Electrophysiology

Scisense Electrophysiology
Minimally Invasive Intracardiac Biopotential Measurements
for Rodent Models

Eight electrodes (octopolar) for measuring up to four simultaneous

intracardiac biopotentials
Stimulate and record from the same Catheter
Compatible with most biopotential amplifiers and stimulators

RL-200-fly Rev. C 11/16

Intracardiac Biopotential Measurements
Traditional surface ECG measurements provide total cardiac electrical signal but lack the precision for detailed
signal propagation studies or regional measurements. It is possible to use epicardial surface electrodes to
measure regional electrical potentials; however, it is an invasive procedure. Scisense EP Catheters offer a
minimally invasive means for a more in-depth analysis of biopotential propagation through the heart.

ELECTROPHYSIOLOGY PARAMETERS Principles of Operation

VARIABLE DESCRIPTION Each of the 8 electrodes on a Scisense EP Catheter are
QR-I QR Interval controlled independently by either an Interface Box or
QT-I QT Interval unique Interface Cable. The Interface Box (FI893B) allows
RR-I RR Interval connection to any bioamplifier or stimulator via 2 mm pin
PR-I PR Interval receptacles. This provides the researcher complete control
ST-I ST Interval over which electrodes are used for recording or stimulation
(pacing). In addition, reference pins are provided to achieve an
ERP Effective Refractory Periods
appropriate ground. Alternatively, an Interface Cable can be
QRS QRS, P Widths
used that terminates in 2 mm pins relating to electrodes 1-8:
QTD QT Dispersion this is particularly convenient if the bioamplifier or stimulator
HR Instantaneous Heart Rate has 2 mm pin receptacles (FC-EPPIN8-4). For those researchers
R-H R Wave Height with proprietary connections or a unique interface on their
P-H P Wave Height bioamplifier or stimulator we offer an Interface Cable with
T-H T Wave Height striped ends, allowing you to complete the connection as
*Please contact Transonic for a more complete list desired (FC-EP-OPEN-5).
of parameters based upon specific analysis software
package being used. Considering these options, any commercially available
stimulator or biopotential amplifier can be used in conjunction
with a Scisense EP Catheter. Likewise, any data acquisition
system which is compatible with the stimulator/bioamplifier
may be used to collect and analyze data.
Please Contact Transonic or your nearest Sales Representative
for suggested third party systems.
Electrophysiology (EP) Catheters
Transonic Scisense offers a 1.1F octapolar (8 electrode) Catheter for use in mice and a 1.6F octapolar Catheter
for use in rats. These Catheters come with a standard ring spacing of 0.5 mm and 1.0 mm, respectively,
but can be customized to suit any specific application. Our octapolar EP Catheters offer advantages over
traditional surface ECG in that you can gain detailed information about the propagation and timing of atrial
and ventricular electrical signals. Up to 4 intracardiac electrograms can be recorded simultaneously. The same
Catheter can be used to pace the heart as well as record electrical activity.

SMOOTH PROFILE:
Reduces potential damage to endothelial lining during catheterization
Allows for easy passage through valves (can be inserted and withdrawn repeatedly)
Ability to pass through remodeled arteries

TUBING MATERIAL:
Provides ideal balance of flexibility and rigidity, ensuring easy insertion and maneuverability
Will not fray like many other Catheter materials which, over time, will irritate vascular lining and valves
Small diameter of tubing minimizes impact on aortic flow, resulting in more physiologic data

APPLICATIONS
Bundle of His characterization
SA node characterization
General signal propagation
Comparison between basal, medial
and apical regions in the left ventricle
Endocardial ECG assessment
Endocardial Electrogram recording from right ventricle Regional atrial assessment
(bipolar measurement from electrodes 7 and 8 at the apex)
Conduction studies
Qualification of cardiac insult

INSERTION & PLACEMENT

Right Jugular Vein insertion for
placement within the RA or RV
Right Carotid Artery insertion for
placement within the LV
Esophageal insertion for placement
beside the heart

Endocardial Electrogram recording from right atrium

(bipolar measurement from electrodes 7 and 8 at the valve)
 Electrophysiology

Electrophysiology Control Unit & Cables

ELECTROPHYSIOLOGY CATHETER INTERFACE BOX INTERFACE CABLE
The Scisense FI893B EP Catheter Interface Box is FC-EPEC-4 - Scisense Extension Cable for Octapolar
a simple device designed to connect a Scisense EP EP Catheter (Redel-Redel)
Catheter to any bioamplifier and/or stimulator.
The Interface Box has eight pin receptacles which
correspond to one of eight electrodes positioned
on the Catheter. A cable from the bioamplifier
and/or stimulator which terminates in a 3 mm pin
connection is then used to connect any single, pair,
or multiple electrodes for recording/stimulating.
Transonic carries a selection of third party
stimulators and amplifiers along with acquisition
hardware/software solutions to create a fully
functional cardiac biopotential setup for your
research lab.

OCTAPOLAR CATHETER SPECIFICATIONS

PARAMETER VALUE
0.010 or .254 mm wide
Electrode Dimensions (Mouse)
0.014 or 0.37 mm diameter
0.010 or 0.254 mm wide
Electrode Dimensions (Rat)
0.025 or 0.635 mm diameter
Electrode Material 80/20 Platinum/Iridium
Catheter Material Polyimide single lumen
Catheter Color Black
Catheter Length 18 or 457 mm
Connector Redel 8 pin. Pin 1= electrode 1

Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement

equipment. Founded in 1983, Transonic sells gold standard transit-time ultrasound
flowmeters and monitors for surgical, hemodialysis, pediatric critical care, perfusion,
interventional radiology and research applications. In addition, Transonic provides
www.transonic.com pressure and pressure volume systems, laser Doppler flowmeters and telemetry systems.

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