review address the effects of TF-CBT versus control
groups and the efficacy of reducing PTSD and comorbid disorders in the pediatric population.
Therefore, all the articles directly relate to the researchers PICOT question which asks about the
effect of TF-CBT versus control in reducing PTSD and comorbid anxiety and depression in the
pediatric population diagnosed with PTSD. Among all 5 studies, there was a consensus that the
use of TF-CBT was effective in reducing symptoms of PTSD (Jensen et al., 2014; Goldbeck et
al., 2016; Konanur et al., 2015; Nixon et al., 2012; Shirk et al., 2014). However, 2 of the studies
did not outperform the control group (Shirk et al., 2014; Nixon et al., 2012). Implications for
practice are difficult to extract from the evidence due to the inability to deem it superior to
controls. Furthermore, the existing literature does not agree on the definition of trauma-focused
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cognitive behavioral therapy. In order to demonstrate the true efficacy of TF-CBT, further
research is needed. Follow-up research necessitates the need for an absolute definition of TF-
CBT, and utilization of the same tools used consistently across trials for the same variables.
Limitations
Many limitations were imposed in regard to this integrative review. The topic is not
heavily researched, including only five articles within the past five years, so it is not an
exhaustive examination. Also, the researcher does not have adequate experience in completing
Because of the scant amount of literature on the topic, and a discord in the measurements
of the variables amongst the articles, the extraction of results is difficult to compare. Because of
the nature of the sampling method in all of the studies, all the studies included are prone to bias
(Coughlan et al., 2007, Jensen et al., 2014; Goldbeck et al., 2016; Konanur et al., 2015; Nixon et
al., 2012; Shirk et al., 2014). Also, 4 of the studies fail to explicitly mention the theoretical
framework (Jensen et al., 2014; Goldbeck et al., 2016; Konanur et al., 2015; Nixon et al., 2012).
Without a theoretical framework, a study is prone to a weak study design (Coughlan et al., 2007).
Conclusions
Findings from this integrative review are inconclusive. Three studies demonstrate the
significance of TF-CBT over controls in the reduction of PTSD and comorbidities (Jensen et al.,
2014; Goldbeck et al., 2016; Konanur et al., 2015); Two studies of TF-CBT do not outperform
the control groups (Nixon et al., 2012; Shirk et al., 201). Overall, it cannot be concluded if TF-
CBT is more effective than controls at reducing the symptoms of PTSD and anxiety and
depression in youth.
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References
Coughlan, M., Cronin, P., & Ryan, F. (2007). Step-by-step guide to critiquing research. Part 1:
10.12968/bjon.2007.16.11.23681
Goldbeck, L., Muche, R., Sachser, C., Tutus, D., & Rosner, R. (2016). Effectiveness of trauma-
focused cognitive behavioral therapy for children and adolescents: A randomized control
trial in eight German mental health clinics. Psychotherapy and Psychosomatics 85(1),
159-170.
Jensen, T.K., Holt, T., Ormhaug, S.M., Egeland, K., Granly, L., Hoaas, L.C., Hukkelberg, S.S.,
Indregard, T., & Shirley, D.S. (2014). A randomized effectiveness study comparing
trauma-focused cognitive behavioral therapy with therapy as usual for youth. Journal of
Konanur, S., Muller, R.T., Cinamon, J.S., Thornback, K., & Zorzella, K.P. (2015). Effectiveness
Nixon, R.D., Sterk, J., & Pearce, A. (2012). A randomized trial of cognitive behavior therapy and
cognitive therapy for children with posttraumatic stress disorder following single-incident
Shirk, S.R., DePrince, A.P., Crisostomo, P.S., & Labus, J. (2013). Cognitive behavioral therapy for
lem Statement symptoms (PTSS). Although trauma-focused treatments are available, many do
not receive the appropriate care.
This study aims to fill the current gaps in the literature and investigate the
effectiveness of TF-CBT in a range of different German child and adolescent
mental health services compared to a waiting-list group.
Conceptual/theor not discussed
etical Framework
Design/Method/P Quantitative Experimental
hilosophical Single blind stratified (by severity of PTSS) parallel-group randomized control
Underpinnings trial
Sample/ Eight German child and adolescent mental health clinics
Setting/Ethical 73 patients receiving TF-CBT; 84 patients allocated to waiting list.
Considerations All the legal guardians of the study participants gave their informed written
consent and the young patients gave their informed written assent.
The study received ethics approval from the IRB at the University of Ulm
Major Variables Experimental Group= Adolescents who received TF-CBT treatment. Outcomes
Studied (and their measured by: Remission of PTSD diagnosis, remission of comorbid mental
definition), if disorders, improvement of psychosocial functioning, reduction of self-reported
appropriate and care-giver reported PTSS, post-traumatic cognitions, general behavioral and
emotional symptoms, symptoms of anxiety and depression, and improvement of
quality of life
patients caregivers.
The patients quality of life was assessed by self-reports and caregiver reports on
the Inventory of Quality of Life for Children (ILK).
Data Analysis Descriptive Statistics frequencies, means, standard deviations, t-tests
Findings/Discussi Study demonstrates the superiority of TF-CBT to WL in terms of remission of
on PTSS and dysfunctional trauma-related cognitions, PTSD diagnoses and a broad
range of comorbid symptoms such as depression, anxiety and other internalizing
and externalizing symptoms.
TF-CBT was superior to WL in improving the patients psychosocial functioning.
Improvement of quality of life was not greater in the intervention group.
Findings showed that TF-CBT was effective independent to age, gender, trauma
type, level of specialization of the therapist, and the therapists individual
experience with the treatment model. Patients age and comorbidity were
significantly associated with treatment response, indicating that younger patients
and patients with fewer comorbid disorders are most susceptible to remission of
PTSS.
Appraisal/Worth TF-CBT improves symptoms of PTSD and comorbidities.
to practice The younger the patient is and the less comorbidities, the greater the outcome.
This experiment involved the parents in the therapy process.
First Author Tine K. Jensen (2014) Jensen is affiliated with the Norwegian Centre for
(Year)/Qualificati Violence and Traumatic Stress Studies and Department of Psychology at the
ons University of Solo, Norway
Background/Prob Traumatic events happen to children over the world. If untreated, it may lead to
lem Statement many mental health problems. There is an increase of anxiety and mood disorders
in those children who have experienced a traumatic event.
There is a gap in research whether TF-CBT is just as effective in community
clinics, in children with multiple trauma, or in comparison with usual care. They
also sought to examine whether TF-CBT is also applicable outside the United
States.
Conceptual/theor Not mentioned in the study
etical Framework
Design/Method/P Quantitative
hilosophical Randomized effectiveness study
Underpinnings
Sample/ 156 boys and girls between the ages of 10 to 18, from 8 community clinics for
Setting/Ethical children and adolescents with trauma-related symptoms in Norway.
Considerations
Study was approved by the Regional Committee for Medical and Health Research
Ethics. Written active consent to participate was provided by both the children and
their parents.
Major Variables TF-CBT versus care as usual
Studied (and their Primary outcome measure: PTSS
definition), if Secondary outcome measures: associated symptoms
appropriate
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Measurement PTSS measured using the CPSS (Self-report questionnaire) and the Clinician
Tool/Data Administered PSTD Scale for Children and Adolescents (CAPS-CA).
Collection Secondary outcomes measured using Mood and Feelings Questionnaire (MFQ);
Method the Screen for Child Anxiety-Related Disorders (SCARED) and the Strengths and
Difficulties Questionnaire (SDQ).
Data Analysis Power analysis; descriptive statistics to investigate the characteristics of the
sample; mixed effects model on the outcome measures; Intention-to-treat (ITT)
models. Statistics program R and SPSS version 17.
Findings/Discussi Youth in both treatment groups showed significant improvement from pre- to post
on therapy in terms of PTSS, depression, and anxiety and general mental health
functioning.
For the group that received TF-CBT the negative impact of PTSS on daily
functioning, depressive symptoms, and general mental health problems scored
significantly lower than those in the TAU group post treatment.
Significantly fewer participants that received TF-CBT met the diagnostic criteria
for full PTSD treatment.
TF-CBT may be more effective in reducing a wide range of symptoms than usual
care.
Appraisal/Worth Because PTSD often co-occurs with other disorders, it is important for clinicians
to practice to consider when treating for PTSD.
First Author Konanur, S. (2015) The author is affiliated with the Department of Psychology,
(Year)/Qualificati Faculty of Health, York University, Canada
ons
Background/Probl Research has documented the negative sequelae of trauma in children.
em Statement The provision of a timely and effective trauma-focused intervention, in this case,
TF-CBT
Conceptual/theore Not mentioned in the article
tical Framework
Design/Method/P Quantitative
hilosophical The researchers hypothesized a reported reduction in PTS following TF-CBT.
Underpinnings
Sample/ 113 children 10 to 12 years old, recruited from different community centers in
Setting/Ethical Canada.
Considerations Ethical considerations not mentioned
Major Variables TF-CBT vs. waiting list (no therapy)
Studied (and their Symptoms of PTS
definition), if Comorbid factors of PTS
appropriate
Appraisal/Worth Long-term efficacy is demonstrated in this study for TF-CBT, showing lasting
to practice reductions in PTSD and correlated symptoms.