SOAL CAMPURAN

Exercices workshop GHS untuk Industri

Tanggal 25 April 2006

Exercise: , Team:
Names:

GHS classification of mixture

Substance name: I Pyridine /II Phenyl Hydrazine /III Epichlorohydrine
93 / 5 / 2 % Mixture
CAS number: I 110-86-1 /II 100-63-0 /III 106-89-8
Molecular formula: I C5H5N /II C6H5NHNH2 /III C3H5OCl
Molecular weight: I 79.1 /II 108.1 /III 92.5

Physical and chemical properties:

Appearance: I colorless to yellow liquid /II colorless to yellow liquid or crystal /III colorless liquid
Melting point: I /II 19.5 /III -25.6 degree C
o
Boiling point: I 240 F ( /II 243.5 /III 117.9 degree C
Specific gravity: I 0.98 /II 1.1 /III 1.18
Flash point: I 68oF (20 oC) /II 190oF (88oC) /III 93oF (33.9oC)
Explosion limit: I /II /III 2.3 34.4 %Vol
Water Solubility: I /II poor /III 6.6 wt%

Classification of Physical & Chemical Hazards

Classification basis:
-->Mixture Category: ___
(Simbol: Signal word: Hazard statement: )

Classification of Health Hazards

1. Acute toxicity
Oral:
I Cat. (ATE 891 mg/kg) /II Cat. (ATE 188 mg/kg) /III Cat. (ATE 90 mg/kg)
93 / 5 / 2 % Mixture
100/ATEmix = ( )+( ) + ( )
ATEmix = mg/kg,
Classification basis: ____ < ATEmix
-->Mixture Category:
(Simbol: Signal word: Hazard statement: )

1
Dermal:
I Cat. (ATE 1121 mg/kg) /II Cat. NP (ATE infinity mg/kg) /III Cat. (ATE 300 mg/kg)
93 / 5 / 2 % Mixture
100/ATEmix = ( ) + ( )+ ( )
ATEmix = mg/kg, Classification basis: < ATEmix
-->Mixture category:
(Simbol: Signal word: Hazard statement: )

Inhalation;
(mg/L) (mg/L) (mg/L)
I Cat. (ATE 4000 ppm) /II Cat. (ATE 2.72 ppm) /III Cat. (ATE 360 ppm)
93 / 5 / 2 % Mixture
100/ATEmix = ( )+( ) +( ) ,
ATEmix = ppm (mg/L), Classification basis: < ATEmix
Mixture category: __
(Simbol: Signal word: Hazard statement: )

2. Skin corrosion/ irritation:

I Cat. 3 /II Cat. 2 /III Cat. 1
93 / 5 / 2 % Mixture
Classification basis: Cat. = %, , Cut-off level =
Mixture category:
(Simbol: Signal word: Hazard statement: )

3. Eye damage/irritation:
I Cat. NC /II Cat. 2 /III Cat. 2
93 / 5 / 2 % Mixture
Classification basis: Cat. = %, Cut-off level =
Mixture category:
(Simbol: Signal word: Hazard statement: )

4. Respiratory/skin sensitization:
Respiratory sensitization:
I Cat. 1 /II Cat. NP /III Cat. NC
93 / 5 / 2 % Mixture
Classification basis: Cat. = %, Cut-off level =
Mixture category:
(Simbol: Signal word: Hazard statement: )

2
Skin sensitization:
I Cat. NC /II Cat. 1 /III Cat. 1
93 / 5 / 2 % Mixture
Classification basis: Cat. = %, Cut-off level =
Mixture category:
(Simbol: Signal word: Hazard statement: )

5. Germ cell mutagenicity:

I Cat. NC /II Cat. 2 /III Cat. 2
93 / 5 / 2 % Mixture
Classification basis: Cat. = __
In almost all in-vitro tests, epichlorohydrin has been found to be positive for gene cell mutagenicity.
In reverse mutation tests using rat typhoid bacillus, the chemical has been found to be positive with or
without the metabolic activation method. It has also been found to be positive in total mutation
assays using yeasts or bacteria, DNA damage tests, sister chromatid exchange (SCE) tests,
DNA excision tests, and mutation tests. Furthermore, the chemical has been found to be positive
in unscheduled DNA synthesis (UDS) tests with rat gastric mucosa and host mediated assays
using mice. 19)
It should be regarded as a chemical substance that may induce heritable mutation in human gene
cell
Cut-off level =
Mixture category: ___
(Simbol: Signal word: Hazard statement: )

6. Carcinogenicity :
I Cat. NC /II Cat. IB /III Cat. IB
93 / 5 / 2 % Mixture
Classification basis: Cat. = %, Cut-off level =
IARC classifies epichlorohydrin in group 2A (probably carcinogenic to humans). 5)
7), 8), 9)
This is primarily based on evidence obtained from animal tests.
Presumably, epichlorohydrin is carcinogenic to humans.
Mixture category: _
(Simbol: Signal word: Hazard statement: )

7. Reproductive toxicity:
I Cat. NC /II Cat. 2 /III Cat. 2
93 / 5 / 2 % Mixture

3
Classification basis: Cat. = %, Cut-off level:

To date, a number of reports have been published concerning epichlorohydrins

reproductive/developmental toxicity. However, adequate evidence has not yet been obtained in
regard to whether or not it affects human reproductive functions/capacity and/or development. 10), 19)
Mixture category:
(Simbol: Signal word: Hazard statement: )

8. Specific target organ/systemic toxicity (Single exposure):

I Cat. NC (target organ: ) /II Cat. 3 (target organ: resp.irritation ) /III Cat. 3 (target
organ: narcotic effects )
93 / 5 / 2 % Mixture
Classification basis: Cat. = %, Cut-off level = %, (target organ : )

Mixture category: ____

(Simbol: Signal word: Hazard statement: )
( )

9. Specific target organ/systemic toxicity (Repeated exposure):

I Cat. NP(target organ: ) /II Cat. 2 (target organ: blood) /III Cat. NP(target organ: )
93 / 5 / 2 % Mixture
Classification basis: Cat. = ___ %, Cut-off level = (target organ: )
Mixture category:
(Simbol: Signal word: Hazard statement: )
( blood)

10. Aspiration hazards:

I Cat. NP /II Cat. NP /III Cat. NP .
93 / 5 / 2 % Mixture
Classification basis: Cat. = %, Cut-off level = %
Mixture category _
(Simbol: Signal word: Hazard statement: )

11. Aquatic environmental hazards:

(1) Acute environmental hazards
Fish acute toxicity:
I Cat. 3(LC50 93.8 mg/l) /II Cat. 1(LC50 0.16 0.25 mg/l) /III Cat. 3(LC50 10.6 mg/l)
93 / 5 / 2 % Mixture

4
 (Additivity method)
(100/LC50mix) = ( )+( ) + ( )
LC50mix = , Classification basis: < LC50mix Cat. acute

(summation method)
I Cat. 3 (M - ) /II Cat. 1 (M 1 ) /III Cat. 3 (M - )
Classification basis: Cat. acute

Crustacea acute toxicity:

I Cat. NC (EC50 180 mg/l) /II Cat. NP (EC50 NA mg/l) /III Cat. 3 (EC50 24 mg/l)
93 / 5 / 2 % Mixture

(Additivity method)
(100/EC50mix) = ( 93/180) + ( 5/ - ) + ( 2 /24 )
EC50mix =
Classification basis: < EC50mix Cat. acute _
(summation method)
I Cat. NC (M 10) /II Cat. NP (M ) /III Cat. 3 (M )
Classification basis: Cat. acute

Algae acute toxicity:

I Cat. 1 (ErC50 .041 mg/l) /II Cat. NC (ErC50 - mg/l) /III Cat. 2 (ErC50 5.4
mg/l)
93 / 5 / 2 % Mixture

(Additivity method)
(100/ErC50mix) = ( 93/0.041 ) + (5/-) + ( 2/5.4)
ErC50mix = , Classification basis: ErC50mix mg/L Cat. Acute _

(summation method)
I Cat. 1 (M 10 ) /II Cat. (M ) /III Cat. (M )
Classification basis: Cat. acute

Acute environmental hazards:

5
 Mixture acute toxicity - Fish: Cat.____
- Crustacea: Cat.____
- Algae: Cat.____

Total Mixture Acute Category:

(Simbol: Signal word: Hazard statement: )

(2) Chronic environmental hazards

Classification basis: Pyridine: Cat.

Phenylhydrazine: Cat. Chronic
Epychlorohydrine: Cat.
Classification basis:

Total Mixture Chronic Category:

(Simbol: Signal word: Hazard statement: )